0. DOCID:19729 SCORE: 0.0028827006095759
DOCNO: 2338953
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: P M Go PM
AUTHOR: H Obertop H
AUTHOR: G Blijham G
AUTHOR: J D Munting JD
AFFILIATION: Afd. Algemene Heelkunde, Academisch Ziekenhuis, Maastricht.
PUBTYPE: Journal Article
JOURNALTITLE: Nederlands tijdschrift voor geneeskunde.
COUNTRY: NETHERLANDS
TITLE: [Breast carcinoma in women younger than 30 years]
PUBDATE: 19900401
Breast cancer is rare in females younger than 30 years. In a retrospective study of 25 women the effects of the early age on diagnosis, treatment and prognosis were investigated. In 21 women there was a clinical or radiological suspicion of carcinoma. Nevertheless, a delay in diagnosis was found in 9 of the 21 patients. In 16 patients stage I tumour was found, in 7 stage II, in I stage III and in I stage IV. After an average follow-up period of 68 months, 20 patients had no tumour recurrence. Tumour stage, treatment and prognosis were comparable with the characteristics reported for other age groups.


1. DOCID:23746 SCORE: 0.00276680153712798
DOCNO: 8623719
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Postmenopause
DESCRIPTOR: Vagina
QUALIFIER: ultrasonography
AUTHOR: A M Weissman AM
AUTHOR: T J Barloon TJ
AFFILIATION: Department of Family Practice, University of Iowa College of Medicine, Iowa City 52242, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: American family physician.
COUNTRY: UNITED STATES
TITLE: Transvaginal ultrasonography in nonpregnant and postmenopausal women.
PUBDATE: 19960501
Compared with transabdominal pelvic ultrasonography, transvaginal ultrasonography provides improved resolution for visualization of female pelvic organs, with less artifact. Transvaginal ultrasonography has superseded the transabdominal approach in many situations. Identification of uterine and adnexal masses can be facilitated with use of transvaginal ultrasonography. Transvaginal ultrasonography is also useful in the evaluation of pelvic pain and suspected pelvic inflammatory disease. Postmenopausal patients with vaginal bleeding or a palpable ovary can be triaged on the basis of transvaginal ultrasonographic findings, avoiding invasive diagnostic procedures in selected patients. Screening average-risk patients for ovarian cancer is not an accepted indication for transvaginal ultrasonography at this time.


2. DOCID:23856 SCORE: 0.00275134020908748
DOCNO: 7602777
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: T Hayakawa T
AUTHOR: S Naruse S
AUTHOR: M Kitagawa M
AUTHOR: T Kondo T
AFFILIATION: 2nd Department of Internal Medicine, Nagoya University School of Medicine.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: JAPAN
TITLE: [Elastase]
PUBDATE: 19950501
Elastases are unique among the proteases in that they are capable of hydrolyzing the scleroprotein elastin. The enzymes include pancreatic elastases 1 (Protease E) and 2, and neutrophil elastase. These three elastases also have esterase and amidase activity toward synthetic substrates such as succinyl-trialanine-p-nitroanilide. Although the three enzymes are similar to each other in enzyme activity, they are quite different in immunoactivity. Therefore, each elastase has its own specific immunoassay either by RIA or EIA. Serum immunoreactive pancreatic elastases reflect disease conditions of pancreatic diseases, especially acute pancreatitis and pancreatic cancer. On the other hand, serum neutrophil elastase increases in various inflammatory diseases or conditions.


3. DOCID:18062 SCORE: 0.00272253102133966
DOCNO: 1609218
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: J P Droz JP
AUTHOR: A Kramar A
AUTHOR: P Wibault P
AUTHOR: J J Perrin JJ
AUTHOR: A Roche A
AUTHOR: B Escudier B
AUTHOR: G Missenard G
AUTHOR: B H Court BH
AFFILIATION: D├ępartement de M├ędecine, Institut Gustave-Roussy, Villejuif.
PUBTYPE: Journal Article
JOURNALTITLE: La Revue du praticien.
COUNTRY: FRANCE
TITLE: [Therapeutic strategy in metastatic renal cancer]
PUBDATE: 19920501
Prognostic factors have been described in metastatic renal cell cancer: performance status, weight loss, elevated erythrocyte sedimentation rate, presence of liver metastases. The treatment for a patient with good prognosis consists of: surgical exeresis of solitary metastasis, immunotherapy by either interferon or interleukin 2. Treatment in case of a rom prognosis is a combination of supportive care, orthopedic surgery for pathologic fracture or medullar compression, antalgic radiotherapy, embolization, nephrectomy for hematuria, and analgesic treatments.


4. DOCID:21384 SCORE: 0.0026727349084393
DOCNO: 8741467
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Stents
QUALIFIER: complications
QUALIFIER: therapy
AUTHOR: T Ojika T
AUTHOR: N Mukouyama N
AUTHOR: T Murata T
AUTHOR: H Hasegawa H
AFFILIATION: Department of Thoracic Surgery, Nagoya Daini Red Cross Hospital, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Kyobu geka. The Japanese journal of thoracic surgery.
COUNTRY: JAPAN
TITLE: [A case report of relapsed esophageal cancer with tracheal stenosis treated with expandable metallic stent placement]
PUBDATE: 19960801
A 63-year-old male who suffered from relapsed esophageal cancer in the thoracic lymphonode causing severe tracheal stenosis, was treated by expandable metallic stent (EMS) placement. Dyspnea has disappeared immediately after EMS placement and the patient has been free from dyspnea until his death. EMS has been very effective for the therapy of tracheal stenosis by esophageal cancer.


5. DOCID:21412 SCORE: 0.00267273309165572
DOCNO: 8858767
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Therapy
DESCRIPTOR: Pediatrics
DESCRIPTOR: Surgery
AUTHOR: M L Brandt ML
AFFILIATION: Department of Surgery, Baylor College of Medicine, Houston, TX, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in pediatric surgery.
COUNTRY: UNITED STATES
TITLE: Gene therapy in pediatric surgery.
PUBDATE: 19960801
Gene transfer has become a reality during the last decade. The basic principles of molecular biology, gene transfer, and the problems associated with this new technology have direct implications for the treatment of pediatric surgical patients. Research into applications of gene transfer in the treatment of disorders of the bone marrow, cancer, hemophilia, hepatic and metabolic disease, cystic fibrosis, and vascular disease is rapidly progressing. These areas of research may dramatically affect the care of pediatric surgical patients in the future.


6. DOCID:19455 SCORE: 0.00259125340425354
DOCNO: 8112159
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: M T Yang MT
AFFILIATION: Tumor Hospital of Sun Yatsen University of Medical Sciences, Guangzhou.
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua wai ke za zhi [Chinese journal of surgery].
COUNTRY: CHINA
TITLE: [Treatment of male breast cancer: an analysis of 41 cases]
PUBDATE: 19930501
41 male patients with breast cancer confirmed pathologically were treated. Of these, 35 were treated by radical mastectomy and 6 by modified radical mastectomy. The patients with axillary lymphatic metastasis were treated by postoperative radiotherapy, chemotherapy. The overall 5-, 10- and 15-year survival rates were 67.6%, 53.3% and 55.0%, respectively. The 15 year survival rates of TNM stage I-II and III patients were 55% and 50% respectively. We conclude that radical or modified radical mastectomy is the rational therapy for male breast cancer. The patients in stage III will benefit from postoperative adjuvant therapy in terms of improving prognosis.


7. DOCID:19535 SCORE: 0.00259125114961187
DOCNO: 7515843
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: R M Singhal RM
AUTHOR: R Jindel R
AUTHOR: A K Gupta AK
AFFILIATION: Dept. of Radiotherapy, All India Institute of Medical Sciences, New Delhi.
PUBTYPE: Journal Article
JOURNALTITLE: Indian journal of cancer.
COUNTRY: INDIA
TITLE: Bleomycin, cisplatinum and ifosfamide infusion chemotherapy in advanced/recurrent cancer of cervix.
PUBDATE: 19931201
Twenty one patients age ranging from 26-70 years, with biopsy proven recurrent/advanced carcinoma of the cervix were treated with bleomycin, cisplatinum and ifosfamide infusion therapy. 88% patients reported subjective improvement. The objective response rate was 66.6% (Complete 38% and partial 28.5%). Side effects were mainly nausea, vomiting, and alopecia. Treatment related fever was common. Hematuria and reversible encephalopathy with ifosfamide were seen in three and two patients respectively. These results indicate that BIP infusion chemotherapy is an active and safe combination for treatment of advanced/recurrent cervical cancer.


8. DOCID:19938 SCORE: 0.00257928311421688
DOCNO: 1707022
AUTHOR: L Kumar L
AUTHOR: V L Bhargava VL
AFFILIATION: Department of Medical Oncology and Gynaecology, All India Institute of Medical Sciences, New Delhi.
PUBTYPE: Journal Article
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: Chemotherapy in recurrent and advanced cervical cancer.
PUBDATE: 19910201
Twenty-five patients, ranging from 21 to 61 years of age (median = 45 years), with histologically proven recurrent and advanced cervical cancer were treated with chemotherapy using a combination of bleomycin, ifosfamide, and cis-platinum (BIP). Twenty-one patients were evaluable for response. Ninety percent of patients achieved a subjective response. An objective response was noted in 14 of 21 (66.6%) patients: complete in 4 (19%) and partial in 10 (47.6%). Side effects were mainly nausea/vomiting, alopecia, myelosuppression, reversible encephalopathy, and impaired renal function. One patient died from the toxic effects of chemotherapy. These results indicate that BIP is an active combination in recurrent cervical cancer with acceptable toxicity.


9. DOCID:22604 SCORE: 0.00257768386546615
DOCNO: 9639728
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: C Chen C
AUTHOR: Z Hua Z
AUTHOR: X Jin X
AFFILIATION: Shanghai Ruijin Hospital.
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua fu chan ke za zhi.
COUNTRY: CHINA
TITLE: [The mechanisms of progesterone treatment on endometrial carcinoma]
PUBDATE: 19970701
OBJECTIVE: To study the mechanisms of the exogenic progestrerone treatment on endometrial carcinoma. METHODS: We observed the morphologic changes of the endometrial cancer cells treated by exogenic progesterone with light and electronic microscopy. RESULTS: The main changes of the tumor cell treated were well differentiation, increase in secretory activity and apoptosis of tumor cells. CONCLUSIONS: Progesterone may directly affect tumor cells, inhibit the growth of tumor cells and lead to well differentiation. Clinically with preoperative and postoperative progesterone therapy, it can decrease the peritoneum implantation and metastasis, and also decrease the recurrence after operation.


10. DOCID:16963 SCORE: 0.00257609556302674
DOCNO: 8324987
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: pathology
QUALIFIER: adverse effects
AUTHOR: D L Larson DL
AFFILIATION: Department of Plastic and Reconstructive Surgery, Medical College of Wisconsin, Milwaukee.
PUBTYPE: Journal Article
JOURNALTITLE: Clinics in plastic surgery.
COUNTRY: UNITED STATES
TITLE: Long-term effects of radiation therapy in the head and neck.
PUBDATE: 19930701
The treatment and cure of cancer of the head and neck carry morbidity regardless of the disease process or modality employed. Although the effects of surgery are usually immediately obvious, those of radiotherapy evolve over time. This article reviews the long-term effects of radiotherapy for cancer of the oral cavity in adults and cancer of the mid and lower face in children and adolescents.


11. DOCID:19129 SCORE: 0.00249148584621636
DOCNO: 1589802
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: radiotherapy
QUALIFIER: therapeutic use
AUTHOR: E B Silberstein EB
AUTHOR: A H Elgazzar AH
AUTHOR: A Kapilivsky A
AFFILIATION: University of Cincinnati Medical Center, OH 45267.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in nuclear medicine.
COUNTRY: UNITED STATES
TITLE: Phosphorus-32 radiopharmaceuticals for the treatment of painful osseous metastases.
PUBDATE: 19920101
Phosphorus-32, employed as the orthophosphate or polyphosphate, can reduce or relieve the pain of osteoblastic metastases without serious hematologic toxicity, especially if used as a single injection. Uptake of this beta-emitter by osteoblastic-reactive bone and possibly by tumor and other cells can lead to pain reduction and often to cell killing. Efficacy has been demonstrated for the treatment of pain in 84% of 322 breast cancer patients and 77% of 444 prostate cancer patients found in a review of the literature. These results match those of the newer radiopharmaceuticals currently under investigation.


12. DOCID:18932 SCORE: 0.00242619759190324
DOCNO: 8103565
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antineoplastic Agents
AUTHOR: S Tsukagoshi S
AFFILIATION: Cancer Chemotherapy Center, Japanese Foundation for Cancer Research.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: JAPAN
TITLE: [Recent development of new anticancer drugs in Japan]
PUBDATE: 19930701
Recent development of new anticancer drugs in Japan was reviewed. Since there are a high incidence of cancer of the digestive organs, lung cancer and breast cancer in Japan, we have been looking for novel anticancer drugs effective against these solid cancers. Currently, some of fluoropyrimidine compounds, methotrexate analogues, tubulin inhibitors from plant origins have shown their clinical activities against human non-small cell lung cancer and/or breast cancer. As the end-point on these drug development, we have put an emphasis to find drugs to contribute for the survival prolongation and improvement of quality of life of the treated patients.


13. DOCID:18531 SCORE: 0.00232242266719305
DOCNO: 2313881
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Life Style
QUALIFIER: prevention & control
QUALIFIER: organization & administration
QUALIFIER: prevention & control
AUTHOR: A Oshima A
AUTHOR: M Nakamura M
AFFILIATION: Dept. of Cancer Prevention, Osaka Cancer Prevention and Detection Center.
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Life-style and cancer prevention. Activities of the Department of Cancer Prevention, Osaka Cancer Prevention and Detection Center]
PUBDATE: 19900201
The role of the Department of Cancer Prevention, Osaka Cancer Prevention and Detection Center which was established in 1987 is to conduct practical research works in the area of primary prevention of cancer through life-style modification. We have so far examined the applicability and efficacy of such tools as population-based smoking cessation contest, nicotine gum, health risk appraisal and "Know Your Body" program. The outline of our activities and future plans are introduced.


14. DOCID:18426 SCORE: 0.00230191465126683
DOCNO: 1375513
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiopathology
QUALIFIER: physiopathology
AUTHOR: P S Steeg PS
AFFILIATION: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in oncology.
COUNTRY: UNITED STATES
TITLE: Invasion and metastasis.
PUBDATE: 19920201
Tumor metastasis remains a major cause of death for cancer patients. From a clinical perspective, treatment of metastatic disease remains difficult. The initial tumor cell invasive and locomotive events have been completed in many patients by the time of cancer diagnosis and surgery. This observation focuses attention on the last steps in the metastatic cascade for therapeutic development, ie, angiogenesis and colonization at the metastatic site. Emerging themes in metastasis research, including the molecular characterization of protease production and angiogenesis, the interrelationship of growth and metastasis, and the genetic control of the metastatic process are discussed.