0. DOCID:14645 SCORE: 0.00389758277713238
DOCNO: 3622436
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Teratogens
QUALIFIER: methods
QUALIFIER: drug effects
AUTHOR: K E Whitby KE
PUBTYPE: Journal Article
JOURNALTITLE: Environmental health perspectives.
COUNTRY: UNITED STATES
TITLE: Teratological research using in vitro systems. III. Embryonic organs in culture.
PUBDATE: 19870601
A search of literature published through the spring of 1986 yielded approximately 95 citations for the following embryonic organs in culture: kidney, pancreas, skin, palate, craniofacial tissue, tooth, lens, bones, digits, and liver. However, only the in vitro organ culture of the palate and tooth are reviewed in this paper. The other organ culture systems were not reported as teratogenic screens. Although some organs may have the potential for such use, many are currently used for evaluation of the pathogenesis associated with congenital abnormalities, cancer, or transplacental carcinogenesis, or in studies of the structure and function of differentiating organs, and will not be included in this review.


1. DOCID:15120 SCORE: 0.0038147290456901
DOCNO: 3586341
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: rehabilitation
QUALIFIER: rehabilitation
AUTHOR: T Hirai T
AUTHOR: S Aratani S
AUTHOR: K Yoshinaka K
AUTHOR: T Toge T
AUTHOR: M Niimoto M
AUTHOR: T Hattori T
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Clinical studies on the complaints of survivors living more than 3 months after total gastrectomy]
PUBDATE: 19870301
From 1973 to 1983, 802 patients with gastric cancer were operated on. Out of them, 292 (36.4%) received total gastrectomy. Reconstruction was performed mainly by the Billroth II procedure associated with the closure of the afferent loop according to Plenk's method. 90 patients living more than 3 months complained of the following: heartburn, 18 (20%); reflux, 12 (13.3%); retrosternal pain, 3 (3.3%); stenotic sensation, 23 (25.6%); diarrhea, 10 (11.1%); abdominal pain, 14 (15.6%); and dumping syndrome, 6 (6.7%). It seems to indicate that the quality of life after total gastrectomy is satisfactory.


2. DOCID:15985 SCORE: 0.00380962397832128
DOCNO: 3811915
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: secondary
QUALIFIER: secondary
QUALIFIER: pathology
AUTHOR: I Matsumoto I
AUTHOR: M Furusato M
AUTHOR: I Inomata I
AUTHOR: T Wada T
AUTHOR: S Aizawa S
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Acta pathologica japonica.
COUNTRY: JAPAN
TITLE: Prostatic cancer presenting as metastatic adenocarcinoma of sphenoid sinus.
PUBDATE: 19861101
Prostatic cancer is commonly manifested by obstructive uropathy, regional lymphatic metastases, and hematogenous metastases to the axial skeleton. It is relatively rare that initial signs begin with the involvement of other sites. Intracranial metastases especially are seldom found and may be unfamiliar to not only pathologists but also to physicians. In this article, we present a case where the metastasis was first manifest as a sphenoid sinus tumor prior to the demonstration of the primary site and the prostate was confirmed to be primary by biopsy specimen with immunoperoxidase method. In addition to discussing the route of the tumor spread, we deal with a prostatic specific antigen efficient for identifying the primary site.


3. DOCID:15574 SCORE: 0.00371765808412823
DOCNO: 2815391
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: P C Gøtzsche PC
PUBTYPE: Journal Article
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: DENMARK
TITLE: [Attitudes of medical students to randomization or free choice in breast cancer surgery and a suggestion for a new study design]
PUBDATE: 19891001
Six research models for breast cancer surgery were presented and debated in a two hour lecture to second year medical students. Half of the students (38/68) preferred a model which offered the woman the opportunity of choosing between tumorectomy and mastectomy after preceding randomization; one fourth preferred free choice without randomization. Descriptive ethical studies in the population after previous detailed information seem necessary to elucidate which research models the population are willing to accept as potential patients. In trials of therapies where the patients may be assumed to have individual preferences, a design is proposed with free choice between alternatives and secondary randomization among those who are unable to decide.


4. DOCID:15512 SCORE: 0.00371763494528783
DOCNO: 2900800
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genes, ras
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: K Honda K
AUTHOR: K Ishizaki K
AUTHOR: M Ikenaga M
AUTHOR: J Toguchida J
AUTHOR: T Inamoto T
AUTHOR: K Tanaka K
AUTHOR: K Ozawa K
AFFILIATION: Second Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Human genetics.
COUNTRY: GERMANY, WEST
TITLE: Increased frequency of specific alleles of the c-Ha-ras gene in Japanese cancer patients.
PUBDATE: 19880801
We have examined the c-Ha-ras locus in 145 cancer patients of a mixed group and 164 normal individuals in Japan for restriction fragment length polymorphisms and compared the allele distributions in normal and cancer populations. The c-Ha-ras gene is highly polymorphic in Japanese as previously reported in Caucasians. Two rare alleles were found to be present with increased frequencies in Japanese cancer patients. These results suggest that genotype analysis of the c-Ha-ras gene could be used to detect cancer-prone individuals.


5. DOCID:14051 SCORE: 0.00359722222544183
DOCNO: 2424586
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Kidney Transplantation
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: A W Osiason AW
AUTHOR: R J Polackwich RJ
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Curative, platinum-based cytoxic drug therapy in a renal transplant recipient with metastatic testicular cancer.
PUBDATE: 19860801
Since June 1979, the authors have had the opportunity to treat a renal homograph recipient who developed primary embryonal cell testicular carcinoma with retroperitoneal and pulmonary metastases. This patient was treated with an induction chemotherapy protocol of vinblastine sulfate, bleomycin, and cisplatin and has remained free of disease through June 1985, without loss of his renal homograph. Cisplatin-based cytoxic drug therapy can be delivered safely to a renal transplant recipient without causing kidney damage, and, in this case, achieved a cure of metastatic testicular cancer.


6. DOCID:14156 SCORE: 0.00347605107726226
DOCNO: 3376370
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: radiotherapy
AUTHOR: H Sommerkamp H
AUTHOR: M Rupprecht M
AUTHOR: G Bruggmoser G
AUTHOR: M Wannenmacher M
AFFILIATION: Abteilung für Urologie, Klinikum der Universität Freiburg.
PUBTYPE: Journal Article
JOURNALTITLE: Der Urologe. Ausg. A.
COUNTRY: GERMANY, WEST
TITLE: [Determinants of local tumor control in interstitial radiotherapy of prostatic cancer]
PUBDATE: 19880301
Clinical followup of 52 patients treated with I-125 implants for localized prostatic cancer demonstrated local control in 85% and failure in 15%. Determining factors for local control or failure were analyzed and underline that homogeneous dose distribution is the most important factor for local control in interstitial radiotherapy. With the use of I-125 seeds this can only be achieved in small-volume (T2) stages with refined technique. For larger tumor volumes (T3) an external boost or the use of other radionuclides is preferable.


7. DOCID:15969 SCORE: 0.00347414621745511
DOCNO: 3341110
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Magnetic Resonance Imaging
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: S T Houston ST
AUTHOR: L W Jones LW
AUTHOR: V Waluch V
AFFILIATION: Department of Urology, Montefiore Medical Center, Bronx, New York.
PUBTYPE: Journal Article
JOURNALTITLE: Urology.
COUNTRY: UNITED STATES
TITLE: Nuclear magnetic resonance imaging in detecting and staging prostatic cancer.
PUBDATE: 19880201
Thirteen patients were examined for grade, stage, and extent of their prostatic cancer, utilizing nuclear magnetic resonance imaging (MRI) and clinical workup for metastases. Of these 13 patients, 12 had known prostatic cancer proved by needle biopsy or by pathologic examination of transurethral prostatectomy tissue. Five of these patients underwent radical surgery allowing further correlation of clinical findings and MRI data with the surgical pathologic findings. MRI of the prostate was found to be a sensitive modality in detecting prostatic carcinoma and showing extension of disease in some cases. Also, in some cases it was not always possible to differentiate between prostatic carcinoma and benign prostatic hyperplasia with MRI.


8. DOCID:15043 SCORE: 0.00334603097774451
DOCNO: 3540811
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Child Psychology
DESCRIPTOR: Family Characteristics
DESCRIPTOR: Personality
QUALIFIER: psychology
AUTHOR: J V Lavigne JV
AUTHOR: M J Schulein MJ
AUTHOR: Y S Hahn YS
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Pain.
COUNTRY: NETHERLANDS
TITLE: Psychological aspects of painful medical conditions in children. II. Personality factors, family characteristics and treatment.
PUBDATE: 19861101
In part II of a two-part series, the psychological aspects of painful medical conditions and their treatment are reviewed. While considerable attention has been devoted to the study of personality, family characteristics, treatment of recurrent abdominal pain, growing pains and headaches, with few exceptions these studies have significant methodological problems. Studies of the psychological aspects of pain associated with such pediatric disorders as cancer, sickle cell anemia, juvenile rheumatoid arthritis, and burns are generally only beginning to emerge, but at least a few of the single-case studies show appropriate attention to methodology. Areas needing further research are discussed.


9. DOCID:15747 SCORE: 0.00328074027602757
DOCNO: 3959337
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: K Namatame K
AUTHOR: M Ookubo M
AUTHOR: K Suzuki K
AUTHOR: H Sagawa H
AUTHOR: T Nagashima T
AUTHOR: Y Kataba Y
AUTHOR: U Maruyama U
AUTHOR: H Watanabe H
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [A clinicopathological study of five cases of adenosquamous carcinoma of the stomach]
PUBDATE: 19860201
Five cases of adenosquamous carcinoma with resected stomach were subjected to this study, and the clinicopathological characteristics of this condition were described. The five patients represented 0.8% of 589 cases of resected stomach. There were two men and three women ranging in age from 40 to 70 (average, 62.8). Macroscopically, the adenosquamous carcinomas were all advanced gastric cancer situated in the lower body along the lesser curvature of the stomach, averaging 7.6 cm in size. The characteristic finding was the histologically differentiated type, invading to the serosa. Lymph node metastasis was most prominent.


10. DOCID:15307 SCORE: 0.00317904041409932
DOCNO: 3094119
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Diathermy
DESCRIPTOR: Short-Wave Therapy
QUALIFIER: therapy
AUTHOR: A Okuma A
AUTHOR: H Terashima H
AUTHOR: Y Torii Y
AUTHOR: H Nakata H
AUTHOR: H Inatomi H
PUBTYPE: Journal Article
JOURNALTITLE: Journal of UOEH.
COUNTRY: JAPAN
TITLE: [Radiation therapy combined with hyperthermia in advanced cancer]
PUBDATE: 19860901
Radiation therapy combined with radiofrequency (RF) hyperthermia was performed on 5 advanced cancer patients. Included were one each with urinary bladder cancer, hepatoma with left axillary node metastasis, breast cancer, tongue cancer with left cervical metastasis, and mandibular cancer. All had large tumours, which were judged to be uncontrollable by radiotherapy alone. They were treated with irradiation (Linac: 10 MV X-ray 1.8-2.0 Gy/day, 5 days/week), followed within an hour by RF hyperthermia once or twice a week. Partial response was obtained in the urinary bladder cancer patient. Surface overheating around the margin of electrodes occurred in all but no severe complications were observed.


11. DOCID:15433 SCORE: 0.00316510660120275
DOCNO: 3678014
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug effects
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: enzymology
QUALIFIER: pharmacology
AUTHOR: X M Xia XM
AUTHOR: S Y Yu SY
AFFILIATION: Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua zhong liu za zhi [Chinese journal of oncology].
COUNTRY: CHINA
TITLE: [Mechanism of the anticancer action of selenium--influence on glycolysis and its key enzyme]
PUBDATE: 19870701
The aerobic glycolysis rate and mitochondria-bound hexokinase activity of ascitic liver cancer cells are 8 and 50 times as high as those of the normal liver cells, and they can be inhibited by Na2SeO3 in concentration below 10 micrograms/ml. The inhibitory effect increases with selenium concentration. In contrast, Na2SeO3 at the same concentration does not significantly affect the glycolysis rate and mitochondria-bound hexokinase activity of the normal liver cells. The selective action of selenium on energy metabolism of the liver cancer cells may account for its inhibitory effect on cancer cells.


12. DOCID:13642 SCORE: 0.00309860411903208
DOCNO: 3570803
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Background Radiation
DESCRIPTOR: Radiation, Ionizing
QUALIFIER: epidemiology
AUTHOR: K S Nambi KS
AUTHOR: S D Soman SD
PUBTYPE: Journal Article
JOURNALTITLE: Health physics.
COUNTRY: UNITED STATES
TITLE: Environmental radiation and cancer in India.
PUBDATE: 19870501
The hormesis hypothesis, which suggests that ecologically realistic low levels of ionising radiations may be beneficial to humans, seems to be substantiated significantly by the data available on cancer incidence/mortality rates and environmental radiation levels in various cities and states of India. Where the radiation level is greater, cancer risk is invariably less. The annual cancer incidence rate (per 100,000 population) seems to decrease by 0.03/microSv increase in the external background radiation dose from a hypothetical incidence level of 79 per 100,000 corresponding to "zero environmental radiation".


13. DOCID:12741 SCORE: 0.00299753769218766
DOCNO: 3135421
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: J M Patterson JM
AUTHOR: E H Ray EH
AUTHOR: O A Mendiondo OA
AUTHOR: W D Medina WD
AUTHOR: W F Gee WF
AFFILIATION: Department of Urology, Lexington Clinic, Kentucky 40504.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: A new treatment for invasive squamous cell bladder cancer: the Nigro regimen: preoperative chemotherapy and radiation therapy.
PUBDATE: 19880801
We report 5 cases of invasive squamous cell bladder cancer treated with preoperative mitomycin C and 5-fluorouracil in combination with preoperative external beam radiation therapy (the Nigro regimen), and the subsequent apparent cure of 3 of the 5 patients.


14. DOCID:15291 SCORE: 0.00296014874470349
DOCNO: 3548958
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Blood
QUALIFIER: therapy
QUALIFIER: therapeutic use
AUTHOR: G J Ventura GJ
AUTHOR: A U Buzdar AU
AUTHOR: S Kau S
AUTHOR: B Lichtiger B
AUTHOR: G N Hortobagyi GN
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Cancer treatment reports.
COUNTRY: UNITED STATES
TITLE: Clinical trial of plasma perfusion over immobilized staphylococcal protein A in metastatic breast cancer.
PUBDATE: 19870401
Nineteen patients with metastatic breast cancer refractory to conventional therapy were treated with plasma perfusion over 200 mg of staphylococcal Protein A immobilized on a silica matrix. Fever and chills (33%), pain at the site of tumor (18%), and dyspnea (16%) were the most frequent toxic effects encountered. Four patients (21%) developed a disseminated rash which necessitated cessation of treatment. Of 16 patients evaluable for response, one achieved a minor response of chest wall disease and two had no change in hepatic metastases for 4 and 5 months' duration. Potential mechanisms of antitumor effect are discussed.