0. DOCID:31545 SCORE: 0.00373333309188603
DOCNO: 12957803
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Taxoids
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: analogs & derivatives
QUALIFIER: physiology
AUTHOR: Mario Campone M
AUTHOR: Jean-Louis Merlin JL
AUTHOR: Pierre Fumoleau P
AFFILIATION: Centre René-Gauducheau, boulevard Jacques-Monod, 44805 Saint-Herblain, France. m-capone@nantes.fnclcc.fr
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Bulletin du cancer.
COUNTRY: France
TITLE: [Role of the combination of trastuzumab and taxanes in the therapeutic management of cancer of the breast: from preclinical data to clinical application]
PUBDATE: 20030701
Taxanes are major drugs in the treatment of breast metastatic cancer. Since 1990, the mechanisms implicated in carcinogenesis are better understood and the oncoprotein HER2 is a potential target. Trastuzumab is a monoclonal antibody that binds to this transmembrane glycoprotein. This antibody demonstrated a significant activity in clinical trials. In this review, we discuss the preclinical (mechanisms of action) and clinical data with the combination of trastuzumab and taxanes.


1. DOCID:30771 SCORE: 0.00335490485907122
DOCNO: 11969233
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mass Screening
QUALIFIER: epidemiology
QUALIFIER: prevention & control
AUTHOR: Jean Faivre J
AUTHOR: Anne-Marie Bouvier AM
AUTHOR: Claire Bonithon-Kopp C
AFFILIATION: Faculté de Médecine Registre Associé, INSERM-InVS, EPI INSERM 0106, Dijon Cedex, 21079, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Best practice & research. Clinical gastroenterology.
COUNTRY: England
TITLE: Epidemiology and screening of colorectal cancer.
PUBDATE: 20020401
Knowledge of the descriptive epidemiology of colorectal cancer is essential to a better understanding of the aetiology of the disease and the development of screening strategies. Considerable research efforts have been launched over the last 15 years to evaluate the ability of screening tests to decrease the incidence and mortality of colorectal cancer. This chapter provides a worldwide update of the incidence of colorectal cancer and reviews the evidence for screening for colorectal cancer based on published studies.


2. DOCID:31696 SCORE: 0.00325730175275714
DOCNO: 12440206
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: etiology
QUALIFIER: complications
QUALIFIER: therapy
QUALIFIER: methods
AUTHOR: V S Zemskov VS
AUTHOR: Ia M Susak IaM
AUTHOR: I O Koval's'ka IO
AUTHOR: Ie R Deneka IeR
AUTHOR: O V Kravchenko OV
AUTHOR: Ie A Kriuchyna IeA
PUBTYPE: Journal Article
JOURNALTITLE: Klinichna khirurhiia / Ministerstvo okhorony zdorov'ia Ukraïny, Naukove tovarystvo khirurhiv Ukraïny.
COUNTRY: Ukraine
TITLE: [Ethanol injections in the integrated treatment of non-resectable malignant pancreatic tumor complicated by jaundice]
PUBDATE: 20020901
Results of treatment were analyzed in 28 patients with nonresectable pancreatic cancer (III-IV stages) complicated by jaundice, to whom in complex of treatment (biliodigestive shunting, in some of patients with hepatic dearterialyzation, gastroenterostomy, pancreatodigestive shunting) 96% ethanol was injected into the tumor. The complications frequency had constituted 21.4%, mortality--14.3%, the life span of operated patients--9 months at average. Sings of early and late "postethylizational" positive pancreatic cancer pathomorphosis were established.


3. DOCID:31154 SCORE: 0.00325577345275095
DOCNO: 16214043
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antineoplastic Agents
DESCRIPTOR: Drug Design
DESCRIPTOR: Interprofessional Relations
DESCRIPTOR: Research Personnel
QUALIFIER: organization & administration
QUALIFIER: methods
QUALIFIER: organization & administration
AUTHOR: George R P Blackledge GR
AFFILIATION: AstraZeneca Pharmaceuticals, Medical Oncology, Alderley House, Alderley Park, Macclesfield, Cheshire SK10 4TF, UK. george.blackledge@astrazeneca.com
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: European journal of cancer (Oxford, England : 1990)
COUNTRY: England
TITLE: The difficulties industry is facing with investigators.
PUBDATE: 20051001
The number of new agents being developed for the treatment of cancer has, over the past 10 years, increased dramatically which has resulted in increased interactions between the pharmaceutical industry that discover and develop most new agents and investigators in academic institutions, hospitals and office practices. This close interaction has inevitably led to a number of issues being identified on both sides and this paper will attempt to identify some of these and propose solutions.


4. DOCID:30452 SCORE: 0.00325567327538449
DOCNO: 14655157
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammary Glands, Human
DESCRIPTOR: Ultrasonography, Mammary
QUALIFIER: ultrasonography
QUALIFIER: ultrasonography
AUTHOR: Ryszard Maciejewski R
AUTHOR: Barbara Madej B
AUTHOR: Franciszek Burdan F
AUTHOR: Tadeusz Łoś T
AUTHOR: Elzbieta Radzikowska E
AUTHOR: Anna Wieczorkiewicz-Płaza A
AFFILIATION: Department of Human Anatomy, Medical University School of Lublin, Poland.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Folia morphologica.
COUNTRY: Poland
TITLE: Mammary gland anatomy and the role of mammography and ultrasonography in the early diagnostics of breast cancer. A case report.
PUBDATE: 20031101
Progress in imaging techniques has brought a solution to the problem of the early diagnosis of breast cancer. An interesting case of breast cancer is presented here, pictures of the malignant tumour are demonstrated and the usefulness of new diagnostic methods analysed. The presentation of this case may contribute to greater effectiveness in early breast cancer detection.


5. DOCID:31815 SCORE: 0.00320840756542339
DOCNO: 12525358
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genes, p53
QUALIFIER: drug therapy
QUALIFIER: genetics
AUTHOR: Jean Bénard J
AUTHOR: Jean-Charles Ahomadégbé JC
AFFILIATION: Unité de génétique tumorale, Service de génétique, Département de biologie clinique, Institut Gustave-Roussy, 94800 Villejuif, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Bulletin du cancer.
COUNTRY: France
TITLE: [p53 status and response to chemotherapy]
PUBDATE: 20021201
Numerous studies deal with "p53 status" in patients' tumors (mutated/wild gene status, protein level and functionality) to predict chemotherapy efficacy. Analyses of various cancers, especially breast cancers, lead to controversy that is apparent due to heterogeneity of their design. Recent data from literature lead now to consider i) the nature of chemotherapeutic agents and the regimen, ii) the cancer tissue type, and iii) the histological response of the primary. Molecular actors of senescence, cytostasis and apoptosis, which are responsible of cytotoxic response of cancer cells, are currently under elucidation.


6. DOCID:29454 SCORE: 0.0030049006801144
DOCNO: 14655109
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunotherapy
QUALIFIER: immunology
QUALIFIER: therapy
AUTHOR: Kamila Wojas K
AUTHOR: Jacek Tabarkiewicz J
AUTHOR: Jacek Roliński J
AFFILIATION: Department of Clinical Immunology, Medical University, Lublin, Poland. kamilawojas@poczta@onet.pl
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Folia morphologica.
COUNTRY: Poland
TITLE: Dendritic cells in cancer immunotherapy - a short review.
PUBDATE: 20031101
Dendritic cells (DCs) are rare leukocytes that are uniquely potent in their recent application to therapeutic cancer vaccines. Isolated DCs loaded with tumour antigen ex vivo and administered as a cellular vaccine have been found to induce protective and therapeutic anti-tumour immunity. In the present report we describe the most common methods of culturing DCs and delivering tumour antigens and we summarise clinical trials of cancer immunotherapy using DCs-based vaccines.


7. DOCID:29453 SCORE: 0.00300489801606242
DOCNO: 16304559
AUTHOR: R Newton R
AUTHOR: T Ribeiro T
AUTHOR: D Casabonne D
AUTHOR: E Alvarez E
AUTHOR: A Touzé A
AUTHOR: T Key T
AUTHOR: P Coursaget P
AFFILIATION: Epidemiology & Genetics Unit, Department of Health Sciences, Heslington, York, UK. Rob.newton@egu.york.ac.uk
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: England
TITLE: Antibody levels against BK virus and prostate, kidney and bladder cancers in the EPIC-Oxford cohort.
PUBDATE: 20051101
In a case-control study nested within the EPIC-Oxford cohort, there were no statistically significant differences in the prevalence or titre of antibodies against BK virus measured in plasma taken prior to diagnosis between cases with cancer of the prostate (n=31), kidney (n=5) or bladder (n=9) and controls (n=45).


8. DOCID:29434 SCORE: 0.00300489514582717
DOCNO: 14738401
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: isolation & purification
QUALIFIER: chemistry
QUALIFIER: isolation & purification
AUTHOR: Diaa T A Youssef DT
AFFILIATION: Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt. youssefdiaa@hotmail.com
PUBTYPE: Journal Article
JOURNALTITLE: Journal of natural products.
COUNTRY: United States
TITLE: Tasnemoxides A-C, new cytotoxic cyclic norsesterterpene peroxides from the Red Sea sponge Diacarnus erythraenus.
PUBDATE: 20040101
Tasnemoxides A-C (1-3), three new cytotoxic cyclic norsestertepene peroxides, were isolated from the Red Sea sponge Diacarnus erythraenus, together with the known compound sigmosceptrellin B (4). The structural determination of the isolated compounds was based on extensive 1D and 2D NMR studies and mass spectral determinations. Compounds 1-3 showed moderate cytotoxicity against three cancer cell lines.


9. DOCID:31478 SCORE: 0.00290963937053534
DOCNO: 16399449
OWNER: NLM
STATUS: In-Process
AUTHOR: Bernard J Cummings BJ
AFFILIATION: Department of Radiation Oncology, Princess Margaret Hospital/University of Toronto, Toronto, Ontario M5G 2M9, Canada. Bernard.Cummings@rmp.uhn.on.ca
PUBTYPE: Journal Article
JOURNALTITLE: Seminars in oncology.
COUNTRY: United States
TITLE: Current management of anal canal cancer.
PUBDATE: 20051201
Combined-modality therapy consisting of radiation therapy and 5-fluorouracil plus mitomycin remains the standard treatment for localized anal canal cancer, permitting preservation of organ function and achieving high response and survival rates. Current trials are evaluating the ability to deliver higher doses of radiation therapy over shorter intervals. Currently, the most common indication for radical surgery is failure of chemoradiation. Metastatic disease is less responsive to chemoradiation treatment. Neoadjuvant and adjuvant strategies are being evaluated, and additional drugs including capecitabine, irinotecan, and oxaliplatin are being assessed in treatment of localized and advanced disease.


10. DOCID:31032 SCORE: 0.00290946197121107
DOCNO: 16286898
OWNER: NLM
STATUS: In-Process
AUTHOR: Christian Morath C
AUTHOR: Vedat Schwenger V
AUTHOR: Jan Schmidt J
AUTHOR: Martin Zeier M
AFFILIATION: Department of Nephrology, University of Heidelberg, Heidelberg, Germany. christian_morath@med.uni-heidelberg.de
PUBTYPE: Journal Article
JOURNALTITLE: Transplantation.
COUNTRY: United States
TITLE: Transmission of malignancy with solid organ transplants.
PUBDATE: 20050901
Donor-derived malignancy is found in about 0.02-0.2% of allograft recipients. With an increasing number of older donors, this problem will gain more relevance in the future. We wish to review the current literature on tumor transmission with solid organ transplants and focus on the consequences of an extension of the donor pool, such as by the use of donors with a history of cancer. Finally, suggestions are made for screening regimens for living as well as cadaveric donors to minimize the risk of inadvertent tumor transmission.


11. DOCID:30903 SCORE: 0.00290940298119812
DOCNO: 16336852
OWNER: NLM
STATUS: In-Data-Review
AUTHOR: Niels T Kroman NT
AUTHOR: Øjvind Lidegaard Ø
AUTHOR: Marianne Ewertz Kvistgaard ME
AFFILIATION: Amtssygehuset i Herlev, Brystkirurgisk Afdeling F, Herlev. kroman@dadlnet.dk
PUBTYPE: Journal Article
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: Denmark
TITLE: [Is the rising incidence of breast cancer a consequence of lifestyle?]
PUBDATE: 20051201
The incidence of breast cancer in Denmark has increased about 2-3% every year in the past decades. In this review the established risk factors for the disease are presented and the changes over time in these factors are described. It is concluded that a large part of the rise in incidence can be explained by changes in established risk factors. The potential measures for prevention of the disease seem to be changes in birth patterns and and increased focus on obesity and alcohol use.


12. DOCID:30715 SCORE: 0.0029088980833283
DOCNO: 15688077
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: classification
QUALIFIER: pharmacokinetics
QUALIFIER: trends
AUTHOR: Vladimir P Torchilin VP
AFFILIATION: Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, USA. v.torchilin@neu.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nature reviews. Drug discovery.
COUNTRY: England
TITLE: Recent advances with liposomes as pharmaceutical carriers.
PUBDATE: 20050201
Liposomes - microscopic phospholipid bubbles with a bilayered membrane structure - have received a lot of attention during the past 30 years as pharmaceutical carriers of great potential. More recently, many new developments have been seen in the area of liposomal drugs - from clinically approved products to new experimental applications, with gene delivery and cancer therapy still being the principal areas of interest. For further successful development of this field, promising trends must be identified and exploited, albeit with a clear understanding of the limitations of these approaches.


13. DOCID:29553 SCORE: 0.00289366668165762
DOCNO: 15320364
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: pharmacology
QUALIFIER: trends
QUALIFIER: pharmacology
QUALIFIER: trends
AUTHOR: Ena Segota E
AUTHOR: Ronald M Bukowski RM
AFFILIATION: Taussig Cancer Center, Cleveland Clinic Foundation, OH 44195, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cleveland Clinic journal of medicine.
COUNTRY: United States
TITLE: The promise of targeted therapy: cancer drugs become more specific.
PUBDATE: 20040701
Toxic chemotherapeutic agents are slowly being supplemented by a new generation of drugs that recognize specific targets in or on cancer cells. Although these molecular and genetic approaches are in their infancy, they hold the promise of more effective therapies with markedly fewer side effects. Several targeted agents are already approved by the US Food and Drug Administration (FDA) for use in malignancies, and numerous others are in clinical trials.


14. DOCID:29344 SCORE: 0.0028530336917239
DOCNO: 15753655
OWNER: NLM
STATUS: In-Process
AUTHOR: Paola Marcato P
AUTHOR: Maya Shmulevitz M
AUTHOR: Patrick W Lee PW
AFFILIATION: Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada.
PUBTYPE: Journal Article
JOURNALTITLE: Cell cycle (Georgetown, Tex.)
COUNTRY: United States
TITLE: Connecting reovirus oncolysis and Ras signaling.
PUBDATE: 20050401
Reovirus is a benign virus with innate oncolytic activity and is a potential novel therapeutic for a number of cancers. Reovirus can replicate in, and induce death of cancerous cells having an activated Ras pathway. Ras activation leads to the inactivation of cellular antiviral mechanisms, specifically removing the translation block on reovirus transcripts. This review outlines recent progress towards elucidating the molecular connection between the Ras-signaling pathway and reovirus replication.