0. DOCID:26957 SCORE: 0.00252166348923786
DOCNO: 10399438
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: ultrastructure
QUALIFIER: pathology
QUALIFIER: ultrastructure
QUALIFIER: ultrastructure
QUALIFIER: ultrastructure
QUALIFIER: ultrastructure
AUTHOR: V I Tsygankov VI
AUTHOR: S I Shvets SI
AUTHOR: G L Mogileva GL
AUTHOR: V M Kindialov VM
AUTHOR: N P Mel'nikova NP
PUBTYPE: Journal Article
JOURNALTITLE: Klinicheskaia laboratornaia diagnostika.
COUNTRY: RUSSIA
TITLE: [The nuclear morphotypes of epithelial cells in breast diseases]
PUBDATE: 19990501
Staining of the nucleolar ribosome organizer with AgNO3 followed by computer analysis of images by discriminant analysis helped distinguish 6 morphological types in the cells of cytological preparations of mammary glands. Comparison of the morphometrical data and results of visual examination of cells showed that the first type included nonproliferating fibroadenoma and mastopathy, type 2 fibroadenoma and mastopathy with moderate proliferation of epithelium, type 3 fibroadenoma and mastopathy with precancer epithelial proliferation, and types 4-6 included malignant proliferating cells which are compatible with well, moderately, and poorly differentiated cancer.
1. DOCID:18824 SCORE: 0.00241691483493225
DOCNO: 2260877
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: therapeutic use
QUALIFIER: secondary
QUALIFIER: pathology
QUALIFIER: secondary
QUALIFIER: therapeutic use
AUTHOR: K Kanda K
AUTHOR: S Waki S
AUTHOR: M Uchimura M
AUTHOR: H Kida H
AUTHOR: K Narita K
AUTHOR: N Harada N
AFFILIATION: Dept. of Surgery, Hamamatsu Medical Center.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [A case of bone and lung metastasis of breast cancer successfully treated with radiotherapy, chemotherapy and endocrine therapy]
PUBDATE: 19901201
A 34-year-old female patient with breast cancer metastasizing to bone had a remission after a course of treatment with medroxyprogesterone acetate (MPA) 1,200 mg/day, but again had a metastasis to the lungs. The patient was then instituted on a combination therapy with UFT 400 mg/day, and MPA 1,200 mg/day. As a result, the pulmonary metastasis disappeared, along with the consolidation of the bone involved.
2. DOCID:31263 SCORE: 0.00238417567254218
DOCNO: 15546933
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosome Aberrations
DESCRIPTOR: Database Management Systems
DESCRIPTOR: Software
DESCRIPTOR: User-Computer Interface
QUALIFIER: methods
QUALIFIER: methods
QUALIFIER: methods
AUTHOR: Bernhard Hiller B
AUTHOR: Jutta Bradtke J
AUTHOR: Harald Balz H
AUTHOR: Harald Rieder H
AFFILIATION: Institut für Klinische Genetik der Phillipps-Universität Marburg, Bahnhofstrasse 7, 35037 Marburg, Germany.
PUBTYPE: Journal Article
JOURNALTITLE: Bioinformatics (Oxford, England)
COUNTRY: England
TITLE: CyDAS: a cytogenetic data analysis system.
PUBDATE: 20050401
For statistical analyses in cancer cytogenetics, the genomic changes encoded by the karyotype must be translated into numerical codes. We developed a program, which extracts chromosomal gains and losses as well as breakpoints from the karyotype. The changes are compiled in tables according to the chromosome bands involved and/or depicted in projection to the respective chromosome ideogram. The data are ready to be integrated into further statistical analyses. The program may be run as desktop or Internet application.
3. DOCID:30637 SCORE: 0.00235693702923702
DOCNO: 15043429
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: chemistry
QUALIFIER: isolation & purification
QUALIFIER: chemistry
AUTHOR: Ahmed A Hussein AA
AUTHOR: Icela Barberena I
AUTHOR: Todd L Capson TL
AUTHOR: Thomas A Kursar TA
AUTHOR: Phyllis D Coley PD
AUTHOR: Pablo N Solis PN
AUTHOR: Mahabir P Gupta MP
AFFILIATION: Centro de Investigaciones Farmacognósticas de la Flora Panameña (CIFLORPAN), Facultad de Farmacia, Universidad de Panamá, Apartado 10767, Estafeta Universitaria, Panama, Republic of Panama.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of natural products.
COUNTRY: United States
TITLE: New cytotoxic naphthopyrane derivatives from Adenaria floribunda.
PUBDATE: 20040301
Bioassay-guided fractionation of an EtOAc/MeOH extract of Adenaria floribunda young leaves using MCF-7, H-460, and SF-268 cancer cell lines yielded four new active compounds named adenaflorins A-D (1-4). Their chemical structures were determined by spectroscopic means. Adenaflorin A (1) was the most cytotoxic.
4. DOCID:25662 SCORE: 0.00230632249274813
DOCNO: 11247482
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Intensive Care
QUALIFIER: surgery
QUALIFIER: methods
QUALIFIER: surgery
AUTHOR: G V Bondar' GV
AUTHOR: A V Borota AV
AUTHOR: S E Zolotukhin SE
AUTHOR: K N Oleĭnikov KN
AUTHOR: G G Psaras GG
AUTHOR: S D Vasil'ev SD
PUBTYPE: Journal Article
JOURNALTITLE: Klinichna khirurhiia / Ministerstvo okhorony zdorov'ia Ukraïny, Naukove tovarystvo khirurhiv Ukraïny.
COUNTRY: Ukraine
TITLE: [Intensive therapy and strategy of management of patients with rectal cancer after the colonic descending to the perineum]
PUBDATE: 20001201
Optimal tactic for management of the patients on various stages of treatment was elaborated together with surgical procedure, basing on the experience of 3500 operations conduction for cancer recti, mainly abdominal resection with colon descendant to perineum. Methods of preoperative preparation and anesthesiological support were stated as well as the tactics of postoperative management of patients.
5. DOCID:23046 SCORE: 0.00225422990060723
DOCNO: 9234939
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: secondary
QUALIFIER: secondary
QUALIFIER: pathology
AUTHOR: G H Eltabbakh GH
AUTHOR: M S Piver MS
AUTHOR: B A Werness BA
AFFILIATION: Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: Primary peritoneal adenocarcinoma metastatic to the brain.
PUBDATE: 19970701
Primary peritoneal adenocarcinoma is a relatively newly identified disease entity whose clinical behavior is not fully recognized. We report a case of a patient with progressive primary peritoneal adenocarcinoma who developed brain metastases and died shortly afterward. The incidence of central nervous system metastases in 72 patients with documented primary peritoneal adenocarcinoma was 1.4%. The risk factors, clinical behavior, and prognosis of patients with primary peritoneal adenocarcinoma metastatic to the central nervous system seem to be similar to those of patients with epithelial ovarian cancer metastatic to the central nervous system.
6. DOCID:26617 SCORE: 0.00220589800459228
DOCNO: 9852402
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Expression Regulation, Neoplastic
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: J Fujimoto J
AUTHOR: R Hirose R
AUTHOR: H Sakaguchi H
AUTHOR: T Tamaya T
AFFILIATION: Department of Obstetrics and Gynecology, Gifu University School of Medicine, Tsukasa-machi, Gifu City, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncology.
COUNTRY: SWITZERLAND
TITLE: Estrogen dependency in uterine endometrial cancers.
PUBDATE: 19981201
Estrogen dependency in uterine endometrial cancers involves complicated tumor biology. A transformed phenotype of uterine endometrial cancers is supported by estrogen-dependent oncogene (c-Ha-ras, c-fos and c-jun) expressions. The relative overexpression of estrogen receptor exon 5 splicing variant and the damaged expression of progesterone receptor A, which belong to a lack of estrogen dependency, are related to metastatic potential. The estrogen-related metastatic processes, detachment, invasion and angiogenesis in some uterine endometrial cancers can be inhibited by progestins.
7. DOCID:26929 SCORE: 0.00215105662617208
DOCNO: 11089384
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: secondary
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: J R Green JR
AFFILIATION: Novartis Pharma AG, Basel, Switzerland. jonathan.green@pharma.novartis.com
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Medizinische Klinik (Munich, Germany : 1983)
COUNTRY: GERMANY
TITLE: Anti-tumor potential of bisphosphonates.
PUBDATE: 20001001
In addition to inhibiting bone resorption, bisphosphonates also exert anti-tumor effects. The most potent compounds are the newer, nitrogen-containing bisphosphonates such as zoledronic acid. In vitro, bisphosphonates inhibit proliferation and induce apoptosis in human tumor cell lines, and interfere with cell adhesion, invasion and growth factor secretion. The combination of bisphosphonates with other anti-cancer drugs such as paclitaxel or tamoxifen markedly enhances these effects. In vivo, zoledronic acid has recently been shown to inhibit angiogenesis. Although bisphosphonates are very effective against bone metastases, their in vivo anti-tumor potential against visceral metastases remains to be explored.
8. DOCID:26258 SCORE: 0.0020698602578752
DOCNO: 9567249
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Bile
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: A Hiraki A
AUTHOR: H Ueoka H
AUTHOR: M Tabata M
AUTHOR: K Kiura K
AUTHOR: A Bessho A
AUTHOR: H Yamane H
AUTHOR: N Nogami N
AUTHOR: M Harada M
AFFILIATION: Second Department of Medicine, Okayama University Medical School, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Lung cancer (Amsterdam, Netherlands)
COUNTRY: IRELAND
TITLE: Spontaneous biloma as a complication of small cell lung cancer.
PUBDATE: 19980201
Biloma is an extraductular collection of bile within a defined capsular space. Prior reports have documented an association between biloma and abdominal trauma, and between biloma and iatrogenic injury resulting from abdominal surgery, percutaneous catheter drainage, or transhepatic cholangiogram. To our knowledge, bilomas have not previously been associated with lung cancer. We report a case of spontaneous biloma that developed as a complication of small cell lung cancer.
9. DOCID:26251 SCORE: 0.0020698601601307
DOCNO: 9763866
AUTHOR: M Bontenbal M
AUTHOR: R de Wit R
AUTHOR: J G Klijn JG
AUTHOR: C Seynaeve C
AFFILIATION: Academisch Ziekenhuis Rotterdam-Daniel den Hoed Kliniek, afd. Interne Oncologie, Rotterdam.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nederlands tijdschrift voor geneeskunde.
COUNTRY: NETHERLANDS
TITLE: [Chemotherapy in metastasized breast carcinoma]
PUBDATE: 19980701
Metastatic breast cancer is still an incurable disease. Standard hormonal and chemotherapeutic treatment modalities yield at the best a survival advantage of 1 to 2 years. However, palliation is still the second, very important goal of treatment for metastatic disease. First-line chemotherapeutic treatment with an anthracycline-containing regimen induces a response in about half the patients. In second-line treatment docetaxel is an effective agent even in patients failing first-line therapy with an anthracycline-containing regimen. There is no effective standard third-line chemotherapy scheme.
10. DOCID:31576 SCORE: 0.00200878131097522
DOCNO: 12154411
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Disease Models, Animal
QUALIFIER: genetics
AUTHOR: Laurie Jackson-Grusby L
AFFILIATION: Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts, MA 02142, USA. jackson@wi.mit.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncogene.
COUNTRY: England
TITLE: Modeling cancer in mice.
PUBDATE: 20020801
The laboratory mouse is one of the most powerful tools for both gene discovery and validation in cancer genetics. Recent technological advances in engineering the mouse genome with chromosome translocations, latent alleles, and tissue-specific and temporally regulated mutations have provided more exacting models of human disease. The marriage of mouse tumor models with rapidly evolving methods to profile genetic and epigenetic alterations in tumors, and to finely map genetic modifier loci, will continue to provide insight into the key pathways leading to tumorigenesis. These discoveries hold great promise for identifying relevant drug targets for treating human cancer.
11. DOCID:31916 SCORE: 0.00196574033651935
DOCNO: 12850768
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: blood supply
QUALIFIER: physiopathology
AUTHOR: Andréas Bikfalvi A
AFFILIATION: Laboratoire des mécanismes moléculaires de l'angiogenèse (Inserm E0113), Université Bordeaux I, avenue des Facultés, 33405 Talence. a.bikfalvi@croissance.u-bordeaux.fr
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Bulletin du cancer.
COUNTRY: France
TITLE: [Tumor angiogenesis]
PUBDATE: 20030501
Recent advances in the understanding of the molecular control of angiogenesis have shown that this process is essential for tumor development and spread. The identification of a great many of ligands, receptors or intracellular signalling molecules have allowed to unravel some of the regulatory loops involved. Especially noteworthy is the fact that developmental regulators seem now to play a role in tumor angiogenesis. Furthermore, these studies have allowed to identify novel therapeutic targets and to develop novel molecules and strategies for cancer therapy. This indicates that tumor angiogenesis is at present a major focus of cancer research.
12. DOCID:23854 SCORE: 0.00196556999262513
DOCNO: 7661586
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: Y Sun Y
AUTHOR: X R Zhang XR
AUTHOR: W B Yin WB
AUTHOR: D F Chen DF
AUTHOR: R G Zhang RG
AUTHOR: D W Zhang DW
AFFILIATION: Department of Medical Oncology, Chinese Academy of Medical Sciences, Beijing.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Multicenter Study
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: Prospective multimodality treatment of SCLC--experience during the past 18 years.
PUBDATE: 19950801
Lung cancer has been one of the leading malignancies in China. Since 1989 it has ranked first among common malignancies in the male population, and second in females. In 1975, a multimodality treatment study group for lung cancer was organized in our institute. The group has since expanded to 15 institutions in the Beijing and Tianjin area during the past four years. The present communication is based on our experiences and data, and tries to explain the treatment strategy of our study group.
13. DOCID:19662 SCORE: 0.00193971214723087
DOCNO: 8462335
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: R J Mayer RJ
AFFILIATION: Dana-Farber Cancer Institute, Harvard Medical School, Boston 02115.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Chest.
COUNTRY: UNITED STATES
TITLE: Overview: the changing nature of esophageal cancer.
PUBDATE: 19930401
Squamous cell carcinomas of the esophagus, while still frequent in many locations throughout the world, now comprise a smaller percentage of esophageal cancers in the United States than was previously believed. Such tumors occur most often in black men and in association with tobacco and alcohol abuse. Adenocarcinomas of the distal esophagus represent an increasing proportion of esophageal tumors. These neoplasms arise in columnar epithelium (ie, Barrett's esophagus) or extend into the esophagus from their site of origin in the proximal stomach. Esophageal adenocarcinomas appear more often in white than black subjects and in men more than women. The clinical features and diagnostic approaches to squamous cell tumors and adenocarcinomas of the esophagus are similar.
14. DOCID:27314 SCORE: 0.0019336054580768
DOCNO: 9633320
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Indians, North American
QUALIFIER: organization & administration
QUALIFIER: ethnology
QUALIFIER: prevention & control
AUTHOR: H F Clarke HF
AUTHOR: R Joseph R
AUTHOR: M Deschamps M
AUTHOR: T G Hislop TG
AUTHOR: P R Band PR
AUTHOR: R Atleo R
AFFILIATION: Registered Nurses Association, British Columbia, Vancouver.
PUBTYPE: Journal Article
JOURNALTITLE: The Canadian nurse.
COUNTRY: CANADA
TITLE: Reducing cervical cancer among First Nations women.
PUBDATE: 19980301
First Nations women in British Columbia have a four to six times higher mortality rate from cancer of the cervix than do women in the general population. Their participation in the provincial Cervical Cytology Screening Program (CCSP) is less regular and less frequent than other women in B.C. Likewise, they have more difficulty in obtaining culturally suitable health care services from respectful and consistent professionals. These issues should be of critical concern to nurses, as nurses provide the majority of health services to First Nations people.