0. DOCID:7078 SCORE: 0.00450588493425437
DOCNO: 707739
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secretion
QUALIFIER: secretion
QUALIFIER: physiopathology
QUALIFIER: physiopathology
AUTHOR: J A Gregg JA
AUTHOR: M M Sharma MM
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: Endoscopic measurement of pancreatic juice secretory flow rates and pancreatic secretory pressures after secretin administration in human controls and in patients with acute relapsing pancreatitis, chronic pancreatitis, and pancreatic cancer.
PUBDATE: 19781101
Secretory flow rates were measured inside the main pancreatic duct during endoscopic retrograde cholangiopancreatography (ERCP) in patients with acute relapsing pancreatitis, chronic pancreatitis, and pancreatic cancer and in controls after intravenous administration of secretin. Peak secretory flow rates in these groups were 5.04 +/- 1.74, 0.71 +/-1.28, 0.60 +/- 1.37, and 4.13 +/- 0.88 ml/min, respectively. Peak secretory pressures were also measured intraductally in patients with acute relapsing pancreatitis and pancreatic cancer and in controls and were 402 +/- 69, 75 +/- 161, and 403 +/- 99 mm pancreatic juice, respectively. Peak secretory flow rates and pressures measured in controls during constant administration of secretin were similar to those measured when secretin was administered as a bolus.

1. DOCID:6811 SCORE: 0.00412986020611089
DOCNO: 372655
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Carcinogens
DESCRIPTOR: Mutagens
QUALIFIER: methods
AUTHOR: L A Poirier LA
AUTHOR: E K Weisburger EK
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Selection of carcinogens and related compounds tested for mutagenic activity.
PUBDATE: 19790401
A list of 102 chemicals was prepared for subsequent mutagenesis assays in a National Cancer Institute program to determine the extent of correlation between carcinogenesis and mutagenesis in standardized assays. The chemicals were divided into five major categories: 37 aromatic amines, 11 polycyclic aromatic hydrocarbons, 8 nitrosamines and nitrosamides, 16 alkylating agents, and a miscellaneous category consisting of 11 heterocyclic compounds, 7 amides, ureas and acylating agents, 5 antimetabolites, 4 inorganic chemicals, and 3 promoters. The chemicals were further described as procarcinogens (requiring metabolic activation to exert their biologic activities), ultimate carcinogens (direct-acting chemicals not requiring metabolic activation), and noncarcinogens (compounds shown to be inactive in one or more adequate carcinogenicity tests). An extensive bibliography documents the selection and categorization of the compounds.

2. DOCID:5835 SCORE: 0.00360406114584618
DOCNO: 7233140
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: analysis
QUALIFIER: complications
AUTHOR: A B Gasser AB
AUTHOR: C Jeannet C
AUTHOR: D Depierre D
AUTHOR: B Courvoisier B
PUBTYPE: Journal Article
JOURNALTITLE: Schweizerische medizinische Wochenschrift.
COUNTRY: SWITZERLAND
TITLE: [Urinary and serum hydroxyproline in the diagnosis of bone metastases of prostatic cancer]
PUBDATE: 19810201
Of 31 patients with prostatic cancer, 21 have skeletal metastases proven by bone scintigraphy and/or radiology. The sensitivity and specificity of the following measurements are compared: total urinary hydroxyproline, urinary hydroxyproline/creatinine ratio, free serum hydroxyproline, alkaline and prostatic phosphatases and serum calcium. The hydroxyproline/creatinine ratio is the most sensitive measurement for the diagnosis of bone metastasis, while total urinary hydroxyproline excretion per 24 hours is the most specific. Free serum hydroxyproline has no particular significance for this diagnosis. The alkaline and acid phosphatases are elevated but are not specific. Serum calcium decreases when skeletal metastases are present.

3. DOCID:7203 SCORE: 0.00353308815927719
DOCNO: 7245287
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: analogs & derivatives
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: U Raju U
AUTHOR: S Kadner S
AUTHOR: M Levitz M
AUTHOR: A Kaganowicz A
AUTHOR: A Blaustein A
PUBTYPE: Journal Article
JOURNALTITLE: Steroids.
COUNTRY: UNITED STATES
TITLE: Glucosiduronidation and esterification of androsterone by human breast tumors in vitro.
PUBDATE: 19810401
The metabolism of 3H-androsterone was studied in homogenates (fortified with uridine 5'-diphosphoglucuronic acid and adenosine 3'-phosphate 5'-phosphosulfate) of eighteen breast tumors, one muscle underlying the primary breast carcinoma and metastatic axillary lymph nodes from a patient with suspected primary breast cancer. The major metabolites identified were less polar than androsterone. On saponification these lipoidal derivatives afforded androsterone as the only product (3 to 48%). Unmetabolized androsterone and lesser quantities of epiandrosterone, 5 alpha-androstane- alpha, 17 beta-diol and 5 alpha-androstane-3,17-dione comprised the free steroid fraction. Androsterone glucosiduronate was isolated (0.17-4.1%) from weight breast tumor homogenates and from the node tissue incubation (17%). There was no apparent correlation between glucuronyltransferase activity and histopathology or estrogen receptor content.

4. DOCID:6260 SCORE: 0.00345085097395095
DOCNO: 652189
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Bone Neoplasms
DESCRIPTOR: Breast Neoplasms
AUTHOR: P Bianucci P
AUTHOR: F Iacovacci F
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Minerva medica.
COUNTRY: ITALY
TITLE: [A case of atypical bone metastasis from breast carcinoma]
PUBDATE: 19780301
Clinical and radiographical data are presented for a case of suspected pathological fracture of the right ulna in a 66-yr-old women mastectomised two years previously. Multiple skeletal lesions were noted, often morphologically different from those usually observed in metastasis of breast cancer, with a fibrous and cystic appearance reminiscent of von Recklinhausen's disease. However, indisputable serohumoral data, the histological picture on biopsy, and repair of bone as a result of immuno-antiblastic management showed that true metastases were involved. The radiographical picture and the response to therapy make it clear that atypical bone pictures must be carefully watched, since metastasis from breast cancer may be responsible for special morphological and structural features requiring close differential investigation.

5. DOCID:6983 SCORE: 0.00344679996651169
DOCNO: 7248897
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Lung Neoplasms
QUALIFIER: diagnostic use
QUALIFIER: secondary
QUALIFIER: radionuclide imaging
QUALIFIER: analogs & derivatives
AUTHOR: M A Quraishi MA
AUTHOR: J J Costanzi JJ
AUTHOR: S Balachandran S
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Iodocholesterol adrenal scanning for the detection of adrenal metastases in lung cancer and its clinical significance.
PUBDATE: 19810801
Detection of adrenal metastases is difficult. Since metastatic growth fails to destroy sufficient adrenal tissue to produce clinical symptoms of adrenal insufficiency, and since adrenal metastases have been reported in 28--36% of autopsied patients with primary lung cancer, the authors studied 25 patients with lung cancer by using iodocholesterol adrenal scans. Six patients (24%) were found to have abnormal scans suggestive of adrenal metastases by this technique. Two of these patients were confirmed by biopsy to have adrenal metastases. Four of the six patients died within a mean of six weeks of the positive scan. Iodocholesterol adrenal scanning appears to be a promising noninvasive technique in the detection of adrenal metastases. The prognostic significance of adrenal metastases is discussed.

6. DOCID:5551 SCORE: 0.00342262489460117
DOCNO: 7377466
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: R L Goldman RL
PUBTYPE: Letter
JOURNALTITLE: The American journal of surgical pathology.
COUNTRY: UNITED STATES
TITLE: Liver cancer and oral contraceptives.
PUBDATE: 19800401
The author read with interest the article "Combined epithelial and sarcomatous elements in a liver cancer associated with oral contraceptive use" (American Journal of Surgical Pathology 3: 185, 190, 1979). The authors attributed the bimorphism to imply a collision tumor. Some years ago the author reported a rhabdomyosarcohepatoma in an adult and felt that the neoplasm, based on hepatic embryology, represented variable differentiation in a growth derived from a common progenitor cell type. Of more importance is the association of a malignant hepatic tumor with oral contraceptive use. This association was also recorded, and a recent review of this subject appears quite germane.

7. DOCID:7391 SCORE: 0.00314576107578103
DOCNO: 417794
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemically induced
QUALIFIER: chemically induced
QUALIFIER: drug therapy
QUALIFIER: adverse effects
AUTHOR: S B Kapadia SB
AUTHOR: J R Krause JR
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Ovarian carcinoma terminating in acute nonlymphocytic leukemia following alkylating agent therapy.
PUBDATE: 19780501
Rapidly fatal acute myelogenous leukemia (AML) occurred in a woman with advanced (Stage III) ovarian carcinoma who was treated with thiotepa for 30 months. This patient was 1 of 10 long term survivors and represented less than 2% of patients with advanced ovarian carcinoma with regional metastases who received long term chemotherapy during the period 1947-1975. Acute leukemia developed 44 months after initial diagnosis and was preceded by a 10 month period of pancytopenia following cessation of thiotepa. The leukemia did not respond to treatment and the patient expired 3 weeks after its onset. At autopsy, leukemic infiltration of organs was seen, but there was no evidence of carcinoma. A review of the literature suggests that the development of AML reported in ovarian cancer patients is related to alkylating agent therapy.

8. DOCID:7727 SCORE: 0.00305386264685109
DOCNO: 453245
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: W E Lucas WE
AUTHOR: S S Yen SS
PUBTYPE: Journal Article
JOURNALTITLE: American journal of obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: A study of endocrine and metabolic variables in postmenopausal women with endometrial carcinoma.
PUBDATE: 19790501
Although an underlying endocrine-metabolic disorder has been implicated as causally related to the development of endometrial carcinoma, data to support such an association are ambiguous and/or contradictory. In this prospective study of 16 consecutive nonobese postmenopausal women with endometrial carcinoma and 16 cancer-free postmenopausal women matched for age and weight, fasting values for growth hormone (GH), insulin, prolactin, follicle-stimulating hormone, luteinizing hormone, estrone (E1), and estradiol (E2) were measured on 3 consecutive days. Intravenous glucose tolerance, pituitary GH release in response to arginine infusion, hyperglycemia, and hypoglycemia, and insulin secretion in response to arginine infusion and to hyperglycemia were analyzed. Our data show that these endocrine-metabolic profiles were not significantly different between the cancer patients and control subjects, suggesting that the postmenopausal women with endometrial cancer who is not obese exhibits no accountable endocrine or metabolic disorders.

9. DOCID:5111 SCORE: 0.00272356543555441
DOCNO: 6102295
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: mortality
AUTHOR: T J Powles TJ
AUTHOR: R C Coombes RC
AUTHOR: I E Smith IE
AUTHOR: J M Jones JM
AUTHOR: H T Ford HT
AUTHOR: J C Gazet JC
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Failure of chemotherapy to prolong survival in a group of patients with metastatic breast cancer.
PUBDATE: 19800301
Overall survival of patients with primary breast cancer has not improved in the past ten years, despite increasing use of multiple-drug chemotherapy for treatment of metastases. Furthermore, there has been no improvement in survival from first metastasis, and survival may even have been shortened in some patients given chemotherapy. Chemotherapy probably does prolong survival in some patients, and further studies should be undertaken to identify these patients in advance.

10. DOCID:5918 SCORE: 0.0026494179894189
DOCNO: 7287476
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: J E Altwein JE
PUBTYPE: Journal Article
JOURNALTITLE: Helvetica chirurgica acta.
COUNTRY: SWITZERLAND
TITLE: [Current aspects of hormonal therapy in prostate cancer]
PUBDATE: 19810801
The following endocrine treatment modalities have been used in advanced prostatic carcinoma: 1. orchiectomy plus estrogens; 2. primary orchiectomy with delayed estrogen employment; 3. initial estrogen therapy with delayed orchiectomy; 4. initial cyproterone acetate or medroxyprogesterone acetate; 5. a combination treatment: estramustine phosphate, cyproterone acetate or estrogens plus bromocriptine. The application of phase-III studies permits the subsequent conclusions: Simultaneous orchiectomy is to no advantage (exception: urinary stasis). Cyproterone acetate does neither yield better nor worse results regarding survival than estrogen alone, but has fewer side effects. Estrogens and cyproterone acetate produce a rise of serum prolactin justifying the use of bromocriptine (or lisuride). Estramustine phosphate should be reserved for relapsing prostatic cancer.

11. DOCID:6817 SCORE: 0.00256399554842463
DOCNO: 663808
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
AUTHOR: K J Syrjänen KJ
AUTHOR: L H Hjelt LH
PUBTYPE: Journal Article
JOURNALTITLE: Surgery, gynecology & obstetrics.
COUNTRY: UNITED STATES
TITLE: Tumor-host interrelationships in carcinoma of the female breast.
PUBDATE: 19780701
Three hundred and two carcinomas of the female breast were studied histologically with special reference to the morphologic aspects of the tumor, its surrounding host tissue and the regional lymph nodes. The nuclear grade of the tumor was positively correlated with the five year survival rate of the patient. Tumor metastases in the regional lymph nodes were observed to be a sign of a poor prognosis. The stromal lymphocyte and mast cell reactions did not correlate with the frequency of nodal metastases or the five year survival rate. Sinus histiocytosis in the lymph nodes was a sign of favorable five year survival because of its presence in cancer-free nodes only. The paracortical activity of the lymph nodes was an important determinant of whether or not tumor metastases appear in the node.

12. DOCID:4923 SCORE: 0.00249861302831333
DOCNO: 7445771
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: surgery
QUALIFIER: etiology
QUALIFIER: etiology
AUTHOR: P Georgacopulo P
AUTHOR: G Tataranni G
AUTHOR: A Franchella A
AUTHOR: P Gilli P
PUBTYPE: Journal Article
JOURNALTITLE: Zeitschrift für Kinderchirurgie und Grenzgebiete.
COUNTRY: GERMANY, WEST
TITLE: Ureterosigmoidostomy and cancer of the colon. Report of a case.
PUBDATE: 19800701
A possible and quite frequent complication of uretero-sigmoidostomy can be the late development of a colic cancer at the site of the ureteric reimplantation. On the basis of the literature and of a personal observation, the accent is put on what can be done to discover the tumor in any early phase; the possibility that the increased risk of cancer should limit the colic urinary diversions for an exstrophy of the bladder is also discussed.

13. DOCID:4672 SCORE: 0.00249662676231499
DOCNO: 647625
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: M A Scheinberg MA
AUTHOR: A Masuda A
AUTHOR: J A Maluf JA
AUTHOR: N F Mendes NF
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Monocyte function in patients with solid neoplasms during immunotherapy with Corynebacterium parvum.
PUBDATE: 19780501
The present studies were performed in order to evaluate monocyte function in patients with solid neoplasms before and after administration of C. parvum. The results demonstrate that monocytes from cancer patients display increased numbers of C3 and Fc receptor sites after administration of C. parvum. It is concluded that characterization of monocyte receptor activity may be helpful in monitoring the effects of immunotherapy in the immune system.

14. DOCID:6317 SCORE: 0.00249042430266832
DOCNO: 7193376
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Aneuploidy
QUALIFIER: ultrastructure
AUTHOR: A Zimmermann A
PUBTYPE: Journal Article
JOURNALTITLE: Der Urologe. Ausg. A.
COUNTRY: GERMANY, WEST
TITLE: [Aneuploidia in malignant tumors of testis and their lymphatic metastases (author's transl)]
PUBDATE: 19801101
DNA-estimations, done by flow-through-cytophotometry, were performed in 18 malignant tumors of testis. Aneuploid stemlines which are specific for cancers were found in 17 cases. The only exception was a so called "occult seminoma". It showed only a small difference between the stem-line of tumor and normal cells of testis. So, by using DNA-estimation, it was possible to make a correct diagnosis all 18 patients, suffering from tumor of the testis. The aneuploid stem-lines of seminomas did not differ from those of other cancers. The type of proliferative behavior seems to be a criterion for prognosis. Lymphatic nodes with and without formation of metastases very clearly showed differences in the DNA-content of their nuclei.