0. DOCID:10874 SCORE: 0.00453019950641536
DOCNO: 6236973
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: physiopathology
AUTHOR: P M Pour PM
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Environmental health perspectives.
COUNTRY: UNITED STATES
TITLE: Histogenesis of exocrine pancreatic cancer in the hamster model.
PUBDATE: 19840601
There is strong evidence that induced pancreatic adenomas and carcinomas derive from ductal and ductular cells in the pancreas. We base our beliefs on our knowledge of the embryology and histology of the pancreas in Syrian golden hamsters, along with the sequential alterations that occur during exocrine pancreatic tumor formation. This concept also has been supported by much experimental evidence, including autoradiographic, immunologic and in vitro studies. We also present other viewpoints on the origin of pancreatic cancer histogenesis and outline certain areas of disagreement. We report the development of acinar cell lesions under certain experimental dietary conditions in hamsters (the lesions resemble those commonly seen in the rat pancreatic tumor model) and the nature of these lesions.


1. DOCID:14649 SCORE: 0.00436451504395416
DOCNO: 3563506
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: classification
QUALIFIER: chemically induced
AUTHOR: B N Ames BN
AUTHOR: R Magaw R
AUTHOR: L S Gold LS
PUBTYPE: Journal Article
JOURNALTITLE: Science.
COUNTRY: UNITED STATES
TITLE: Ranking possible carcinogenic hazards.
PUBDATE: 19870401
This review discusses reasons why animal cancer tests cannot be used to predict absolute human risks. Such tests, however, may be used to indicate that some chemicals might be of greater concern than others. Possible hazards to humans from a variety of rodent carcinogens are ranked by an index that relates the potency of each carcinogen in rodents to the exposure in humans. This ranking suggests that carcinogenic hazards from current levels of pesticide residues or water pollution are likely to be of minimal concern relative to the background levels of natural substances, though one cannot say whether these natural exposures are likely to be of major or minor importance.


2. DOCID:11670 SCORE: 0.00388987399444542
DOCNO: 3856058
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: adverse effects
AUTHOR: W L Morison WL
AUTHOR: S P Kelley SP
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Sunlight suppressing rejection of 280- to 320-nm UV-radiation-induced skin tumors in mice.
PUBDATE: 19850201
Repeated exposure of female C3H/HeNCR- mice to sunlight prevented the normal immunologic rejection of a UV-induced tumor. This systemic immunologic alteration was transferred to syngeneic lethally X-irradiated animals with lymphoid cells from mice exposed to sunlight. The lymphoid cells also were able to suppress the capacity of lymphoid cells from normal animals to reject a UV-induced tumor. The 295- to 320-nm wave band appeared to be responsible for this immunosuppressive effect of sunlight because suppression was prevented by filtration of the radiation through Mylar and by application of a sunscreen containing para-aminobenzoic acid. These observations may have importance in understanding the pathogenesis of sunlight-induced skin cancer in humans.


3. DOCID:15220 SCORE: 0.00364490001804306
DOCNO: 3466679
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Polymorphism, Genetic
DESCRIPTOR: Y Chromosome
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: R S Verma RS
AUTHOR: S Thomas S
AUTHOR: M Coleman M
AUTHOR: R T Silver RT
AUTHOR: H Dosik H
PUBTYPE: Journal Article
JOURNALTITLE: Cancer genetics and cytogenetics.
COUNTRY: UNITED STATES
TITLE: Length polymorphisms of the human Y chromosome in patients with chronic myelogenous leukemia.
PUBDATE: 19870201
The extent of length heteromorphisms of the human Y chromosomes was measured in 50 patients with chronic myelogenous leukemia and was compared with 50 normal controls. No significant difference (p greater than 0.05) in the size of the Y chromosome was noted between these two groups. These findings differ from an earlier investigation, where a longer heterochromatic segment of Y chromosome was noted in malignant tumors and it was stressed that constitutive heterochromatin plays a role in susceptibility of cancer. Present investigation, however, suggests that this is not the case in patients with chronic myelogenous leukemia.


4. DOCID:9980 SCORE: 0.00354356948289623
DOCNO: 4054702
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: P E Coode PE
AUTHOR: K W Chan KW
AUTHOR: Y T Chan YT
PUBTYPE: Journal Article
JOURNALTITLE: Gut.
COUNTRY: ENGLAND
TITLE: Polyps and diverticula of the large intestine: a necropsy survey in Hong Kong.
PUBDATE: 19851001
The study is based on a prospective survey of 200 necropsies, to determine the prevalence of colonic polyps and diverticula in Hong Kong. Adenomatous polyps were found in 34% of men and 19% of women. The corresponding figures for hyperplastic polyps were 22% and 15%. When compared with European countries having similar rates for colorectal cancer, the polyp pattern by type, prevalence, and distribution is very similar. For diverticula the prevalence rate in this study was only 5%; most of these were situated in the caecum. This is at marked variance to the European pattern.


5. DOCID:13304 SCORE: 0.00339006321519636
DOCNO: 3732910
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
QUALIFIER: mortality
AUTHOR: A Tiitinen A
AUTHOR: M Forss M
AUTHOR: I Aho I
AUTHOR: E Vesterinen E
AUTHOR: U Nieminen U
PUBTYPE: Journal Article
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: Endometrial adenocarcinoma: clinical outcome in 881 patients and analysis of 146 patients whose deaths were due to endometrial cancer.
PUBDATE: 19860901
Throughout 1970-1975, 881 patients were treated at Departments I and II of Obstetrics and Gynecology, Helsinki University Central Hospital. They were treated mainly by using surgery and/or radiotherapy combined with adjuvant progestin therapy. The over-all uncorrected 5-year survival rate was 72.2% and corrected rate was 82.1%. In 146 out of 245 cases death was due to endometrial cancer, and this group was analyzed separately.


6. DOCID:10850 SCORE: 0.00332332606863271
DOCNO: 6373246
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Health Policy
QUALIFIER: classification
QUALIFIER: classification
QUALIFIER: prevention & control
AUTHOR: F P Perera FP
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Environmental research.
COUNTRY: UNITED STATES
TITLE: The genotoxic/epigenetic distinction: relevance to cancer policy.
PUBDATE: 19840601
Should federal agencies use separate, less stringent guidelines for regulating epigenetic or nongenotoxic carcinogens on the assumption that thresholds are likely to exist for these agents? This article reviews recent initiatives by the Environmental Protection Agency that either propose or informally adopt this approach in light of responses from the scientific community and a review of the recent literature. Relevant background is provided by current research concerning the role of chromosomal damage and oncogene activation in carcinogenesis along with findings that classical promoters or "epigenetic" agents can induce both DNA damage and chromosomal rearrangements. The conclusion is that such a revision of cancer policy is not now supported by available scientific data concerning chemical carcinogenesis.


7. DOCID:10794 SCORE: 0.00332332554798974
DOCNO: 4061372
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
AUTHOR: K J Pandya KJ
AUTHOR: F M Muggia FM
AUTHOR: R T Skeel RT
AUTHOR: G Falkson G
AUTHOR: B M Kaplan BM
AUTHOR: D S Ettinger DS
PUBTYPE: Journal Article
JOURNALTITLE: American journal of clinical oncology : the official publication of the American Radium Society.
COUNTRY: UNITED STATES
TITLE: A phase II study of bisantrene in advanced refractory breast cancer. An Eastern Cooperative Oncology Group pilot study.
PUBDATE: 19851001
Thirty patients with advanced refractory breast cancer received bisantrene 260 mg/m2 intravenously every 3 weeks. Reversible myelosuppression was the most commonly observed side effect. Four patients (13.3%) achieved objective partial response (90% confidence intervals 3-24%), while two patients (6.6%) had disease improvement with a PR + IMP rate of 19.9%. Seven additional patients (23.3%) had stabilization of disease. This drug has antitumor activity against breast cancer and warrants further study, particularly if problems with drug delivery are overcome.


8. DOCID:15945 SCORE: 0.0032197917563151
DOCNO: 2571865
AUTHOR: W J Hrushesky WJ
AUTHOR: A Z Bluming AZ
AUTHOR: S A Gruber SA
AUTHOR: R B Sothern RB
AFFILIATION: Department of Medicine, Albany Medical College of Union University, New York.
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Menstrual influence on surgical cure of breast cancer.
PUBDATE: 19891001
In a retrospective study of 44 premenopausal women who underwent resection of a primary breast cancer and were followed for 5 to 12 years, disease recurrence and metastasis were more frequent and more rapid in women who had been operated upon during the perimenstrual period (days 0-6 and 21-36 of the menstrual cycle). By multivariate analysis, the time of resection in relation to the menstrual cycle is an independent predictor of the likelihood of future metastatic disease. Patients who underwent resection during the perimenstrual period had a more than quadrupled risk of recurrence and death compared with women operated upon during days 7 to 20 of the menstrual cycle.


9. DOCID:15507 SCORE: 0.00315558245003012
DOCNO: 2902830
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: drug therapy
AUTHOR: T Tsuruo T
AFFILIATION: Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo.
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Therapeutic approaches for multidrug resistance]
PUBDATE: 19881001
One of the major problems in cancer chemotherapy is the development of drug resistance during treatment. In the treatment of tumors with antitumor agents, tumor cells can acquire resistance to the drugs. This type of resistance is called as acquired drug resistance and the acquired drug resistances is a major factor for limiting the clinical use of antitumor agents. The elucidation of the resistance mechanisms has progressed well recently owing to the application of cellular and molecular techniques in addition to the usual biological and biochemical techniques. In this article, the mechanisms of cellular resistance, especially those of multidrug resistance at a molecular level, and possible approaches to overcoming drug resistance are described and discussed.


10. DOCID:11260 SCORE: 0.00303941827697746
DOCNO: 3929394
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: radiotherapy
QUALIFIER: etiology
QUALIFIER: radiotherapy
AUTHOR: J Kaplan J
AUTHOR: L Loftus L
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Southern medical journal.
COUNTRY: UNITED STATES
TITLE: Bladder cancer after pelvic irradiation for cervical cancer.
PUBDATE: 19850901
Pelvic irradiation for gynecologic malignancy is associated with several late neoplastic and nonneoplastic complications in the irradiated field; however, this association has been infrequently recognized in primary care literature. We present two cases of bladder cancer that developed 16 and 19 years, respectively, after pelvic irradiation for cervical cancer. The frequent occurrence in older women of cystitis, hematuria, and nonspecific bowel and bladder symptoms of a benign origin obscures identification of late neoplastic complications after pelvic irradiation. Based on experimental and epidemiologic evidence, we believe cost-effective screening methods should be investigated to allow earlier detection of neoplasms; and, in the interim, a high index of suspicion for bladder cancer is warranted in this growing population of high-risk patients.


11. DOCID:10437 SCORE: 0.00300442752887299
DOCNO: 6823725
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Kidney Neoplasms
QUALIFIER: secondary
QUALIFIER: secondary
AUTHOR: B I Carr BI
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Urology.
COUNTRY: UNITED STATES
TITLE: Renal carcinoma manifesting as breast mass.
PUBDATE: 19830201
A patient is described who initially presented with Stage I breast carcinoma and then with a T2, N0, M0 carcinoma of a kidney with moderately well-differentiated clear-cell features. Five years later, a contralateral breast mass developed which was histologically identical with renal primary tumor. Breast metastasis from renal primary carcinoma has been noted in the literature in 6 other cases, although this is only the third actual case report. This is the first case report of such a bizarre progression of disease. This patient is currently well, without clinically detectable tumor and illustrates the variable nature of metastatic renal cancer. The literature on renal cancer metastasizing to the breast is reviewed.


12. DOCID:15188 SCORE: 0.00294985979601389
DOCNO: 2845621
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Lymph Node Excision
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: P Jaeger P
AUTHOR: D Hauri D
AFFILIATION: Urologische Klinike, Universit├Ątsspital, Z├╝rich.
PUBTYPE: Journal Article
JOURNALTITLE: Der Urologe. Ausg. A.
COUNTRY: GERMANY, WEST
TITLE: [Retroperitoneal lymphadenectomy in non-seminomatous stage I, IIa and IIb testicular tumors]
PUBDATE: 19880901
Between 1961 and 1985, 190 retroperitoneal lymph node dissections (RLND) have been performed in the Urological Clinic of the University Hospital of Zurich in patients with low stage (I, IIa, IIb) non seminomatous germ-cell testicular cancer. Indication, operative technic, complications (8,9%, dry ejaculation in 27%) and the results of the operation are pointed out (relapse rate in stage I: 10%, IIa: 35%, IIb: 59% without and 14% with adjuvant chemotherapy). The question is analysed if this primary surgical approach in this primary surgical approach in these stages, simultaneously a diagnostic and therapeutic procedure, is still indicated in the era of efficacious chemotherapy.


13. DOCID:15988 SCORE: 0.00292194648430973
DOCNO: 3089746
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: M F Brennan MF
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Digestive diseases and sciences.
COUNTRY: UNITED STATES
TITLE: Malnutrition in patients with gastrointestinal malignancy. Significance and management.
PUBDATE: 19860901
Malnutrition is a common accompaniment of gastrointestinal malignancy. The etiology of such malnutrition is multifactorial, but, when present, is a poor prognostic sign. Simple causes of decreased intake such as obstruction are readily overcome by distal enteral or parenteral feeding. Metabolic abnormalities that limit the efficacy of parenteral nutrition in such patients have been identified and, although not uniform, give further insight into the manner in which the host and the tumor partition energy and substrate. Widespread use of adjunctive parenteral nutrition in patients undergoing chemotherapy or radiation therapy for gastrointestinal malignancy has not improved tolerance or efficacy of such treatment. Nutritional support of the malnourished patient with a gastrointestinal cancer, prior to a major operation, has been shown to decrease perioperative morbidity and mortality.


14. DOCID:15515 SCORE: 0.00278610037336644
DOCNO: 2835481
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: drug effects
QUALIFIER: pharmacology
QUALIFIER: drug effects
AUTHOR: H A Mazzullo HA
AUTHOR: J Attwood J
AUTHOR: J D Delhanty JD
AFFILIATION: Department of Genetics and Biometry, University College London.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of medical genetics.
COUNTRY: ENGLAND
TITLE: Familial polyposis coli: no evidence for increased sensitivity to mitomycin C.
PUBDATE: 19880401
Spontaneous chromosome instability is well established for the dominantly inherited cancer prone condition, familial polyposis coli (FPC), but conflicting results have been obtained regarding sensitivity to mitomycin C (MMC). We have investigated cell survival in fibroblasts and the induction of sister chromatid exchanges and chromosome damage in lymphocytes and fibroblasts after MMC treatment. We can find no evidence for a differential response of FPC cells as measured by any of these parameters, although individual FPC fibroblast cultures did show an enhanced chromosomal response. Overall, the FPC mutation does not appear to result in defective DNA repair in response to MMC.