0. DOCID:22745 SCORE: 0.00338646378574755
DOCNO: 7724852
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Glass
QUALIFIER: trends
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Regulatory toxicology and pharmacology : RTP.
COUNTRY: UNITED STATES
TITLE: Postscript: science and public policy on synthetic vitreous fibers.
PUBDATE: 19941201
Rapid advances are being made in our understanding of the interaction of airborne fibers with biological tissues. It is possible to reduce human exposures and potential risk to lung cancer and fibrosis if current science and models are fully utilized. However, the criteria used by IARC and NTP in their cancer classifications have not kept pace with current science and, in fact, remain entrenched in the scientific vagaries present in the 1960's. As long as public policy cannot keep pace with contemporary scientific understanding, we are doomed to a world of exaggerated risks, inappropriate regulations, misguided priorities, inadequate funding for social and environmental programs, mass anxiety, and skepticism about scientific research.

1. DOCID:23745 SCORE: 0.00326462499017414
DOCNO: 8630975
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Cycle
DESCRIPTOR: Chromosome Fragility
QUALIFIER: ultrastructure
QUALIFIER: genetics
AUTHOR: N Capalash N
AUTHOR: R C Sobti RC
AFFILIATION: Center for Biotechnology, Panjab University, Chandigarh, India.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer genetics and cytogenetics.
COUNTRY: UNITED STATES
TITLE: Spontaneous genomic fragility and cell cycle progression in lymphocytes of patients with cervical carcinoma.
PUBDATE: 19960501
Thirty patients with invasive carcinoma of the cervix, along with 15 age-matched healthy females as controls, were studied to examine the frequency of spontaneous SCEs, chromosomal aberrations (CAs), and cell cycle progression in lymphocytes. The frequency of SCEs and TCAs was statistically significant in the patients over the control group. The correlation of SCEs and TCAs with the stage of cancer, age, and number of pregnancies was also made. The cell cycle of lymphocytes showed its prolongation in the patients, as is evident from the higher proportion of cells at M1 (metaphase of first cell division after 72 hours).

2. DOCID:21951 SCORE: 0.00313002314200156
DOCNO: 8542243
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: therapy
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
AUTHOR: V K Hamasaki VK
AUTHOR: E E Vokes EE
AFFILIATION: Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Medical oncology (Northwood, London, England)
COUNTRY: ENGLAND
TITLE: Interferons and other cytokines in head and neck cancer.
PUBDATE: 19950301
The use of cytokines in head and neck cancer is increasingly under investigation. Clinical trials have tested the interferons, interleukin-2 and other cytokines as single agents and in various combinations. The addition of interferon to the cisplatin and 5-fluorouracil (5-FU) regimens (with and without leucovorin) has been explored. A randomized international trial comparing cisplatin and 5-FU with cisplatin, 5-FU and interferon-alpha 2b is in progress.

3. DOCID:23941 SCORE: 0.00294485998253548
DOCNO: 8834313
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: metabolism
AUTHOR: S Masood S
AFFILIATION: Department of Pathology, University of Florida Health Science Center/Jacksonville 32209, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Diagnostic cytopathology.
COUNTRY: UNITED STATES
TITLE: Prognostic factors in breast cancer: use of cytologic preparations.
PUBDATE: 19951201
There is increasing evidence that certain morphological features and biological markers found in breast tumors may provide prognostic information by predicting the risk of recurrence and metastasis in early breast cancer. This information may also be important in choosing therapeutic options in patients with advanced disease. Prognostic testing is commonly performed on surgically excised lesions. However, there are clinical conditions in which a surgical specimen may not be suitable or available for such analysis. In these circumstances, fine-needle aspiration biopsy and imprint preparation provide an attractive sample for prognostic testings. This review summarizes the current approach to the use of cytologic preparation for assessment of established and newly recognized prognostic factors.

4. DOCID:22824 SCORE: 0.002784861597122
DOCNO: 7784155
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiography
QUALIFIER: radiography
QUALIFIER: methods
AUTHOR: F Mimura F
AUTHOR: M Kusumoto M
AUTHOR: R Ono R
AUTHOR: T Nakamura T
AUTHOR: M Endo M
AUTHOR: M Zhang M
AUTHOR: K Kimura K
AUTHOR: E Itouji E
AUTHOR: M Kono M
AFFILIATION: Department of Radiology, Kobe University, School of Medicine.
PUBTYPE: Journal Article
JOURNALTITLE: Nippon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica.
COUNTRY: JAPAN
TITLE: [Assessment by three-dimensional CT of pleural indentation or invasion by peripheral lung cancer]
PUBDATE: 19950401
We evaluated the effectiveness of three-dimensional (3D) CT for pleural indentation or invasion by peripheral lung cancer adjacent to pleura. Pleural indentation was shown in three of nine cases on conventional CT, and six cases were demonstrated three-dimensionally. 3D-CT was superior to conventional CT in demonstrating pleural indentation. Pleural invasion could not be assessed on 3D-CT because the pleura adjacent to the tumor was not visualized.

5. DOCID:23818 SCORE: 0.00277723054069957
DOCNO: 9103006
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: S O Kolset SO
AUTHOR: C A Drevon CA
AUTHOR: K Prydz K
AFFILIATION: Institutt for ernaeringsforskning, Universitetet i Oslo, Blindern.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Tidsskrift for den Norske laegeforening.
COUNTRY: NORWAY
TITLE: [Proteoglycans and pathology--new aspects]
PUBDATE: 19970301
It is well documented that proteoglycans are involved in a wide range of pathological conditions. Recently published results in international journals provide new information on the role of proteoglycans in such conditions. A mutation in the gene encoding for a cell surface proteoglycan has been demonstrated in overgrowth syndromes. A proteoglycan has been isolated from urine and shown to induce cachexia in cancer patients. Furthermore, in both achondrogenesis and colon cancer, the reduced ability to sulphate proteoglycans is due to genetic defects in cellular sulfate transporters. Finally, fibrosis has been inhibited in glomerulonephritic mice by transferring the gene for decorin, a transforming growth factor beta-1 binding proteoglycan, into muscle tissue.

6. DOCID:22534 SCORE: 0.00259575448203499
DOCNO: 9177139
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: B Hofstad B
AUTHOR: M Vatn M
AFFILIATION: Division of Gastroenterology, Ullevaal University Hospital, Oslo, Norway.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gastrointestinal endoscopy clinics of North America.
COUNTRY: UNITED STATES
TITLE: Growth rate of colon polyps and cancer.
PUBDATE: 19970701
Malignancy potential of colorectal polyps increases with size. The growth rate and destiny of each polyp is virtually unknown. It was recently shown that polyps smaller than 10 mm left in situ may partly regress or partly increase in size, whereas one quarter of polyps are unchanged after 3 years. Polyps smaller than 5 mm show a mean increase in size, whereas polyps measuring 5 to 9 mm show a mean decrease in size. Methodologic problems with the measurement of polyps and cancer are discussed. More studies of polyp growth related to risk factors are warranted.

7. DOCID:23623 SCORE: 0.00253659467796945
DOCNO: 8884808
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Patient Advocacy
DESCRIPTOR: Patient Participation
QUALIFIER: psychology
AUTHOR: S Leigh S
PUBTYPE: Journal Article
JOURNALTITLE: Oncology (Williston Park, N.Y.)
COUNTRY: UNITED STATES
TITLE: Survivorship and pancreatic cancer: the role of advocacy.
PUBDATE: 19960901
The past 20 years have witnessed important changes in the manner in which many people with cancer are opting to deal with their disease. In the past, patients yielded to their physicians' treatment choices and assumed that they would be told all they needed to know about their condition. Today, many people with cancer are taking more active, assertive roles, demanding second opinions and treatment option information, and seeking partnerships with their physicians in making decisions and managing their overall health-care programs. This article describes the growing cancer survivorship movement, explores the varying levels of involvement that people with pancreatic cancer may choose, and highlights resources available to help individuals and their families hone their survival skills.

8. DOCID:22755 SCORE: 0.00248818172306915
DOCNO: 7962976
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: T Yamamoto T
AUTHOR: H Ohkubo H
AUTHOR: I Katayama I
AUTHOR: K Nishioka K
AFFILIATION: Department of Dermatology, Tokyo Metropolitan Bokuto Hospital, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of dermatology.
COUNTRY: JAPAN
TITLE: Dermatomyositis with multiple skin ulcers showing vasculitis and membrano-cystic lesion.
PUBDATE: 19940901
A 63-year-old woman with dermatomyositis (DM) developed multiple punched-out ulcers of the skin. She had not only a past history of gastric cancer 10 years prior to the onset of DM, but also a familial history of cancer. A skin biopsy from one of the ulcers revealed both vasculitis and membrano-cystic lesion in the same specimen. She died of interstitial pneumonitis one year after the onset of DM. Vasculitis and membrano-cystic lesion may be an important marker of a poor prognosis in DM.

9. DOCID:22139 SCORE: 0.00225218256874948
DOCNO: 7561896
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Quassins
QUALIFIER: isolation & purification
QUALIFIER: analogs & derivatives
QUALIFIER: chemistry
AUTHOR: S Ohnishi S
AUTHOR: N Fukamiya N
AUTHOR: M Okano M
AUTHOR: K Tagahara K
AUTHOR: K H Lee KH
AFFILIATION: Department of Interdisciplinary Studies of Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashihiroshima, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of natural products.
COUNTRY: UNITED STATES
TITLE: Bruceosides D, E, and F, three new cytotoxic quassinoid glucosides from Brucea javanica.
PUBDATE: 19950701
Three new quassinoid glucosides, bruceosides D [1], E [2], and F [3], were isolated from Brucea javanica, and their structures were elucidated by spectral evidence and chemical transformation to known compounds. Compounds 1-3 show selective cytotoxicity in the leukemia and non-small cell lung, colon, CNS, melanoma, and ovarian cancer cell lines with log GI50 values in the range of -4.14 to -5.72.

10. DOCID:23582 SCORE: 0.00219299273334175
DOCNO: 8166672
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Alkyl and Aryl Transferases
DESCRIPTOR: Genes, ras
QUALIFIER: pharmacology
QUALIFIER: metabolism
AUTHOR: G C Prendergast GC
AUTHOR: J B Gibbs JB
AFFILIATION: Department of Cancer Research, Merck Research Laboratories, West Point, PA 19486.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: BioEssays : news and reviews in molecular, cellular and developmental biology.
COUNTRY: ENGLAND
TITLE: Ras regulatory interactions: novel targets for anti-cancer intervention?
PUBDATE: 19940301
Advances in the understanding of Ras oncoprotein function suggest novel points for anti-tumor intervention. First, upstream-acting guanine nucleotide exchange factors and SH2/SH3 domain-containing adaptor proteins that link Ras with growth factor receptor tyrosine kinases have recently been characterized. Second, work on downstream-acting Ras effector functions including the Ras GTPase-activating protein (p120GAP) and the Raf kinase has revealed direct biochemical interactions that are functionally required for oncogenic Ras signalling. We summarize progress in these areas and discuss the potential for novel applications to anti-cancer chemotherapy.

11. DOCID:23493 SCORE: 0.00219298601322691
DOCNO: 9513699
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: instrumentation
QUALIFIER: diagnosis
QUALIFIER: nursing
QUALIFIER: diagnosis
QUALIFIER: nursing
AUTHOR: D L Boshaw DL
AFFILIATION: Morehead Memorial Hospital, Eden, NC., USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: AORN journal.
COUNTRY: UNITED STATES
TITLE: New instrumentation allows for removal of nonpalpable breast lesions.
PUBDATE: 19970801
Breast cancer is the second leading cause of cancer deaths in women. Approximately 90% of breast cancer is curable if it is diagnosed and treated early. Increasingly, women are participating in mammographic screenings, which result in earlier detection of nonpalpable lesions. In the past, surgical removal was not an option for small lesions, and frequent mammographic monitoring was required until patients' lesions were large enough for needle core biopsies or needle localization for open surgical biopsies. Technology now has combined stereotactic imaging with a minimally invasive biopsy system for removal of these nonpalpable lesions. This capability for accurate early diagnosis and intervention is essential in improving patients' survival rates.

12. DOCID:21139 SCORE: 0.0021639793132816
DOCNO: 7661527
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: classification
AUTHOR: A Ferlito A
AUTHOR: D F Harrison DF
AUTHOR: B J Bailey BJ
AUTHOR: L W DeSanto LW
AFFILIATION: Department of Otolaryngology, University of Padua, Italy.
PUBTYPE: Journal Article
JOURNALTITLE: The Annals of otology, rhinology, and laryngology.
COUNTRY: UNITED STATES
TITLE: Are clinical classifications for laryngeal cancer satisfactory?
PUBDATE: 19950901
All clinical classifications for laryngeal cancer are compromises based on clinical and imaging evaluations, with no concern for important elements such as phenotype, host-tumor relationship, and any concomitant nonneoplastic disease. The various staging systems are critically examined along with a report on the outcome of an international survey on the applicability of the TNM system in relation to laryngeal neoplasms, promoted by The Laryngeal Cancer Association.

13. DOCID:20537 SCORE: 0.00210609268410079
DOCNO: 8995103
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Aged
DESCRIPTOR: Mass Screening
QUALIFIER: prevention & control
AUTHOR: B Robinson B
AUTHOR: C Beghé C
AFFILIATION: Division of Geriatrics, University of South Florida College of Medicine, Tampa, Florida, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Clinics in geriatric medicine.
COUNTRY: UNITED STATES
TITLE: Cancer screening in the older patient.
PUBDATE: 19970201
Effective treatment of several types of malignant diseases has developed substantially over the past four decades, with ever improving survival rates for cancers found in early stages. Among older patients, however, the cancer death rates remain elevated. This article explores the value of early screening for several types of malignant disease in the older patient.

14. DOCID:20861 SCORE: 0.00210001446086305
DOCNO: 7537910
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Palliative Care
QUALIFIER: surgery
AUTHOR: M Markman M
AFFILIATION: Cleveland Clinic Cancer Center, OH, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Seminars in oncology.
COUNTRY: UNITED STATES
TITLE: Surgery for support and palliation in patients with malignant disease.
PUBDATE: 19950401
Surgery is the major curative treatment modality for patients with malignant disease. However, surgery also plays an important role in supportive and palliative care of cancer patients. In settings in which maintaining quality of life rather than prolongation of survival is the major goal of treatment, the potential morbidity of more extensive surgical procedures must be carefully weighed against their possible benefits, and alternative options (if available and appropriate) should be carefully considered.