0. DOCID:15782 SCORE: 0.00530113259966847
DOCNO: 2749148
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immune Tolerance
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: B Clair B
AUTHOR: B R├ęgnier B
PUBTYPE: Journal Article
JOURNALTITLE: La Revue du praticien.
COUNTRY: FRANCE
TITLE: [Infectious pneumopathies in immunosuppressed patients]
PUBDATE: 19890601
Infective pneumonia occurring in immunocompromised patients is characterized by its multiple causes which create diagnostic problems and by the need for a prompt treatment. The principal criteria pointing to a specific organism are the causes of immunodeficiency (now usually due to treatment of blood diseases or cancers, organ transplantation and AIDS) and the radiological features of the pneumonia. Confirming the diagnosis frequently requires features of the pneumonia. Confirming the diagnosis frequently requires invasive explorations which in any case are limited by the patient's fragility. Consequently, empirical therapeutic measures are initiated, at least initially, taking into account all likely assumptions. The severity and frequency of these lung infections make it desirable to develop preventive measures applying to the patient himself (antibiotic prophylaxis) or to his environment.


1. DOCID:15836 SCORE: 0.00520581780584693
DOCNO: 2433019
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Recurrence, Local
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapeutic use
AUTHOR: F M Torti FM
AUTHOR: B L Lum BL
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Superficial bladder cancer. Risk of recurrence and potential role for interferon therapy.
PUBDATE: 19870201
Superficial bladder tumors--cancer in situ (CIS) and papillary transitional carcinoma of the bladder--are the most frequent presentations of bladder cancer, the second most common disease of the urethelial tract. These superficial tumors demonstrate a tendency to recur, either at the same stage and grade or as deeply invasive tumors. To some extent, the likelihood of tumor recurrence can be predicted, based on certain risk factors. Furthermore, the probability of recurrence can be altered through appropriate clinical interventions. A review of the literature, much of which is preliminary, suggests that interferon therapy for bladder cancer may modify the biologic behavior of this disease and provide clinical benefit for some patients.


2. DOCID:3568 SCORE: 0.0046872465078062
DOCNO: 779490
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: pathology
AUTHOR: G Gabbiani G
AUTHOR: J Csank-Brassert J
AUTHOR: J C Schneeberger JC
AUTHOR: Y Kapanci Y
AUTHOR: P Trenchev P
AUTHOR: E J Holborow EJ
PUBTYPE: Journal Article
JOURNALTITLE: The American journal of pathology.
COUNTRY: UNITED STATES
TITLE: Contractile proteins in human cancer cells. Immunofluorescent and electron microscopic study.
PUBDATE: 19760601
The presence of contractile proteins in human cancer cells has been studied by means of: a) immunofluorescent staining using specific antibodies, and b) electron microscopy in order to detect the presence of cytoplasmic filaments. The tissues examined were: normal human skin, basal cell carcinoma of the skin, squamous cell carcinomas (of skin, oral cavity, and larynx), normal nonlactating mammary gland, and infiltrating mammary carcinoma with or without fibrosis. Normal tissues were negative after immunnoflurosescent staining of contractile proteins and contained no or minimal amounts of microfilaments as judged by electron microscopy. Tumor cells were strongly positive after immunoflouorescent staining for actin, myosin, light and heavy meromyosin but were negative for tropomyosin. Moreover, they contained prominent microfilaments (40 to 80 A in diameter) with some filaments (100 to 120 A in diameter) scattered in between. It appears that malignant cells contain an increased amount of contractile proteins, organized in the form of a filamentous apparatus, when compared to their normal counterparts. The study of the presence of contractile proteins in tumor cells may be of potential importance in evaluating malignant growth.


3. DOCID:7078 SCORE: 0.00450588493425437
DOCNO: 707739
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secretion
QUALIFIER: secretion
QUALIFIER: physiopathology
QUALIFIER: physiopathology
AUTHOR: J A Gregg JA
AUTHOR: M M Sharma MM
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: Endoscopic measurement of pancreatic juice secretory flow rates and pancreatic secretory pressures after secretin administration in human controls and in patients with acute relapsing pancreatitis, chronic pancreatitis, and pancreatic cancer.
PUBDATE: 19781101
Secretory flow rates were measured inside the main pancreatic duct during endoscopic retrograde cholangiopancreatography (ERCP) in patients with acute relapsing pancreatitis, chronic pancreatitis, and pancreatic cancer and in controls after intravenous administration of secretin. Peak secretory flow rates in these groups were 5.04 +/- 1.74, 0.71 +/-1.28, 0.60 +/- 1.37, and 4.13 +/- 0.88 ml/min, respectively. Peak secretory pressures were also measured intraductally in patients with acute relapsing pancreatitis and pancreatic cancer and in controls and were 402 +/- 69, 75 +/- 161, and 403 +/- 99 mm pancreatic juice, respectively. Peak secretory flow rates and pressures measured in controls during constant administration of secretin were similar to those measured when secretin was administered as a bolus.


4. DOCID:2538 SCORE: 0.00425434757170333
DOCNO: 872120
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Surveillance, initial assessment, and subsequent progress of patients with superficial bladder cancer in a prospective longitudinal study. National Bladder Cancer Collaborative Group A (NBCCGA).
PUBDATE: 19770801
Through a bladder cancer surveillance protocol, a sizable population of patients suitable for characterizing the dynamics and patterns of recurrent superficial transitional cell carcinoma has been identified. One hundred thirty-three patients have been followed after their first occurrence of transitional cell carcinoma (Stage O or A). Only patients whose tumors were considered to be completely removed by transurethral resection and who were not treated by any other means were included. Although a full year of follow-up is not yet complete, recurrent bladder carcinoma has been noted in 44 (33%). Most of these recurrences were identified at the first follow-up cystoscopy and the majority were present at the site of the initial lesion. Tumor size, grade, and stage did not appear to influence recurrence, whereas multiplicity did. The relevance of these findings to various theories about the mechanism of recurrence is discussed.


5. DOCID:13319 SCORE: 0.0041902375329154
DOCNO: 2667128
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: psychology
QUALIFIER: psychology
AUTHOR: F Stiefel F
AUTHOR: M Volkenandt M
AUTHOR: W Breitbart W
AFFILIATION: Psychiatry Service, Memorial Sloan Kettering Cancer Center, New York, New York 10021.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Schweizerische medizinische Wochenschrift.
COUNTRY: SWITZERLAND
TITLE: [Suicide and cancer]
PUBDATE: 19890601
Epidemiological studies demonstrate that cancer patients are at increased risk of suicide. While affective illness and alcoholism are the most important determinants of suicide in the physically healthy population, vulnerability to suicide in cancer patients is influenced by a number of other factors including psychosocial and psychosomatic effects of advanced illness, pain, organic mental syndromes and preexisting psychopathology. Ways of influencing these risk factors are discussed, together with their use in preventive care and management of suicidal cancer patients.


6. DOCID:6811 SCORE: 0.00412986020611089
DOCNO: 372655
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Carcinogens
DESCRIPTOR: Mutagens
QUALIFIER: methods
AUTHOR: L A Poirier LA
AUTHOR: E K Weisburger EK
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Selection of carcinogens and related compounds tested for mutagenic activity.
PUBDATE: 19790401
A list of 102 chemicals was prepared for subsequent mutagenesis assays in a National Cancer Institute program to determine the extent of correlation between carcinogenesis and mutagenesis in standardized assays. The chemicals were divided into five major categories: 37 aromatic amines, 11 polycyclic aromatic hydrocarbons, 8 nitrosamines and nitrosamides, 16 alkylating agents, and a miscellaneous category consisting of 11 heterocyclic compounds, 7 amides, ureas and acylating agents, 5 antimetabolites, 4 inorganic chemicals, and 3 promoters. The chemicals were further described as procarcinogens (requiring metabolic activation to exert their biologic activities), ultimate carcinogens (direct-acting chemicals not requiring metabolic activation), and noncarcinogens (compounds shown to be inactive in one or more adequate carcinogenicity tests). An extensive bibliography documents the selection and categorization of the compounds.


7. DOCID:11574 SCORE: 0.00398717457010898
DOCNO: 7066218
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Protective Devices
DESCRIPTOR: Respiratory Protective Devices
QUALIFIER: adverse effects
QUALIFIER: mortality
QUALIFIER: mortality
AUTHOR: B K Wignall BK
AUTHOR: A J Fox AJ
PUBTYPE: Journal Article
JOURNALTITLE: British journal of industrial medicine.
COUNTRY: ENGLAND
TITLE: Mortality of female gas mask assemblers.
PUBDATE: 19820201
A 30-year follow-up study of the mortality of 500 women employed in manufacturing gas masks during the second world war showed a pronounced excess of deaths from mesothelioma and lung cancer. Although these women were subject only to short periods of exposure, greater excesses were found for those exposed for between one and five years than for those exposed for under one year. Even in the latter group, however, five deaths from lung cancer and four deaths from mesothelioma were recorded compared with 1.5 deaths and 0.1 deaths expected (p approximately equal to 0.02). An excess of deaths from cancer of the ovary was also found, and this appeared to be related to exposure to asbestos.


8. DOCID:11571 SCORE: 0.00398717432430441
DOCNO: 6176444
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: L A Cole LA
AUTHOR: S Birken S
AUTHOR: S Sutphen S
AUTHOR: R O Hussa RO
AUTHOR: R A Pattillo RA
PUBTYPE: Journal Article
JOURNALTITLE: Endocrinology.
COUNTRY: UNITED STATES
TITLE: Absence of the COOH-terminal peptide on ectopic human chorionic gonadotropin beta-subunit (hCG beta).
PUBDATE: 19820601
A comparison of the physical properties and immunoreactivity of ectopic hCG beta from cultured cervical cancer cells and standard hCG beta was performed. The heterogeneity of the preparations was examined by ion-exchange chromatography, and the molecular size by analytical gel filtration. Two distinct forms of ectopic hCG beta were identified. One form was indistinguishable from standard hCG beta, while the other, although larger, lacked the characteristic COOH-terminal peptide (CTP). This was shown by the failure of antisera specific for determinants on the cTP to recognize this molecule, and by the apparent absence of the 0-linked oligosaccharides and thermolysin cleavage site normally found in this region.


9. DOCID:3267 SCORE: 0.00395667081055273
DOCNO: 1088828
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: S Feldman S
AUTHOR: W T Hughes WT
AUTHOR: C B Daniel CB
PUBTYPE: Journal Article
JOURNALTITLE: Pediatrics.
COUNTRY: UNITED STATES
TITLE: Varicella in children with cancer: Seventy-seven cases.
PUBDATE: 19750901
The purpose of this study was to characterize varicella in childhood cancer patients. Seventeen of the 77 patients reviewed were in remission and off all therapy for 3 to 22 months. No one in this group died from varicella or had evidence of visceral dissemination. Among the remaining 60 patients, all of whom were receiving anticancer theapy when they developed varicella, 19 (32%) had visceral dissemination and 4 died, for a mortality rate of 7%. Each of the deaths was associated with primary varicella pneumonitis, with or without acute encephalitis. Visceral dissemination was not related to type or status of malignancy or to duration of specific anticancer therapy. Varicella was more likely to disseminate in children with absolute lymphopenia, less than 500 cells per cubic millimeter, than in patients with higher lymphocyte counts. Cessation of anticancer theapy prior to the onset of lesions appeared to lessen the risk of dissemination. These results show that varicella is more severe in cancer patients on therapy than the general population or in patients who have completed therapy, but is not highly fatal.


10. DOCID:11645 SCORE: 0.00385918860785884
DOCNO: 7085384
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Tomography, X-Ray Computed
QUALIFIER: radiography
QUALIFIER: radiography
AUTHOR: P G Giri PG
AUTHOR: J W Walsh JW
AUTHOR: T A Hazra TA
AUTHOR: J H Texter JH
AUTHOR: W W Koontz WW
PUBTYPE: Journal Article
JOURNALTITLE: International journal of radiation oncology, biology, physics.
COUNTRY: UNITED STATES
TITLE: Role of computed tomography in the evaluation and management of carcinoma of the prostate.
PUBDATE: 19820201
Between January 1978 to March 1980, 25 patients with biopsy-proven prostate carcinoma were evaluated by computerized tomography (CT). CT differed from clinical stage in 7 of 25 patients (28%). In 6 of the 7 patients, change in stage resulted because of demonstration of extracapsular extension and/or pelvic lymph node involvement. Twelve of the 25 patients (48%) underwent surgery with histological confirmation of CT findings. Ct identified nodal involvement accurately in 10 of 12 patients (83%). We recommend use of CT for initial staging, treatment planning and assessment of response in the management of prostate cancer.


11. DOCID:11476 SCORE: 0.00374913599191092
DOCNO: 6870892
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: isolation & purification
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: S Hakomori S
AUTHOR: E Nudelman E
AUTHOR: S B Levery SB
AUTHOR: C M Patterson CM
PUBTYPE: Journal Article
JOURNALTITLE: Biochemical and biophysical research communications.
COUNTRY: UNITED STATES
TITLE: Human cancer-associated gangliosides defined by a monoclonal antibody (IB9) directed to sialosyl alpha 2 leads to 6 galactosyl residue: a preliminary note.
PUBDATE: 19830601
A new monoclonal antibody (IB9) was prepared by hybridoma technique directed specifically to sialosyl alpha 2 leads to 6 galactosyl residue. With this reagent, accumulation of two major gangliosides in human colonic and liver adenocarcinoma has been detected, and these gangliosides were isolated and characterized as structures A and B (below). Another ganglioside with a ceramide nonasaccharide structure, which reacted to anti-X-hapten antibody after desialylation, was also isolated and partially characterized. (formula; see text) These gangliosides were absent or present in very small quantity in normal tissue and may represent human cancer-associated markers.


12. DOCID:3708 SCORE: 0.0037210857240662
DOCNO: 1009004
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mitosis
QUALIFIER: physiopathology
AUTHOR: S Gelfant S
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of dermatology.
COUNTRY: ENGLAND
TITLE: The cell cycle in psoriasis: a reappraisal.
PUBDATE: 19761201
The current belief that the clinical manifestations of psoriasis (excessive scaling) are due to a twelve-fold speeding up or shortening of the cell division cycle time of the germinative cells in psoriatic epidermis (from 457 to 37-5 h) is shown to be incorrect. A new concept is introduced--that the germinative layer in human epidermis is composed of not one, but three separate and distinct populations of epidermal cells. First, there are cycling cells which are actively moving through the cell cycle. Then there are two categories of non-cycling cells (blocked in the G1 or the G2 periods of the cell cycle) which are capable of moving into the proliferative pool upon specific stimulation. Thus, increased epidermal cell proliferation in active lesions of psoriasis would be brought about mainly by a recruitment or a relase of the two categories of non-cycling cells. The idea that germinative epidermal cells are primarily non-cycling, leads to the suggestion of focusing attention on non-cycling cells (rather than on cycling cells) for the control and treatment of psoriasis. It might be worthwhile considering treating psoriatic patients during periods of clinical remission--with factors to keep the germinative cells in the non-cycling state--rather than during psoriatic flare up--with cancer chemotherapy drugs.


13. DOCID:14897 SCORE: 0.00363638469404329
DOCNO: 3019974
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Dietary Fiber
QUALIFIER: epidemiology
AUTHOR: M Kuratsune M
AUTHOR: T Honda T
AUTHOR: H N Englyst HN
AUTHOR: J H Cummings JH
PUBTYPE: Journal Article
JOURNALTITLE: Japanese journal of cancer research : Gann.
COUNTRY: JAPAN
TITLE: Dietary fiber in the Japanese diet as investigated in connection with colon cancer risk.
PUBDATE: 19860801
The low risk of colon cancer among the Japanese suggests a high intake of dietary fiber. Composite diets for 1959, 1970, and 1979 were prepared using food consumption data from the National Nutrition Survey in Japan and analyzed for non-starch polysaccharides (NSP) at the Dunn Clinical Nutrition Centre in Cambridge. The results showed that average intake of NSP by Japanese in the above years did not exceed 13 g per day, which is as low as the corresponding intake by the Scandinavians and the British, whose risk of colon cancer is known to be high.


14. DOCID:2647 SCORE: 0.00362969414450895
DOCNO: 805659
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: J R van Nagell JR
AUTHOR: Q A Pletsch QA
AUTHOR: D M Goldenberg DM
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: A study of cyst fluid and plasma carcinoembryonic antigen in patients with cystic ovarian neoplasms.
PUBDATE: 19750601
Cyst fluid and plasma carcinoembryonic antigen (CEA) levels were measured in 11 patients with ovarian cyst-adenocarcinoma and in 16 patients with benign ovarian neoplasms. In patients with ovarian cancer, plasma CEA levels were not elevated above 2.5 ng/ml unless cyst fluid CEA levels were 4 to 16 mu-g/ml. In this series, cystic and plasma CEA levels were elevated most consistently in patients with mucinous ovarian tumors. Furthermore, on the basis of molecular size and immunoreactivity by immunodiffusion, ovarian cancer cyst fluid CEA and colonic cancer CEA had similar immunochemical properties. Consistent with the findings in other neoplasms, follow-up studies showed that plasma CEA levels returned to the normal range between 2 and 12 weeks after surgical excision of the ovarian tumor. It is concluded that plasma CEA is of value in the management of patients with ovarian mucinous cystadenocarcinoma.