0. DOCID:10778 SCORE: 0.00439433607982996
DOCNO: 7201343
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
AUTHOR: M S Blumenreich MS
AUTHOR: B Needles B
AUTHOR: A Yagoda A
AUTHOR: P Sogani P
AUTHOR: H Grabstald H
AUTHOR: W F Whitmore WF
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Intravesical cisplatin for superficial bladder tumors.
PUBDATE: 19820901
Cisplatin, 50-150 mg in a maximum concentration of 1 mg/ml, was administered intravesically each week to 24 patients with multiple, recurrent carcinoma in situ and/or bladder tumors confined to the mucosa and lamina propria. All patients had a history of multiple transurethral resections and four had received prior chemotherapy. Response was evaluated by urinary cytology, cystoscopy, and biopsy. In a total of 237 weekly doses, toxicities included mild dysuria, pruritus, rash and in one patient, acute anaphylaxis. Only three (13%) patients were classified as achieving complete remission. Cisplatin, in the dose and schedule employed, is ineffective in controlling superficial bladder cancer.

1. DOCID:10065 SCORE: 0.00391395032104526
DOCNO: 6833019
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Brachytherapy
QUALIFIER: radiotherapy
AUTHOR: B van der Werf-Messing B
AUTHOR: R S Menon RS
AUTHOR: W C Hop WC
PUBTYPE: Journal Article
JOURNALTITLE: International journal of radiation oncology, biology, physics.
COUNTRY: UNITED STATES
TITLE: Carcinoma of the urinary bladder category T3NxMo treated by the combination of radium implant and external irradiation: second report.
PUBDATE: 19830201
Forty-one patients with bladder cancer, T3NxMo, with a diameter not exceeding 5 cm, were treated by 3 times 350 rad external irradiation, radium implant at reduced dose, and an additional 3000 rad external irradiation ("Radium 55%"). Survival is excellent where there is a high or medium degree of differentiation without vascular invasion in the biopsy specimen; prognosis is poor if a low degree of differentiation is combined with vascular invasion. The future therapeutic approach will be adapted to this finding.

2. DOCID:11344 SCORE: 0.00381013428084233
DOCNO: 3971331
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Diploidy
QUALIFIER: genetics
AUTHOR: S R Wolman SR
AUTHOR: H S Smith HS
AUTHOR: M Stampfer M
AUTHOR: A J Hackett AJ
PUBTYPE: Journal Article
JOURNALTITLE: Cancer genetics and cytogenetics.
COUNTRY: UNITED STATES
TITLE: Growth of diploid cells from breast cancers.
PUBDATE: 19850301
Cell cultures were derived from normal and cancerous breast tissues and from metastases by methods that selected for relatively adherent epithelial aggregates. Karyotypic analyses of first or second passage cultures yielded predominantly normal diploid cells. Nonclonal aberrations were more common in tumor-derived than in normal cultures. Three of the cultures that originated from metastases were characterized by abnormal clones. These results support observations based on DNA content, which indicate that a considerable fraction of breast cancers are composed predominantly of diploid cells. They differ greatly from chromosomal findings in long-term cultures of tumor effusions and thus emphasize the karyotypic diversity that can be found in tumors from a single tissue of origin--the breast.

3. DOCID:11183 SCORE: 0.0037303329361322
DOCNO: 7105515
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammography
QUALIFIER: radiography
AUTHOR: M J Homer MJ
PUBTYPE: Journal Article
JOURNALTITLE: Clinical obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Mammographic detection of breast cancer.
PUBDATE: 19820601
Mammography, whether film or xerography, is a complementary examination to breast palpation in the detection of breast cancer. According to the guidelines of the American Cancer Society, mammography should be performed on every asymptomatic woman, at least once, over the age of 35. Annual mammography after 50 is also advised. The radiation dose to the breast from current equipment is so low as to not be considered a factor in denying a woman this screening examination. Mammography has a role in evaluating the woman with solitary and multiple breast masses. It is the only proved reliable modality able to detect nonpalpable breast cancers and small tumors less than 2 cm in size. All nonpalpable lesions should be excised by directed biopsy, using a preoperative localization technique.

4. DOCID:11340 SCORE: 0.00356301466555595
DOCNO: 3919928
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: standards
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
QUALIFIER: standards
QUALIFIER: radiotherapy
AUTHOR: G E Hanks GE
AUTHOR: J J Diamond JJ
AUTHOR: S Kramer S
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: The need for complex technology in radiation oncology. Correlations of facility characteristics and structure with outcome.
PUBDATE: 19850501
The Patterns of Care Study data are used to correlate therapy equipment and practice characteristics with outcome, using Hodgkin's disease, prostate cancer, and cervix cancer as examples. The shift to linear accelerators and higher photon energy is supported, as is the increased use of treatment simulators. Part-time practitioners of radiation therapy and facilities whose only equipment is a less-than-80-cm cobalt unit have poor technical support and exhibit poor staging, poor achievement of minimum tumor dose, and poor patient follow-up as compared to the national average or best-performing strata of practice. These facilities should either upgrade their equipment, technical support, and level of practice or close.

5. DOCID:10719 SCORE: 0.00348926601918554
DOCNO: 6415310
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antineoplastic Combined Chemotherapy Protocols
QUALIFIER: pharmacology
AUTHOR: M Ogawa M
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Current clinical status of new anticancer drugs]
PUBDATE: 19830801
4'-Epiadriamycin demonstrated considerable efficacies in lymphomas, breast cancer and soft part sarcomas with reduced gastrointestinal, hematologic and probably cardiac toxicities. Mitoxantrone appears to be established the clinical role in lymphomas, acute leukemia and breast cancer with mild clinical toxicities. A new analogous compound of cisplatinum CBDCA concluded phase I study and the dose limiting factor was thrombocytopenia. It is of interest that the drug had responders in ovarian cancer during phase I study. The results reported in new anthracyclines; marcellomycin, carminomycin and 4-demethoxydaunorubicin, anthraquinones; ametantrone and bisantrene, new cisplatinums; CHIP, DACCP and TNO-6, and various other drugs including mAMSA, 5'-DFUR, spirogermanium, VP-16-213 and AZQ were reviewed.

6. DOCID:10713 SCORE: 0.0034892620786624
DOCNO: 7092542
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Colonoscopy
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: J S Abrams JS
PUBTYPE: Journal Article
JOURNALTITLE: Archives of surgery (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: A second look at colonoscopy: indications, failures, and costs.
PUBDATE: 19820701
Results of colonoscopy and colonoscopic polypectomy in 599 patients have been reviewed. Added experience has not decreased the number of failures--failure to examine the entire colon, polyps not retrieved for histological examination ("lost polyps"), undetected ("missed") lesions, and false-negative biopsy specimens. The incidence of invasive carcinoma in polyps measuring under 1 cm is less than 1%; polypectomy should be reserved for larger lesions or demonstrated growth of small polyps. Diagnostic colonoscopy in selected patients (those with persistent gross or occult rectal bleeding but normal results from sigmoidoscopic and barium enema studies) demonstrates a causative lesion in greater than 25% and detects a cancer in 5% to 10% of patients.

7. DOCID:11386 SCORE: 0.00333811967831961
DOCNO: 6669094
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: G Zajicek G
PUBTYPE: Journal Article
JOURNALTITLE: Medical hypotheses.
COUNTRY: ENGLAND
TITLE: On the improving chances of the cancer patient.
PUBDATE: 19831201
The cancer hazard rate (or force of mortality) of all cancer survival curves of the 4th Report on End Results in Cancer, continuously declines. This pattern recurs also in breast cancer patients refusing treatment. The declining hazard rate is most conspicuous in Cancer and much less pronounced in other chronic diseases. In most of them the hazard rate actually increases. Such is obvious in any actuarial life table, in which the rising pattern represents aging and will therefore be denominated herewith as Aging pattern. It accompanies also many chronic diseases e.g. diabetes, following operation for peptic ulcer, young survivors from coronary occlusion, or cirrhosis. The cancer hazard rate exhibits a trend observable during regeneration and is viewed here to reflect a regenerative process operating in cancer which is ascribed to Neoplasia.

8. DOCID:9625 SCORE: 0.00324047149851002
DOCNO: 6694919
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: administration & dosage
QUALIFIER: physiopathology
QUALIFIER: therapy
AUTHOR: L Taddeini L
AUTHOR: J C Rotschafer JC
PUBTYPE: Journal Article
JOURNALTITLE: Postgraduate medicine.
COUNTRY: UNITED STATES
TITLE: Pain syndromes associated with cancer. Achieving effective relief.
PUBDATE: 19840101
Pain occurs frequently in patients with cancer and, if uncontrolled, may lead to depression, deep anxiety, insomnia, and progressive mental and physical deterioration. Pain can be effectively relieved in the majority of cases by balanced use of pharmacologic agents and other treatment modalities, including surgery, chemotherapy, and radiation therapy. A thorough evaluation of the patient's complaints and an accurate diagnosis of the causes and mechanism of pain are mandatory for the formulation of an effective and individualized treatment plan. Continuing emotional support is essential to the relief of suffering in patient and family.

9. DOCID:10261 SCORE: 0.00300299830676562
DOCNO: 6656681
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: adverse effects
QUALIFIER: etiology
AUTHOR: T M Ong TM
AUTHOR: W Z Whong WZ
AUTHOR: R G Ames RG
PUBTYPE: Journal Article
JOURNALTITLE: Medical hypotheses.
COUNTRY: ENGLAND
TITLE: Gastric cancer in coal miners: an hypothesis of coal mine dust causation.
PUBDATE: 19831001
An hypothesis is proposed to explain the elevated incidence of gastric cancer among coal miners. Inhaled coal mine dust, especially the larger particles, is cleared from the lung and tracheobronchial tree by mucociliary function, swallowed, and introduced into the stomach. Organic and/or inorganic materials in the dust can undergo intra-gastric nitrosation and/or interaction with exogenous chemicals to form carcinogenic compounds which in turn may lead to precancerous lesions, which may subsequently develop into gastric cancer. This sequence of events, however, depends upon occupational exposures as well as life-style features and individual genetic predisposition.

10. DOCID:10204 SCORE: 0.00300297080204108
DOCNO: 6513004
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: K Sakai K
AUTHOR: H Sueyama H
AUTHOR: M Saito M
AUTHOR: T Kitamura T
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Multiple primary cancers in patients with malignant lymphoma]
PUBDATE: 19840901
This study of 502 patients with malignant lymphoma revealed the following: In all, 18 cases (3.6%) of histologically confirmed multiple primary cancers were found. Eleven cases of second malignancies were observed after diagnosis of malignant lymphoma, whereas 7 cases of malignant lymphoma occurred after other malignancies. The expected number of second malignancies in 502 patients with malignant lymphoma was calculated as 4.94 by the person-years approach. The observed number (11) was significantly higher than the expected (p less than 0.01). There was, however, no case of second malignancy considered to be related to the previous radiotherapy.

11. DOCID:11688 SCORE: 0.00299805230617835
DOCNO: 6585580
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: S Watanabe S
AUTHOR: T Kodama T
AUTHOR: Y Shimosato Y
AUTHOR: H Arimoto H
AUTHOR: T Sugimura T
AUTHOR: K Suemasu K
AUTHOR: M Shiraishi M
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Multiple primary cancers in 5,456 autopsy cases in the National Cancer Center of Japan.
PUBDATE: 19840501
Multiple primary malignant neoplasms in 5,456 consecutive autopsy cases from 1962 to 1981 in the National Cancer Center were analyzed. There were 285 (5.2%) double primary cancers, 58 (1.1%) triple or more, and 65 (1.2%) minute cancers of the thyroid or prostate gland. Higher incidence of second cancer is observed in cancers of the oropharynx, intestine, larynx, uterus, bladder, and thyroid. Organ association between the two cancers was present in certain organs; for example, there was a tendency for upper gastrointestinal tract cancers to be associated with lower gastrointestinal tract cancers. Influence of histologic subtypes in multiple cancer cases is discussed for lung cancer.

12. DOCID:8581 SCORE: 0.00286985302965751
DOCNO: 7142471
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: K M Halprin KM
AUTHOR: M Comerford M
AUTHOR: J R Taylor JR
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the American Academy of Dermatology.
COUNTRY: UNITED STATES
TITLE: Cancer in patients with psoriasis.
PUBDATE: 19821101
In a study of 150 non-PUVA-treated patients with psoriasis matched against a control group of patients with diabetes, the incidence of skin cancer in the psoriasis group was 1.96/yr, which was three times that of the diabetes patients. This figure is statistically significant. The prevalence of internal cancer was only half that of the patients with diabetes. This figure, however, is not significant.

13. DOCID:9223 SCORE: 0.00280388319832417
DOCNO: 3839573
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: instrumentation
QUALIFIER: drug therapy
AUTHOR: E A Obbens EA
AUTHOR: M E Leavens ME
AUTHOR: J W Beal JW
AUTHOR: Y Y Lee YY
PUBTYPE: Journal Article
JOURNALTITLE: Neurology.
COUNTRY: UNITED STATES
TITLE: Ommaya reservoirs in 387 cancer patients: a 15-year experience.
PUBDATE: 19850901
We reviewed records of 387 patients with cancer who had Ommaya reservoirs placed between October 1967 and December 1982. Complications of reservoir placement were reported in 27 patients, including intracranial hemorrhage (5 patients) and reservoir malfunction (15 patients). In 15 of 19 patients with meningitis, the infection was linked to the reservoir. The organism most frequently implicated was Staphylococcus epidermidis. Seizures, leukoencephalopathy, and pericatheter necrosis were seen in 10 patients who had received intraventricular chemotherapy.

14. DOCID:11475 SCORE: 0.00279740307878761
DOCNO: 6683644
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: M Beer M
AUTHOR: G Cocconi G
AUTHOR: G Ceci G
AUTHOR: M Varini M
AUTHOR: F Cavalli F
PUBTYPE: Journal Article
JOURNALTITLE: European journal of cancer & clinical oncology.
COUNTRY: ENGLAND
TITLE: A phase II study of cisplatin in advanced gastric cancer.
PUBDATE: 19830601
Twenty patients with recurrent or metastatic gastric adenocarcinoma and prior chemotherapy were treated with cisplatin, 60-120 mg/m2 as a 6-hr infusion repeated every 3 weeks. There were 4 partial responses in 18 evaluable patients. Seven patients had stable disease. Time to progression ranged from 6 to 28 weeks. Median WBC nadir was 3.2 X 10(3)/mm3 (range, 1.5-7.1) and platelet nadir 120 X 10(3)/mm3 (range, 13-220). A transient increase in serum creatinine was observed in 6 cases, and nausea and vomiting in all. We conclude that this drug is active in stomach cancer and that it warrants further trials in combination chemotherapy.