0. DOCID:2118 SCORE: 0.00269664502373342
DOCNO: 60916
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: F E Mohs FE
PUBTYPE: Journal Article
JOURNALTITLE: Archives of dermatology.
COUNTRY: UNITED STATES
TITLE: Chemosurgery for skin cancer: fixed tissue and fresh tissue techniques.
PUBDATE: 19760201
Complete microscopical control of the excision of cancer of the skin is achieved by removing tissues layer by layer and examining the undersurface of each layer by means of frozen sections. If the cancer is extensive and complicated or if it is of a type readily spread over an excisional surface, the tissues are fixed in situ with zinc chloride prior to excision (chemosurgery, fixed tissue technique). If the cancer is not too extensive or complicated, the tissues are excised in the fresh, unfixed state (chemosurgery, fresh tissue technique). Both techniques are highly reliable; for example, in two consecutive series of basal cell carcinomas treated chemosurgically, the five-year rate of cure was 99.3% for the 9,351 lesions removed by the fixed tissue technique and 97% for the 127 lesions removed by the fresh tissue technique.


1. DOCID:9587 SCORE: 0.00247979483256959
DOCNO: 7091905
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: S G Jenkinson SG
AUTHOR: M W Banschbach MW
PUBTYPE: Journal Article
JOURNALTITLE: The American review of respiratory disease.
COUNTRY: UNITED STATES
TITLE: Radioimmunoassay determinations of prostaglandin E in pleural effusions of varying causes.
PUBDATE: 19820701
The concentrations of prostaglandin E (PgE) were measured in pleural fluid samples from 26 consecutive patients with pleural effusions of varying causes. The PgE concentrations were significantly increased in exudates when compared with transudates and provided a single measurement to separate these 2 classifications of pleural fluid. The highest concentrations of PgE were found in exudates associated with tuberculous pleuritis and metastatic lung cancer. Simultaneous measurement of pleural fluid and plasma PgE concentrations in patients with malignant effusions revealed that pleural fluid concentrations did not reflect plasma concentrations.


2. DOCID:2363 SCORE: 0.00229675860165
DOCNO: 1008990
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: N Matthews N
AUTHOR: R H Whitehead RH
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Inhibition of K cell function by human breast cancer sera.
PUBDATE: 19761201
Sera from breast cancer patients and from female controls were tested for inhibition of lysis of antibody-coated target cells by human leukocytes (K cells). Sera from 39% of breast cancer patients, but from only 8% of controls, inhibited lysis by more than 30%. This inhibition was unrelated to the stage of the disease, the patient's age or whether the patient was pre- or post-operative. Inhibition was apparently not due to anti-HLA antibodies and did not correlate with the IgG level or anti-complementary activity of the serum. On fractionation by gel-filtration, inhibitory activity was found in fractions of higher molecular weight than IgG. As no IgG could be detected in these fractions, inhibition is probably not due to immune complexes containing IgG antibody. The inhibitory factor may well contribute to the immunosuppressed status of a proportion of breast cancer patients.


3. DOCID:2308 SCORE: 0.00222170717084209
DOCNO: 1190632
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasms, Radiation-Induced
QUALIFIER: etiology
QUALIFIER: adverse effects
QUALIFIER: etiology
AUTHOR: F O Becker FO
AUTHOR: S G Economou SG
AUTHOR: H W Southwick HW
AUTHOR: R Eisenstein R
PUBTYPE: Journal Article
JOURNALTITLE: Annals of internal medicine.
COUNTRY: UNITED STATES
TITLE: Adult thyroid cancer after head and neck irradiation in infancy and childhood.
PUBDATE: 19750901
We report the surgical-pathologic findings in 15 adults who had a history of irradiation of the head and neck in childhood. These patients we selected for thyroid surgery because of a "cold" area or areas detected on 99mTc thyroid scan, with or without palpable thyroid abnormalities. Eight of the fifteen patients had thyroid cancer, and 3 had atypical adenomas. We found multiple lesions in 12 patients. Macroscopic and microscopic malignancy in a location different from the cold area or areas occurred in 5 of the 8 cancer patients. In vitro of these findings, we recommend that adults who received irradiation to the head and neck in childhood and who have been found to have an abnormal thyroid scan or thyroid examination, or both, have a total thyroidectomy...


4. DOCID:7964 SCORE: 0.00220635249487027
DOCNO: 92359
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antibodies, Neoplasm
DESCRIPTOR: Antigens, Neoplasm
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: K M Sheikh KM
AUTHOR: F P Quismorio FP
AUTHOR: G J Friou GJ
AUTHOR: Y T Lee YT
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Ductular carcinoma of the breast: serum antibodies to tumor-associated antigens.
PUBDATE: 19791201
Serum antibodies to tumor-associated antigens of breast carcinoma have been studied by indirect immunofluorescence in 109 patients with breast carcinoma and 125 controls, including age/sex matched normal individuals, patients with nonmalignant disease, and patients with malignant disease other than breast cancer. We report here that sera of a large proportion of patients with ductular carcinoma of the breast have antibodies to cell surface and/or intracellular antigens of autologous tumor cells and include evidence that the antigens are absent from a considerable range of normal and other types of malignant tissues. In addition to testing of control sera, specificity of the reacting antibodies was investigated further by testing of sera with normal breast tissue and the absorption of sera from breast cancer patients with various normal tissues and cancer cells. The significance of the findings in breast cancer is discussed.


5. DOCID:9780 SCORE: 0.00219600093846364
DOCNO: 6606627
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: S Pollack S
AUTHOR: A Micali A
AUTHOR: D W Kinne DW
AUTHOR: W E Enker WE
AUTHOR: N Geller N
AUTHOR: H F Oettgen HF
AUTHOR: M K Hoffmann MK
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: Endotoxin-induced in vitro release of interleukin-1 by cancer patients' monocytes: relation to stage of disease.
PUBDATE: 19831201
The in vitro release of IL-1 by monocytes in response to endotoxin was subnormal in many patients with breast cancer, malignant melanoma or colorectal cancer but not in patients with benign tumors of the breast or colon. In each of these groups, IL-1 release was low in patients with early cancer, normal in patients with regional metastases, and low in patients with disseminated cancer.


6. DOCID:7235 SCORE: 0.0021745216328525
DOCNO: 7284243
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Line
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: S Kondo S
AUTHOR: K Aso K
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of dermatology.
COUNTRY: ENGLAND
TITLE: Establishment of a cell line of human skin squamous cell carcinoma in vitro.
PUBDATE: 19810801
A cell line of a squamous cell carcinoma of human skin (HSC-I) has been established in vitro, and successfully maintained proliferative in continuous tissue culture for about 2 1/2 years since March 1978. Another cell line (HSC-Ib) has been established in vitro from the recurrence of the same cancer. It has been maintained for about 8 months since December 1979. 3T3 feeders were used in the initial cultures in both cases. The cells grow in a monolayer in vitro and are epithelioid with anaplastic features. Chromosome analysis of HSC-I, frozen and thawed HSC-I, the transplanted tumour in a nude mouse and HSC-Ib all showed hypotetraploidy with the modal number 80, which reconfirms that HSC-I derives from the original skin tumour. The cell line is available to other investigators.


7. DOCID:15296 SCORE: 0.00216547595077628
DOCNO: 3812437
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Regression Analysis
AUTHOR: S D Walter SD
AUTHOR: A R Feinstein AR
AUTHOR: C K Wells CK
PUBTYPE: Journal Article
JOURNALTITLE: American journal of epidemiology.
COUNTRY: UNITED STATES
TITLE: Coding ordinal independent variables in multiple regression analyses.
PUBDATE: 19870201
The authors present a coding scheme for ordinal independent variables which may be used in various forms of regression analysis. The scheme is useful in dose-response analyses, when the objective is to identify contrasts in the dependent (or response) variable between successive levels of the independent variable, or to identify critical threshold values of the independent variables at which significant changes occur in the response. An example is given of evaluating the survival of lung cancer patients according to their stage of symptomatology. The authors discuss the interpretation of the regression coefficients when this coding scheme is used with linear regression, logistic regression, or in the proportional hazards regression model.


8. DOCID:3102 SCORE: 0.00215895501819814
DOCNO: 908479
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
QUALIFIER: mortality
AUTHOR: O Bonnevie O
PUBTYPE: Journal Article
JOURNALTITLE: Gastroenterology.
COUNTRY: UNITED STATES
TITLE: Causes of death in duodenal and gastric ulcer.
PUBDATE: 19771101
An analysis has been made of 235 deaths that occurred among 1905 patients with peptic ulcer who constituted a random sample of the occurrence of ulcer disease in an area of Denmark comprising half a million inhabitants. The disease itself, according to the death certificate, was considered the primary cause of death in 10% of the cases; half of these had been operated on immediately before death. The other patients died more frequently than expected from the following causes: chronic bronchitis, pulmonary emphysema, cancer of the lung, cirrhosis of the liver, and cancer of the pancreas. Although the comorbidity with chronic bronchitis and emphysema was especially pronounced in patients with gastric ulcer, the association with liver cirrhosis and cancer of the pancreas occurred only in patients with duodenal ulcer. In women the mortality rate attributable to cardiac and vascular diseases was lower than expected. No excess coincidence of suicide was found. Berkson's fallacy is considered to be of much less importance as a possible explanation of the comorbidity found in the present study than in the majority of publications concerned with this question.


9. DOCID:6428 SCORE: 0.00215435192150114
DOCNO: 758556
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Metastasis
QUALIFIER: radiography
AUTHOR: J S Nystrom JS
AUTHOR: J M Weiner JM
AUTHOR: R M Wolf RM
AUTHOR: J R Bateman JR
AUTHOR: M V Viola MV
PUBTYPE: Journal Article
JOURNALTITLE: JAMA : the journal of the American Medical Association.
COUNTRY: UNITED STATES
TITLE: Identifying the primary site in metastatic cancer of unknown origin. Inadequacy of roentgenographic procedures.
PUBDATE: 19790101
Two hundred sixty-six patients with metastatic nonsquamous carcinoma of unknown origin underwent upper and lower gastrointestinal series, intravenous pyelograms, and chest roentgenograms (CR) for location of a primary cancer site. Of 129 identified cancer sites, only 22 were verified antemortem, whereas necropsy disclosed 25 cases with false-positive examination results. The CR patterns thought typical for lung cancer (eg, single mass lesion and hilar or mediastinal adenopathy) were often shown (43%) to represent metastatic lesions. Because contrast roentgenographic studies are costly, uncomfortable, of low yield, and often misleading, they should be limited to cases with specific organ dysfunction.


10. DOCID:2143 SCORE: 0.00214903512645117
DOCNO: 848523
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: prevention & control
AUTHOR: S E Brown SE
AUTHOR: H H Allen HH
AUTHOR: R N Robins RN
PUBTYPE: Journal Article
JOURNALTITLE: American journal of obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: The use of delayed primary wound closure in preventing wound infections.
PUBDATE: 19770401
Delayed primary wound closure was performed in 146 patients considered at risk of developing wound infection according to established criteria. These patients were matched individually for age, weight, diagnosis, and the use of prophylactic antibiotics with 146 patients undergoing immediate wound closure during the same time period. The matched pairs were subdivided into five categories depending on the indication for delayed closure; obesity, cancer, "above and below" procedure, infection, and opened bowel. In all categories the incidence of wound infection was significantly lower in the patients with delayed closure. The over-all infection rate was reduced from 23.3% in the control group to 2.1% in the study group. Hospital stay was unaffected. Delayed primary wound closure provides a safe, simple, effective means of reducing the incidence of wound infection.


11. DOCID:9486 SCORE: 0.0021197626498024
DOCNO: 4002077
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: blood
AUTHOR: D O'Donnell D
AUTHOR: A M Meyers AM
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.
COUNTRY: SOUTH AFRICA
TITLE: Hypophosphataemic osteomalacia misdiagnosed as metastatic carcinoma. A case report.
PUBDATE: 19850601
A 60-year-old woman presented with diffuse bone pain 12 months after simple mastectomy. During investigation for metastatic disease it was realized that her pain had preceded the mastectomy by 2 years and that the biochemical and radiological findings were inconsistent with metastatic disease. The findings of phosphaturia, hypophosphataemia, normocalcaemia and normal renal function without hyperparathyroidism are discussed in the light of the rarity of such findings in a 60-year-old adult and, in particular, in a patient with cancer of the breast.


12. DOCID:2205 SCORE: 0.00211026330180032
DOCNO: 799961
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chemical Industry
QUALIFIER: adverse effects
QUALIFIER: adverse effects
AUTHOR: M Karstadt M
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Environmental health perspectives.
COUNTRY: UNITED STATES
TITLE: PVC: health implications and production trends.
PUBDATE: 19761001
Poly(vinyl chloride) (PVC) is a complex plastic system. Individual components of the PVC system, including residual vinyl chloride monomer (RVCM) and certain additives, may pose risks of harm to human health. There have been significant reductions in the RVCM content of PVC resin since 1974, reducing the cancer risk of workers in PVC fabrication plants and consumers of PVC products. A "no-effect" level for vinyl chloride monomer (VCM)-induced carcinogenesis has not been found to date; therefore, the significance of human exposure to low levels of RVCM remains to be determined. Exposure to PVC dust may cause pulmonary dysfunctions. Pulmonary and other possible health effects of PVC dust require further study. The PVC plastics system should be characterized as to interactions among its various components and as to interactions of the components and the PVC system as a whole with biological systems.


13. DOCID:1948 SCORE: 0.00207649604657593
DOCNO: 1254716
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: biosynthesis
QUALIFIER: metabolism
QUALIFIER: microbiology
AUTHOR: J B Brooks JB
AUTHOR: M J Selin MJ
AUTHOR: C C Alley CC
PUBTYPE: Journal Article
JOURNALTITLE: Journal of clinical microbiology.
COUNTRY: UNITED STATES
TITLE: Electron capture gas chromatography study of the acid and alcohol products of Clostridium septicum and Clostridium chauvoei.
PUBDATE: 19760201
The metabolic products produced by several strains of Clostridium septicum obtained from patients and animals, along with strains of Clostridium chauvoei, were studied in chopped meat glucose medium by electron capture gas-liquid chromatography (EC-GLC). The strains of C. septicum and C. chauvoei were shown to comprise five different metabolic groups. Both the EC-GLC study and the O and H antigenic study performed previously showed that strains of C. septicum comprise a heterogeneous group. One type of metabolic profile was found only in strains of C. chauvoei. The O antigen types and EC-GLC metabolic types of C. septicum correlated fairly well in isolates from cancer patients but not in stock culture and animal isolates.


14. DOCID:15984 SCORE: 0.0020586945930826
DOCNO: 11648245
OWNER: KIE
STATUS: MEDLINE
DESCRIPTOR: Adolescent
DESCRIPTOR: Jurisprudence
DESCRIPTOR: Minors
DESCRIPTOR: Parents
DESCRIPTOR: Religion
DESCRIPTOR: Treatment Refusal
PUBTYPE: Legal Cases
JOURNALTITLE: West's California reporter.
COUNTRY: United States
TITLE: In re Eric B.
PUBDATE: 19870201
The issue presented in this appeal was whether a California juvenile court could order a five-year-old boy to undergo periodic medical monitoring to detect the possible recurrence of cancer, notwithstanding objections by the child's parents that such an order offended their Christian Science beliefs. Although the parents had consented to removal of the boy's eye following a diagnosis of cancer, and had permitted court-ordered chemotherapy and radiation treatment, they opposed recommendations that the boy be monitored over a two-year period for possible recurrence of the cancer. The juvenile court intervened and ordered that the parents comply with the recommendations. The parents filed a motion to reconsider the monitoring order on both statutory and constitutional grounds. The Superior Court denied the motion and the Court of Appeal affirmed.