0. DOCID:1727 SCORE: 0.00247788624531822
DOCNO: 931204
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: D T Kiang DT
AUTHOR: B J Kennedy BJ
PUBTYPE: Journal Article
JOURNALTITLE: Annals of internal medicine.
COUNTRY: UNITED STATES
TITLE: Tamoxifen (antiestrogen) therapy in advanced breast cancer.
PUBDATE: 19771201
Fifty-nine postmenopausal women with advanced breast cancer were treated with tamoxifen (antiestrogen), 20 mg orally twice a day for at least 2 months. They had been previously treated with other types of hormonal therapy or intensive chemotherapies, or both. Nineteen of the 59 patients (32%) had either a complete response (seven patients) or partial response (12 patients). The median duration of response was 9+ months. Tumors containing estrogen receptors and those that responded to previous hormonal manipulation tended to respond to tamoxifen (60% and 69%, respectively). Patients with receptor-negative tumor or with a history of failure of previous hormonal treatments did not respond to tamoxifen therapy. Tamoxifen is effective against advanced breast cancer. Side effects of the treatment were mild.


1. DOCID:7473 SCORE: 0.00237658900712131
DOCNO: 313889
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Colony-Stimulating Factors
QUALIFIER: pharmacology
QUALIFIER: drug effects
QUALIFIER: drug effects
QUALIFIER: immunology
AUTHOR: M Hayashi M
AUTHOR: J Okabe J
AUTHOR: M Hozumi M
PUBTYPE: Journal Article
JOURNALTITLE: Gann = Gan.
COUNTRY: JAPAN
TITLE: Sensitization of resistant myeloid leukemia clone cells by anti-cancer drugs to factor-stimulating differentiation.
PUBDATE: 19790401
Studies were made on the effect of cancer chemotherapeutic drugs on in vitro differentiation of a clone (R4) of mouse myeloid leukemic cells (MI) that is resistant to inducers. Treatment of the cells with 50% ascitic fluid (an inducer) plus 0.25 microgram/ml of adriamycin or 0.3 microgram/ml of daunomycin induced phagocytic activity and suppressed cell growth, but had little effect on cell viability; treatment with ascitic fluid or the drugs alone had no effect. In combination with ascitic fluid, mitomycin-C, hydroxyurea, 5-fluorouracil, or bleomycin also induced phagocytic activity, but 6-mercaptopurine, amethopterin, or aminopterin did not. These drugs also induced other differentiation-associated properties, lysozyme activity, and locomotive activity. The present results indicate that some cancer chemotherapeutic drugs sensitive resistant leukemic cells to an inducer of cell differentiation.


2. DOCID:6711 SCORE: 0.00237268206229774
DOCNO: 6250510
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Activities of Daily Living
DESCRIPTOR: Outcome and Process Assessment (Health Care)
DESCRIPTOR: Rehabilitation
AUTHOR: S K Forer SK
AUTHOR: L S Miller LS
PUBTYPE: Journal Article
JOURNALTITLE: Archives of physical medicine and rehabilitation.
COUNTRY: UNITED STATES
TITLE: Rehabilitation outcome: comparative analysis of different patient types.
PUBDATE: 19800801
Postdischarge progress in 11 types of patients was analyzed with regard to eating, dressing, transfers, bladder management, ambulation, cognition, language comprehension and speech, placement (living arrangement), and mortality rates. Of 273 patients admitted, 263 were available for foillow-up, which disclosed that patients with lower bladder management and cognition scores are more likely to be directed into restrictive discharge placements (p < 0.05), and that CVA patients with right and left cerebral hemisphere involvement, cancer patients, and patients with brain stem infarctions make significant postdischarge gains in ADL (p < 0.05). The majority of patients showed continual improvement after discharge, some making significant gains in functional competency. Such program evaluation offers a systematic method for forecasting post-discharge outcome.


3. DOCID:5356 SCORE: 0.00230381030575813
DOCNO: 632904
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Drug Hypersensitivity
QUALIFIER: adverse effects
AUTHOR: G T Krishnamurthy GT
PUBTYPE: Journal Article
JOURNALTITLE: Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
COUNTRY: UNITED STATES
TITLE: Human reaction to bovine TSH: concise communication.
PUBDATE: 19780301
The incidence of allergic reactions to bovine TSH and its relation to dose have been studied in 42 patients with thyroid cancer who had total ablation of functioning thyroidal tissue and have been followed prospectively for up to 25 yr. Of these patients, 43% showed an allergic reaction to bovine TSH. The remaining 57% have shown no reaction, even though they have received cumulative TSH doses larger than those who did show a reaction. The reaction rate is linear up to a cumulative dose of 150 units and is not dose-related therafter.


4. DOCID:2189 SCORE: 0.00230039194745859
DOCNO: 954507
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: J Stadler J
AUTHOR: W Müller W
AUTHOR: H R Henche HR
AUTHOR: R Sauer R
PUBTYPE: Journal Article
JOURNALTITLE: Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen.
COUNTRY: GERMANY, WEST
TITLE: [Treatment of pathologic fractures]
PUBDATE: 19760601
Eight pathologic fractures of benign and 52 of malignant origin are reported. Open reduction and rigid internal fixation should be performed to give the patient the use of his affected limb as soon as this can be accomplished. Treatment consists of internal fixation in lesions of the shaft and prosthetic replacement in the case of lesions near joints. Only very rarely a primary amputation must be performed. Malignant fractures are most frequently caused by metastases from breast cancers. The treatment will at least make nursing easier, and three-quarters of these patients can be mobilized. The combination of surgical treatment and radiotherapy is discussed. In spite of this approach the average time of survival of 14 months is short because a pathological fracture due to a malignant tumor is a late symptom of the disease.


5. DOCID:3364 SCORE: 0.00225728825153068
DOCNO: 805571
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Preoperative Care
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: G A Higgins GA
AUTHOR: J H Conn JH
AUTHOR: P H Jordan PH
AUTHOR: E W Humphrey EW
AUTHOR: B Roswit B
AUTHOR: R J Keehn RJ
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Annals of surgery.
COUNTRY: UNITED STATES
TITLE: Preoperative radiotherapy for colorectal cancer.
PUBDATE: 19750501
In a prospective randomized trial, 700 patients with a confirmed histological diagnosis of adenocarcinoma of the rectum or rectosigmoid were randomized to receive radiotherapy prior to operation (2000 to 2500 rads in two weeks) or surgery alone. Five year observed survival in the 453 patients on whom "curative" resection was possible was 48.5% in the X-ray treated group compared with 38.8% in controls, while in the 305 having low lying lesions requiring abdominoperineal resection, survival in the treated group was 46.9% compared with 34.3% in controls. Although suggestive of a treatment benefit, neither is considered statistically significant. Histologically positive lymph nodes were found in 41.2% of the control group and in only 27.8% of the patients receiving radiotherapy. Reveiw of all patients who died during the study shows a consistently lower death rate from cancer in the radiotherapy group. Although this study suggests a treatment benefit from preoperative radiotherapy, further studies now in progress by this group and others are necessary to determine the optimal dose regimen.


6. DOCID:6830 SCORE: 0.00224121742864527
DOCNO: 7005782
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: H Rübben H
AUTHOR: H H Dahm HH
AUTHOR: W Lutzeyer W
PUBTYPE: Journal Article
JOURNALTITLE: Onkologie.
COUNTRY: SWITZERLAND
TITLE: [Clinical diagnosis of bladder cancer]
PUBDATE: 19801001
The minimum requirements of the International Union against Cancer (UICC) to assess the TNM-classification of urothelial bladder cancer include since 1978 the clinical examination, urography, cystoscopy, bimanual palpation under anesthesia and biopsy or transurethral resection of the tumor. The single biopsy of the tumor should be supplemented by multiple biopsies of all bladder walls in combination with the resection of the tumor to diagnose multifocal tumor growth. The exfoliative urinary cytology should be included in the routine diagnostic regimen: cytology is helpful in detection of severe dysplasia and controls the histologically determined grade of the tumor. In selected cases computer tomography improves the accuracy of clinical evaluation of the depth of tumor infiltration. In our hands the lymphangiography can not assess the regional lymph node metastases: therefore, the staging operation is recommended before radical cystectomy is performed.


7. DOCID:3609 SCORE: 0.00223369999352619
DOCNO: 1015500
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
AUTHOR: A R Walker AR
AUTHOR: D P Burkitt DP
PUBTYPE: Journal Article
JOURNALTITLE: The American journal of digestive diseases.
COUNTRY: UNITED STATES
TITLE: Colonic cancer--hypotheses of causation, dietary prophylaxis, and future research.
PUBDATE: 19761001
Colonic cancer is rare in primitive populations. In western populations it was uncommon in the past, but now accounts for about 3% of all deaths. The cause almost certainly lies with dietary changes. Probably, alterations in bowel milieu interieur, from interaction between metabolites and microbacteria, promote carcinogenesis. Changes in intakes of protein, fat, sugar, refined cereal products, and crude fiber have been advanced as predisposing or causative factors. Evidence suggests that (i) fall in fiber intake, but (ii) rise in fat intake, in their ability to increase fecal concentrations of bile acids and sterols (possible precursors of carcinogens) are most likely to be culpable. As preventive measures, a significant rise in fiber intake is practicable only from regular bran ingestion. A major reduction in fat intake is grossly unlikely. Even were rigorous dietary changes implemented, an early fall in colonic cancer incidence is highly improbable due to the long-term character of the disease. Future research must include characterization of the diet, metabolism, and disease pattern of segments of western populations who have low colonic cancer mortality rates; also, elucidation of the bearing of various intakes of different food components on the biochemistry and microbiology of the feces.


8. DOCID:3648 SCORE: 0.0022321288632164
DOCNO: 1121232
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Laryngectomy
DESCRIPTOR: Voice
AUTHOR: G P Moore GP
PUBTYPE: Journal Article
JOURNALTITLE: The Laryngoscope.
COUNTRY: UNITED STATES
TITLE: Voice problems following limited surgical excision.
PUBDATE: 19750401
The published literature contains relatively few references to vocal rehabilitation for persons with partial laryngectomy. Articles on various types of surgery indicate that many individuals develop satisfactory voice following limited surgery, particularly supraglottic procedures. An informal questionnaire completed by 10 larngologists who had had substantial experience with sub-total laryngectomy revealed that an average of 25 percent of their patients with laryngeal cancer receive partial laryngectomy. Lesions limited to the epiglottis, supraglottic areas or one vocal cord are regularly treated by limited excision. Half of the questionnaires indicated that partial laryngectomy can be used for bilateral vocal cord lesions under certain circumstances. The questionnaire confirmed the published reports that most of the subsequent voices were satisfactory or good and many recover without special vocal retraining. Non reported employment of partial laryngectomy for sub-glottal cancer. Hemilaryngectomy and cordectomy frequently resulted in some impairment of voice. Speech therapy is often recommended when possible. Therapy applicable to voice following partial laryngectomy combines five emphases: 1. strengthening glottic closure and loudness of the voice; 2. improving the efficiency of breath expenditure; 3. increasing the articulatory skill and intelligibility of speech; 4. recognizing and compensating for hearing loss; and 5. aiding the patient to reduce detrimental environmental influences and to adjust to his environmental requirements.


9. DOCID:6829 SCORE: 0.00218545438655138
DOCNO: 6166019
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mastectomy
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: A P Cipolloni AP
AUTHOR: P Collini P
AUTHOR: L Pierini L
AUTHOR: R Rossi R
AUTHOR: L Cenciotti L
PUBTYPE: Journal Article
JOURNALTITLE: Quaderni Sclavo di diagnostica clinica e di laboratorio.
COUNTRY: ITALY
TITLE: [Protein, immunological and "Gc", "Gm" and "Inv" picture in high-risk mastectomized subjects]
PUBDATE: 19800301
In the field of research on cancer we studied 294 women of which 142 who had undergone mastectomy, 70 selected for a high risk group, 82 normal. In order to determine some parameters who characterize the three groups we research for each the globulin factor Gc, Gm, and Inv, the proteic fractions and the immunoglobulins, as already pointed out by other investigators. The study of data points out results some times not according to previous reports. Comparing people who had undergone mastectomy and who had been selected for a high risk group, on the bases of GC phenotype together with immunoglobulins we obtained interesting values that characterize and delimit the two groups.


10. DOCID:2872 SCORE: 0.00216178921878589
DOCNO: 318914
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: J P Horstmann JP
AUTHOR: G G Pietra GG
AUTHOR: J A Harman JA
AUTHOR: N G Cole NG
AUTHOR: S Grinspan S
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Spontaneous regression of pulmonary leiomyomas during pregnancy.
PUBDATE: 19770101
Multiple pulmonary nodular densities simulating metastastic cancer were discovered in a routine chest roentgenogram of a 30-year-old pregnant woman. Lung biopsy revealed nodules composed of smooth muscle and collagenous tissue containing entrapped glandular elements. The lesions were initially interpreted as multiple pulmonary fibroleiomyomatous hamartomas (MPFLH). During pregnancy and the post-partum period, the pulmonary nodules regressed spontaneously. Critical analysis of the published cases as well as our own case indicates that multiple pulmonary fibroleiomyomatous hamartomas (MPFLH) cannot be distinguished from benign metastasizing leiomyoma (BML) by either clinical, roentgenographic, or pathologic criteria and that all represent pulmonary metastases from a primary uterine neoplasm. The spontaneous regression of the pulmonary nodules in the present case as well as the increased risk for development of progressive pulmonary insufficiency in the pre-menopausal patients indicates an apparent hormonal dependence. Total abdominal hysterectomy and bilateral salpingo-oophorectomy appears to be the treatment of choice.


11. DOCID:7925 SCORE: 0.00215447367188701
DOCNO: 745959
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Endoscopy
DESCRIPTOR: Rectum
DESCRIPTOR: Sigmoidoscopy
AUTHOR: R Lambert R
AUTHOR: C Olive C
AUTHOR: R Chabanon R
PUBTYPE: Journal Article
JOURNALTITLE: La Nouvelle presse médicale.
COUNTRY: FRANCE
TITLE: [Fibrorectosigmoidoscopy. Results of 476 cases (author's transl)]
PUBDATE: 19781201
A fibrorectosigmoidoscope, 60 cm in length has been systematically applied in the endoscopy unit to the exploration of the distal colon. Technical parameters have been analysed in 300 patients: --immediate enema preparation was satisfactory (95% of examinations), --tolerance was good (96% of examinations), --mean length of colon explored reached 48,5 cm, --mean length of duration reached 5,15 mn. Efficacy in the detection of colonic lesions was tested in 476 patients (symptomatic or asymptomatic). Tumoral lesions were detected in 105 patients, with a total of 125 adenomas and 31 cancers; 71 lesions were found in the area that could be explored by a rigid rectosigmoidoscope (0-19 cm) while 85 were beyond this limit (20-60 cm). The fibre endoscope explores a larger territory (rectum + sigmoid), resulting in increased efficacy in the detection of colonic lesions. It should therefore replace progressively the rigid instrument in spite of its higher cost.


12. DOCID:2927 SCORE: 0.00214369313029026
DOCNO: 1212649
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: B S Danes BS
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: The gardner syndrome. A study in cell culture.
PUBDATE: 19751201
Tetraploidy was increased in skin fibroblast cultures derived from three probands with the Gardner syndrome and nine affected members of one family as compared to that occurring in cultures from five unaffected family members as well as from six relatives by marriage and 15 normals grown in the laboratory at the same time under the same conditions. Tetraploidy was present at the first subculture (2 weeks after the initial biopsy was cultured) and for each line studied the percentage of dividing cells showing tetraploidy remained constant. Increased occurrence of tetraploidy was not observed in skin fibroblast cultures from patients with the genetic disorders familial polyposis coli, familial osteomas, and familial fibromatosis (neurofibromatosis), each of which show one of the four abnormal tissue growths observed in the Gardner syndrome. The relationship of the observed tetraploidy to the increased risk of such patients to develop abnormal growths and cancer has not been established. The increased tetraploidy should be of value in identifying the presence of the gene for the Gardner syndrome in high risk families.


13. DOCID:7962 SCORE: 0.00206819575588575
DOCNO: 120351
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: R Dietz R
AUTHOR: H J Wilhelm HJ
AUTHOR: W Schätzle W
PUBTYPE: Journal Article
JOURNALTITLE: HNO.
COUNTRY: GERMANY, WEST
TITLE: [Ten years experience with combination therapy for tonsillar malignancies (author's transl)]
PUBDATE: 19790901
From 1968 to 1978, 125 patients with cancer of the tonsil have been treated by the Departments of Radiology and Otolaryngology at the University Hospital, Homburg-Saar. Although all patients were unirradiated, many had previously undergone a surgical procedure. Most of the cancers when seen were in advanced stages. The three-year and five-year survival rates were 38.6 and 23.5% respectively. Reticulum cell sarcomas, Schmincke's tumors and non-keratinized squamous cell carcinomas had better prognoses than keratinized squamous cell carcinomas. Our findings indicate that the volume of large tumors should be reduced by surgical means before irradiation since irradiation alone resulted in a higher relapse rate in the advanced cancers. Various methods for radiotherapy either before or after surgery for different tumor stages are discussed. The combination of chemotherapy with radiation to make use of the so-called "partial synchronisation effect" in cases of inoperable extensive primary tumors or relapses is described.


14. DOCID:7544 SCORE: 0.00206413044845605
DOCNO: 374755
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Kidney Transplantation
QUALIFIER: etiology
QUALIFIER: adverse effects
QUALIFIER: adverse effects
QUALIFIER: complications
AUTHOR: H W Herr HW
AUTHOR: D E Engen DE
AUTHOR: J Hostetler J
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Malignancy in uremia: dialysis versus transplantation.
PUBDATE: 19790501
The incidence of cancer was compared in 499 dialysis patients and 121 renal transplant recipients. De novo malignancy developed in 15 patients on chronic dialysis (3 per cent) and in 6 transplant recipients (4.9 per cent), a significant increase over the expected number in the age-matched general population. There was no difference in the incidence of cancer in uremic patients on dialysis or after transplantation. A total of 10 dialysis patients (67 per cent) and 1 transplant patient (16 per cent) died of cancer. Neoplasms in the dialysis patients were the common types of mesenchymal tumors, while superficial skin cancers were seen more frequently in the transplant recipients. The differences in tumor types accounted for the higher mortality rate from cancer in the dialysis patients and may reflect different patterns of immunosuppression in these 2 patient populations.