0. DOCID:23136 SCORE: 0.00276186518452937
DOCNO: 9050139
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Therapy
DESCRIPTOR: Gene Transfer Techniques
DESCRIPTOR: Genetic Vectors
QUALIFIER: methods
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: M G Sanda MG
AFFILIATION: Department of Urology, Ann Arbor Veterans Administration Medical Center, MI, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in urologic oncology.
COUNTRY: UNITED STATES
TITLE: Biological principles and clinical development of prostate cancer gene therapy.
PUBDATE: 19970201
Several clinical trials of prostate cancer gene therapy are underway. The therapeutic genes being evaluated by these and other, forthcoming, trials include immunogenes, cell death-inducing genes, antioncogenes, and tumor suppressor genes. Constraints of current gene transfer vectors limit, to local-regional targeting, those gene therapy strategies that do not rely on an intervening immune response. Preclinical models predict modest, if any, therapeutic effects with current forms of prostate cancer gene therapy. Using biological surrogate endpoints and applying further preclinical advances will allow clinical prostate cancer gene therapy to attain its full potential.

1. DOCID:22535 SCORE: 0.00272897341590551
DOCNO: 9143847
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Biopsy, Needle
DESCRIPTOR: Immunohistochemistry
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: analysis
AUTHOR: I S Quinodoz IS
AUTHOR: S D Berger SD
AUTHOR: P Schafer P
AUTHOR: S Remadi S
AFFILIATION: Division de Pathologie Clinique, Hôpital Cantonal Universitaire, Geneva, Switzerland.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Diagnostic cytopathology.
COUNTRY: UNITED STATES
TITLE: Adenoid cystic carcinoma of the breast: utility of immunocytochemical study with collagen IV on fine-needle aspiration.
PUBDATE: 19970501
A case of adenoid cystic carcinoma (ACC) of the breast in a 71-year-old woman is reported. This neoplasm accounts for about 0.1% of all breast cancers. The mammography showed a well-delineated mass without calcifications. Cytologic examination of percutaneous fine-needle aspiration (FNA) material gave the diagnostic of ACC, which was confirmed by histologic examination. This report emphasizes the utility of immunocytochemical study with collagen IV antibody on FNA material of this uncommon tumor.

2. DOCID:20652 SCORE: 0.00270582675543764
DOCNO: 8742094
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: drug therapy
AUTHOR: P L Dellemijn PL
AUTHOR: C J Vecht CJ
AFFILIATION: Department of Neurology, Sint Joseph, Ziekenhuis, The Netherlands.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Anti-cancer drugs.
COUNTRY: ENGLAND
TITLE: Towards better pain treatment in cancer.
PUBDATE: 19960101
This review focuses on ways to ameliorate diagnosis and treatment of cancer-related pain with currently available knowledge and methods. The first part indicates how to improve pain assessment and diagnosis in the cancer patient. The second part evaluates current views for adequate pain management based on evidence of double-blind analgesic trials in cancer-related pain and deals with misconceptions in established symptomatic therapy.

3. DOCID:23764 SCORE: 0.00270465348689421
DOCNO: 7735542
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Television
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: methods
QUALIFIER: methods
AUTHOR: A Saito A
AUTHOR: N Yagi N
AUTHOR: K Miura K
AUTHOR: Y Takano Y
AFFILIATION: Section of Thoracic Surgery, Akita Red Cross Hospital, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Surgical laparoscopy & endoscopy.
COUNTRY: UNITED STATES
TITLE: Video-assisted right lower lobectomy for a lung cancer with mini-thoracotomy.
PUBDATE: 19950201
We report a case of T1N0M0 lung cancer in which we successfully performed video-assisted right lower lobectomy and mediastinal lymph node dissection. The lobectomy was done on a 64-year-old woman who had a 2-cm adenocarcinoma in the right lower lobe. The procedure could be done safely and adequately using three trocars and a 5-cm mini-thoracotomy. The patient had an uncomplicated postoperative course and was satisfied with minimal postoperative pain, quick recovery, and minute skin scars. Video-assisted lobectomy may be a reasonable approach in selected patients of primary lung carcinoma.

4. DOCID:21670 SCORE: 0.00261510264755687
DOCNO: 9165503
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Clinical Trials, Phase III
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
AUTHOR: R Gams R
AFFILIATION: Division of Hematology/Oncology Ohio State University, Columbus, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncology (Williston Park, N.Y.)
COUNTRY: UNITED STATES
TITLE: Phase III trials of toremifene vs tamoxifen.
PUBDATE: 19970501
Three pivotal phase III trials conducted in North America and Europe served as the basis for the application for approval of toremifene (Fareston) by the FDA. These trials demonstrated that 60 mg/d of toremifene is safe and effective in the treatment of advanced breast cancer in postmenopausal women. The studies also indicated that, on the basis of antitumor efficacy, as well as safety, toremifene is at least equivalent to tamoxifen and may have some long-term advantages.

5. DOCID:22525 SCORE: 0.00254503847941354
DOCNO: 9450419
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: history
QUALIFIER: history
AUTHOR: L LeMoine L
AFFILIATION: Dr. Everett Chalmers Hospital, Fredericton, N.B.
PUBTYPE: Biography
PUBTYPE: Historical Article
PUBTYPE: Journal Article
JOURNALTITLE: Canadian oncology nursing journal = Revue canadienne de nursing oncologique.
COUNTRY: CANADA
TITLE: Essiac: an historical perspective.
PUBDATE: 19971101
It is believed that over one-half of people diagnosed with cancer will at some point use an unconventional therapy (Hopkins & Brigden, 1991). In light of this, nurses have a professional responsibility to learn about unconventional therapies (Fletcher, 1992) so they can help their patients make informed choices. This article focuses on Essiac, an unconventional therapy that has historically and is presently being used by some cancer patients. While reasons patients might choose unconventional therapies are identified, the majority of this article focuses on the history of Essiac, where it stands today, and the need for sound scientific research.

6. DOCID:21276 SCORE: 0.0025359499871264
DOCNO: 8820870
AUTHOR: L S Jones LS
AFFILIATION: Dept of Developmental Biology and Anatomy, University of South Carolina School of Medicine, Columbia 29208, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Trends in neurosciences.
COUNTRY: ENGLAND
TITLE: Integrins: possible functions in the adult CNS.
PUBDATE: 19960201
Integrins comprise a large family of heterodimeric proteins that mediate cell-cell and cell-extracellular-matrix adhesive connections. There is an extensive literature on their importance in neural development and cancer, but evidence for the existence of integrins in the adult CNS has emerged only recently. With growing immunohistochemical and molecular biological evidence for the presence of integrins in the adult CNS, a variety of functions from microglial migration to synaptic rearrangements can be considered for these adhesive proteins.

7. DOCID:23947 SCORE: 0.00251065180573866
DOCNO: 8677399
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Clinical Trials
AUTHOR: J J Dignam JJ
AUTHOR: L A Weissfeld LA
AUTHOR: S J Anderson SJ
AFFILIATION: Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pa 15261, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Statistics in medicine.
COUNTRY: ENGLAND
TITLE: Methods for bounding the marginal survival distribution.
PUBDATE: 19950901
For time to event data with many potential failure types, one cannot uniquely determine the distribution of time to a specific event type, or marginal survival distribution, in the case where event types are mutually exclusive. In this paper we discuss several methods for estimating functions that bound the non-identifiable marginal survival distribution in the competing risks problem. We compute and compare bounds for data simulated from two bivariate survival distributions. Results show that the methods provide a suitable estimate of the marginal survival probability when one has specified dependence correctly. Data from a large clinical trial for breast cancer illustrate the methods.

8. DOCID:20736 SCORE: 0.00247055322703345
DOCNO: 7647308
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: physiology
QUALIFIER: etiology
AUTHOR: J Pines J
AFFILIATION: Wellcome/CRC Institute, Cambridge, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in cancer biology.
COUNTRY: UNITED STATES
TITLE: Cyclins, CDKs and cancer.
PUBDATE: 19950401
The connections between cancer and the basic machinery of the cell cycle have taken a surprisingly long time to become apparent. However, the past 2 years has seen a dramatic increase in the number of cell cycles regulators that have been implicated as either protooncogenes or as tumour suppressor genes. In this review I will attempt to show how perturbations in the known cell cycle regulators may play a part in the process of oncogenesis.

9. DOCID:21803 SCORE: 0.00244518394750928
DOCNO: 10161507
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Managed Care Programs
QUALIFIER: therapeutic use
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: P P Gerbino PP
AUTHOR: M Goldsmith M
AUTHOR: J T Kenney JT
AUTHOR: C Lindley C
AUTHOR: J Nolte J
AUTHOR: W Quan W
AUTHOR: P R Reich PR
PUBTYPE: Journal Article
JOURNALTITLE: Medical interface.
COUNTRY: UNITED STATES
TITLE: Antiemetic therapy in managed care oncology: roundtable discussion.
PUBDATE: 19960901
Few diagnoses are feared more by patients than cancer. In addition to the life-threatening nature of many cancers, the spectre of very difficult the treatment provides patients with little or no level of comfort. However, recent advances in the treatment of the side effects of cancer chemotherapy are helping to change these attitudes. On April 4, 1996, a panel of experts was convened to discuss these issues and how they affect MCOs.

10. DOCID:21232 SCORE: 0.00236394381766042
DOCNO: 8763560
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: methods
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: G Champault G
AUTHOR: M Bron M
AUTHOR: J M Catheline JM
AUTHOR: A Mercadier A
AFFILIATION: Service de Chirurgie Générale et Digestive (Pr. G. Champault), Hôpital Jean-Verdier, Bondy.
PUBTYPE: Journal Article
JOURNALTITLE: Journal de chirurgie.
COUNTRY: FRANCE
TITLE: [Does laparoscopic surgery affect immunity?]
PUBDATE: 19960401
In a prospective study including 20 laparoscopic cholecystectomies, markers of the humoral (immunoglobuline) and cell mediated (lymphocytes and sub population T4/T8) have been assessed on 1st, 3nd and 8th post-operative days. There is no significant variation (except total lymphocyte count) within the limits of normality. This study suggests that laparoscopic surgery dont affect immunity. Laparoscopy seems to be preferable for immunodepressed patients (AIDS, cancer).

11. DOCID:22015 SCORE: 0.0023232018004345
DOCNO: 7669496
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: M F Burattini MF
AUTHOR: R Cristofani R
AUTHOR: P Campi P
AUTHOR: A Bufalari A
AUTHOR: A Morabito A
AUTHOR: A Servoli A
AUTHOR: E Moriconi E
AUTHOR: E Ricci E
AUTHOR: V Scalercio V
AUTHOR: V Lauro V
AFFILIATION: Dipartimento di Chirurgia ed Emergenze Chirurgiche, Università degli Studi di Perugia.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Il Giornale di chirurgia.
COUNTRY: ITALY
TITLE: [Gastric cancer in the geriatric patient: our experience]
PUBDATE: 19950401
The Authors report their experience in the management of 68 patients aged over 70 years affected by gastric cancer: 64 of them were operated. After some considerations on patients status, nutritional and immunological conditions, operative risk and cancer characteristics the Authors, on the basis of the results obtained, discuss about the opportunity of surgical therapy and relative adequate surgical techniques in the elderly.

12. DOCID:21595 SCORE: 0.00227375911890699
DOCNO: 9388518
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: administration & dosage
QUALIFIER: radiotherapy
AUTHOR: J Shimazaki J
AUTHOR: S Isaka S
AUTHOR: K Akakura K
AUTHOR: S Akimoto S
AUTHOR: S Morita S
AFFILIATION: Department of Urology, School of Medicine, Chiba University, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Prostate cancer]
PUBDATE: 19971101
Up to stage B1 or prostate cancer with N0-1 positive lymph node may be curable by monotherapy of either radical prostatectomy or irradiation. Localized but more advanced stages (B2 and C), however, are difficult to cure. To further improve the prognosis in these stages, a new treatment modality is proposed; pelvic lymphadenectomy, followed by irradiation with neoadjuvant and adjuvant endocrine therapy. An average 2-year followup is favorable. Further studies is awaited to make conclusion.

13. DOCID:23394 SCORE: 0.00225466306187514
DOCNO: 9280222
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: H Wagner H
AFFILIATION: H. Lee Moffitt Cancer Center and Research Institute, and the Department of Radiology, University of South Florida, Tampa 33612, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Seminars in oncology.
COUNTRY: UNITED STATES
TITLE: Radiation therapy in the management of patients with unresectable stage IIIA and IIIB non-small cell lung cancer.
PUBDATE: 19970801
Treatment of patients with unresectable stage IIIA and IIIB non-small cell lung cancer with conventional radiation therapy has resulted in poor local control, a high rate of systemic failure, and 5-year survival of less than 10%. Recent modification in radiation treatment planning, dose delivery, and fractionization has demonstrated significantly improved median and 2-year survival, comparable in some trials to that achieved with induction chemotherapy followed by radiation. Current trials focus on combining systemic therapy with dose-intense radiation therapy to improve with local and systemic control.

14. DOCID:21969 SCORE: 0.00224699424374057
DOCNO: 8015812
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: A Szánthó A
AUTHOR: A Demeter A
AUTHOR: Z Papp Z
AFFILIATION: Semmelweis Orvostudományi Egyetem, I. Szülészeti és Nögyógyászati Klinika, Budapest.
PUBTYPE: Journal Article
JOURNALTITLE: Orvosi hetilap.
COUNTRY: HUNGARY
TITLE: [Management of cervical cancer patients in Hungary]
PUBDATE: 19940501
The authors made an exact investigation of the treatment of patients suffering from cervical cancer during one year period. Out of the data of 101 gynecological wards 1700 cases were evaluated. The authors evaluated the different ways of treatment with respect to the international requirements on the base of hystological results. They elaborated the operative methods in every stage of cervical cancers, with more details on radical hysterectomy and regional lymphadenectomy. The authors suggest that patients suffering from cervical cancer should be treated by standardized principles based on international scientific experiences.