0. DOCID:23258 SCORE: 0.00489581994529001
DOCNO: 7497468
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: analogs & derivatives
QUALIFIER: chemistry
AUTHOR: D Nakae D
AUTHOR: Y Mizumoto Y
AUTHOR: E Kobayashi E
AUTHOR: O Noguchi O
AUTHOR: Y Konishi Y
AFFILIATION: Department of Oncological Pathology, Nara Medical University, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer letters.
COUNTRY: IRELAND
TITLE: Improved genomic/nuclear DNA extraction for 8-hydroxydeoxyguanosine analysis of small amounts of rat liver tissue.
PUBDATE: 19951101
Using two different commercially available extraction kits, genomic/nuclear DNA could be recovered from rat liver samples as small as 10 mg. Background 8-hydroxydeoxyguanosine levels in such DNA were low and stable at 0.26-0.30 +/- 0.01-0.03/10(5) guanine residues. The minimum tissue wet weight required for the accurate 8-hydroxydeoxyguanosine analysis was 25 mg. The present results indicate that routine and reliable assessment of the involvement of oxidative DNA damage in the development of various diseases, including cancer, is feasible using a variety of tissue sources.


1. DOCID:23870 SCORE: 0.00449690246118673
DOCNO: 7816410
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Breast Self-Examination
QUALIFIER: diagnosis
AUTHOR: W H Hindle WH
AFFILIATION: Department of Obstetrics and Gynecology, University of Southern California, Los Angeles.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Obstetrics and gynecology clinics of North America.
COUNTRY: UNITED STATES
TITLE: The diagnostic evaluation.
PUBDATE: 19940901
Breast symptoms are appropriately evaluated by a breast-oriented history and by the diagnostic triad of clinical breast examination, FNA, and mammography. In the case of a palpable dominant mass, concordance of the diagnostic triad yields a reliable clinical diagnosis. If there is not concordance, or if there is any doubt about the diagnosis either on the part of the physician or the patient, open surgical biopsy provides the definitive histologic diagnosis. The goal in clinical practice is to detect nonpalpable cancers by ordering screening mammography for all patients eligible by age, history, or both. The long-term cancer-free survival of women treated for nonpalpable breast cancer is excellent.


2. DOCID:19930 SCORE: 0.00442590954186466
DOCNO: 2305043
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Models, Statistical
QUALIFIER: epidemiology
QUALIFIER: adverse effects
QUALIFIER: epidemiology
AUTHOR: S A Feig SA
AUTHOR: S M Ehrlich SM
AFFILIATION: Department of Radiology, Jefferson Medical College and Thomas Jefferson University Hospital, Philadelphia, PA 19107.
PUBTYPE: Journal Article
JOURNALTITLE: Radiology.
COUNTRY: UNITED STATES
TITLE: Estimation of radiation risk from screening mammography: recent trends and comparison with expected benefits.
PUBDATE: 19900301
On the basis of recent epidemiologic studies, the National Institutes of Health in 1985 provided a new estimate for radiation risk to the breast that employed a relative risk model and acknowledged greater dependence on age at exposure. Lifetime risks from a single mammogram may be calculated from this estimate and are lower than those based on the previous 1977 National Cancer Institute estimate. Possible years of life expectancy lost from annual mammography beginning at age 40 years may also be calculated and are negligible compared with estimates for years of life expectancy gained from such screening.


3. DOCID:18521 SCORE: 0.00441562281213178
DOCNO: 2084339
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemically induced
QUALIFIER: therapeutic use
QUALIFIER: adverse effects
QUALIFIER: chemically induced
QUALIFIER: drug therapy
AUTHOR: E V Gembitskiĭ EV
AUTHOR: A S Portnoĭ AS
AUTHOR: A V Begunov AV
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Klinicheskaia meditsina.
COUNTRY: USSR
TITLE: [Diagnosis and therapeutic correction of changes in the cardiovascular system of patients with prostatic cancer treated with estrogens]
PUBDATE: 19901201
Estrogen-related cardiovascular dysfunction was noted in 23 out of 30 patients with prostatic cancer (PC). Coronary subjects with PC suffered from cardiac pain evident on ECG necessitating correction by effective doses of coronary active drugs. PC patients with essential hypertension exhibited frequent headache, progressive edema of the legs, drastic hypertensive reactions. It is held that estrogen therapy for prostatic cancer should be preceded and monitored by therapeutic evaluation responsible for optimal conditions to prevent and early diagnose cardiovascular complications.


4. DOCID:19291 SCORE: 0.00436241714472716
DOCNO: 8393415
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Virus Cultivation
QUALIFIER: growth & development
AUTHOR: O Faff O
AUTHOR: B A Murray BA
AUTHOR: V Erfle V
AUTHOR: R Hehlmann R
AFFILIATION: Medizinische Poliklinik, Universität München, FRG.
PUBTYPE: Journal Article
JOURNALTITLE: FEMS microbiology letters.
COUNTRY: NETHERLANDS
TITLE: Large scale production and purification of human retrovirus-like particles related to the mouse mammary tumor virus.
PUBDATE: 19930501
Human retrovirus-like particles related to mouse mammary tumor virus (MMTV) are secreted in a steroid-dependent manner by the breast cancer cell line T47D. We report the successful large scale production and purification of these particles from culture supernatants of T47D cells and describe the experimental conditions established for this purpose. Thus, mg amounts of particles were produced by large scale culturing of T47D cells in an autoharvesting roller bottle system and purified by differential centrifugation and continuous flow ultracentrifugation on density gradients with a 50% recovery and a 350-fold enrichment.


5. DOCID:22294 SCORE: 0.00422503384471498
DOCNO: 8546457
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: economics
QUALIFIER: economics
QUALIFIER: therapy
AUTHOR: N Koinuma N
AFFILIATION: Dept. of Hospital and Health Care Administration, Tohoku University School of Medicine.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Cancer and health economics]
PUBDATE: 19960101
Health economics on cancer medicine is a supportive tool of cancer care and is becoming one of the essential weapons against cancer. Its principal roles are to enhance the quality and efficacy and to secure the finance necessary to the cancer care. The economic aspects of cancer medicine and the methods of economic evaluation are overviewed with emphasis on cost-benefit, cost-effectiveness and cost-utility analysis. The operational and interpretational checkpoints are introduced, and the problems and prospects of the practical use of the methods on clinical settings such as cancer chemotherapy are discussed.


6. DOCID:22903 SCORE: 0.00412596398184603
DOCNO: 8655866
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Eating
DESCRIPTOR: Nutrition
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: K J Joshipura KJ
AUTHOR: W C Willett WC
AUTHOR: C W Douglass CW
AFFILIATION: Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, Mass. 02115, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the American Dental Association (1939)
COUNTRY: UNITED STATES
TITLE: The impact of edentulousness on food and nutrient intake.
PUBDATE: 19960401
The authors collected dietary intake data about the food and nutrient intake of 49,501 male health professionals. Edentulous participants consumed fewer vegetables, less fiber and carotene, and more cholesterol, saturated fat and calories than participants with 25 or more teeth. These factors could increase the risks of cancer and cardiovascular disease. Mean differences in intake ranged from 2 to 13 percent, independent of age, smoking, exercise and profession. Longitudinal analyses suggest that tooth loss may lead to detrimental changes in diet.


7. DOCID:21475 SCORE: 0.00389348730007232
DOCNO: 8765942
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: blood supply
QUALIFIER: therapy
AUTHOR: H M Hoogewoud HM
AFFILIATION: Department Radiologie, Kantonsspital Freiburg.
PUBTYPE: Journal Article
JOURNALTITLE: Schweizerische medizinische Wochenschrift.
COUNTRY: SWITZERLAND
TITLE: [Transvascular percutaneous intervention in tumors: principles and indications]
PUBDATE: 19960701
The techniques of interventional radiology in cancer therapy have been known for several years. Like other radiologic specialties it has benefited from rapid developments in imaging and catheter technology. The indications for percutaneous vascular therapy of tumors are generally palliative and have a curative intention only in rare conditions. Interventional techniques are useful in therapy of tumor bleeding and preoperatively to lessen the risk of hemorrhage. They effectively reduce tumor bulk and provide symptomatic relief. The techniques, indications, results and complications of transvascular therapy of tumors are described.


8. DOCID:21440 SCORE: 0.00389347932795224
DOCNO: 8991583
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: M Espié M
AUTHOR: C Cuvier C
AFFILIATION: Hôpital Saint-Louis, Paris.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Contraception, fertilité, sexualité (1992)
COUNTRY: FRANCE
TITLE: [Treatment of breast cancer during pregnancy]
PUBDATE: 19961101
Breast cancer occurring during pregnancy is a rare clinical situation. A multidisciplinary approach is needed involving an obstetrician a medical oncologist and a surgeon. It should be treated according to the same principles applied in non pregnant patients. Abortion or termination of pregnancy don't improve survival. Decisions regarding abortion should be based on the desires of the patient and on therapeutic necessities. Surgery if necessary is always possible, radiation therapy should be avoided by reason of fetal toxicity, chemotherapy if absolutely necessary is possible after the first trimester.


9. DOCID:21212 SCORE: 0.00379029432311364
DOCNO: 8092120
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: L G Feun LG
AUTHOR: N Savaraj N
AUTHOR: P Benedetto P
AUTHOR: S Waldman S
AUTHOR: M Collier M
AUTHOR: N J Clendennin NJ
AFFILIATION: Sylvester Comprehensive Cancer Center, University of Miami, Florida 33136.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: American journal of clinical oncology.
COUNTRY: UNITED STATES
TITLE: Oral piritrexim in advanced bladder cancer: an effective drug after progression on MVAC chemotherapy?
PUBDATE: 19941001
Four patients with advanced or metastatic bladder cancer progressing after MVAC chemotherapy were treated with oral piritrexim. Three of the four patients were evaluable for response, and all three had a partial response to treatment. Piritrexim may be an effective drug for bladder cancer after progression on MVAC chemotherapy.


10. DOCID:21172 SCORE: 0.00379025967980319
DOCNO: 9006610
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Health Services Accessibility
QUALIFIER: therapy
QUALIFIER: statistics & numerical data
AUTHOR: B R Tulloh BR
AUTHOR: M E Goldsworthy ME
AFFILIATION: Echuca Regional Health, VIC.
PUBTYPE: Journal Article
JOURNALTITLE: The Medical journal of Australia.
COUNTRY: AUSTRALIA
TITLE: Breast cancer management: a rural perspective.
PUBDATE: 19970101
Audit of a general surgical practice in the rural Victorian town of Echuca identified 28 new patients with breast cancer between September 1992 and August 1995 (10% of those with breast conditions). The rural setting was no impediment to breast conservation (achieved in 68% of the 25 who had surgery) or to a multidisciplinary approach (management was planned in conjunction with an oncologist and/or specialist breast surgeon for 26 of the 28 patients).


11. DOCID:23130 SCORE: 0.00377330613676051
DOCNO: 9111106
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Diagnostic Errors
QUALIFIER: diagnosis
QUALIFIER: standards
AUTHOR: R M DeMay RM
AFFILIATION: Section of Cytopathology, University of Chicago, Ill 60637-1470, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Archives of pathology & laboratory medicine.
COUNTRY: UNITED STATES
TITLE: Common problems in Papanicolaou smear interpretation.
PUBDATE: 19970301
No test ever invented has been as successful as the Papanicolaou smear in preventing cancer. Despite its remarkable success in cervical cancer prevention, however, the Papanicolaou smear is not a perfect test. Sampling errors account for a significant number of false-negative cases. Diagnostic errors occur in even the finest cytology laboratories. Yet, for women who develop cervical cancer, these errors pale in comparison with failure to screen patients adequately in the first place. This paper examines some of the problems that result in failure of the Papanicolaou smear to prevent cervical cancer, with an emphasis on common problems in Papanicolaou smear interpretation.


12. DOCID:17955 SCORE: 0.00375013649632517
DOCNO: 2233589
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Aging
DESCRIPTOR: Sex Factors
QUALIFIER: mortality
AUTHOR: B Böhm B
AUTHOR: K Nouchirvani K
AUTHOR: H P Hucke HP
AUTHOR: W Stock W
AFFILIATION: Chirurgische Abteilung, Marien-Hospitals Düsseldorf.
PUBTYPE: Journal Article
JOURNALTITLE: Medizinische Klinik (Munich, Germany : 1983)
COUNTRY: GERMANY
TITLE: [The effect of age and sex on localization, tumor stage and prognosis of colorectal carcinoma]
PUBDATE: 19901001
In a retrospective study including 946 cases with colorectal cancer we analysed age, sex, distribution and stage. There was a significant higher prevalence in women and in all tumor stages women were older than men. The frequencies of Dukes C and proximal colon cancer was significantly higher in women. In older patients we found an increasing incidence of proximal cancer. Instead of tumor stage the age, sex and distribution showed no influence on the outcome.


13. DOCID:19305 SCORE: 0.00374255884961038
DOCNO: 1405166
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: Y Fujii Y
AUTHOR: J Ajima J
AUTHOR: A Tosaka A
AUTHOR: H Sekine H
AUTHOR: K Ohya K
AUTHOR: S Kitahara S
AUTHOR: H Ohashi H
AUTHOR: K Oka K
AFFILIATION: Division of Urology, Kanto Central Hospital.
PUBTYPE: Journal Article
JOURNALTITLE: Nippon Hinyōkika Gakkai zasshi. The japanese journal of urology.
COUNTRY: JAPAN
TITLE: [Asymptomatic multilocular cystic renal cell carcinoma]
PUBDATE: 19920801
From January 1982 to December 1989, we experienced seven multilocular cystic renal cell carcinomas (MLCRCCs) in 36 asymptomatic renal cancers incidentally diagnosed, and none in 23 symptomatic renal cancers (p less than 0.05). No multiocular cystic nephromas (MLCNs) appeared in either group. Though MLCRCCs have been considered to be, in general, extremely rare, they do occur in asymptomatic renal cancers. A multiloculated renal mass with thick septum discovered in an adult by ultrasonography or CT scan should be suspected as being a MLCRCC rather than a MLCN.


14. DOCID:19160 SCORE: 0.00370626892981316
DOCNO: 2217209
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Carcinogens
DESCRIPTOR: Mice
DESCRIPTOR: Rats
QUALIFIER: methods
AUTHOR: B N Ames BN
AUTHOR: L S Gold LS
AFFILIATION: Division of Biochemistry and Molecular Biology, University of California, Berkeley 94720.
PUBTYPE: Journal Article
JOURNALTITLE: Proceedings of the National Academy of Sciences of the United States of America.
COUNTRY: UNITED STATES
TITLE: Chemical carcinogenesis: too many rodent carcinogens.
PUBDATE: 19901001
The administration of chemicals at the maximum tolerated dose (MTD) in standard animal cancer tests is postulated to increase cell division (mitogenesis), which in turn increases rates of mutagenesis and thus carcinogenesis. The animal data are consistent with this mechanism, because a high proportion--about half--of all chemicals tested (whether natural or synthetic) are indeed rodent carcinogens. We conclude that at the low doses of most human exposures, where cell killing does not occur, the hazards to humans of rodent carcinogens may be much lower than is commonly assumed.