0. DOCID:2118 SCORE: 0.00269664502373342
DOCNO: 60916
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: F E Mohs FE
PUBTYPE: Journal Article
JOURNALTITLE: Archives of dermatology.
COUNTRY: UNITED STATES
TITLE: Chemosurgery for skin cancer: fixed tissue and fresh tissue techniques.
PUBDATE: 19760201
Complete microscopical control of the excision of cancer of the skin is achieved by removing tissues layer by layer and examining the undersurface of each layer by means of frozen sections. If the cancer is extensive and complicated or if it is of a type readily spread over an excisional surface, the tissues are fixed in situ with zinc chloride prior to excision (chemosurgery, fixed tissue technique). If the cancer is not too extensive or complicated, the tissues are excised in the fresh, unfixed state (chemosurgery, fresh tissue technique). Both techniques are highly reliable; for example, in two consecutive series of basal cell carcinomas treated chemosurgically, the five-year rate of cure was 99.3% for the 9,351 lesions removed by the fixed tissue technique and 97% for the 127 lesions removed by the fresh tissue technique.


1. DOCID:2363 SCORE: 0.00229675860165
DOCNO: 1008990
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: N Matthews N
AUTHOR: R H Whitehead RH
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Inhibition of K cell function by human breast cancer sera.
PUBDATE: 19761201
Sera from breast cancer patients and from female controls were tested for inhibition of lysis of antibody-coated target cells by human leukocytes (K cells). Sera from 39% of breast cancer patients, but from only 8% of controls, inhibited lysis by more than 30%. This inhibition was unrelated to the stage of the disease, the patient's age or whether the patient was pre- or post-operative. Inhibition was apparently not due to anti-HLA antibodies and did not correlate with the IgG level or anti-complementary activity of the serum. On fractionation by gel-filtration, inhibitory activity was found in fractions of higher molecular weight than IgG. As no IgG could be detected in these fractions, inhibition is probably not due to immune complexes containing IgG antibody. The inhibitory factor may well contribute to the immunosuppressed status of a proportion of breast cancer patients.


2. DOCID:2308 SCORE: 0.00222170717084209
DOCNO: 1190632
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasms, Radiation-Induced
QUALIFIER: etiology
QUALIFIER: adverse effects
QUALIFIER: etiology
AUTHOR: F O Becker FO
AUTHOR: S G Economou SG
AUTHOR: H W Southwick HW
AUTHOR: R Eisenstein R
PUBTYPE: Journal Article
JOURNALTITLE: Annals of internal medicine.
COUNTRY: UNITED STATES
TITLE: Adult thyroid cancer after head and neck irradiation in infancy and childhood.
PUBDATE: 19750901
We report the surgical-pathologic findings in 15 adults who had a history of irradiation of the head and neck in childhood. These patients we selected for thyroid surgery because of a "cold" area or areas detected on 99mTc thyroid scan, with or without palpable thyroid abnormalities. Eight of the fifteen patients had thyroid cancer, and 3 had atypical adenomas. We found multiple lesions in 12 patients. Macroscopic and microscopic malignancy in a location different from the cold area or areas occurred in 5 of the 8 cancer patients. In vitro of these findings, we recommend that adults who received irradiation to the head and neck in childhood and who have been found to have an abnormal thyroid scan or thyroid examination, or both, have a total thyroidectomy...


3. DOCID:3102 SCORE: 0.00215895501819814
DOCNO: 908479
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
QUALIFIER: mortality
AUTHOR: O Bonnevie O
PUBTYPE: Journal Article
JOURNALTITLE: Gastroenterology.
COUNTRY: UNITED STATES
TITLE: Causes of death in duodenal and gastric ulcer.
PUBDATE: 19771101
An analysis has been made of 235 deaths that occurred among 1905 patients with peptic ulcer who constituted a random sample of the occurrence of ulcer disease in an area of Denmark comprising half a million inhabitants. The disease itself, according to the death certificate, was considered the primary cause of death in 10% of the cases; half of these had been operated on immediately before death. The other patients died more frequently than expected from the following causes: chronic bronchitis, pulmonary emphysema, cancer of the lung, cirrhosis of the liver, and cancer of the pancreas. Although the comorbidity with chronic bronchitis and emphysema was especially pronounced in patients with gastric ulcer, the association with liver cirrhosis and cancer of the pancreas occurred only in patients with duodenal ulcer. In women the mortality rate attributable to cardiac and vascular diseases was lower than expected. No excess coincidence of suicide was found. Berkson's fallacy is considered to be of much less importance as a possible explanation of the comorbidity found in the present study than in the majority of publications concerned with this question.


4. DOCID:2143 SCORE: 0.00214903512645117
DOCNO: 848523
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: prevention & control
AUTHOR: S E Brown SE
AUTHOR: H H Allen HH
AUTHOR: R N Robins RN
PUBTYPE: Journal Article
JOURNALTITLE: American journal of obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: The use of delayed primary wound closure in preventing wound infections.
PUBDATE: 19770401
Delayed primary wound closure was performed in 146 patients considered at risk of developing wound infection according to established criteria. These patients were matched individually for age, weight, diagnosis, and the use of prophylactic antibiotics with 146 patients undergoing immediate wound closure during the same time period. The matched pairs were subdivided into five categories depending on the indication for delayed closure; obesity, cancer, "above and below" procedure, infection, and opened bowel. In all categories the incidence of wound infection was significantly lower in the patients with delayed closure. The over-all infection rate was reduced from 23.3% in the control group to 2.1% in the study group. Hospital stay was unaffected. Delayed primary wound closure provides a safe, simple, effective means of reducing the incidence of wound infection.


5. DOCID:2205 SCORE: 0.00211026330180032
DOCNO: 799961
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chemical Industry
QUALIFIER: adverse effects
QUALIFIER: adverse effects
AUTHOR: M Karstadt M
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Environmental health perspectives.
COUNTRY: UNITED STATES
TITLE: PVC: health implications and production trends.
PUBDATE: 19761001
Poly(vinyl chloride) (PVC) is a complex plastic system. Individual components of the PVC system, including residual vinyl chloride monomer (RVCM) and certain additives, may pose risks of harm to human health. There have been significant reductions in the RVCM content of PVC resin since 1974, reducing the cancer risk of workers in PVC fabrication plants and consumers of PVC products. A "no-effect" level for vinyl chloride monomer (VCM)-induced carcinogenesis has not been found to date; therefore, the significance of human exposure to low levels of RVCM remains to be determined. Exposure to PVC dust may cause pulmonary dysfunctions. Pulmonary and other possible health effects of PVC dust require further study. The PVC plastics system should be characterized as to interactions among its various components and as to interactions of the components and the PVC system as a whole with biological systems.


6. DOCID:1948 SCORE: 0.00207649604657593
DOCNO: 1254716
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: biosynthesis
QUALIFIER: metabolism
QUALIFIER: microbiology
AUTHOR: J B Brooks JB
AUTHOR: M J Selin MJ
AUTHOR: C C Alley CC
PUBTYPE: Journal Article
JOURNALTITLE: Journal of clinical microbiology.
COUNTRY: UNITED STATES
TITLE: Electron capture gas chromatography study of the acid and alcohol products of Clostridium septicum and Clostridium chauvoei.
PUBDATE: 19760201
The metabolic products produced by several strains of Clostridium septicum obtained from patients and animals, along with strains of Clostridium chauvoei, were studied in chopped meat glucose medium by electron capture gas-liquid chromatography (EC-GLC). The strains of C. septicum and C. chauvoei were shown to comprise five different metabolic groups. Both the EC-GLC study and the O and H antigenic study performed previously showed that strains of C. septicum comprise a heterogeneous group. One type of metabolic profile was found only in strains of C. chauvoei. The O antigen types and EC-GLC metabolic types of C. septicum correlated fairly well in isolates from cancer patients but not in stock culture and animal isolates.


7. DOCID:2787 SCORE: 0.00204120029400124
DOCNO: 236398
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Plants, Toxic
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: S S Hecht SS
AUTHOR: R M Ornaf RM
AUTHOR: D Hoffmann D
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Chemical studies on tobacco smoke. XXXIII. N' -nitrosonornicotine in tobacco: analysis of possible contributing factors and biologic implications.
PUBDATE: 19750501
A chemical analytic method to determine N'-nitrosonornicotine (NNN) and N' -nitrosoanabasine (NAB) in tobacco was developed. NNN was found in the unburned tobacco of commercial products at concentrations betweeen 0.3 and 88.6 mug/g. The highest levels were observed in highly fermented snuff (29.1 mug/g) and fine-cut chewing tobacco (88.6 mug/g). NAB was not detected (smaller than 0.5 ng/g) in any tobacco examined. Two new tobacco components, N' -carbomethoxynornicotine and N' -carbomethoxyanabasine,were found. Possible origins of NNN in tobacco were discussed, especially in relation to concentrations of nitrite, nitate, and alkaloids, and in relation to pH and curing. Biologic implications, including the possible function of NNN (the first organic carcinogen isolated from unburned tobacco) as a causative factor in cancer of the oral cavity in tobacco chewers and betel quid chewers, were also discussed.


8. DOCID:1691 SCORE: 0.00195082139613889
DOCNO: 912857
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: blood
AUTHOR: R A Cox RA
AUTHOR: M Gokcen M
PUBTYPE: Journal Article
JOURNALTITLE: Clinical biochemistry.
COUNTRY: CANADA
TITLE: An improved filter-disc assay for 3H-DNA and serum deoxyribonucleases.
PUBDATE: 19771001
1. The filter-paper disc assay for tritium-labeled nucleic acids was modified to reduce washing and manipulation. Evaluation of the procedure indicated greatly enhanced counting efficiency for tritium, complete removal of nuclease digestion products and retention of even nanogram levels of radioactive DNA on the discs in the presence of protein. The modified assay was quite sensitive and had a coefficient of variation of 5.2%. Quite low concentrations of DNase I and endogenous human serum nuclease activity were readily measured by the improved technique, 22 sera yielding a mean value equivalent to about 0.5 ng DNase I/ml serum. We are now using the disc assay to follow serum DNA and DNase levels in patients with autoimmune disorders and various types of cancers.


9. DOCID:3289 SCORE: 0.00193671775303733
DOCNO: 187320
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antigens, Neoplasm
DESCRIPTOR: Antigens, Viral
DESCRIPTOR: Cell Transformation, Neoplastic
DESCRIPTOR: Simplexvirus
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: M F Notter MF
AUTHOR: J J Docherty JJ
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Reaction of antigens isolated from herpes simplex virus-transformed cells with sera of squamous cell carcinoma patients.
PUBDATE: 19761201
Antigens isolated from herpes simplex virus type 1, herpes simplex virus type 2, or cytomegalovirus-transformed hamster cells were tested against 66 sera from non-cancer individuals or patients with different types of cancer. By use of the microcomplement fixation procedure to quantify all antigen-antibody interactions, it was observed that 94% (p less than 0.001) of all sera from patients with squamous cell carcinoma reacted with antigens from herpes simplex virus type 1-transformed cells, while 84% (p less than 0.001) of the same sera reacted with antigen preparations from herpes simplex virus type 2-transformed cells. When sera from patients with adenocarcinoma, sarcoma, liposarcoma, and melanoma were tested against these antigens, there was no significant difference in their reactivity from sera of noncancer patients. When sera from all individuals (normal and cancer) were tested against antigens from cytomegalovirus-transformed cells, no significant reaction pattern developed. These studies are the first to describe the isolation of a reactive tumor-associated protein from herpes simplex virus-transformed cells.


10. DOCID:2264 SCORE: 0.00181178031304007
DOCNO: 71208
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
AUTHOR: N I Nissen NI
AUTHOR: T Pajak T
AUTHOR: O Glidewell O
AUTHOR: H Blom H
AUTHOR: M Flaherty M
AUTHOR: D Hayes D
AUTHOR: R McIntyre R
AUTHOR: J F Holland JF
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer treatment reports.
COUNTRY: UNITED STATES
TITLE: Overview of four clinical studies of chemotherapy for stage III and IV non-Hodgkin's lymphomas by the Cancer and Leukemia Group B.
PUBDATE: 19770901
This paper presents an overview of four Cancer and Leukemia Group B studies in 1266 patients with stage III-IV non-Hodgkin's lymphoma. The cases were analyzed across protocols; the major prognostic determinants were prior chemotherapy, age, and histology. The four studies proved that cyclophosphamide maintenance was superior to no maintenance even after prolonged intensive induction chemotherapy. Furthermore, the reinforcement program of monthly pulse doses of vincristine and prednisone, whose value was established in the treatment of acute leukemia, led to highly significant improvement in remission duration and survival. Other facets of the chemotherapy programs are still being subjected to analysis, but this report sets out some preliminary conclusions.


11. DOCID:3961 SCORE: 0.00171767459217651
DOCNO: 1026759
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Breast Neoplasms
DESCRIPTOR: Pregnancy Complications
AUTHOR: M Dargent M
AUTHOR: M Mayer M
AUTHOR: J Lansac J
AUTHOR: J L Carret JL
PUBTYPE: Journal Article
JOURNALTITLE: Journal de gynécologie, obstétrique et biologie de la reproduction.
COUNTRY: FRANCE
TITLE: [Breast cancer and pregnancy. Apropos of 96 cases followed for 3 and 1/2 years at the Centre Léon Bérard, Lyons]
PUBDATE: 19760901
96 cases where cancer of the breast and pregnancy were associated have been studied at the Léon Bérard Centre of Lyon with a follow-up of at least 3 years. Those patients who had a malignant tumour of the breast, which was treated, and then became pregnant (19 cases) were not made any worse (79 per cent survival in 5 years). This was quite independent of the outcome of the pregnancy. On the other hand, those women (54 cases) in which the cancer was discovered and treated during pregnancy had a far worse prognosis (20 per cent survival in 5 years). This prognosis was made worse by the discovery of the cancer in the third trimester of the pregnancy, and by the presence of lymph node involvement, by termination of pregnancy and by weaning. When malignant tumours were discovered during breast-feeding or weaning (23 cases) the prognosis was equally bad (23 per cent survival in 3 years). The authors discuss the frequency of the association of cancer of the breast and pregnancy, as well as the different factors in the prognosis. They attempt to outline the management that should be carried out in the light of recent publications on this subject.


12. DOCID:2966 SCORE: 0.00166296216962191
DOCNO: 991097
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: R W Nesto RW
AUTHOR: B Cady B
AUTHOR: R A Oberfield RA
AUTHOR: A G Pazianos AG
AUTHOR: F A Salzman FA
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Rebound response after estrogen therapy for metastatic breast cancer.
PUBDATE: 19761001
The estrogen rebound response in metastatic breast cancer has been reported in the past as a rare and short-lived phenomenon, not clearly associated with any aspect of the patient's clinical profile. In this series, 25% of patients responding to estrogen therapy had a further response when they no longer received the hormone. The median duration of this palliation was a minimum of 18 months and was similar to that of the initial estrogen response. Patients with a rebound response had significantly longer disease-free intervals before estrogen therapy and estrogen remissions than those who did not have a rebound response. These clinical factors may, therefore, be helpful in predicting the chances of a rebound response in any given patient. It is urged that patients be observed for objective improvement without therapy upon escape from estrogen palliation. Further palliative therapy should not be offered until definite progression of disease has been documented after any rebound response that occurs.


13. DOCID:3002 SCORE: 0.00166295629826863
DOCNO: 1089474
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: R M Heyn RM
PUBTYPE: Clinical Trial
PUBTYPE: Controlled Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: The role of chemotherapy in the management of soft tissue sarcomas.
PUBDATE: 19750301
Prior to the use of chemotherapy, survival for rhabdomyosarcoma which had been completely resected was 50-60%. A controled study done by Children's Cancer Study Group showed the effectiveness of combined chemotherapy used as part of primary therapy in similar patients. Children who received actinomycin D (Act D) and vincristine (Vcr) for 1 year after surgery and radiotherapy had a lower metastatic rate than those who received none. This combination resulted in an 89% survival in patients with localized disease which was surgically resectable. Patients with microscopic residual disease had a 91% survival. With more aggressive use of combined chemotherapy, experience has accumulated demonstrating improved response and survival in both localized and gross residual disease. Combinations of Act D, Vcr, and cyclophosphamide can reduce initial tumor size, making large tumor masses more amenable to surgery and radiotherapy. Currently, an intergroup study is testing the response to four different drug combinations and the duration of therapy needed for various stages of the disease.


14. DOCID:3127 SCORE: 0.00159760477160164
DOCNO: 406035
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemically induced
QUALIFIER: chemically induced
QUALIFIER: adverse effects
QUALIFIER: adverse effects
AUTHOR: R E Fechner RE
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Influence of oral contraceptives on breast diseases.
PUBDATE: 19770601
Three sources of information are available pertaining to the effect of oral contraceptive hormones on the breast: 1) toxicity experiments in animals; 2) histologic examinations of breast tissue from women taking hormones; and 3) epidemiologic studies of women using hormones. Animals treated with hormones at doses equivalent to the human contraceptive level have not developed cancer of the breast at a greater than expected frequency. Monkeys, the one experimental animal with a reproductive cycle similar to humans, have not developed cancer during long-term hormone administration except for a single animal which likely represents a chance occurrence. In humans, histologic studies of breast tissue have failed to identify abnormalities which could be attributed to hormones with rare exceptions of secretory change indistinguishable from normal lactating breast. Epidemiologic studies have usually shown a decreased frequency of benign breast disease and neither an increase nor a decrease in carcinoma of the breast. The one exception to the latter statement is a possible increased risk of cancer in long-term users who have had previous surgery for benign breast disease.