0. DOCID:10120 SCORE: 0.00295026230827014
DOCNO: 7078910
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: J Chu J
AUTHOR: H K Tamimi HK
AUTHOR: M Ek M
AUTHOR: D C Figge DC
PUBTYPE: Journal Article
JOURNALTITLE: Obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Stage I vulvar cancer: criteria for microinvasion.
PUBDATE: 19820601
Thirty-eight women with stage I epidermoid carcinoma of the vulva were studied retrospectively in an attempt to define the criteria for conservative therapy in early invasive vulvar cancer. Among the 38 women, 23 met the 6 criteria established for early invasive carcinoma of the vulva. In those 23 women, there were no nodal metastases. Depth of stromal invasion correlated strongly with the degree of tumor differentiation and the presence of carcinoma in situ (CIS). Stromal invasion less than 3 mm and presence of CIS were predictive of no involvement of the lymph nodes or endothelial-like space.

1. DOCID:11128 SCORE: 0.00285254549118537
DOCNO: 3877314
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: analysis
AUTHOR: M Schena M
AUTHOR: A Quadri A
AUTHOR: G Ragazzoni G
AUTHOR: P Corti P
PUBTYPE: Journal Article
JOURNALTITLE: Quaderni Sclavo di diagnostica clinica e di laboratorio.
COUNTRY: ITALY
TITLE: [Alpha 1-antitrypsin as a tumor marker]
PUBDATE: 19850301
In this work we intended: a) to confirm the correlation between the increase of serum levels of alpha 1-antitrypsin (ATT) and neoplastic disease; b) to verify in what tumoural diseases the increase of ATT has a specific significance. Therefore we have examined 164 patients: 60 represented the control group and 104 were suffering from neoplastic diseases. We have subdivided the nest group according to histological type and tumour location. The result of this work has demonstrated that the increase of ATT is really determined by the existence of neoplastic disease, more than histological type or location of cancer. The AAT represents a diagnostic index of neoplastic diseases, highly sensitive but little specific.

2. DOCID:15166 SCORE: 0.00279336007912101
DOCNO: 2511733
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: U Lekholm U
AUTHOR: G Stenman G
AFFILIATION: Brånemark Clinic, Public Dental Health Service of Gothenburg, Sweden.
PUBTYPE: Journal Article
JOURNALTITLE: Acta odontologica Scandinavica.
COUNTRY: NORWAY
TITLE: Induction of oral cancer by 7,12-dimethylbenz[a]anthracene in rats with liver cirrhosis.
PUBDATE: 19891001
The effects of carbon tetrachloride-induced liver cirrhosis and xerostomia on oral carcinogenesis were studied in rats given the lipid-soluble carcinogen 7,12-dimethylbenz-[a]anthracene (DMBA). The first carcinoma was detected after only 1 month of DMBA applications. After a further 8 months 85% of the animals had developed one or more squamous cell carcinomas. The latency period for DMBA-induced oral cancer in cirrhotic rats with xerostomia was markedly reduced in comparison with previous findings from xerostomic rats without liver cirrhosis. The results support earlier epidemiologic studies indicating a relationship between liver cirrhosis and oral cancer.

3. DOCID:11701 SCORE: 0.00265139730860227
DOCNO: 6883269
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: R C Hamaker RC
AUTHOR: M I Singer MI
AUTHOR: W W Shockley WW
AUTHOR: N Pugh N
AUTHOR: H Shidnia H
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Irradiated mandibular autografts.
PUBDATE: 19830901
The cosmetic and functional disability associated with mandibular resection has been a major problem to the patient with direct invasion of the mandible by oral cancer. Marginal resections with combined postoperative radiation therapy have frequently been substituted for the more preferred segmental resections and resultant deformities. Presented are 15 cases of oral cavity cancer involving resection of the mandible, immediate radiation to 10,000 rad, and primary reconstruction as irradiated mandibular autografts. The longest following is 4 years and 3 months, with a success rate of 66%. Morbidity is minimal as compared to autogenous bone grafting. Tumor size, previous radiation, or use of regional flaps have not been a factor in the success of this method in reconstruction of the mandible primarily.

4. DOCID:15412 SCORE: 0.00256793984109176
DOCNO: 2923414
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
QUALIFIER: mortality
AUTHOR: C P Armstrong CP
AUTHOR: S J Whitelaw SJ
AFFILIATION: Derriford Hospital, Plymouth, Devon.
PUBTYPE: Journal Article
JOURNALTITLE: Annals of the Royal College of Surgeons of England.
COUNTRY: ENGLAND
TITLE: Death from unsuspected colorectal cancer.
PUBDATE: 19890101
An analysis of all subjects undergoing autopsy in the Plymouth Health District over a 10-year period revealed 61 cases of unsuspected colorectal cancer. The carcinoma was the primary cause of death in 57 cases and surgical treatment for cure might have been possible in over one-half. The 61 subjects accounted for 4.1% of all cases of fatal colorectal cancer in this area. Examination by means of rectal digital palpation, rigid sigmoidoscopy and flexible sigmoidoscopy might have diagnosed 10, 24 and 41 carcinomas respectively. This study has demonstrated that a significant number of colorectal cancers remain undetected until after death. These cases should be included in future studies of colorectal cancer.

5. DOCID:15222 SCORE: 0.00251551908048822
DOCNO: 3812981
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analogs & derivatives
QUALIFIER: chemical synthesis
AUTHOR: P H Stern PH
AUTHOR: R M Hoffman RM
PUBTYPE: Journal Article
JOURNALTITLE: Analytical biochemistry.
COUNTRY: UNITED STATES
TITLE: The chemical synthesis of high specific-activity [35S]adenosylhomocysteine.
PUBDATE: 19861101
The study of the family of transmethylases, critical to normal cellular function and often altered in cancer, can be facilitated by the availability of a high specific-activity S-adenosylhomocysteine. We report the two-step preparation of [35S]adenosylhomocysteine from [35S]methionine at a specific activity of 1420 Ci/mmol in an overall yield of 24% by a procedure involving demethylation of the [35S]methionine to [35S]homocysteine followed by condensation with 5'-chloro-5'-deoxyadenosine. The ease of the reactions, ready availability and low cost of the reagents and high specific-activity and stability of the product make the procedure an attractive one with many uses, and superior to current methodology.

6. DOCID:14953 SCORE: 0.00248575172762862
DOCNO: 3825158
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: E Wenzl E
AUTHOR: M Wunderlich M
AUTHOR: F Herbst F
AUTHOR: M Schemper M
AUTHOR: W Feil W
AUTHOR: R Rauhs R
AUTHOR: R Schiessel R
PUBTYPE: Journal Article
JOURNALTITLE: Wiener klinische Wochenschrift.
COUNTRY: AUSTRIA
TITLE: [Consequences of after-care in colorectal cancer]
PUBDATE: 19861201
Results of a computer supported follow-up-program on patients with colorectal cancer are presented. Between 1978 and 1985 1024 patients underwent these program, the drop-out-rate was 18%. 231 recurrences in 137 patients were discovered (40% local recurrence, 30% liver metastases and 30% others). 54% of patients with local recurrence and 43% with liver metastases were free of symptoms. Radical surgery was performed in 47% of local recurrences and in 24% of liver metastases. The three year survival rate after radical surgery for recurrence amounted to 28% for local recurrences and to 31% for liver metastases.

7. DOCID:1727 SCORE: 0.00247788624531822
DOCNO: 931204
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: D T Kiang DT
AUTHOR: B J Kennedy BJ
PUBTYPE: Journal Article
JOURNALTITLE: Annals of internal medicine.
COUNTRY: UNITED STATES
TITLE: Tamoxifen (antiestrogen) therapy in advanced breast cancer.
PUBDATE: 19771201
Fifty-nine postmenopausal women with advanced breast cancer were treated with tamoxifen (antiestrogen), 20 mg orally twice a day for at least 2 months. They had been previously treated with other types of hormonal therapy or intensive chemotherapies, or both. Nineteen of the 59 patients (32%) had either a complete response (seven patients) or partial response (12 patients). The median duration of response was 9+ months. Tumors containing estrogen receptors and those that responded to previous hormonal manipulation tended to respond to tamoxifen (60% and 69%, respectively). Patients with receptor-negative tumor or with a history of failure of previous hormonal treatments did not respond to tamoxifen therapy. Tamoxifen is effective against advanced breast cancer. Side effects of the treatment were mild.

8. DOCID:13735 SCORE: 0.00240185602670066
DOCNO: 3357390
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: pathology
AUTHOR: O I Shcherbenko OI
PUBTYPE: Journal Article
JOURNALTITLE: Meditsinskaia radiologiia.
COUNTRY: USSR
TITLE: [Survival and prognostic factors in radiation and combination therapy of bone metastases of breast cancer]
PUBDATE: 19880401
A retrospective analysis of the survival and mean life rates of 107 patients with breast cancer metastases to the skeletal bones was performed. In non-randomized groups there was no significant correlation of long-term therapeutic results and the type of fractionation, a total radiation dose value, chemo- or hormonotherapy. Prognosis was better in patients in whom solitary metastases were detected 5 and more years after primary treatment. In such cases radiation therapy was indicated at doses sufficient for eradication or stable stabilization of a focus using the most sparing dose fractionation regimens.

9. DOCID:7473 SCORE: 0.00237658900712131
DOCNO: 313889
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Colony-Stimulating Factors
QUALIFIER: pharmacology
QUALIFIER: drug effects
QUALIFIER: drug effects
QUALIFIER: immunology
AUTHOR: M Hayashi M
AUTHOR: J Okabe J
AUTHOR: M Hozumi M
PUBTYPE: Journal Article
JOURNALTITLE: Gann = Gan.
COUNTRY: JAPAN
TITLE: Sensitization of resistant myeloid leukemia clone cells by anti-cancer drugs to factor-stimulating differentiation.
PUBDATE: 19790401
Studies were made on the effect of cancer chemotherapeutic drugs on in vitro differentiation of a clone (R4) of mouse myeloid leukemic cells (MI) that is resistant to inducers. Treatment of the cells with 50% ascitic fluid (an inducer) plus 0.25 microgram/ml of adriamycin or 0.3 microgram/ml of daunomycin induced phagocytic activity and suppressed cell growth, but had little effect on cell viability; treatment with ascitic fluid or the drugs alone had no effect. In combination with ascitic fluid, mitomycin-C, hydroxyurea, 5-fluorouracil, or bleomycin also induced phagocytic activity, but 6-mercaptopurine, amethopterin, or aminopterin did not. These drugs also induced other differentiation-associated properties, lysozyme activity, and locomotive activity. The present results indicate that some cancer chemotherapeutic drugs sensitive resistant leukemic cells to an inducer of cell differentiation.

10. DOCID:6711 SCORE: 0.00237268206229774
DOCNO: 6250510
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Activities of Daily Living
DESCRIPTOR: Outcome and Process Assessment (Health Care)
DESCRIPTOR: Rehabilitation
AUTHOR: S K Forer SK
AUTHOR: L S Miller LS
PUBTYPE: Journal Article
JOURNALTITLE: Archives of physical medicine and rehabilitation.
COUNTRY: UNITED STATES
TITLE: Rehabilitation outcome: comparative analysis of different patient types.
PUBDATE: 19800801
Postdischarge progress in 11 types of patients was analyzed with regard to eating, dressing, transfers, bladder management, ambulation, cognition, language comprehension and speech, placement (living arrangement), and mortality rates. Of 273 patients admitted, 263 were available for foillow-up, which disclosed that patients with lower bladder management and cognition scores are more likely to be directed into restrictive discharge placements (p < 0.05), and that CVA patients with right and left cerebral hemisphere involvement, cancer patients, and patients with brain stem infarctions make significant postdischarge gains in ADL (p < 0.05). The majority of patients showed continual improvement after discharge, some making significant gains in functional competency. Such program evaluation offers a systematic method for forecasting post-discharge outcome.

11. DOCID:11601 SCORE: 0.00234727478786527
DOCNO: 3981808
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: methods
AUTHOR: Y Takatsuka Y
AUTHOR: A Sugitachi A
AUTHOR: K Morimoto K
AUTHOR: I Sakamoto I
AUTHOR: T Kawahara T
PUBTYPE: Journal Article
JOURNALTITLE: Japanese journal of clinical oncology.
COUNTRY: JAPAN
TITLE: Transcatheter arterial chemo-embolization (TAC-E) for patients with locally advanced breast cancer.
PUBDATE: 19850301
Preoperative transcatheter arterial chemo-embolization (TAC-E) was used for 19 patients with locally advanced breast cancer, to eradicate the extensive loco-regional areas prior to surgery and hopefully to reduce the postoperative recurrence rate. The results were as follows: (1) Each primary tumor showed marked regression within 2 weeks after TAC-E. (2) Surgicopathology confirmed the excellent efficacy of TAC-E against both primary tumors and metastatic lymph node tumors. (3) Side effects due to this treatment were few, compared with other forms of cancer chemotherapy. (4) The prognosis of each patient was good. We conclude that preoperative TAC-E has a great potential for the treatment of locally advanced breast cancer.

12. DOCID:9855 SCORE: 0.00232594599773609
DOCNO: 4036653
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: psychology
AUTHOR: N Manos N
AUTHOR: J Christakis J
PUBTYPE: Journal Article
JOURNALTITLE: Acta psychiatrica Scandinavica.
COUNTRY: DENMARK
TITLE: Coping with cancer: psychological dimensions.
PUBDATE: 19850701
Cancer has a profound psychological impact upon the patient and his family, and the psychological responses, primarily of the patient himself, the close family, physician and nursing personnel, but also of the extended family, and society in general, become a complex interrelationship. Some of the most important psychological aspects of cancer are reviewed. These include the psychological responses of the patient, such as denial, vulnerability, coping strategies, hope, depression, suicide, reaction to diagnosis, and the management of the family, and the psychological responses and attitudes of the physician and nursing personnel. Based on the above psychological analysis some guidelines are offered to help in coping with cancer.

13. DOCID:11148 SCORE: 0.00230500270251909
DOCNO: 6593623
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: trends
QUALIFIER: trends
AUTHOR: J P Riordan JP
AUTHOR: R J Stewart RJ
AUTHOR: N E Pearce NE
AUTHOR: W H Isbister WH
PUBTYPE: Journal Article
JOURNALTITLE: The New Zealand medical journal.
COUNTRY: NEW ZEALAND
TITLE: Changes in the pattern of disease managed by general surgeons in New Zealand, 1940-80.
PUBDATE: 19841101
Changes in the pattern of disease managed by general surgeons in New Zealand, were assessed for the period 1940-80, using the public hospital admission and cancer incidence data of a representative selection of diseases. During the forty-year period, there was an increase in the incidence of four of the five cancers studied, and an increase in admission rate for non-specific abdominal pain, head injury (indicated by skull fracture), peripheral arterial disease (indicated by aortic aneurysm), gall-stone disease and pancreatitis, large bowel disorders and breast diseases. There was a decline in admission rate for appendicitis, stomach disorders and goitre.

14. DOCID:5356 SCORE: 0.00230381030575813
DOCNO: 632904
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Drug Hypersensitivity
QUALIFIER: adverse effects
AUTHOR: G T Krishnamurthy GT
PUBTYPE: Journal Article
JOURNALTITLE: Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
COUNTRY: UNITED STATES
TITLE: Human reaction to bovine TSH: concise communication.
PUBDATE: 19780301
The incidence of allergic reactions to bovine TSH and its relation to dose have been studied in 42 patients with thyroid cancer who had total ablation of functioning thyroidal tissue and have been followed prospectively for up to 25 yr. Of these patients, 43% showed an allergic reaction to bovine TSH. The remaining 57% have shown no reaction, even though they have received cumulative TSH doses larger than those who did show a reaction. The reaction rate is linear up to a cumulative dose of 150 units and is not dose-related therafter.