0. DOCID:10120 SCORE: 0.00295026230827014
DOCNO: 7078910
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: J Chu J
AUTHOR: H K Tamimi HK
AUTHOR: M Ek M
AUTHOR: D C Figge DC
PUBTYPE: Journal Article
JOURNALTITLE: Obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Stage I vulvar cancer: criteria for microinvasion.
PUBDATE: 19820601
Thirty-eight women with stage I epidermoid carcinoma of the vulva were studied retrospectively in an attempt to define the criteria for conservative therapy in early invasive vulvar cancer. Among the 38 women, 23 met the 6 criteria established for early invasive carcinoma of the vulva. In those 23 women, there were no nodal metastases. Depth of stromal invasion correlated strongly with the degree of tumor differentiation and the presence of carcinoma in situ (CIS). Stromal invasion less than 3 mm and presence of CIS were predictive of no involvement of the lymph nodes or endothelial-like space.


1. DOCID:11128 SCORE: 0.00285254549118537
DOCNO: 3877314
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: analysis
AUTHOR: M Schena M
AUTHOR: A Quadri A
AUTHOR: G Ragazzoni G
AUTHOR: P Corti P
PUBTYPE: Journal Article
JOURNALTITLE: Quaderni Sclavo di diagnostica clinica e di laboratorio.
COUNTRY: ITALY
TITLE: [Alpha 1-antitrypsin as a tumor marker]
PUBDATE: 19850301
In this work we intended: a) to confirm the correlation between the increase of serum levels of alpha 1-antitrypsin (ATT) and neoplastic disease; b) to verify in what tumoural diseases the increase of ATT has a specific significance. Therefore we have examined 164 patients: 60 represented the control group and 104 were suffering from neoplastic diseases. We have subdivided the nest group according to histological type and tumour location. The result of this work has demonstrated that the increase of ATT is really determined by the existence of neoplastic disease, more than histological type or location of cancer. The AAT represents a diagnostic index of neoplastic diseases, highly sensitive but little specific.


2. DOCID:15166 SCORE: 0.00279336007912101
DOCNO: 2511733
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: U Lekholm U
AUTHOR: G Stenman G
AFFILIATION: Brånemark Clinic, Public Dental Health Service of Gothenburg, Sweden.
PUBTYPE: Journal Article
JOURNALTITLE: Acta odontologica Scandinavica.
COUNTRY: NORWAY
TITLE: Induction of oral cancer by 7,12-dimethylbenz[a]anthracene in rats with liver cirrhosis.
PUBDATE: 19891001
The effects of carbon tetrachloride-induced liver cirrhosis and xerostomia on oral carcinogenesis were studied in rats given the lipid-soluble carcinogen 7,12-dimethylbenz-[a]anthracene (DMBA). The first carcinoma was detected after only 1 month of DMBA applications. After a further 8 months 85% of the animals had developed one or more squamous cell carcinomas. The latency period for DMBA-induced oral cancer in cirrhotic rats with xerostomia was markedly reduced in comparison with previous findings from xerostomic rats without liver cirrhosis. The results support earlier epidemiologic studies indicating a relationship between liver cirrhosis and oral cancer.


3. DOCID:11701 SCORE: 0.00265139730860227
DOCNO: 6883269
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: R C Hamaker RC
AUTHOR: M I Singer MI
AUTHOR: W W Shockley WW
AUTHOR: N Pugh N
AUTHOR: H Shidnia H
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Irradiated mandibular autografts.
PUBDATE: 19830901
The cosmetic and functional disability associated with mandibular resection has been a major problem to the patient with direct invasion of the mandible by oral cancer. Marginal resections with combined postoperative radiation therapy have frequently been substituted for the more preferred segmental resections and resultant deformities. Presented are 15 cases of oral cavity cancer involving resection of the mandible, immediate radiation to 10,000 rad, and primary reconstruction as irradiated mandibular autografts. The longest following is 4 years and 3 months, with a success rate of 66%. Morbidity is minimal as compared to autogenous bone grafting. Tumor size, previous radiation, or use of regional flaps have not been a factor in the success of this method in reconstruction of the mandible primarily.


4. DOCID:15412 SCORE: 0.00256793984109176
DOCNO: 2923414
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
QUALIFIER: mortality
AUTHOR: C P Armstrong CP
AUTHOR: S J Whitelaw SJ
AFFILIATION: Derriford Hospital, Plymouth, Devon.
PUBTYPE: Journal Article
JOURNALTITLE: Annals of the Royal College of Surgeons of England.
COUNTRY: ENGLAND
TITLE: Death from unsuspected colorectal cancer.
PUBDATE: 19890101
An analysis of all subjects undergoing autopsy in the Plymouth Health District over a 10-year period revealed 61 cases of unsuspected colorectal cancer. The carcinoma was the primary cause of death in 57 cases and surgical treatment for cure might have been possible in over one-half. The 61 subjects accounted for 4.1% of all cases of fatal colorectal cancer in this area. Examination by means of rectal digital palpation, rigid sigmoidoscopy and flexible sigmoidoscopy might have diagnosed 10, 24 and 41 carcinomas respectively. This study has demonstrated that a significant number of colorectal cancers remain undetected until after death. These cases should be included in future studies of colorectal cancer.


5. DOCID:15222 SCORE: 0.00251551908048822
DOCNO: 3812981
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analogs & derivatives
QUALIFIER: chemical synthesis
AUTHOR: P H Stern PH
AUTHOR: R M Hoffman RM
PUBTYPE: Journal Article
JOURNALTITLE: Analytical biochemistry.
COUNTRY: UNITED STATES
TITLE: The chemical synthesis of high specific-activity [35S]adenosylhomocysteine.
PUBDATE: 19861101
The study of the family of transmethylases, critical to normal cellular function and often altered in cancer, can be facilitated by the availability of a high specific-activity S-adenosylhomocysteine. We report the two-step preparation of [35S]adenosylhomocysteine from [35S]methionine at a specific activity of 1420 Ci/mmol in an overall yield of 24% by a procedure involving demethylation of the [35S]methionine to [35S]homocysteine followed by condensation with 5'-chloro-5'-deoxyadenosine. The ease of the reactions, ready availability and low cost of the reagents and high specific-activity and stability of the product make the procedure an attractive one with many uses, and superior to current methodology.


6. DOCID:14953 SCORE: 0.00248575172762862
DOCNO: 3825158
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: E Wenzl E
AUTHOR: M Wunderlich M
AUTHOR: F Herbst F
AUTHOR: M Schemper M
AUTHOR: W Feil W
AUTHOR: R Rauhs R
AUTHOR: R Schiessel R
PUBTYPE: Journal Article
JOURNALTITLE: Wiener klinische Wochenschrift.
COUNTRY: AUSTRIA
TITLE: [Consequences of after-care in colorectal cancer]
PUBDATE: 19861201
Results of a computer supported follow-up-program on patients with colorectal cancer are presented. Between 1978 and 1985 1024 patients underwent these program, the drop-out-rate was 18%. 231 recurrences in 137 patients were discovered (40% local recurrence, 30% liver metastases and 30% others). 54% of patients with local recurrence and 43% with liver metastases were free of symptoms. Radical surgery was performed in 47% of local recurrences and in 24% of liver metastases. The three year survival rate after radical surgery for recurrence amounted to 28% for local recurrences and to 31% for liver metastases.


7. DOCID:13735 SCORE: 0.00240185602670066
DOCNO: 3357390
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: pathology
AUTHOR: O I Shcherbenko OI
PUBTYPE: Journal Article
JOURNALTITLE: Meditsinskaia radiologiia.
COUNTRY: USSR
TITLE: [Survival and prognostic factors in radiation and combination therapy of bone metastases of breast cancer]
PUBDATE: 19880401
A retrospective analysis of the survival and mean life rates of 107 patients with breast cancer metastases to the skeletal bones was performed. In non-randomized groups there was no significant correlation of long-term therapeutic results and the type of fractionation, a total radiation dose value, chemo- or hormonotherapy. Prognosis was better in patients in whom solitary metastases were detected 5 and more years after primary treatment. In such cases radiation therapy was indicated at doses sufficient for eradication or stable stabilization of a focus using the most sparing dose fractionation regimens.


8. DOCID:11601 SCORE: 0.00234727478786527
DOCNO: 3981808
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: methods
AUTHOR: Y Takatsuka Y
AUTHOR: A Sugitachi A
AUTHOR: K Morimoto K
AUTHOR: I Sakamoto I
AUTHOR: T Kawahara T
PUBTYPE: Journal Article
JOURNALTITLE: Japanese journal of clinical oncology.
COUNTRY: JAPAN
TITLE: Transcatheter arterial chemo-embolization (TAC-E) for patients with locally advanced breast cancer.
PUBDATE: 19850301
Preoperative transcatheter arterial chemo-embolization (TAC-E) was used for 19 patients with locally advanced breast cancer, to eradicate the extensive loco-regional areas prior to surgery and hopefully to reduce the postoperative recurrence rate. The results were as follows: (1) Each primary tumor showed marked regression within 2 weeks after TAC-E. (2) Surgicopathology confirmed the excellent efficacy of TAC-E against both primary tumors and metastatic lymph node tumors. (3) Side effects due to this treatment were few, compared with other forms of cancer chemotherapy. (4) The prognosis of each patient was good. We conclude that preoperative TAC-E has a great potential for the treatment of locally advanced breast cancer.


9. DOCID:9855 SCORE: 0.00232594599773609
DOCNO: 4036653
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: psychology
AUTHOR: N Manos N
AUTHOR: J Christakis J
PUBTYPE: Journal Article
JOURNALTITLE: Acta psychiatrica Scandinavica.
COUNTRY: DENMARK
TITLE: Coping with cancer: psychological dimensions.
PUBDATE: 19850701
Cancer has a profound psychological impact upon the patient and his family, and the psychological responses, primarily of the patient himself, the close family, physician and nursing personnel, but also of the extended family, and society in general, become a complex interrelationship. Some of the most important psychological aspects of cancer are reviewed. These include the psychological responses of the patient, such as denial, vulnerability, coping strategies, hope, depression, suicide, reaction to diagnosis, and the management of the family, and the psychological responses and attitudes of the physician and nursing personnel. Based on the above psychological analysis some guidelines are offered to help in coping with cancer.


10. DOCID:11148 SCORE: 0.00230500270251909
DOCNO: 6593623
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: trends
QUALIFIER: trends
AUTHOR: J P Riordan JP
AUTHOR: R J Stewart RJ
AUTHOR: N E Pearce NE
AUTHOR: W H Isbister WH
PUBTYPE: Journal Article
JOURNALTITLE: The New Zealand medical journal.
COUNTRY: NEW ZEALAND
TITLE: Changes in the pattern of disease managed by general surgeons in New Zealand, 1940-80.
PUBDATE: 19841101
Changes in the pattern of disease managed by general surgeons in New Zealand, were assessed for the period 1940-80, using the public hospital admission and cancer incidence data of a representative selection of diseases. During the forty-year period, there was an increase in the incidence of four of the five cancers studied, and an increase in admission rate for non-specific abdominal pain, head injury (indicated by skull fracture), peripheral arterial disease (indicated by aortic aneurysm), gall-stone disease and pancreatitis, large bowel disorders and breast diseases. There was a decline in admission rate for appendicitis, stomach disorders and goitre.


11. DOCID:14768 SCORE: 0.0021883065552906
DOCNO: 3152403
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: diagnosis
AUTHOR: N A Iscoe NA
AUTHOR: J D McKee JD
AUTHOR: A M Arenson AM
AUTHOR: J P Szalai JP
AFFILIATION: Division of Medical Oncology, Toronto-Bayview Regional Cancer Centre, Ontario, Canada.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of clinical ultrasound : JCU.
COUNTRY: UNITED STATES
TITLE: Observer error in the characterization of hepatic lesions in patients with neoplastic liver disease.
PUBDATE: 19881001
Sixteen patients with known neoplastic liver disease underwent 20 ultrasound examinations by two separate teams to determine the level of agreement in the measurement of lesion size and sonographic characteristics. The intraclass correlation coefficient for the observations on lesion size was r = 0.97 (95% lower confidence limit r = 0.96). We conclude that sonographic estimation of the size of neoplastic liver lesions in highly reproducible and that the measurements obtained may be safely incorporated into the criteria of response for cancer clinical trials.


12. DOCID:11617 SCORE: 0.00215703429458451
DOCNO: 6205174
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: analysis
QUALIFIER: immunology
AUTHOR: T Homma T
AUTHOR: H Oguchi H
AUTHOR: S Kawa S
AUTHOR: A Nagata A
AUTHOR: S Furuta S
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Pancreatic oncofetal antigen (POA) and carcinoma of the pancreas]
PUBDATE: 19840501
Pancreatic oncofetal antigen (POA) was purified from fetal pancreas and migrated in beta-region electrophoretically. Its molecular weight was 80 X 10(4) daltons. Enzyme immunoassay for serum POA revealed that elevated levels of POA were found in sera of patients with pancreatic cancer. By a serological screening of 440 out-patients with combined assay of tumor markers including POA, 4 cases of pancreatic cancer were found. POA was demonstrated in the ductal cells of fetal pancreas and cancer cells of duct cell type pancreatic adenocarcinoma immunohistochemically. Elevated levels of serum POA of patients with pancreatic cancer was probably derived from cancer tissue. These findings indicate that serum POA assay is clinically useful.


13. DOCID:15968 SCORE: 0.00215173479672996
DOCNO: 2450536
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genes
DESCRIPTOR: Proteins
QUALIFIER: pharmacology
QUALIFIER: genetics
QUALIFIER: drug effects
AUTHOR: M Roberts M
AUTHOR: J Wallace J
AUTHOR: J M Jeltsch JM
AUTHOR: M Berry M
AFFILIATION: Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Faculté de Médecine, Strasbourg, France.
PUBTYPE: Journal Article
JOURNALTITLE: Biochemical and biophysical research communications.
COUNTRY: UNITED STATES
TITLE: The 5' flanking region of the human pS2 gene mediates its transcriptional activation by estrogen in MCF-7 cells.
PUBDATE: 19880201
The pS2 gene is transcriptionally induced by oestrogen in the human breast cancer cell line MCF-7. We demonstrate here that the 5' flanking sequences (-3000 to +10 bp) of the pS2 gene possess the properties of an oestrogen-inducible promoter. Interestingly, this oestrogen induction could not be demonstrated in transient transfection assays in MCF-7 cells, but only in stably transformed MCF-7 cells, which suggests that some factors responsible for oestrogen induction may be present in limiting amounts in these cells and absent in HeLa cells.


14. DOCID:15283 SCORE: 0.00214551457807162
DOCNO: 3437595
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: adverse effects
AUTHOR: J Miyakoshi J
AUTHOR: M Hirata M
AUTHOR: W Oda W
AUTHOR: E J Cragoe EJ
AUTHOR: C Inagaki C
AFFILIATION: Radioisotope Laboratory, Faculty of Medicine, Kyoto University, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Japanese journal of pharmacology.
COUNTRY: JAPAN
TITLE: Sensitization to heat by amiloride analogues in Chinese hamster cells.
PUBDATE: 19871001
Effects of five amiloride analogues on thermal cell killing were examined using Chinese hamster V-79 cells. When cells were exposed to 42 degrees C hyperthermia in the presence of 0.2 mM amiloride or its analogue, cell survival decreased with increasing exposure time, as compared with that for exposure to 42 degrees C alone. The degree of the thermosensitizing effect varied among the test compounds, and three analogues were found to be more potent than amiloride. The results suggest that some of the amiloride analogues may be useful as hyperthermic sensitizers in the clinical treatment of cancer.