0. DOCID:26957 SCORE: 0.00252166348923786
DOCNO: 10399438
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: ultrastructure
QUALIFIER: pathology
QUALIFIER: ultrastructure
QUALIFIER: ultrastructure
QUALIFIER: ultrastructure
QUALIFIER: ultrastructure
AUTHOR: V I Tsygankov VI
AUTHOR: S I Shvets SI
AUTHOR: G L Mogileva GL
AUTHOR: V M Kindialov VM
AUTHOR: N P Mel'nikova NP
PUBTYPE: Journal Article
JOURNALTITLE: Klinicheskaia laboratornaia diagnostika.
COUNTRY: RUSSIA
TITLE: [The nuclear morphotypes of epithelial cells in breast diseases]
PUBDATE: 19990501
Staining of the nucleolar ribosome organizer with AgNO3 followed by computer analysis of images by discriminant analysis helped distinguish 6 morphological types in the cells of cytological preparations of mammary glands. Comparison of the morphometrical data and results of visual examination of cells showed that the first type included nonproliferating fibroadenoma and mastopathy, type 2 fibroadenoma and mastopathy with moderate proliferation of epithelium, type 3 fibroadenoma and mastopathy with precancer epithelial proliferation, and types 4-6 included malignant proliferating cells which are compatible with well, moderately, and poorly differentiated cancer.


1. DOCID:31263 SCORE: 0.00238417567254218
DOCNO: 15546933
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosome Aberrations
DESCRIPTOR: Database Management Systems
DESCRIPTOR: Software
DESCRIPTOR: User-Computer Interface
QUALIFIER: methods
QUALIFIER: methods
QUALIFIER: methods
AUTHOR: Bernhard Hiller B
AUTHOR: Jutta Bradtke J
AUTHOR: Harald Balz H
AUTHOR: Harald Rieder H
AFFILIATION: Institut für Klinische Genetik der Phillipps-Universität Marburg, Bahnhofstrasse 7, 35037 Marburg, Germany.
PUBTYPE: Journal Article
JOURNALTITLE: Bioinformatics (Oxford, England)
COUNTRY: England
TITLE: CyDAS: a cytogenetic data analysis system.
PUBDATE: 20050401
For statistical analyses in cancer cytogenetics, the genomic changes encoded by the karyotype must be translated into numerical codes. We developed a program, which extracts chromosomal gains and losses as well as breakpoints from the karyotype. The changes are compiled in tables according to the chromosome bands involved and/or depicted in projection to the respective chromosome ideogram. The data are ready to be integrated into further statistical analyses. The program may be run as desktop or Internet application.


2. DOCID:30637 SCORE: 0.00235693702923702
DOCNO: 15043429
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: chemistry
QUALIFIER: isolation & purification
QUALIFIER: chemistry
AUTHOR: Ahmed A Hussein AA
AUTHOR: Icela Barberena I
AUTHOR: Todd L Capson TL
AUTHOR: Thomas A Kursar TA
AUTHOR: Phyllis D Coley PD
AUTHOR: Pablo N Solis PN
AUTHOR: Mahabir P Gupta MP
AFFILIATION: Centro de Investigaciones Farmacognósticas de la Flora Panameña (CIFLORPAN), Facultad de Farmacia, Universidad de Panamá, Apartado 10767, Estafeta Universitaria, Panama, Republic of Panama.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of natural products.
COUNTRY: United States
TITLE: New cytotoxic naphthopyrane derivatives from Adenaria floribunda.
PUBDATE: 20040301
Bioassay-guided fractionation of an EtOAc/MeOH extract of Adenaria floribunda young leaves using MCF-7, H-460, and SF-268 cancer cell lines yielded four new active compounds named adenaflorins A-D (1-4). Their chemical structures were determined by spectroscopic means. Adenaflorin A (1) was the most cytotoxic.


3. DOCID:25662 SCORE: 0.00230632249274813
DOCNO: 11247482
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Intensive Care
QUALIFIER: surgery
QUALIFIER: methods
QUALIFIER: surgery
AUTHOR: G V Bondar' GV
AUTHOR: A V Borota AV
AUTHOR: S E Zolotukhin SE
AUTHOR: K N Oleĭnikov KN
AUTHOR: G G Psaras GG
AUTHOR: S D Vasil'ev SD
PUBTYPE: Journal Article
JOURNALTITLE: Klinichna khirurhiia / Ministerstvo okhorony zdorov'ia Ukraïny, Naukove tovarystvo khirurhiv Ukraïny.
COUNTRY: Ukraine
TITLE: [Intensive therapy and strategy of management of patients with rectal cancer after the colonic descending to the perineum]
PUBDATE: 20001201
Optimal tactic for management of the patients on various stages of treatment was elaborated together with surgical procedure, basing on the experience of 3500 operations conduction for cancer recti, mainly abdominal resection with colon descendant to perineum. Methods of preoperative preparation and anesthesiological support were stated as well as the tactics of postoperative management of patients.


4. DOCID:26617 SCORE: 0.00220589800459228
DOCNO: 9852402
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Expression Regulation, Neoplastic
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: J Fujimoto J
AUTHOR: R Hirose R
AUTHOR: H Sakaguchi H
AUTHOR: T Tamaya T
AFFILIATION: Department of Obstetrics and Gynecology, Gifu University School of Medicine, Tsukasa-machi, Gifu City, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncology.
COUNTRY: SWITZERLAND
TITLE: Estrogen dependency in uterine endometrial cancers.
PUBDATE: 19981201
Estrogen dependency in uterine endometrial cancers involves complicated tumor biology. A transformed phenotype of uterine endometrial cancers is supported by estrogen-dependent oncogene (c-Ha-ras, c-fos and c-jun) expressions. The relative overexpression of estrogen receptor exon 5 splicing variant and the damaged expression of progesterone receptor A, which belong to a lack of estrogen dependency, are related to metastatic potential. The estrogen-related metastatic processes, detachment, invasion and angiogenesis in some uterine endometrial cancers can be inhibited by progestins.


5. DOCID:26929 SCORE: 0.00215105662617208
DOCNO: 11089384
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: secondary
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: J R Green JR
AFFILIATION: Novartis Pharma AG, Basel, Switzerland. jonathan.green@pharma.novartis.com
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Medizinische Klinik (Munich, Germany : 1983)
COUNTRY: GERMANY
TITLE: Anti-tumor potential of bisphosphonates.
PUBDATE: 20001001
In addition to inhibiting bone resorption, bisphosphonates also exert anti-tumor effects. The most potent compounds are the newer, nitrogen-containing bisphosphonates such as zoledronic acid. In vitro, bisphosphonates inhibit proliferation and induce apoptosis in human tumor cell lines, and interfere with cell adhesion, invasion and growth factor secretion. The combination of bisphosphonates with other anti-cancer drugs such as paclitaxel or tamoxifen markedly enhances these effects. In vivo, zoledronic acid has recently been shown to inhibit angiogenesis. Although bisphosphonates are very effective against bone metastases, their in vivo anti-tumor potential against visceral metastases remains to be explored.


6. DOCID:26258 SCORE: 0.0020698602578752
DOCNO: 9567249
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Bile
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: A Hiraki A
AUTHOR: H Ueoka H
AUTHOR: M Tabata M
AUTHOR: K Kiura K
AUTHOR: A Bessho A
AUTHOR: H Yamane H
AUTHOR: N Nogami N
AUTHOR: M Harada M
AFFILIATION: Second Department of Medicine, Okayama University Medical School, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Lung cancer (Amsterdam, Netherlands)
COUNTRY: IRELAND
TITLE: Spontaneous biloma as a complication of small cell lung cancer.
PUBDATE: 19980201
Biloma is an extraductular collection of bile within a defined capsular space. Prior reports have documented an association between biloma and abdominal trauma, and between biloma and iatrogenic injury resulting from abdominal surgery, percutaneous catheter drainage, or transhepatic cholangiogram. To our knowledge, bilomas have not previously been associated with lung cancer. We report a case of spontaneous biloma that developed as a complication of small cell lung cancer.


7. DOCID:26251 SCORE: 0.0020698601601307
DOCNO: 9763866
AUTHOR: M Bontenbal M
AUTHOR: R de Wit R
AUTHOR: J G Klijn JG
AUTHOR: C Seynaeve C
AFFILIATION: Academisch Ziekenhuis Rotterdam-Daniel den Hoed Kliniek, afd. Interne Oncologie, Rotterdam.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nederlands tijdschrift voor geneeskunde.
COUNTRY: NETHERLANDS
TITLE: [Chemotherapy in metastasized breast carcinoma]
PUBDATE: 19980701
Metastatic breast cancer is still an incurable disease. Standard hormonal and chemotherapeutic treatment modalities yield at the best a survival advantage of 1 to 2 years. However, palliation is still the second, very important goal of treatment for metastatic disease. First-line chemotherapeutic treatment with an anthracycline-containing regimen induces a response in about half the patients. In second-line treatment docetaxel is an effective agent even in patients failing first-line therapy with an anthracycline-containing regimen. There is no effective standard third-line chemotherapy scheme.


8. DOCID:31576 SCORE: 0.00200878131097522
DOCNO: 12154411
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Disease Models, Animal
QUALIFIER: genetics
AUTHOR: Laurie Jackson-Grusby L
AFFILIATION: Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts, MA 02142, USA. jackson@wi.mit.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncogene.
COUNTRY: England
TITLE: Modeling cancer in mice.
PUBDATE: 20020801
The laboratory mouse is one of the most powerful tools for both gene discovery and validation in cancer genetics. Recent technological advances in engineering the mouse genome with chromosome translocations, latent alleles, and tissue-specific and temporally regulated mutations have provided more exacting models of human disease. The marriage of mouse tumor models with rapidly evolving methods to profile genetic and epigenetic alterations in tumors, and to finely map genetic modifier loci, will continue to provide insight into the key pathways leading to tumorigenesis. These discoveries hold great promise for identifying relevant drug targets for treating human cancer.


9. DOCID:31916 SCORE: 0.00196574033651935
DOCNO: 12850768
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: blood supply
QUALIFIER: physiopathology
AUTHOR: Andréas Bikfalvi A
AFFILIATION: Laboratoire des mécanismes moléculaires de l'angiogenèse (Inserm E0113), Université Bordeaux I, avenue des Facultés, 33405 Talence. a.bikfalvi@croissance.u-bordeaux.fr
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Bulletin du cancer.
COUNTRY: France
TITLE: [Tumor angiogenesis]
PUBDATE: 20030501
Recent advances in the understanding of the molecular control of angiogenesis have shown that this process is essential for tumor development and spread. The identification of a great many of ligands, receptors or intracellular signalling molecules have allowed to unravel some of the regulatory loops involved. Especially noteworthy is the fact that developmental regulators seem now to play a role in tumor angiogenesis. Furthermore, these studies have allowed to identify novel therapeutic targets and to develop novel molecules and strategies for cancer therapy. This indicates that tumor angiogenesis is at present a major focus of cancer research.


10. DOCID:27314 SCORE: 0.0019336054580768
DOCNO: 9633320
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Indians, North American
QUALIFIER: organization & administration
QUALIFIER: ethnology
QUALIFIER: prevention & control
AUTHOR: H F Clarke HF
AUTHOR: R Joseph R
AUTHOR: M Deschamps M
AUTHOR: T G Hislop TG
AUTHOR: P R Band PR
AUTHOR: R Atleo R
AFFILIATION: Registered Nurses Association, British Columbia, Vancouver.
PUBTYPE: Journal Article
JOURNALTITLE: The Canadian nurse.
COUNTRY: CANADA
TITLE: Reducing cervical cancer among First Nations women.
PUBDATE: 19980301
First Nations women in British Columbia have a four to six times higher mortality rate from cancer of the cervix than do women in the general population. Their participation in the provincial Cervical Cytology Screening Program (CCSP) is less regular and less frequent than other women in B.C. Likewise, they have more difficulty in obtaining culturally suitable health care services from respectful and consistent professionals. These issues should be of critical concern to nurses, as nurses provide the majority of health services to First Nations people.


11. DOCID:27966 SCORE: 0.0019301410961885
DOCNO: 10442380
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: radiotherapy
AUTHOR: W Hoffmann W
AUTHOR: M Schiebe M
AUTHOR: J Dethling J
AUTHOR: C Martin C
AFFILIATION: Department of Radio-Oncology and Radiotherapy, Braunschweig Community Hospital, University of Hannover Medical School, Germany.
PUBTYPE: Clinical Trial
PUBTYPE: Clinical Trial, Phase I
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Oncology (Williston Park, N.Y.)
COUNTRY: UNITED STATES
TITLE: UFT plus calcium folinate plus radiotherapy for recurrent rectal cancer.
PUBDATE: 19990701
Uracil and tegafur (in a molar ratio of 4:1 [UFT]) plus calcium folinate comprise the components of the oral agent, Orzel, which appears to have activity comparable to intravenously administered 5-fluorouracil. This article describes the design of an open-label, disease-oriented, phase I trial of UFT plus calcium folinate in combination with simultaneous pelvic radiation for recurrent rectal cancer. This trial is designed to determine the maximum tolerated dose and dose-limiting toxicity of this regimen.


12. DOCID:27949 SCORE: 0.00193014068563524
DOCNO: 9818227
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: D L Page DL
AUTHOR: J F Simpson JF
AFFILIATION: Division of Anatomic Pathology, Vanderbilt University Medical Center, Medical Center North, Nashville, TN 37232, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in oncology.
COUNTRY: UNITED STATES
TITLE: Pathology of preinvasive and excellent prognosis breast cancer.
PUBDATE: 19981101
Our review of recent developments in breast cancer involving the evaluation of patients' tissues is aimed at indicators of increased cancer risk (i.e., the atypical hyperplasias) and lesions without metastatic capacity at time of detection, but those lesions with sufficient risk of attaining metastasis that treatment is mandated (i.e., the ductal carcinomas in situ). We also include invasive lesions with little capacity for metastatic behavior, and highlight the histologic criteria for their recognition, as well as their biologic and clinical characterization. Also discussed are advances in the understanding of diagnostic techniques, particularly core needle biopsy.


13. DOCID:27609 SCORE: 0.00192604700735708
DOCNO: 9800117
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Health Behavior
QUALIFIER: prevention & control
AUTHOR: F Baker F
AFFILIATION: Behavioral Research Center, American Cancer Society, Atlanta, GA 30329-4251, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in oncology.
COUNTRY: UNITED STATES
TITLE: Behavioral science applied to cancer screening.
PUBDATE: 19980901
Behavioral science has played an important role in gaining an understanding of behavior related to use of cancer screening; however, thus far this role has been limited mainly to breast and cervical cancer screening. Progress has been made recently in identifying barriers to cancer screening in underserved populations, the role of provider behavior in promoting screening adherence, and in beginning to understand behavioral issues related to genetic susceptibility. Research based on behavioral science theory is increasing, and there is need for more of this type of theory-based research focused on screening for other types of cancer in addition to breast and cervical screening.


14. DOCID:27630 SCORE: 0.00192604604498341
DOCNO: 9932085
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Taxoids
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: C Couteau C
AUTHOR: J P Armand JP
AFFILIATION: Service d'oncologie médicale, hôpital Tenon, Paris, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Bulletin du cancer.
COUNTRY: FRANCE
TITLE: [Irinotecan-containing combinations in solid tumors, except colonic carcinomas]
PUBDATE: 19981201
Irinotecan is a new topoisomerase I inhibitor. It has demonstrated antitumor activity in solid tumors, independently of the histologic type, and in squamous cervical carcinoma. Its original mechanism of action offers the possibility to combine it with other drugs. In vitro and in vivo studies have demonstrated synergistic activity between irinotecan, cisplatin and etoposide. This article reviews the main published phases I and II studies with irinotecan. The limiting toxicity of combination schedules in neutropenia. The best results were obtained with the association cisplatin-irinotecan in lung cancer. For the combination etoposide-irinotecan the best schedule of administration remains to be determined.