0. DOCID:2118 SCORE: 0.00269664502373342
DOCNO: 60916
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: F E Mohs FE
PUBTYPE: Journal Article
JOURNALTITLE: Archives of dermatology.
COUNTRY: UNITED STATES
TITLE: Chemosurgery for skin cancer: fixed tissue and fresh tissue techniques.
PUBDATE: 19760201
Complete microscopical control of the excision of cancer of the skin is achieved by removing tissues layer by layer and examining the undersurface of each layer by means of frozen sections. If the cancer is extensive and complicated or if it is of a type readily spread over an excisional surface, the tissues are fixed in situ with zinc chloride prior to excision (chemosurgery, fixed tissue technique). If the cancer is not too extensive or complicated, the tissues are excised in the fresh, unfixed state (chemosurgery, fresh tissue technique). Both techniques are highly reliable; for example, in two consecutive series of basal cell carcinomas treated chemosurgically, the five-year rate of cure was 99.3% for the 9,351 lesions removed by the fixed tissue technique and 97% for the 127 lesions removed by the fresh tissue technique.


1. DOCID:26957 SCORE: 0.00252166348923786
DOCNO: 10399438
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: ultrastructure
QUALIFIER: pathology
QUALIFIER: ultrastructure
QUALIFIER: ultrastructure
QUALIFIER: ultrastructure
QUALIFIER: ultrastructure
AUTHOR: V I Tsygankov VI
AUTHOR: S I Shvets SI
AUTHOR: G L Mogileva GL
AUTHOR: V M Kindialov VM
AUTHOR: N P Mel'nikova NP
PUBTYPE: Journal Article
JOURNALTITLE: Klinicheskaia laboratornaia diagnostika.
COUNTRY: RUSSIA
TITLE: [The nuclear morphotypes of epithelial cells in breast diseases]
PUBDATE: 19990501
Staining of the nucleolar ribosome organizer with AgNO3 followed by computer analysis of images by discriminant analysis helped distinguish 6 morphological types in the cells of cytological preparations of mammary glands. Comparison of the morphometrical data and results of visual examination of cells showed that the first type included nonproliferating fibroadenoma and mastopathy, type 2 fibroadenoma and mastopathy with moderate proliferation of epithelium, type 3 fibroadenoma and mastopathy with precancer epithelial proliferation, and types 4-6 included malignant proliferating cells which are compatible with well, moderately, and poorly differentiated cancer.


2. DOCID:9587 SCORE: 0.00247979483256959
DOCNO: 7091905
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: S G Jenkinson SG
AUTHOR: M W Banschbach MW
PUBTYPE: Journal Article
JOURNALTITLE: The American review of respiratory disease.
COUNTRY: UNITED STATES
TITLE: Radioimmunoassay determinations of prostaglandin E in pleural effusions of varying causes.
PUBDATE: 19820701
The concentrations of prostaglandin E (PgE) were measured in pleural fluid samples from 26 consecutive patients with pleural effusions of varying causes. The PgE concentrations were significantly increased in exudates when compared with transudates and provided a single measurement to separate these 2 classifications of pleural fluid. The highest concentrations of PgE were found in exudates associated with tuberculous pleuritis and metastatic lung cancer. Simultaneous measurement of pleural fluid and plasma PgE concentrations in patients with malignant effusions revealed that pleural fluid concentrations did not reflect plasma concentrations.


3. DOCID:18824 SCORE: 0.00241691483493225
DOCNO: 2260877
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: therapeutic use
QUALIFIER: secondary
QUALIFIER: pathology
QUALIFIER: secondary
QUALIFIER: therapeutic use
AUTHOR: K Kanda K
AUTHOR: S Waki S
AUTHOR: M Uchimura M
AUTHOR: H Kida H
AUTHOR: K Narita K
AUTHOR: N Harada N
AFFILIATION: Dept. of Surgery, Hamamatsu Medical Center.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [A case of bone and lung metastasis of breast cancer successfully treated with radiotherapy, chemotherapy and endocrine therapy]
PUBDATE: 19901201
A 34-year-old female patient with breast cancer metastasizing to bone had a remission after a course of treatment with medroxyprogesterone acetate (MPA) 1,200 mg/day, but again had a metastasis to the lungs. The patient was then instituted on a combination therapy with UFT 400 mg/day, and MPA 1,200 mg/day. As a result, the pulmonary metastasis disappeared, along with the consolidation of the bone involved.


4. DOCID:31263 SCORE: 0.00238417567254218
DOCNO: 15546933
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosome Aberrations
DESCRIPTOR: Database Management Systems
DESCRIPTOR: Software
DESCRIPTOR: User-Computer Interface
QUALIFIER: methods
QUALIFIER: methods
QUALIFIER: methods
AUTHOR: Bernhard Hiller B
AUTHOR: Jutta Bradtke J
AUTHOR: Harald Balz H
AUTHOR: Harald Rieder H
AFFILIATION: Institut für Klinische Genetik der Phillipps-Universität Marburg, Bahnhofstrasse 7, 35037 Marburg, Germany.
PUBTYPE: Journal Article
JOURNALTITLE: Bioinformatics (Oxford, England)
COUNTRY: England
TITLE: CyDAS: a cytogenetic data analysis system.
PUBDATE: 20050401
For statistical analyses in cancer cytogenetics, the genomic changes encoded by the karyotype must be translated into numerical codes. We developed a program, which extracts chromosomal gains and losses as well as breakpoints from the karyotype. The changes are compiled in tables according to the chromosome bands involved and/or depicted in projection to the respective chromosome ideogram. The data are ready to be integrated into further statistical analyses. The program may be run as desktop or Internet application.


5. DOCID:30637 SCORE: 0.00235693702923702
DOCNO: 15043429
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: chemistry
QUALIFIER: isolation & purification
QUALIFIER: chemistry
AUTHOR: Ahmed A Hussein AA
AUTHOR: Icela Barberena I
AUTHOR: Todd L Capson TL
AUTHOR: Thomas A Kursar TA
AUTHOR: Phyllis D Coley PD
AUTHOR: Pablo N Solis PN
AUTHOR: Mahabir P Gupta MP
AFFILIATION: Centro de Investigaciones Farmacognósticas de la Flora Panameña (CIFLORPAN), Facultad de Farmacia, Universidad de Panamá, Apartado 10767, Estafeta Universitaria, Panama, Republic of Panama.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of natural products.
COUNTRY: United States
TITLE: New cytotoxic naphthopyrane derivatives from Adenaria floribunda.
PUBDATE: 20040301
Bioassay-guided fractionation of an EtOAc/MeOH extract of Adenaria floribunda young leaves using MCF-7, H-460, and SF-268 cancer cell lines yielded four new active compounds named adenaflorins A-D (1-4). Their chemical structures were determined by spectroscopic means. Adenaflorin A (1) was the most cytotoxic.


6. DOCID:25662 SCORE: 0.00230632249274813
DOCNO: 11247482
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Intensive Care
QUALIFIER: surgery
QUALIFIER: methods
QUALIFIER: surgery
AUTHOR: G V Bondar' GV
AUTHOR: A V Borota AV
AUTHOR: S E Zolotukhin SE
AUTHOR: K N Oleĭnikov KN
AUTHOR: G G Psaras GG
AUTHOR: S D Vasil'ev SD
PUBTYPE: Journal Article
JOURNALTITLE: Klinichna khirurhiia / Ministerstvo okhorony zdorov'ia Ukraïny, Naukove tovarystvo khirurhiv Ukraïny.
COUNTRY: Ukraine
TITLE: [Intensive therapy and strategy of management of patients with rectal cancer after the colonic descending to the perineum]
PUBDATE: 20001201
Optimal tactic for management of the patients on various stages of treatment was elaborated together with surgical procedure, basing on the experience of 3500 operations conduction for cancer recti, mainly abdominal resection with colon descendant to perineum. Methods of preoperative preparation and anesthesiological support were stated as well as the tactics of postoperative management of patients.


7. DOCID:2363 SCORE: 0.00229675860165
DOCNO: 1008990
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: N Matthews N
AUTHOR: R H Whitehead RH
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Inhibition of K cell function by human breast cancer sera.
PUBDATE: 19761201
Sera from breast cancer patients and from female controls were tested for inhibition of lysis of antibody-coated target cells by human leukocytes (K cells). Sera from 39% of breast cancer patients, but from only 8% of controls, inhibited lysis by more than 30%. This inhibition was unrelated to the stage of the disease, the patient's age or whether the patient was pre- or post-operative. Inhibition was apparently not due to anti-HLA antibodies and did not correlate with the IgG level or anti-complementary activity of the serum. On fractionation by gel-filtration, inhibitory activity was found in fractions of higher molecular weight than IgG. As no IgG could be detected in these fractions, inhibition is probably not due to immune complexes containing IgG antibody. The inhibitory factor may well contribute to the immunosuppressed status of a proportion of breast cancer patients.


8. DOCID:23046 SCORE: 0.00225422990060723
DOCNO: 9234939
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: secondary
QUALIFIER: secondary
QUALIFIER: pathology
AUTHOR: G H Eltabbakh GH
AUTHOR: M S Piver MS
AUTHOR: B A Werness BA
AFFILIATION: Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: Primary peritoneal adenocarcinoma metastatic to the brain.
PUBDATE: 19970701
Primary peritoneal adenocarcinoma is a relatively newly identified disease entity whose clinical behavior is not fully recognized. We report a case of a patient with progressive primary peritoneal adenocarcinoma who developed brain metastases and died shortly afterward. The incidence of central nervous system metastases in 72 patients with documented primary peritoneal adenocarcinoma was 1.4%. The risk factors, clinical behavior, and prognosis of patients with primary peritoneal adenocarcinoma metastatic to the central nervous system seem to be similar to those of patients with epithelial ovarian cancer metastatic to the central nervous system.


9. DOCID:2308 SCORE: 0.00222170717084209
DOCNO: 1190632
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasms, Radiation-Induced
QUALIFIER: etiology
QUALIFIER: adverse effects
QUALIFIER: etiology
AUTHOR: F O Becker FO
AUTHOR: S G Economou SG
AUTHOR: H W Southwick HW
AUTHOR: R Eisenstein R
PUBTYPE: Journal Article
JOURNALTITLE: Annals of internal medicine.
COUNTRY: UNITED STATES
TITLE: Adult thyroid cancer after head and neck irradiation in infancy and childhood.
PUBDATE: 19750901
We report the surgical-pathologic findings in 15 adults who had a history of irradiation of the head and neck in childhood. These patients we selected for thyroid surgery because of a "cold" area or areas detected on 99mTc thyroid scan, with or without palpable thyroid abnormalities. Eight of the fifteen patients had thyroid cancer, and 3 had atypical adenomas. We found multiple lesions in 12 patients. Macroscopic and microscopic malignancy in a location different from the cold area or areas occurred in 5 of the 8 cancer patients. In vitro of these findings, we recommend that adults who received irradiation to the head and neck in childhood and who have been found to have an abnormal thyroid scan or thyroid examination, or both, have a total thyroidectomy...


10. DOCID:7964 SCORE: 0.00220635249487027
DOCNO: 92359
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antibodies, Neoplasm
DESCRIPTOR: Antigens, Neoplasm
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: K M Sheikh KM
AUTHOR: F P Quismorio FP
AUTHOR: G J Friou GJ
AUTHOR: Y T Lee YT
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Ductular carcinoma of the breast: serum antibodies to tumor-associated antigens.
PUBDATE: 19791201
Serum antibodies to tumor-associated antigens of breast carcinoma have been studied by indirect immunofluorescence in 109 patients with breast carcinoma and 125 controls, including age/sex matched normal individuals, patients with nonmalignant disease, and patients with malignant disease other than breast cancer. We report here that sera of a large proportion of patients with ductular carcinoma of the breast have antibodies to cell surface and/or intracellular antigens of autologous tumor cells and include evidence that the antigens are absent from a considerable range of normal and other types of malignant tissues. In addition to testing of control sera, specificity of the reacting antibodies was investigated further by testing of sera with normal breast tissue and the absorption of sera from breast cancer patients with various normal tissues and cancer cells. The significance of the findings in breast cancer is discussed.


11. DOCID:26617 SCORE: 0.00220589800459228
DOCNO: 9852402
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Expression Regulation, Neoplastic
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: J Fujimoto J
AUTHOR: R Hirose R
AUTHOR: H Sakaguchi H
AUTHOR: T Tamaya T
AFFILIATION: Department of Obstetrics and Gynecology, Gifu University School of Medicine, Tsukasa-machi, Gifu City, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncology.
COUNTRY: SWITZERLAND
TITLE: Estrogen dependency in uterine endometrial cancers.
PUBDATE: 19981201
Estrogen dependency in uterine endometrial cancers involves complicated tumor biology. A transformed phenotype of uterine endometrial cancers is supported by estrogen-dependent oncogene (c-Ha-ras, c-fos and c-jun) expressions. The relative overexpression of estrogen receptor exon 5 splicing variant and the damaged expression of progesterone receptor A, which belong to a lack of estrogen dependency, are related to metastatic potential. The estrogen-related metastatic processes, detachment, invasion and angiogenesis in some uterine endometrial cancers can be inhibited by progestins.


12. DOCID:9780 SCORE: 0.00219600093846364
DOCNO: 6606627
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: S Pollack S
AUTHOR: A Micali A
AUTHOR: D W Kinne DW
AUTHOR: W E Enker WE
AUTHOR: N Geller N
AUTHOR: H F Oettgen HF
AUTHOR: M K Hoffmann MK
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: Endotoxin-induced in vitro release of interleukin-1 by cancer patients' monocytes: relation to stage of disease.
PUBDATE: 19831201
The in vitro release of IL-1 by monocytes in response to endotoxin was subnormal in many patients with breast cancer, malignant melanoma or colorectal cancer but not in patients with benign tumors of the breast or colon. In each of these groups, IL-1 release was low in patients with early cancer, normal in patients with regional metastases, and low in patients with disseminated cancer.


13. DOCID:7235 SCORE: 0.0021745216328525
DOCNO: 7284243
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Line
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: S Kondo S
AUTHOR: K Aso K
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of dermatology.
COUNTRY: ENGLAND
TITLE: Establishment of a cell line of human skin squamous cell carcinoma in vitro.
PUBDATE: 19810801
A cell line of a squamous cell carcinoma of human skin (HSC-I) has been established in vitro, and successfully maintained proliferative in continuous tissue culture for about 2 1/2 years since March 1978. Another cell line (HSC-Ib) has been established in vitro from the recurrence of the same cancer. It has been maintained for about 8 months since December 1979. 3T3 feeders were used in the initial cultures in both cases. The cells grow in a monolayer in vitro and are epithelioid with anaplastic features. Chromosome analysis of HSC-I, frozen and thawed HSC-I, the transplanted tumour in a nude mouse and HSC-Ib all showed hypotetraploidy with the modal number 80, which reconfirms that HSC-I derives from the original skin tumour. The cell line is available to other investigators.


14. DOCID:15296 SCORE: 0.00216547595077628
DOCNO: 3812437
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Regression Analysis
AUTHOR: S D Walter SD
AUTHOR: A R Feinstein AR
AUTHOR: C K Wells CK
PUBTYPE: Journal Article
JOURNALTITLE: American journal of epidemiology.
COUNTRY: UNITED STATES
TITLE: Coding ordinal independent variables in multiple regression analyses.
PUBDATE: 19870201
The authors present a coding scheme for ordinal independent variables which may be used in various forms of regression analysis. The scheme is useful in dose-response analyses, when the objective is to identify contrasts in the dependent (or response) variable between successive levels of the independent variable, or to identify critical threshold values of the independent variables at which significant changes occur in the response. An example is given of evaluating the survival of lung cancer patients according to their stage of symptomatology. The authors discuss the interpretation of the regression coefficients when this coding scheme is used with linear regression, logistic regression, or in the proportional hazards regression model.