0. DOCID:10778 SCORE: 0.00439433607982996
DOCNO: 7201343
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
AUTHOR: M S Blumenreich MS
AUTHOR: B Needles B
AUTHOR: A Yagoda A
AUTHOR: P Sogani P
AUTHOR: H Grabstald H
AUTHOR: W F Whitmore WF
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Intravesical cisplatin for superficial bladder tumors.
PUBDATE: 19820901
Cisplatin, 50-150 mg in a maximum concentration of 1 mg/ml, was administered intravesically each week to 24 patients with multiple, recurrent carcinoma in situ and/or bladder tumors confined to the mucosa and lamina propria. All patients had a history of multiple transurethral resections and four had received prior chemotherapy. Response was evaluated by urinary cytology, cystoscopy, and biopsy. In a total of 237 weekly doses, toxicities included mild dysuria, pruritus, rash and in one patient, acute anaphylaxis. Only three (13%) patients were classified as achieving complete remission. Cisplatin, in the dose and schedule employed, is ineffective in controlling superficial bladder cancer.

1. DOCID:10065 SCORE: 0.00391395032104526
DOCNO: 6833019
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Brachytherapy
QUALIFIER: radiotherapy
AUTHOR: B van der Werf-Messing B
AUTHOR: R S Menon RS
AUTHOR: W C Hop WC
PUBTYPE: Journal Article
JOURNALTITLE: International journal of radiation oncology, biology, physics.
COUNTRY: UNITED STATES
TITLE: Carcinoma of the urinary bladder category T3NxMo treated by the combination of radium implant and external irradiation: second report.
PUBDATE: 19830201
Forty-one patients with bladder cancer, T3NxMo, with a diameter not exceeding 5 cm, were treated by 3 times 350 rad external irradiation, radium implant at reduced dose, and an additional 3000 rad external irradiation ("Radium 55%"). Survival is excellent where there is a high or medium degree of differentiation without vascular invasion in the biopsy specimen; prognosis is poor if a low degree of differentiation is combined with vascular invasion. The future therapeutic approach will be adapted to this finding.

2. DOCID:14645 SCORE: 0.00389758277713238
DOCNO: 3622436
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Teratogens
QUALIFIER: methods
QUALIFIER: drug effects
AUTHOR: K E Whitby KE
PUBTYPE: Journal Article
JOURNALTITLE: Environmental health perspectives.
COUNTRY: UNITED STATES
TITLE: Teratological research using in vitro systems. III. Embryonic organs in culture.
PUBDATE: 19870601
A search of literature published through the spring of 1986 yielded approximately 95 citations for the following embryonic organs in culture: kidney, pancreas, skin, palate, craniofacial tissue, tooth, lens, bones, digits, and liver. However, only the in vitro organ culture of the palate and tooth are reviewed in this paper. The other organ culture systems were not reported as teratogenic screens. Although some organs may have the potential for such use, many are currently used for evaluation of the pathogenesis associated with congenital abnormalities, cancer, or transplacental carcinogenesis, or in studies of the structure and function of differentiating organs, and will not be included in this review.

3. DOCID:15120 SCORE: 0.0038147290456901
DOCNO: 3586341
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: rehabilitation
QUALIFIER: rehabilitation
AUTHOR: T Hirai T
AUTHOR: S Aratani S
AUTHOR: K Yoshinaka K
AUTHOR: T Toge T
AUTHOR: M Niimoto M
AUTHOR: T Hattori T
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Clinical studies on the complaints of survivors living more than 3 months after total gastrectomy]
PUBDATE: 19870301
From 1973 to 1983, 802 patients with gastric cancer were operated on. Out of them, 292 (36.4%) received total gastrectomy. Reconstruction was performed mainly by the Billroth II procedure associated with the closure of the afferent loop according to Plenk's method. 90 patients living more than 3 months complained of the following: heartburn, 18 (20%); reflux, 12 (13.3%); retrosternal pain, 3 (3.3%); stenotic sensation, 23 (25.6%); diarrhea, 10 (11.1%); abdominal pain, 14 (15.6%); and dumping syndrome, 6 (6.7%). It seems to indicate that the quality of life after total gastrectomy is satisfactory.

4. DOCID:11344 SCORE: 0.00381013428084233
DOCNO: 3971331
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Diploidy
QUALIFIER: genetics
AUTHOR: S R Wolman SR
AUTHOR: H S Smith HS
AUTHOR: M Stampfer M
AUTHOR: A J Hackett AJ
PUBTYPE: Journal Article
JOURNALTITLE: Cancer genetics and cytogenetics.
COUNTRY: UNITED STATES
TITLE: Growth of diploid cells from breast cancers.
PUBDATE: 19850301
Cell cultures were derived from normal and cancerous breast tissues and from metastases by methods that selected for relatively adherent epithelial aggregates. Karyotypic analyses of first or second passage cultures yielded predominantly normal diploid cells. Nonclonal aberrations were more common in tumor-derived than in normal cultures. Three of the cultures that originated from metastases were characterized by abnormal clones. These results support observations based on DNA content, which indicate that a considerable fraction of breast cancers are composed predominantly of diploid cells. They differ greatly from chromosomal findings in long-term cultures of tumor effusions and thus emphasize the karyotypic diversity that can be found in tumors from a single tissue of origin--the breast.

5. DOCID:15985 SCORE: 0.00380962397832128
DOCNO: 3811915
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: secondary
QUALIFIER: secondary
QUALIFIER: pathology
AUTHOR: I Matsumoto I
AUTHOR: M Furusato M
AUTHOR: I Inomata I
AUTHOR: T Wada T
AUTHOR: S Aizawa S
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Acta pathologica japonica.
COUNTRY: JAPAN
TITLE: Prostatic cancer presenting as metastatic adenocarcinoma of sphenoid sinus.
PUBDATE: 19861101
Prostatic cancer is commonly manifested by obstructive uropathy, regional lymphatic metastases, and hematogenous metastases to the axial skeleton. It is relatively rare that initial signs begin with the involvement of other sites. Intracranial metastases especially are seldom found and may be unfamiliar to not only pathologists but also to physicians. In this article, we present a case where the metastasis was first manifest as a sphenoid sinus tumor prior to the demonstration of the primary site and the prostate was confirmed to be primary by biopsy specimen with immunoperoxidase method. In addition to discussing the route of the tumor spread, we deal with a prostatic specific antigen efficient for identifying the primary site.

6. DOCID:11183 SCORE: 0.0037303329361322
DOCNO: 7105515
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammography
QUALIFIER: radiography
AUTHOR: M J Homer MJ
PUBTYPE: Journal Article
JOURNALTITLE: Clinical obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Mammographic detection of breast cancer.
PUBDATE: 19820601
Mammography, whether film or xerography, is a complementary examination to breast palpation in the detection of breast cancer. According to the guidelines of the American Cancer Society, mammography should be performed on every asymptomatic woman, at least once, over the age of 35. Annual mammography after 50 is also advised. The radiation dose to the breast from current equipment is so low as to not be considered a factor in denying a woman this screening examination. Mammography has a role in evaluating the woman with solitary and multiple breast masses. It is the only proved reliable modality able to detect nonpalpable breast cancers and small tumors less than 2 cm in size. All nonpalpable lesions should be excised by directed biopsy, using a preoperative localization technique.

7. DOCID:15574 SCORE: 0.00371765808412823
DOCNO: 2815391
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: P C Gøtzsche PC
PUBTYPE: Journal Article
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: DENMARK
TITLE: [Attitudes of medical students to randomization or free choice in breast cancer surgery and a suggestion for a new study design]
PUBDATE: 19891001
Six research models for breast cancer surgery were presented and debated in a two hour lecture to second year medical students. Half of the students (38/68) preferred a model which offered the woman the opportunity of choosing between tumorectomy and mastectomy after preceding randomization; one fourth preferred free choice without randomization. Descriptive ethical studies in the population after previous detailed information seem necessary to elucidate which research models the population are willing to accept as potential patients. In trials of therapies where the patients may be assumed to have individual preferences, a design is proposed with free choice between alternatives and secondary randomization among those who are unable to decide.

8. DOCID:15512 SCORE: 0.00371763494528783
DOCNO: 2900800
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genes, ras
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: K Honda K
AUTHOR: K Ishizaki K
AUTHOR: M Ikenaga M
AUTHOR: J Toguchida J
AUTHOR: T Inamoto T
AUTHOR: K Tanaka K
AUTHOR: K Ozawa K
AFFILIATION: Second Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Human genetics.
COUNTRY: GERMANY, WEST
TITLE: Increased frequency of specific alleles of the c-Ha-ras gene in Japanese cancer patients.
PUBDATE: 19880801
We have examined the c-Ha-ras locus in 145 cancer patients of a mixed group and 164 normal individuals in Japan for restriction fragment length polymorphisms and compared the allele distributions in normal and cancer populations. The c-Ha-ras gene is highly polymorphic in Japanese as previously reported in Caucasians. Two rare alleles were found to be present with increased frequencies in Japanese cancer patients. These results suggest that genotype analysis of the c-Ha-ras gene could be used to detect cancer-prone individuals.

9. DOCID:14051 SCORE: 0.00359722222544183
DOCNO: 2424586
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Kidney Transplantation
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: A W Osiason AW
AUTHOR: R J Polackwich RJ
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Curative, platinum-based cytoxic drug therapy in a renal transplant recipient with metastatic testicular cancer.
PUBDATE: 19860801
Since June 1979, the authors have had the opportunity to treat a renal homograph recipient who developed primary embryonal cell testicular carcinoma with retroperitoneal and pulmonary metastases. This patient was treated with an induction chemotherapy protocol of vinblastine sulfate, bleomycin, and cisplatin and has remained free of disease through June 1985, without loss of his renal homograph. Cisplatin-based cytoxic drug therapy can be delivered safely to a renal transplant recipient without causing kidney damage, and, in this case, achieved a cure of metastatic testicular cancer.

10. DOCID:11340 SCORE: 0.00356301466555595
DOCNO: 3919928
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: standards
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
QUALIFIER: standards
QUALIFIER: radiotherapy
AUTHOR: G E Hanks GE
AUTHOR: J J Diamond JJ
AUTHOR: S Kramer S
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: The need for complex technology in radiation oncology. Correlations of facility characteristics and structure with outcome.
PUBDATE: 19850501
The Patterns of Care Study data are used to correlate therapy equipment and practice characteristics with outcome, using Hodgkin's disease, prostate cancer, and cervix cancer as examples. The shift to linear accelerators and higher photon energy is supported, as is the increased use of treatment simulators. Part-time practitioners of radiation therapy and facilities whose only equipment is a less-than-80-cm cobalt unit have poor technical support and exhibit poor staging, poor achievement of minimum tumor dose, and poor patient follow-up as compared to the national average or best-performing strata of practice. These facilities should either upgrade their equipment, technical support, and level of practice or close.

11. DOCID:10719 SCORE: 0.00348926601918554
DOCNO: 6415310
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antineoplastic Combined Chemotherapy Protocols
QUALIFIER: pharmacology
AUTHOR: M Ogawa M
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Current clinical status of new anticancer drugs]
PUBDATE: 19830801
4'-Epiadriamycin demonstrated considerable efficacies in lymphomas, breast cancer and soft part sarcomas with reduced gastrointestinal, hematologic and probably cardiac toxicities. Mitoxantrone appears to be established the clinical role in lymphomas, acute leukemia and breast cancer with mild clinical toxicities. A new analogous compound of cisplatinum CBDCA concluded phase I study and the dose limiting factor was thrombocytopenia. It is of interest that the drug had responders in ovarian cancer during phase I study. The results reported in new anthracyclines; marcellomycin, carminomycin and 4-demethoxydaunorubicin, anthraquinones; ametantrone and bisantrene, new cisplatinums; CHIP, DACCP and TNO-6, and various other drugs including mAMSA, 5'-DFUR, spirogermanium, VP-16-213 and AZQ were reviewed.

12. DOCID:10713 SCORE: 0.0034892620786624
DOCNO: 7092542
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Colonoscopy
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: J S Abrams JS
PUBTYPE: Journal Article
JOURNALTITLE: Archives of surgery (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: A second look at colonoscopy: indications, failures, and costs.
PUBDATE: 19820701
Results of colonoscopy and colonoscopic polypectomy in 599 patients have been reviewed. Added experience has not decreased the number of failures--failure to examine the entire colon, polyps not retrieved for histological examination ("lost polyps"), undetected ("missed") lesions, and false-negative biopsy specimens. The incidence of invasive carcinoma in polyps measuring under 1 cm is less than 1%; polypectomy should be reserved for larger lesions or demonstrated growth of small polyps. Diagnostic colonoscopy in selected patients (those with persistent gross or occult rectal bleeding but normal results from sigmoidoscopic and barium enema studies) demonstrates a causative lesion in greater than 25% and detects a cancer in 5% to 10% of patients.

13. DOCID:14156 SCORE: 0.00347605107726226
DOCNO: 3376370
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: radiotherapy
AUTHOR: H Sommerkamp H
AUTHOR: M Rupprecht M
AUTHOR: G Bruggmoser G
AUTHOR: M Wannenmacher M
AFFILIATION: Abteilung für Urologie, Klinikum der Universität Freiburg.
PUBTYPE: Journal Article
JOURNALTITLE: Der Urologe. Ausg. A.
COUNTRY: GERMANY, WEST
TITLE: [Determinants of local tumor control in interstitial radiotherapy of prostatic cancer]
PUBDATE: 19880301
Clinical followup of 52 patients treated with I-125 implants for localized prostatic cancer demonstrated local control in 85% and failure in 15%. Determining factors for local control or failure were analyzed and underline that homogeneous dose distribution is the most important factor for local control in interstitial radiotherapy. With the use of I-125 seeds this can only be achieved in small-volume (T2) stages with refined technique. For larger tumor volumes (T3) an external boost or the use of other radionuclides is preferable.

14. DOCID:15969 SCORE: 0.00347414621745511
DOCNO: 3341110
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Magnetic Resonance Imaging
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: S T Houston ST
AUTHOR: L W Jones LW
AUTHOR: V Waluch V
AFFILIATION: Department of Urology, Montefiore Medical Center, Bronx, New York.
PUBTYPE: Journal Article
JOURNALTITLE: Urology.
COUNTRY: UNITED STATES
TITLE: Nuclear magnetic resonance imaging in detecting and staging prostatic cancer.
PUBDATE: 19880201
Thirteen patients were examined for grade, stage, and extent of their prostatic cancer, utilizing nuclear magnetic resonance imaging (MRI) and clinical workup for metastases. Of these 13 patients, 12 had known prostatic cancer proved by needle biopsy or by pathologic examination of transurethral prostatectomy tissue. Five of these patients underwent radical surgery allowing further correlation of clinical findings and MRI data with the surgical pathologic findings. MRI of the prostate was found to be a sensitive modality in detecting prostatic carcinoma and showing extension of disease in some cases. Also, in some cases it was not always possible to differentiate between prostatic carcinoma and benign prostatic hyperplasia with MRI.