0. DOCID:2118 SCORE: 0.00269664502373342
DOCNO: 60916
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: F E Mohs FE
PUBTYPE: Journal Article
JOURNALTITLE: Archives of dermatology.
COUNTRY: UNITED STATES
TITLE: Chemosurgery for skin cancer: fixed tissue and fresh tissue techniques.
PUBDATE: 19760201
Complete microscopical control of the excision of cancer of the skin is achieved by removing tissues layer by layer and examining the undersurface of each layer by means of frozen sections. If the cancer is extensive and complicated or if it is of a type readily spread over an excisional surface, the tissues are fixed in situ with zinc chloride prior to excision (chemosurgery, fixed tissue technique). If the cancer is not too extensive or complicated, the tissues are excised in the fresh, unfixed state (chemosurgery, fresh tissue technique). Both techniques are highly reliable; for example, in two consecutive series of basal cell carcinomas treated chemosurgically, the five-year rate of cure was 99.3% for the 9,351 lesions removed by the fixed tissue technique and 97% for the 127 lesions removed by the fresh tissue technique.

1. DOCID:2363 SCORE: 0.00229675860165
DOCNO: 1008990
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: N Matthews N
AUTHOR: R H Whitehead RH
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Inhibition of K cell function by human breast cancer sera.
PUBDATE: 19761201
Sera from breast cancer patients and from female controls were tested for inhibition of lysis of antibody-coated target cells by human leukocytes (K cells). Sera from 39% of breast cancer patients, but from only 8% of controls, inhibited lysis by more than 30%. This inhibition was unrelated to the stage of the disease, the patient's age or whether the patient was pre- or post-operative. Inhibition was apparently not due to anti-HLA antibodies and did not correlate with the IgG level or anti-complementary activity of the serum. On fractionation by gel-filtration, inhibitory activity was found in fractions of higher molecular weight than IgG. As no IgG could be detected in these fractions, inhibition is probably not due to immune complexes containing IgG antibody. The inhibitory factor may well contribute to the immunosuppressed status of a proportion of breast cancer patients.

2. DOCID:2308 SCORE: 0.00222170717084209
DOCNO: 1190632
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasms, Radiation-Induced
QUALIFIER: etiology
QUALIFIER: adverse effects
QUALIFIER: etiology
AUTHOR: F O Becker FO
AUTHOR: S G Economou SG
AUTHOR: H W Southwick HW
AUTHOR: R Eisenstein R
PUBTYPE: Journal Article
JOURNALTITLE: Annals of internal medicine.
COUNTRY: UNITED STATES
TITLE: Adult thyroid cancer after head and neck irradiation in infancy and childhood.
PUBDATE: 19750901
We report the surgical-pathologic findings in 15 adults who had a history of irradiation of the head and neck in childhood. These patients we selected for thyroid surgery because of a "cold" area or areas detected on 99mTc thyroid scan, with or without palpable thyroid abnormalities. Eight of the fifteen patients had thyroid cancer, and 3 had atypical adenomas. We found multiple lesions in 12 patients. Macroscopic and microscopic malignancy in a location different from the cold area or areas occurred in 5 of the 8 cancer patients. In vitro of these findings, we recommend that adults who received irradiation to the head and neck in childhood and who have been found to have an abnormal thyroid scan or thyroid examination, or both, have a total thyroidectomy...

3. DOCID:7964 SCORE: 0.00220635249487027
DOCNO: 92359
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antibodies, Neoplasm
DESCRIPTOR: Antigens, Neoplasm
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: K M Sheikh KM
AUTHOR: F P Quismorio FP
AUTHOR: G J Friou GJ
AUTHOR: Y T Lee YT
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Ductular carcinoma of the breast: serum antibodies to tumor-associated antigens.
PUBDATE: 19791201
Serum antibodies to tumor-associated antigens of breast carcinoma have been studied by indirect immunofluorescence in 109 patients with breast carcinoma and 125 controls, including age/sex matched normal individuals, patients with nonmalignant disease, and patients with malignant disease other than breast cancer. We report here that sera of a large proportion of patients with ductular carcinoma of the breast have antibodies to cell surface and/or intracellular antigens of autologous tumor cells and include evidence that the antigens are absent from a considerable range of normal and other types of malignant tissues. In addition to testing of control sera, specificity of the reacting antibodies was investigated further by testing of sera with normal breast tissue and the absorption of sera from breast cancer patients with various normal tissues and cancer cells. The significance of the findings in breast cancer is discussed.

4. DOCID:7235 SCORE: 0.0021745216328525
DOCNO: 7284243
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Line
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: S Kondo S
AUTHOR: K Aso K
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of dermatology.
COUNTRY: ENGLAND
TITLE: Establishment of a cell line of human skin squamous cell carcinoma in vitro.
PUBDATE: 19810801
A cell line of a squamous cell carcinoma of human skin (HSC-I) has been established in vitro, and successfully maintained proliferative in continuous tissue culture for about 2 1/2 years since March 1978. Another cell line (HSC-Ib) has been established in vitro from the recurrence of the same cancer. It has been maintained for about 8 months since December 1979. 3T3 feeders were used in the initial cultures in both cases. The cells grow in a monolayer in vitro and are epithelioid with anaplastic features. Chromosome analysis of HSC-I, frozen and thawed HSC-I, the transplanted tumour in a nude mouse and HSC-Ib all showed hypotetraploidy with the modal number 80, which reconfirms that HSC-I derives from the original skin tumour. The cell line is available to other investigators.

5. DOCID:3102 SCORE: 0.00215895501819814
DOCNO: 908479
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
QUALIFIER: mortality
AUTHOR: O Bonnevie O
PUBTYPE: Journal Article
JOURNALTITLE: Gastroenterology.
COUNTRY: UNITED STATES
TITLE: Causes of death in duodenal and gastric ulcer.
PUBDATE: 19771101
An analysis has been made of 235 deaths that occurred among 1905 patients with peptic ulcer who constituted a random sample of the occurrence of ulcer disease in an area of Denmark comprising half a million inhabitants. The disease itself, according to the death certificate, was considered the primary cause of death in 10% of the cases; half of these had been operated on immediately before death. The other patients died more frequently than expected from the following causes: chronic bronchitis, pulmonary emphysema, cancer of the lung, cirrhosis of the liver, and cancer of the pancreas. Although the comorbidity with chronic bronchitis and emphysema was especially pronounced in patients with gastric ulcer, the association with liver cirrhosis and cancer of the pancreas occurred only in patients with duodenal ulcer. In women the mortality rate attributable to cardiac and vascular diseases was lower than expected. No excess coincidence of suicide was found. Berkson's fallacy is considered to be of much less importance as a possible explanation of the comorbidity found in the present study than in the majority of publications concerned with this question.

6. DOCID:6428 SCORE: 0.00215435192150114
DOCNO: 758556
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Metastasis
QUALIFIER: radiography
AUTHOR: J S Nystrom JS
AUTHOR: J M Weiner JM
AUTHOR: R M Wolf RM
AUTHOR: J R Bateman JR
AUTHOR: M V Viola MV
PUBTYPE: Journal Article
JOURNALTITLE: JAMA : the journal of the American Medical Association.
COUNTRY: UNITED STATES
TITLE: Identifying the primary site in metastatic cancer of unknown origin. Inadequacy of roentgenographic procedures.
PUBDATE: 19790101
Two hundred sixty-six patients with metastatic nonsquamous carcinoma of unknown origin underwent upper and lower gastrointestinal series, intravenous pyelograms, and chest roentgenograms (CR) for location of a primary cancer site. Of 129 identified cancer sites, only 22 were verified antemortem, whereas necropsy disclosed 25 cases with false-positive examination results. The CR patterns thought typical for lung cancer (eg, single mass lesion and hilar or mediastinal adenopathy) were often shown (43%) to represent metastatic lesions. Because contrast roentgenographic studies are costly, uncomfortable, of low yield, and often misleading, they should be limited to cases with specific organ dysfunction.

7. DOCID:2143 SCORE: 0.00214903512645117
DOCNO: 848523
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: prevention & control
AUTHOR: S E Brown SE
AUTHOR: H H Allen HH
AUTHOR: R N Robins RN
PUBTYPE: Journal Article
JOURNALTITLE: American journal of obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: The use of delayed primary wound closure in preventing wound infections.
PUBDATE: 19770401
Delayed primary wound closure was performed in 146 patients considered at risk of developing wound infection according to established criteria. These patients were matched individually for age, weight, diagnosis, and the use of prophylactic antibiotics with 146 patients undergoing immediate wound closure during the same time period. The matched pairs were subdivided into five categories depending on the indication for delayed closure; obesity, cancer, "above and below" procedure, infection, and opened bowel. In all categories the incidence of wound infection was significantly lower in the patients with delayed closure. The over-all infection rate was reduced from 23.3% in the control group to 2.1% in the study group. Hospital stay was unaffected. Delayed primary wound closure provides a safe, simple, effective means of reducing the incidence of wound infection.

8. DOCID:2205 SCORE: 0.00211026330180032
DOCNO: 799961
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chemical Industry
QUALIFIER: adverse effects
QUALIFIER: adverse effects
AUTHOR: M Karstadt M
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Environmental health perspectives.
COUNTRY: UNITED STATES
TITLE: PVC: health implications and production trends.
PUBDATE: 19761001
Poly(vinyl chloride) (PVC) is a complex plastic system. Individual components of the PVC system, including residual vinyl chloride monomer (RVCM) and certain additives, may pose risks of harm to human health. There have been significant reductions in the RVCM content of PVC resin since 1974, reducing the cancer risk of workers in PVC fabrication plants and consumers of PVC products. A "no-effect" level for vinyl chloride monomer (VCM)-induced carcinogenesis has not been found to date; therefore, the significance of human exposure to low levels of RVCM remains to be determined. Exposure to PVC dust may cause pulmonary dysfunctions. Pulmonary and other possible health effects of PVC dust require further study. The PVC plastics system should be characterized as to interactions among its various components and as to interactions of the components and the PVC system as a whole with biological systems.

9. DOCID:1948 SCORE: 0.00207649604657593
DOCNO: 1254716
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: biosynthesis
QUALIFIER: metabolism
QUALIFIER: microbiology
AUTHOR: J B Brooks JB
AUTHOR: M J Selin MJ
AUTHOR: C C Alley CC
PUBTYPE: Journal Article
JOURNALTITLE: Journal of clinical microbiology.
COUNTRY: UNITED STATES
TITLE: Electron capture gas chromatography study of the acid and alcohol products of Clostridium septicum and Clostridium chauvoei.
PUBDATE: 19760201
The metabolic products produced by several strains of Clostridium septicum obtained from patients and animals, along with strains of Clostridium chauvoei, were studied in chopped meat glucose medium by electron capture gas-liquid chromatography (EC-GLC). The strains of C. septicum and C. chauvoei were shown to comprise five different metabolic groups. Both the EC-GLC study and the O and H antigenic study performed previously showed that strains of C. septicum comprise a heterogeneous group. One type of metabolic profile was found only in strains of C. chauvoei. The O antigen types and EC-GLC metabolic types of C. septicum correlated fairly well in isolates from cancer patients but not in stock culture and animal isolates.

10. DOCID:2787 SCORE: 0.00204120029400124
DOCNO: 236398
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Plants, Toxic
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: S S Hecht SS
AUTHOR: R M Ornaf RM
AUTHOR: D Hoffmann D
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Chemical studies on tobacco smoke. XXXIII. N' -nitrosonornicotine in tobacco: analysis of possible contributing factors and biologic implications.
PUBDATE: 19750501
A chemical analytic method to determine N'-nitrosonornicotine (NNN) and N' -nitrosoanabasine (NAB) in tobacco was developed. NNN was found in the unburned tobacco of commercial products at concentrations betweeen 0.3 and 88.6 mug/g. The highest levels were observed in highly fermented snuff (29.1 mug/g) and fine-cut chewing tobacco (88.6 mug/g). NAB was not detected (smaller than 0.5 ng/g) in any tobacco examined. Two new tobacco components, N' -carbomethoxynornicotine and N' -carbomethoxyanabasine,were found. Possible origins of NNN in tobacco were discussed, especially in relation to concentrations of nitrite, nitate, and alkaloids, and in relation to pH and curing. Biologic implications, including the possible function of NNN (the first organic carcinogen isolated from unburned tobacco) as a causative factor in cancer of the oral cavity in tobacco chewers and betel quid chewers, were also discussed.

11. DOCID:7834 SCORE: 0.00203850636815518
DOCNO: 637590
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ampulla of Vater
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: T J Hall TJ
AUTHOR: M O Blackstone MO
AUTHOR: M J Cooper MJ
AUTHOR: R G Hughes RG
AUTHOR: A R Moossa AR
PUBTYPE: Journal Article
JOURNALTITLE: Annals of surgery.
COUNTRY: UNITED STATES
TITLE: Prospective evaluation of endoscopic retrograde cholangiopancreatography in the diagnosis of periampullary cancers.
PUBDATE: 19780301
In a prospective study of 112 patients suspected of periampullary cancer endoscopic retrograde cholangiopancreatography (ERCP) was successfully performed in 87 patients (78%). Technical failures were due to gastric outlet obstruction in four patients and inability to cannulate the ampulla of Vater in 21 patients. Successfully performed ERCP had both a high sensitivity (92%) and specificity (90%) for periampullary cancer. The few errors in pancreatogram interpretation were due to juxta-ductal cancers and difficulty in differentiating duct changes of cancer from those of chronic pancreatitis. Pancreatic cytology, performed in 21 patients, was reliable, diagnosed two pancreatic cancers when the pancreatogram failed and, if used routinely, assists interpretation of the pancreatogram. Retrograde cholangiography provided a correct diagnosis in six jaundiced patients with normal pancreatograms. Three complications of ERCP occurred in this series.

12. DOCID:7296 SCORE: 0.0019708528456427
DOCNO: 6947783
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: A Törnqvist A
AUTHOR: G Ekelund G
AUTHOR: L Leandoer L
PUBTYPE: Journal Article
JOURNALTITLE: The Australian and New Zealand journal of surgery.
COUNTRY: AUSTRALIA
TITLE: Early diagnosis of metachronous colorectal carcinoma.
PUBDATE: 19811001
The frequency of metachronous colorectal tumours in a prospective 20-year series of patients with colorectal cancer is reported. Thirty-one patients, that is 2.1% of the patients operated on for cure, had metachronous carcinomas, and 5.4% had metachronous polyps. One-third of the metachronous carcinomas were diagnosed at scheduled postoperative control examinations, and the others because of their symptoms or at autopsy. The reported metachronous carcinomas are considered to represent failures of follow-up only and not to indicate their true incidence, since their natural course has been arrested by removal of adenomas whenever found. Several of the metachronous tumours were judged to be overlooked synchronous ones, and therefore a thorough postoperative examination of the remaining large bowel is advocated. The finding of subsequent tumours in this series indicates that continuous follow-up is worthwhile.

13. DOCID:1691 SCORE: 0.00195082139613889
DOCNO: 912857
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: blood
AUTHOR: R A Cox RA
AUTHOR: M Gokcen M
PUBTYPE: Journal Article
JOURNALTITLE: Clinical biochemistry.
COUNTRY: CANADA
TITLE: An improved filter-disc assay for 3H-DNA and serum deoxyribonucleases.
PUBDATE: 19771001
1. The filter-paper disc assay for tritium-labeled nucleic acids was modified to reduce washing and manipulation. Evaluation of the procedure indicated greatly enhanced counting efficiency for tritium, complete removal of nuclease digestion products and retention of even nanogram levels of radioactive DNA on the discs in the presence of protein. The modified assay was quite sensitive and had a coefficient of variation of 5.2%. Quite low concentrations of DNase I and endogenous human serum nuclease activity were readily measured by the improved technique, 22 sera yielding a mean value equivalent to about 0.5 ng DNase I/ml serum. We are now using the disc assay to follow serum DNA and DNase levels in patients with autoimmune disorders and various types of cancers.

14. DOCID:6410 SCORE: 0.00194682243479195
DOCNO: 7274633
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: T Iwaguchi T
AUTHOR: H Kitagawa H
AUTHOR: K Hirose K
AUTHOR: T Ishida T
AUTHOR: T Yamamoto T
PUBTYPE: Journal Article
JOURNALTITLE: Gann = Gan.
COUNTRY: JAPAN
TITLE: 5-Di-(2'-tetrahydropyranyl)secalonic acid D as a new antibiotic derivative with anticancer activity.
PUBDATE: 19801201
A pyranyl derivative was chemically synthesized from secalonic acid D, an antibiotic obtained from culture filtrates of Penicillium oxalium, and its anticancer activity towards a highly antigenic rat bladder cancer, BC-47, implanted into inbred ACI/N rat was studied. The anticancer effect of the drug was similar to that of adriamycin. Delayed initiation of treatment, starting 5 days after the cancer implantation, was more effective than treatment starting from day 1. In addition, it was less effective in an immunodeficient host subsequently implanted with BC-47. This compound is thought to retard the cancer cell growth until the appearance of tumor immunity in the host.