0. DOCID:27917 SCORE: 0.00342279938431071
DOCNO: 10950461
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: genetics
AUTHOR: R W Burt RW
AFFILIATION: Department of Medicine, University of Utah, College of Medicine, and Huntsman Cancer Institute, Salt Lake City, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Seminars in gastrointestinal disease.
COUNTRY: UNITED STATES
TITLE: Rare syndromes and genetic testing for colorectal cancer.
PUBDATE: 20000701
The genes responsible for each of the inherited syndromes of intestinal polyposis and colorectal cancer are now known. This knowledge has led to genetic testing for syndrome diagnosis and for determining which persons in an affected family actually have the condition. Genetic testing has also allowed a more precise clinical characterization of each of the syndromes and their subtypes. Optimal application of genetic testing, proper cancer prevention, and management of nonmalignant features of each of the syndromes are the next goals. This report summarizes each of the syndromes, their genetics, and management and provides an approach for genetic testing.


1. DOCID:25174 SCORE: 0.00298481334753327
DOCNO: 11301470
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Angiography
DESCRIPTOR: Radiography, Thoracic
QUALIFIER: blood supply
QUALIFIER: abnormalities
AUTHOR: J M Pilcher JM
AUTHOR: A R Padhani AR
AFFILIATION: Academic Department of Diagnostic Radiology, The Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom. pilmac@waitrose.com
PUBTYPE: Journal Article
JOURNALTITLE: Clinical anatomy (New York, N.Y.)
COUNTRY: United States
TITLE: Problem in diagnostic imaging: Mediastinal venous anomalies.
PUBDATE: 20010501
This article presents as a diagnostic problem a rare mediastinal venous anomaly detected in a patient with a primary intrathoracic tumor. Its appearance on computed tomography (CT) is discussed and compared with that of other developmental mediastinal venous anomalies. The individual CT characteristics of these anomalies and their clinical significance with respect to the management of patients with cancer are also reviewed.


2. DOCID:26843 SCORE: 0.00262554986202171
DOCNO: 11057328
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Taxoids
QUALIFIER: drug therapy
QUALIFIER: pharmacology
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: analogs & derivatives
AUTHOR: K Daido K
AUTHOR: K Arita K
AUTHOR: N Ohashi N
AUTHOR: K Nakamura K
AFFILIATION: Dept. of Respiratory Disease, Hiroshima Red Cross Hospital.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [A case of docetaxel-resistant lung cancer effectively treated with chemotherapy of gemcitabine and vinorelbine]
PUBDATE: 20001001
We report a NSCLC patient effectively treated with anti-cancer agents on an outpatient basis despite chemotherapy with carboplatin and docetaxel, he relapsed after achieving a transient response. Combination chemotherapy with gemcitabine and vinorelbine administered every three weeks in an outpatient clinic caused the lung cancer volume to reduce remarkably. This regimen was well tolerated and suitable for outpatients. Its usefulness as a second line chemotherapy in the treatment of NSCLC should be investigated.


3. DOCID:27293 SCORE: 0.00245860152215008
DOCNO: 10400552
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: European Continental Ancestry Group
QUALIFIER: epidemiology
AUTHOR: N D Pharris-Ciurej ND
AUTHOR: L S Cook LS
AUTHOR: N S Weiss NS
AFFILIATION: Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
PUBTYPE: Journal Article
JOURNALTITLE: American journal of epidemiology.
COUNTRY: UNITED STATES
TITLE: Incidence of testicular cancer in the United States: has the epidemic begun to abate?
PUBDATE: 19990701
In response to a report that testicular cancer incidence in non-Hispanic White males in Los Angeles county had fallen in the 1990s, particularly in young men, the authors analyzed data collected by the Surveillance, Epidemiology, and End Results (SEER) program from 1973 to 1995. While the incidence rate of testicular cancer in US White males ages 15-64 years did stabilize in the first half of the 1990s, after a number of years of a steady increase, there was no indication of an actual decline.


4. DOCID:27610 SCORE: 0.00194908882831869
DOCNO: 9773039
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: pathology
QUALIFIER: secondary
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: secondary
AUTHOR: J P Ferroir JP
AUTHOR: J Cadranel J
AUTHOR: A Khalil A
AUTHOR: C Lebreton C
AUTHOR: S Contant S
AUTHOR: B Milleron B
AFFILIATION: Service de Neurologie, Hôpital Tenon, Paris.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Revue neurologique.
COUNTRY: FRANCE
TITLE: [Intramedullary metastases of bronchogenic carcinoma. Two cases]
PUBDATE: 19980201
Intramedullary metastases are uncommon. We report two cases in patients with small cell bronchogenic cancer. The clinical diagnosis was supported by T1 magnetic resonance imaging after gadolinium injection. A unique medullary metastasis associated with other metastatic localizations was observed in the first patient and multiple intramedullary metastases alone in the second. These secondary intramedullary localizations were highly sensitive to chemotherapy after the first monthly cure in the first patient and after the third in the second patient. We emphasize the importance of chemotherapy in such cases, usually associated with focal radiotherapy.


5. DOCID:25073 SCORE: 0.0019377229764864
DOCNO: 10937726
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: immunology
AUTHOR: J H Chen JH
AUTHOR: F Zou F
AUTHOR: N D Wang ND
AUTHOR: S W Xie SW
AUTHOR: X Zhang X
AFFILIATION: Ministry of Education Key Lab of Bioorganic Chemistry & Molecular Engineering, Department of Chemistry, Peking University, Beijing, PR China. jhchem@chemms.chem.pku.edu.cn
PUBTYPE: Journal Article
JOURNALTITLE: Bioorganic & medicinal chemistry letters.
COUNTRY: ENGLAND
TITLE: Production and application of LPA polyclonal antibody.
PUBDATE: 20000801
By using colloidal gold as a hapten carrier, a kind of antibody against lysophosphatidic acid (LPA) was developed and used to successfully detect 500 ng/mL LPA in dot immunogold filtration assay. Such application of the LPA antibody could offer us a way to diagnose ovarian cancer at its early stage.


6. DOCID:26931 SCORE: 0.00181226682864315
DOCNO: 11073026
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chemotherapy, Adjuvant
DESCRIPTOR: Patient Acceptance of Health Care
QUALIFIER: complications
QUALIFIER: drug therapy
QUALIFIER: complications
AUTHOR: M Colleoni M
AUTHOR: M Mandala M
AUTHOR: G Peruzzotti G
AUTHOR: C Robertson C
AUTHOR: A Bredart A
AUTHOR: A Goldhirsch A
PUBTYPE: Letter
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Depression and degree of acceptance of adjuvant cytotoxic drugs.
PUBDATE: 20001001
An interaction between psychological attitude and outcome in early-stage breast cancer has been postulated, with a possible explanation related to the presumed tendency of depressed patients to be less proactive in obtaining health care. We report on the degree of acceptance of adjuvant chemotherapy in patients with breast cancer who have concomitant depression. Only 20 (51.3%) of the study group accepted and received the proposed chemotherapy compared with 75 (92.2%) of the control group (p<0.0001). Treatment of depression might be essential for tailoring adjuvant treatments with chemotherapy.


7. DOCID:27850 SCORE: 0.00169866354696428
DOCNO: 9738588
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: physiology
AUTHOR: D G Kirsch DG
AUTHOR: M B Kastan MB
AFFILIATION: Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
COUNTRY: UNITED STATES
TITLE: Tumor-suppressor p53: implications for tumor development and prognosis.
PUBDATE: 19980901
The p53 protein plays a central role in modulating cellular responses to cytotoxic stresses by contributing to both cell-cycle arrest and programmed cell death. Loss of p53 function during tumorigenesis can lead to inappropriate cell growth, increased cell survival, and genetic instability. p53 gene mutations occur in approximately half of all malignancies from a wide range of human tumors. In some tumor types, these p53 mutations are associated with poor prognosis and treatment failure. Based on these insights, new approaches are being developed to prevent, diagnose, and treat cancer.


8. DOCID:26600 SCORE: 0.00164912118458781
DOCNO: 10349773
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: surgery
QUALIFIER: diagnosis
QUALIFIER: surgery
QUALIFIER: diagnosis
QUALIFIER: surgery
QUALIFIER: diagnosis
QUALIFIER: surgery
AUTHOR: M Espié M
AFFILIATION: Centre des Maladies du Sein, Hôpital St-Louis, Paris.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Contraception, fertilité, sexualité (1992)
COUNTRY: FRANCE
TITLE: [Therapeutic problems posed by sub-clinical breast cancers]
PUBDATE: 19990401
Screening has led to the earlier detection of non palpable ductal or lobular carcinoma in situ microinvasive carcinoma and invasive breast cancer 1 cm or less in size (minimal breast cancer). Formerly, most of these cancers were cured by mastectomy but the dramatic change in frequency has prompted interest in the role of conservation treatment. Minimal breast cancer is a heterogeneous group of lesions, no single approach will be appropriate for all form of these diseases and methods must be developed to determine the most appropriate treatment for each patient.


9. DOCID:26359 SCORE: 0.00162718011889382
DOCNO: 11301847
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: L Crinò L
AUTHOR: C Calandri C
AUTHOR: A Maestri A
AUTHOR: F Marrocolo F
AFFILIATION: Medical Oncology Unit, Oncology Department, Bellaria Hospital, Bologna, Italy.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncology (Williston Park, N.Y.)
COUNTRY: United States
TITLE: Gemcitabine and cisplatin combination in early-stage non-small-cell lung cancer.
PUBDATE: 20010301
A number of randomized clinical trials now support the conclusion that the combined-modality regimen that includes gemcitabine (Gemzar) and cisplatin (Platinol) may improve survival in disseminated non-small-cell lung cancer. Cisplatin is considered to be the "backbone" of this combination chemotherapy due to its proven activity. The regimen of gemcitabine and cisplatin has been tested and is now considered among the most active combinations in the treatment of disseminated non-small-cell lung cancer.


10. DOCID:26336 SCORE: 0.0016271799105408
DOCNO: 10397460
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Division
DESCRIPTOR: Neovascularization, Pathologic
QUALIFIER: genetics
QUALIFIER: metabolism
AUTHOR: J M Connolly JM
AUTHOR: D P Rose DP
AFFILIATION: Division of Nutrition and Endocrinology, American Health Foundation, Valhalla, NY 10595, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer letters.
COUNTRY: IRELAND
TITLE: Enhanced angiogenesis and growth of 12-lipoxygenase gene-transfected MCF-7 human breast cancer cells in athymic nude mice.
PUBDATE: 19981001
Transfection of the estrogen-dependent and poorly invasive MCF-7 human breast cancer cell line so that it stably overexpressed 12-lipoxygenase and secreted high levels of 12-hydroxyeicosatetraenoic acid when cultured with arachidonate resulted in rapid growth in athymic nude mice when compared with the parental line. This enhanced acquisition of tumor mass was a result of both increased cell proliferation and reduced apoptotic cell death and was accompanied by high angiogenic activity.


11. DOCID:26463 SCORE: 0.00155661196885698
DOCNO: 11883263
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Pregnancy Complications, Neoplastic
DESCRIPTOR: Pregnancy Outcome
AUTHOR: R Sikorski R
AFFILIATION: III Katedry i Kliniki Ginekologii AM w Lublinie.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Ginekologia polska.
COUNTRY: Poland
TITLE: [Pregnancy complicated by a neoplasmatic disease]
PUBDATE: 20011201
The Author reviews the problem of neoplasmatic complications of pregnancy focusing mainly on genital tumors such as vulvar, vaginal, cervical, uterine, tubal and ovarian neoplasms as well as on other pelvic tumors originating from the bladder and bowel. Non-genital neoplasms such as breast cancer, Hodgkin's disease, non-Hodgkin lymphoma, leukemia, melanoma and thyroid cancer are also addressed. Literature data on the incidence of tumors in pregnant women are reviewed and the therapeutic options considering both the mother and the fetus are discussed. Management recommendations are given in cases when following the treatment a patient becomes pregnant again.


12. DOCID:25644 SCORE: 0.00149975722156979
DOCNO: 11798500
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunotherapy
QUALIFIER: therapy
QUALIFIER: immunology
AUTHOR: E di Carlo E
AUTHOR: M Iezzi M
AUTHOR: T Pannellini T
AUTHOR: F Zaccardi F
AUTHOR: A Modesti A
AUTHOR: G Forni G
AUTHOR: P Musiani P
AFFILIATION: Department of Oncology and Neurosciences, G. d'Annunzio University of Chieti, 66100 Chieti, Italy.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of hematotherapy & stem cell research.
COUNTRY: United States
TITLE: Neutrophils in anti-cancer immunological strategies: old players in new games.
PUBDATE: 20011201
This review highlights the new "immunological identity" of neutrophils within the cytokine network and their role in biology of diseases, particularly in tumor biology. The latest preclinical evidence of their involvement in anti-cancer immunotherapeutic and prophylactic strategies will be discussed with particular reference to the real possibilities of transferring experimental results to a clinical setting.


13. DOCID:27210 SCORE: 0.00149610454449423
DOCNO: 9795581
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
AUTHOR: S G Von Essen SG
AUTHOR: S A McCurdy SA
AFFILIATION: Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198-5300, USA. svonesse@unmc.edu
PUBTYPE: Journal Article
JOURNALTITLE: The Western journal of medicine.
COUNTRY: UNITED STATES
TITLE: Health and safety risks in production agriculture.
PUBDATE: 19981001
Production agriculture is associated with a variety of occupational illnesses and injuries. Agricultural workers are at higher risk of death or disabling injury than most other workers. Traumatic injury commonly occurs from working with machinery or animals. Respiratory illness and health problems from exposures to farm chemicals are major concerns, and dermatoses, hearing loss, certain cancers, and zoonotic infections are important problems. Innovative means of encouraging safe work practices are being developed. Efforts are being made to reach all groups of farmworkers, including migrant and seasonal workers, farm youth, and older farmers.


14. DOCID:26077 SCORE: 0.00148175635725267
DOCNO: 10448696
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Lymphatic Metastasis
QUALIFIER: pathology
AUTHOR: E C Grendys EC
AUTHOR: C Salud C
AUTHOR: J K Durfee JK
AUTHOR: J V Fiorica JV
AFFILIATION: Department of Gynecologic Oncology, University of South Florida School of Medicine, Tampa, USA. Grendyec@Moffit.USF.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Surgical oncology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Lymphatic mapping in gynecologic malignancies.
PUBDATE: 19990701
Gynecologic malignancies account for 15% of all cancer diagnosis in women. Primary lymphatic spread is well recognized in vulvar, cervical, uterine, and ovarian carcinomas. Vulvar carcinoma spreads locally to the inguinofemoral lymph nodes in a relatively predictable fashion similar to the local spread of breast carcinoma. Lymphatic mapping using radioactive colloid should provide adequate means to sample these nodal basins while attempting to reduce postoperative morbidity. Methods of vulvar lymphoscintigraphy are described.