0. DOCID:3568 SCORE: 0.0046872465078062
DOCNO: 779490
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: pathology
AUTHOR: G Gabbiani G
AUTHOR: J Csank-Brassert J
AUTHOR: J C Schneeberger JC
AUTHOR: Y Kapanci Y
AUTHOR: P Trenchev P
AUTHOR: E J Holborow EJ
PUBTYPE: Journal Article
JOURNALTITLE: The American journal of pathology.
COUNTRY: UNITED STATES
TITLE: Contractile proteins in human cancer cells. Immunofluorescent and electron microscopic study.
PUBDATE: 19760601
The presence of contractile proteins in human cancer cells has been studied by means of: a) immunofluorescent staining using specific antibodies, and b) electron microscopy in order to detect the presence of cytoplasmic filaments. The tissues examined were: normal human skin, basal cell carcinoma of the skin, squamous cell carcinomas (of skin, oral cavity, and larynx), normal nonlactating mammary gland, and infiltrating mammary carcinoma with or without fibrosis. Normal tissues were negative after immunnoflurosescent staining of contractile proteins and contained no or minimal amounts of microfilaments as judged by electron microscopy. Tumor cells were strongly positive after immunoflouorescent staining for actin, myosin, light and heavy meromyosin but were negative for tropomyosin. Moreover, they contained prominent microfilaments (40 to 80 A in diameter) with some filaments (100 to 120 A in diameter) scattered in between. It appears that malignant cells contain an increased amount of contractile proteins, organized in the form of a filamentous apparatus, when compared to their normal counterparts. The study of the presence of contractile proteins in tumor cells may be of potential importance in evaluating malignant growth.


1. DOCID:7078 SCORE: 0.00450588493425437
DOCNO: 707739
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secretion
QUALIFIER: secretion
QUALIFIER: physiopathology
QUALIFIER: physiopathology
AUTHOR: J A Gregg JA
AUTHOR: M M Sharma MM
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: Endoscopic measurement of pancreatic juice secretory flow rates and pancreatic secretory pressures after secretin administration in human controls and in patients with acute relapsing pancreatitis, chronic pancreatitis, and pancreatic cancer.
PUBDATE: 19781101
Secretory flow rates were measured inside the main pancreatic duct during endoscopic retrograde cholangiopancreatography (ERCP) in patients with acute relapsing pancreatitis, chronic pancreatitis, and pancreatic cancer and in controls after intravenous administration of secretin. Peak secretory flow rates in these groups were 5.04 +/- 1.74, 0.71 +/-1.28, 0.60 +/- 1.37, and 4.13 +/- 0.88 ml/min, respectively. Peak secretory pressures were also measured intraductally in patients with acute relapsing pancreatitis and pancreatic cancer and in controls and were 402 +/- 69, 75 +/- 161, and 403 +/- 99 mm pancreatic juice, respectively. Peak secretory flow rates and pressures measured in controls during constant administration of secretin were similar to those measured when secretin was administered as a bolus.


2. DOCID:2538 SCORE: 0.00425434757170333
DOCNO: 872120
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Surveillance, initial assessment, and subsequent progress of patients with superficial bladder cancer in a prospective longitudinal study. National Bladder Cancer Collaborative Group A (NBCCGA).
PUBDATE: 19770801
Through a bladder cancer surveillance protocol, a sizable population of patients suitable for characterizing the dynamics and patterns of recurrent superficial transitional cell carcinoma has been identified. One hundred thirty-three patients have been followed after their first occurrence of transitional cell carcinoma (Stage O or A). Only patients whose tumors were considered to be completely removed by transurethral resection and who were not treated by any other means were included. Although a full year of follow-up is not yet complete, recurrent bladder carcinoma has been noted in 44 (33%). Most of these recurrences were identified at the first follow-up cystoscopy and the majority were present at the site of the initial lesion. Tumor size, grade, and stage did not appear to influence recurrence, whereas multiplicity did. The relevance of these findings to various theories about the mechanism of recurrence is discussed.


3. DOCID:6811 SCORE: 0.00412986020611089
DOCNO: 372655
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Carcinogens
DESCRIPTOR: Mutagens
QUALIFIER: methods
AUTHOR: L A Poirier LA
AUTHOR: E K Weisburger EK
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Selection of carcinogens and related compounds tested for mutagenic activity.
PUBDATE: 19790401
A list of 102 chemicals was prepared for subsequent mutagenesis assays in a National Cancer Institute program to determine the extent of correlation between carcinogenesis and mutagenesis in standardized assays. The chemicals were divided into five major categories: 37 aromatic amines, 11 polycyclic aromatic hydrocarbons, 8 nitrosamines and nitrosamides, 16 alkylating agents, and a miscellaneous category consisting of 11 heterocyclic compounds, 7 amides, ureas and acylating agents, 5 antimetabolites, 4 inorganic chemicals, and 3 promoters. The chemicals were further described as procarcinogens (requiring metabolic activation to exert their biologic activities), ultimate carcinogens (direct-acting chemicals not requiring metabolic activation), and noncarcinogens (compounds shown to be inactive in one or more adequate carcinogenicity tests). An extensive bibliography documents the selection and categorization of the compounds.


4. DOCID:3267 SCORE: 0.00395667081055273
DOCNO: 1088828
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: S Feldman S
AUTHOR: W T Hughes WT
AUTHOR: C B Daniel CB
PUBTYPE: Journal Article
JOURNALTITLE: Pediatrics.
COUNTRY: UNITED STATES
TITLE: Varicella in children with cancer: Seventy-seven cases.
PUBDATE: 19750901
The purpose of this study was to characterize varicella in childhood cancer patients. Seventeen of the 77 patients reviewed were in remission and off all therapy for 3 to 22 months. No one in this group died from varicella or had evidence of visceral dissemination. Among the remaining 60 patients, all of whom were receiving anticancer theapy when they developed varicella, 19 (32%) had visceral dissemination and 4 died, for a mortality rate of 7%. Each of the deaths was associated with primary varicella pneumonitis, with or without acute encephalitis. Visceral dissemination was not related to type or status of malignancy or to duration of specific anticancer therapy. Varicella was more likely to disseminate in children with absolute lymphopenia, less than 500 cells per cubic millimeter, than in patients with higher lymphocyte counts. Cessation of anticancer theapy prior to the onset of lesions appeared to lessen the risk of dissemination. These results show that varicella is more severe in cancer patients on therapy than the general population or in patients who have completed therapy, but is not highly fatal.


5. DOCID:3708 SCORE: 0.0037210857240662
DOCNO: 1009004
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mitosis
QUALIFIER: physiopathology
AUTHOR: S Gelfant S
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of dermatology.
COUNTRY: ENGLAND
TITLE: The cell cycle in psoriasis: a reappraisal.
PUBDATE: 19761201
The current belief that the clinical manifestations of psoriasis (excessive scaling) are due to a twelve-fold speeding up or shortening of the cell division cycle time of the germinative cells in psoriatic epidermis (from 457 to 37-5 h) is shown to be incorrect. A new concept is introduced--that the germinative layer in human epidermis is composed of not one, but three separate and distinct populations of epidermal cells. First, there are cycling cells which are actively moving through the cell cycle. Then there are two categories of non-cycling cells (blocked in the G1 or the G2 periods of the cell cycle) which are capable of moving into the proliferative pool upon specific stimulation. Thus, increased epidermal cell proliferation in active lesions of psoriasis would be brought about mainly by a recruitment or a relase of the two categories of non-cycling cells. The idea that germinative epidermal cells are primarily non-cycling, leads to the suggestion of focusing attention on non-cycling cells (rather than on cycling cells) for the control and treatment of psoriasis. It might be worthwhile considering treating psoriatic patients during periods of clinical remission--with factors to keep the germinative cells in the non-cycling state--rather than during psoriatic flare up--with cancer chemotherapy drugs.


6. DOCID:2647 SCORE: 0.00362969414450895
DOCNO: 805659
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: J R van Nagell JR
AUTHOR: Q A Pletsch QA
AUTHOR: D M Goldenberg DM
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: A study of cyst fluid and plasma carcinoembryonic antigen in patients with cystic ovarian neoplasms.
PUBDATE: 19750601
Cyst fluid and plasma carcinoembryonic antigen (CEA) levels were measured in 11 patients with ovarian cyst-adenocarcinoma and in 16 patients with benign ovarian neoplasms. In patients with ovarian cancer, plasma CEA levels were not elevated above 2.5 ng/ml unless cyst fluid CEA levels were 4 to 16 mu-g/ml. In this series, cystic and plasma CEA levels were elevated most consistently in patients with mucinous ovarian tumors. Furthermore, on the basis of molecular size and immunoreactivity by immunodiffusion, ovarian cancer cyst fluid CEA and colonic cancer CEA had similar immunochemical properties. Consistent with the findings in other neoplasms, follow-up studies showed that plasma CEA levels returned to the normal range between 2 and 12 weeks after surgical excision of the ovarian tumor. It is concluded that plasma CEA is of value in the management of patients with ovarian mucinous cystadenocarcinoma.


7. DOCID:5835 SCORE: 0.00360406114584618
DOCNO: 7233140
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: analysis
QUALIFIER: complications
AUTHOR: A B Gasser AB
AUTHOR: C Jeannet C
AUTHOR: D Depierre D
AUTHOR: B Courvoisier B
PUBTYPE: Journal Article
JOURNALTITLE: Schweizerische medizinische Wochenschrift.
COUNTRY: SWITZERLAND
TITLE: [Urinary and serum hydroxyproline in the diagnosis of bone metastases of prostatic cancer]
PUBDATE: 19810201
Of 31 patients with prostatic cancer, 21 have skeletal metastases proven by bone scintigraphy and/or radiology. The sensitivity and specificity of the following measurements are compared: total urinary hydroxyproline, urinary hydroxyproline/creatinine ratio, free serum hydroxyproline, alkaline and prostatic phosphatases and serum calcium. The hydroxyproline/creatinine ratio is the most sensitive measurement for the diagnosis of bone metastasis, while total urinary hydroxyproline excretion per 24 hours is the most specific. Free serum hydroxyproline has no particular significance for this diagnosis. The alkaline and acid phosphatases are elevated but are not specific. Serum calcium decreases when skeletal metastases are present.


8. DOCID:3947 SCORE: 0.0035960717349494
DOCNO: 1276626
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: T Kuipers T
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: The British journal of radiology.
COUNTRY: ENGLAND
TITLE: Report on treatment of cancer of the ovary.
PUBDATE: 19760601
A malignant ovarian tumour has been diagnosed in 373 patients referred to the R.R.T.I. from January 1966 to Jun 1972. Serious ovarian carcinoma was the commonest type and occurred in 254 patients. The results in these patients are studied in detail after staging according to F.I.G.O. recommendations. Following surgery and postoperative radiotherapy, chemotherapy was started immediately in all patients with progressive disease and after randomization also in 50 per cent of the others. The three-year survival rate in Stage II patients tended to be more favourable following irridation ofthe pelvis and lumboaortic nodes (55 per cent ) than following radiotherapy restricted to the pelvic area (40 per cent). The dose should be 5-6 krad. The five-year survival was 68 per cent for Stage I, 26 per cent for Stage II and nearly zero for Stages III and IV, as well as for patients referred for treatment of a recurrence. In spite of whole-abdomen irradiation 50 per cent of the patients in the latter three groups were deceased within eight months; therefore chemotherapy should be preferred. The main problem in ovarian cancer is late diagnosis. Evaluation of results is difficult because numerous variable factors concerning pathology and treatment make it necessary to sub-divide the patients into groups too small for statistically reliable conclusions. Each treatment factor should be studied by a group of hospitals.


9. DOCID:7203 SCORE: 0.00353308815927719
DOCNO: 7245287
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: analogs & derivatives
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: U Raju U
AUTHOR: S Kadner S
AUTHOR: M Levitz M
AUTHOR: A Kaganowicz A
AUTHOR: A Blaustein A
PUBTYPE: Journal Article
JOURNALTITLE: Steroids.
COUNTRY: UNITED STATES
TITLE: Glucosiduronidation and esterification of androsterone by human breast tumors in vitro.
PUBDATE: 19810401
The metabolism of 3H-androsterone was studied in homogenates (fortified with uridine 5'-diphosphoglucuronic acid and adenosine 3'-phosphate 5'-phosphosulfate) of eighteen breast tumors, one muscle underlying the primary breast carcinoma and metastatic axillary lymph nodes from a patient with suspected primary breast cancer. The major metabolites identified were less polar than androsterone. On saponification these lipoidal derivatives afforded androsterone as the only product (3 to 48%). Unmetabolized androsterone and lesser quantities of epiandrosterone, 5 alpha-androstane- alpha, 17 beta-diol and 5 alpha-androstane-3,17-dione comprised the free steroid fraction. Androsterone glucosiduronate was isolated (0.17-4.1%) from weight breast tumor homogenates and from the node tissue incubation (17%). There was no apparent correlation between glucuronyltransferase activity and histopathology or estrogen receptor content.


10. DOCID:2368 SCORE: 0.00346158089344262
DOCNO: 1261087
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: biosynthesis
QUALIFIER: immunology
QUALIFIER: biosynthesis
QUALIFIER: biosynthesis
QUALIFIER: biosynthesis
QUALIFIER: biosynthesis
AUTHOR: D B McClelland DB
AUTHOR: D J Shearman DJ
AUTHOR: R F Lai A Fat RF
AUTHOR: R van Furth R
PUBTYPE: Journal Article
JOURNALTITLE: Clinical and experimental immunology.
COUNTRY: ENGLAND
TITLE: In vitro synthesis of immunoglobulins, secretory component, complement and lysozyme by human gastrointestinal tissues. II. Pathological tissues.
PUBDATE: 19760101
An in vitro culture technique has been used to study synthesis of proteins by biopsies of human gastrointestinal mucosa which were obtained at endoscopy or surgery from patients with biliary gastritis, atrophic gastritis, peptic ulcer, gastric cancer, coeliac disease, Crohn's disease and ulcerative colitis. As in normal mucosa, immunoglobulin synthesis was found in all sites, but marked increases, especially in IgG, were seen in biliary gastritis and ulcerative colitis. In untreated coeliac disease, synthesis of IgG and IgM was increased. Synthesis of complement components did not differ from that found in normal mucosa. Increased lysozyme synthesis was seen in Crohn's disease. This study shows that useful information may be acquired from short-term culture studies of the small biopsies obtained with fibre optic endoscopes.


11. DOCID:6260 SCORE: 0.00345085097395095
DOCNO: 652189
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Bone Neoplasms
DESCRIPTOR: Breast Neoplasms
AUTHOR: P Bianucci P
AUTHOR: F Iacovacci F
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Minerva medica.
COUNTRY: ITALY
TITLE: [A case of atypical bone metastasis from breast carcinoma]
PUBDATE: 19780301
Clinical and radiographical data are presented for a case of suspected pathological fracture of the right ulna in a 66-yr-old women mastectomised two years previously. Multiple skeletal lesions were noted, often morphologically different from those usually observed in metastasis of breast cancer, with a fibrous and cystic appearance reminiscent of von Recklinhausen's disease. However, indisputable serohumoral data, the histological picture on biopsy, and repair of bone as a result of immuno-antiblastic management showed that true metastases were involved. The radiographical picture and the response to therapy make it clear that atypical bone pictures must be carefully watched, since metastasis from breast cancer may be responsible for special morphological and structural features requiring close differential investigation.


12. DOCID:6983 SCORE: 0.00344679996651169
DOCNO: 7248897
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Lung Neoplasms
QUALIFIER: diagnostic use
QUALIFIER: secondary
QUALIFIER: radionuclide imaging
QUALIFIER: analogs & derivatives
AUTHOR: M A Quraishi MA
AUTHOR: J J Costanzi JJ
AUTHOR: S Balachandran S
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Iodocholesterol adrenal scanning for the detection of adrenal metastases in lung cancer and its clinical significance.
PUBDATE: 19810801
Detection of adrenal metastases is difficult. Since metastatic growth fails to destroy sufficient adrenal tissue to produce clinical symptoms of adrenal insufficiency, and since adrenal metastases have been reported in 28--36% of autopsied patients with primary lung cancer, the authors studied 25 patients with lung cancer by using iodocholesterol adrenal scans. Six patients (24%) were found to have abnormal scans suggestive of adrenal metastases by this technique. Two of these patients were confirmed by biopsy to have adrenal metastases. Four of the six patients died within a mean of six weeks of the positive scan. Iodocholesterol adrenal scanning appears to be a promising noninvasive technique in the detection of adrenal metastases. The prognostic significance of adrenal metastases is discussed.


13. DOCID:5551 SCORE: 0.00342262489460117
DOCNO: 7377466
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: R L Goldman RL
PUBTYPE: Letter
JOURNALTITLE: The American journal of surgical pathology.
COUNTRY: UNITED STATES
TITLE: Liver cancer and oral contraceptives.
PUBDATE: 19800401
The author read with interest the article "Combined epithelial and sarcomatous elements in a liver cancer associated with oral contraceptive use" (American Journal of Surgical Pathology 3: 185, 190, 1979). The authors attributed the bimorphism to imply a collision tumor. Some years ago the author reported a rhabdomyosarcohepatoma in an adult and felt that the neoplasm, based on hepatic embryology, represented variable differentiation in a growth derived from a common progenitor cell type. Of more importance is the association of a malignant hepatic tumor with oral contraceptive use. This association was also recorded, and a recent review of this subject appears quite germane.


14. DOCID:3575 SCORE: 0.00338812434173169
DOCNO: 72595
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: I H Krakoff IH
AUTHOR: E Cvitkovic E
AUTHOR: V Currie V
AUTHOR: S Yeh S
AUTHOR: C LaMonte C
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Clinical pharmacologic and therapeutic studies of bleomycin given by continuous infusion.
PUBDATE: 19771101
The clinical toxicology, clinical pharmacology, and therapeutic effects of bleomycin given by continuous intravenous infusion were studied in patients with far-advanced unresectable cancer. The toxicity of bleomycin given by that schedule was qualitatively and quantitatively the same as when it was given by daily intravenous "push"; mucocutaneous toxicity occurred regularly after 7-11 days of infusion. Careful monitoring of pulmonary function revealed minor changes in Total Lung Capacity and Pulmonary Diffusion Capacity in nearly all patients; however, overt pulmonary toxicity occurred in only six patients (5%). 111Indium-labeled bleomycin was used to follow blood levels of bleomycin; it correlated well with the levels determined by microbiologic assay and could be measured at levels lower than could be determined by bioassay. Useful therapeutic responses were seen in a variety of tumors; 30% patients with very far-advanced carcinoma of the cervix demonstrated CR or PR, an incidence higher than has been seen with other regimens. Sixty-nine percent of patients with disseminated germ cell neoplasms of the testis, refractory to bleomycin given by conventional dose schedules, have attained partial remission through the continuous infusion of bleomycin.