0. DOCID:27511 SCORE: 0.00304741975270257
DOCNO: 9560835
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: S E DePasquale SE
AUTHOR: A Giordano A
AUTHOR: A E Donnenfeld AE
AFFILIATION: Program in Woman's Oncology, Woman and Infants Hospital, Providence, RI 02905-2499, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Obstetrical & gynecological survey.
COUNTRY: UNITED STATES
TITLE: The genetics of ovarian cancer: molecular biology and clinical application.
PUBDATE: 19980401
Ovarian cancer is the fifth most common malignancy among American women and the fourth leading cause of cancer death. The rapid advances in molecular genetic analysis, presymptomatic detection, and treatment of ovarian cancer are staggering. In this review, both the genetic component and the molecular biology of ovarian cancer are discussed, as well as current recommendations for genetic counseling. It is important for the practicing obstetrician and gynecologist to become familiar with these concepts, for it is he or she who will likely serve as a primary resource of information for these patients.


1. DOCID:27907 SCORE: 0.00303936866054212
DOCNO: 10977932
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: G I Nepomnyashchikh GI
AUTHOR: V A Levitskii VA
AUTHOR: L M Nepomnyashchikh LM
AUTHOR: S V Aidagulova SV
AUTHOR: L A Naumova LA
AUTHOR: I Y Belov IY
AFFILIATION: Laboratory of Ultrastructural Basis of Pathology, Institute of Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk.
PUBTYPE: Journal Article
JOURNALTITLE: Bulletin of experimental biology and medicine.
COUNTRY: United States
TITLE: Instability of bronchial epithelium in chronic pulmonary diseases.
PUBDATE: 20000401
Pathomorphological examination of large bronchi in patients with occupational diseases, lung cancer, and in subjects exposed to radiation revealed structural and functional heterogeneity of the epithelium: the presence of focal atrophy, metaplasia, hyper- and dysplasia in the same biopsy specimen. This phenomenon was termed as instability of the epithelium. Thickness of the epithelium greatly varied, especially, in neoplastic processes. Atrophy and epithelial instability phenomenon are interpreted as morphological markers of ecological and oncological risk.


2. DOCID:27971 SCORE: 0.00303936812577775
DOCNO: 10854151
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genetic Vectors
QUALIFIER: genetics
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: methods
AUTHOR: L C Pagliaro LC
AFFILIATION: Department of Genitourinary Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA. lpagliar@mdanderson.org
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: World journal of urology.
COUNTRY: GERMANY
TITLE: Gene therapy for bladder cancer.
PUBDATE: 20000401
Tumor-suppressor genes can be transferred into tumor cells in vivo using a replication-defective adenoviral vector. P53 mutations are frequent in bladder cancer, and adenovirus-mediated p53 gene transfer is growth-inhibitory to bladder cancer cells in vitro. The vector Ad5CMV-P53, which contains human wild-type p53, is being administered intravesically to patients with bladder cancer in a phase I clinical trial. The results of this study will provide the basis for phase II and phase III trials in which gene therapy will be integrated with existing therapies for improved local control and opportunities for bladder preservation.


3. DOCID:27968 SCORE: 0.00303936766963476
DOCNO: 11561985
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: R Dreicer R
AFFILIATION: Department of Hematology, The Urologic Institute, Cleveland Clinic Foundation, OH 44195, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in urologic oncology.
COUNTRY: United States
TITLE: Neoadjuvant chemotherapy in the management of muscle-invasive bladder cancer.
PUBDATE: 20010801
Muscle-invasive bladder cancer is typically an aggressive solid tumor with the propensity for early systemic dissemination. Although radical cystectomy remains the gold standard intervention, the high rate of systemic failure has prompted investigators to evaluate various strategies to attempt to improve survival, including the early administration of systemic chemotherapy. These efforts have provided mixed results with two recently completed trials providing conflicting results. Other strategies include attempts to both preserve the bladder using combinations of limited surgical resection, systemic chemotherapy, and radiotherapy. This review focuses on the potential of neoadjuvantly administered therapies to impact the management of muscle-invasive bladder cancer.


4. DOCID:26965 SCORE: 0.00280172185847864
DOCNO: 10048254
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Patient Selection
QUALIFIER: therapeutic use
QUALIFIER: complications
QUALIFIER: drug therapy
AUTHOR: C Hassed C
AFFILIATION: Monash University Department of Community Medicine.
PUBTYPE: Journal Article
JOURNALTITLE: Australian family physician.
COUNTRY: AUSTRALIA
TITLE: Choosing an opioid analgesic for cancer patients.
PUBDATE: 19990201
The following is a supplement to the article on the management of cancer pain which appeared in the January edition of AFP. It will provide some more detailed information on the choice and prescribing of opioid analgesics other than morphine for cancer patients. One should, of course, bear in mind many of the comments made in the original article regarding the holistic assessment of patients and their pain, the use of adjuvant therapies and alternatives. For more complete information regarding their use and pharmacokinetics one may need to consult product information, MIMS or one of the excellent short books designed for GPs.


5. DOCID:27318 SCORE: 0.00249955146376783
DOCNO: 9492823
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Circulating Cells
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: secondary
QUALIFIER: drug therapy
QUALIFIER: pathology
AUTHOR: K Tsushima K
AUTHOR: Y Sakata Y
AFFILIATION: First Dept. of Internal Medicine, Hirosaki University, School of Medicine, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Treatment of recurrent gastric cancer]
PUBDATE: 19980201
The recurrence rate of resected gastric cancer with curative intent was around 20%. When early gastric cancer was excluded, the rate was around 30%. Peritoneal dissemination accounted for half the recurrences, and was followed by hematogeneous metastasis, including hepatic metastasis. Chemotherapy was the main treatment modality because the possibility of curative resection was very low. Systemic chemotherapies based on biochemical modulation, particularly CDDP/5-FU therapy, have been routinely performed. For localized diseases, loco-regional therapies like drug administration via hepatic artery and intraperitoneal administration have been also applied.


6. DOCID:27286 SCORE: 0.00249955111377206
DOCNO: 10471049
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Heterozygote Detection
DESCRIPTOR: Mutation
DESCRIPTOR: Protein-Serine-Threonine Kinases
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: D G Bebb DG
AUTHOR: Z Yu Z
AUTHOR: J Chen J
AUTHOR: M Telatar M
AUTHOR: K Gelmon K
AUTHOR: N Phillips N
AUTHOR: R A Gatti RA
AUTHOR: B W Glickman BW
AFFILIATION: Centre for Environmental Health, Department of Biology, University of Victoria, Canada.
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: SCOTLAND
TITLE: Absence of mutations in the ATM gene in forty-seven cases of sporadic breast cancer.
PUBDATE: 19990801
Epidemiological evidence points to an increased risk of breast cancer in ataxia telangiectasia (AT) heterozygote women. Previous attempts to screen early onset or familial breast cancer patients failed to confirm an association. The issue of AT and late onset sporadic breast cancer remained unresolved. We screened 47 women who developed later onset, sporadic breast cancer for ataxia telangiectasia mutated (ATM) mutations. No mutations were found.


7. DOCID:26201 SCORE: 0.00238199802849348
DOCNO: 11446083
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: radiotherapy
QUALIFIER: etiology
AUTHOR: L Kochbati L
AUTHOR: H Boussen H
AUTHOR: S Gritli S
AUTHOR: M Besbes M
AUTHOR: F Benna F
AUTHOR: A Saadi A
AUTHOR: A el May A
AUTHOR: F Ben Ayed F
AUTHOR: A Ladgham A
AUTHOR: M Maalej M
AFFILIATION: Service de radiothérapie, institut Salah-Azaïz Bab Saadoun, Tunis, Tunisie.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer radiothérapie : journal de la Société française de radiothérapie oncologique.
COUNTRY: France
TITLE: [Secondary mandibular fibrosarcoma after chemoradiotherapy for undifferentiated nasopharyngeal carcinoma. Report of a case and review of the literature]
PUBDATE: 20010601
Secondary tumours to radio- and/or chemotherapy have rarely been reported after treatment for head and neck cancers. We report a case of mandibular fibrosarcoma observed 7 years after chemoradiotherapy for undifferentiated nasopharyngeal carcinoma in a patient treated when 20 years old.


8. DOCID:24595 SCORE: 0.00236900995659728
DOCNO: 11299868
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: diagnosis
QUALIFIER: complications
QUALIFIER: diagnosis
AUTHOR: S Saortay S
AUTHOR: L Major L
AUTHOR: E Svastics E
AFFILIATION: Budai MAV Kórház, Sebészeti-Mellkassebészeti Osztály.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Magyar sebészet.
COUNTRY: Hungary
TITLE: [Paraesophageal hiatal hernia complicated with stomach cancer]
PUBDATE: 20010201
The authors present the history of a 79 years old female patient who had to be operated on with paraesophageal hiatal hernia causing cahexia, hematemesis, dysphagia and pain. They found an upside down stomach with cancer inside. They emphasize that endoscopy is very important in the diagnostic process and that cancer can develop even if the stomach is located in the chest.


9. DOCID:27168 SCORE: 0.00231485497597688
DOCNO: 10769574
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Magnetic Resonance Imaging
QUALIFIER: pathology
AUTHOR: D Brisbois D
AUTHOR: J F Biquet JF
AUTHOR: D Hock D
AUTHOR: P Magotteaux P
AFFILIATION: Service d'Imagerie médicale, Les Cliniques Saint-Joseph, Liège.
PUBTYPE: Journal Article
JOURNALTITLE: Revue médicale de Liège.
COUNTRY: BELGIUM
TITLE: [State of the art of pancreatic cancer imaging]
PUBDATE: 20000201
Ultrasonography and CT-scanner remain the first choice nowadays concerning detection and preoperative work-up of pancreatic cancer. MRI offers interesting options for the detection of liver metastases, and high quality of ductal and vascular examination. Actually, while we await a larger diffusion of MR systems and radiological expertise this technique is preferentially indicated as a third-step procedure when ultrasonography and CT-scanner are normal despite a real suspicion. Otherwise, MRI permits with a single non-invasive examination a complete work-up useful to prepare palliative therapy in case of unresectable tumor.


10. DOCID:26609 SCORE: 0.00211384485746381
DOCNO: 9893181
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Adaptation, Psychological
QUALIFIER: psychology
AUTHOR: R S Farr RS
AFFILIATION: National Jewish Medical and Research Center, Denver, CO 80206, USA.
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of allergy and clinical immunology.
COUNTRY: UNITED STATES
TITLE: Coping styles in asthma.
PUBDATE: 19990101
Some patients with asthma cope with their disease in ways that are deleterious to them. The coping styles used by these patients often were used by them before the onset of the asthma, but the asthma amplifies these styles, and the coping styles can amplify the asthma. There are striking similarities between these coping styles and those described in cancer victims. Like the latter, they may reflect denial, anger, bargaining, and depression. Recognition that patients are using these coping styles and appropriate intervention will prevent them from continuing to act in these self-destructive manners.


11. DOCID:24731 SCORE: 0.00208292480384216
DOCNO: 10397491
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: analogs & derivatives
QUALIFIER: pharmacology
AUTHOR: D Subrahmanyam D
AUTHOR: A Venkateswarlu A
AUTHOR: K Venkateswara Rao K
AUTHOR: T V Sastry TV
AUTHOR: G Vandana G
AUTHOR: S A Kumar SA
AFFILIATION: Natural Products Division, Dr. Reddy's Research Foundation, Miyapur, Hyderabad, India.
PUBTYPE: Journal Article
JOURNALTITLE: Bioorganic & medicinal chemistry letters.
COUNTRY: ENGLAND
TITLE: Novel C-ring analogues of 20(S)-camptothecin-part-2: synthesis and in vitro cytotoxicity of 5-C-substituted 20(S)-camptothecin analogues.
PUBDATE: 19990601
A series of 5-C-substituted 20(S)-camptothecin analogues were synthesised and evaluated their in vitro anti-cancer activity. Several of these analogues have showed excellent activity against human tumor cell lines.


12. DOCID:25685 SCORE: 0.00180443572020114
DOCNO: 10374015
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: pathology
QUALIFIER: diagnosis
QUALIFIER: secondary
AUTHOR: J Bertin J
AUTHOR: D Rhamani D
AUTHOR: H Maurice H
AUTHOR: H Pujol H
AFFILIATION: Service de Médecine Interne, Centre Hospitalier, Mende.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Annales d'endocrinologie.
COUNTRY: FRANCE
TITLE: [Intrathyroid metastasis of kidney cancer. A rare case and diagnostic trap]
PUBDATE: 19990301
We report the discovery of a unique renal-cell carcinoma operated 9 years earlier on a thyroidectomy operative specimen. Intra-thyroid metastasis from kidney cancer is uncommon. The average delay to discovery as a painless thyroid nodule is estimated around 6 years following nephrectomy. Pre-operative fine needle aspiration and cytology provide the diagnosis. Prognosis of unique thyroid metastasis of kidney cancer is good despite the distant spread. Surgery is the most common therapeutic attitude.


13. DOCID:26763 SCORE: 0.00168937389211419
DOCNO: 10853137
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
AUTHOR: J M Buatti JM
AUTHOR: S L Meeks SL
AUTHOR: W A Friedman WA
AUTHOR: F J Bova FJ
AFFILIATION: Division of Radiation Oncology, University of Iowa College of Medicine, Iowa City 52242, USA. john-buatti@uiowa.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Surgical oncology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Stereotactic radiosurgery: techniques and clinical applications.
PUBDATE: 20000701
Radiation is a common treatment modality for cancer. Although commonly used, the treatment techniques of radiation delivery have changed substantially. One of the most important changes in implementation is the widespread application of stereotactic techniques and their acceptance into the mainstream of radiotherapeutic delivery. The distinguishing characteristics of stereotactic radiosurgery and its current and future application are important for all physicians to understand. This article discusses these treatment techniques and applications from the perspective of a surgical oncologist.


14. DOCID:26805 SCORE: 0.0016893713980737
DOCNO: 11086415
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hyperthermia, Induced
QUALIFIER: therapeutic use
QUALIFIER: secondary
QUALIFIER: therapeutic use
QUALIFIER: secondary
QUALIFIER: therapy
AUTHOR: T Miura T
AUTHOR: Y Endo Y
AUTHOR: Y Matumoto Y
AUTHOR: H Ikeda H
AFFILIATION: Dept. of Surgery, Miura Hospital.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Intra-arterial infusion chemotherapy in combination with microwave hyperthermia for cancer of head of pancreas and liver metastasis--a case of 16 years survival]
PUBDATE: 20001001
Our experience of arterial infusion chemotherapy combined with regional hyperthermia in the treatment of non-resectable pancreatic cancer was presented. A patient with cancer in the pancreatic head with accompanying extensive metastasis in both hepatic lobes was treated by sub selective aortic infusion of 5-FU and MMC with microwave hyperthermia. Both the cancer in the pancreatic head and the liver metastasis showed complete remission for 16 years.