0. DOCID:27917 SCORE: 0.00342279938431071
DOCNO: 10950461
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: genetics
AUTHOR: R W Burt RW
AFFILIATION: Department of Medicine, University of Utah, College of Medicine, and Huntsman Cancer Institute, Salt Lake City, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Seminars in gastrointestinal disease.
COUNTRY: UNITED STATES
TITLE: Rare syndromes and genetic testing for colorectal cancer.
PUBDATE: 20000701
The genes responsible for each of the inherited syndromes of intestinal polyposis and colorectal cancer are now known. This knowledge has led to genetic testing for syndrome diagnosis and for determining which persons in an affected family actually have the condition. Genetic testing has also allowed a more precise clinical characterization of each of the syndromes and their subtypes. Optimal application of genetic testing, proper cancer prevention, and management of nonmalignant features of each of the syndromes are the next goals. This report summarizes each of the syndromes, their genetics, and management and provides an approach for genetic testing.


1. DOCID:25174 SCORE: 0.00298481334753327
DOCNO: 11301470
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Angiography
DESCRIPTOR: Radiography, Thoracic
QUALIFIER: blood supply
QUALIFIER: abnormalities
AUTHOR: J M Pilcher JM
AUTHOR: A R Padhani AR
AFFILIATION: Academic Department of Diagnostic Radiology, The Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom. pilmac@waitrose.com
PUBTYPE: Journal Article
JOURNALTITLE: Clinical anatomy (New York, N.Y.)
COUNTRY: United States
TITLE: Problem in diagnostic imaging: Mediastinal venous anomalies.
PUBDATE: 20010501
This article presents as a diagnostic problem a rare mediastinal venous anomaly detected in a patient with a primary intrathoracic tumor. Its appearance on computed tomography (CT) is discussed and compared with that of other developmental mediastinal venous anomalies. The individual CT characteristics of these anomalies and their clinical significance with respect to the management of patients with cancer are also reviewed.


2. DOCID:31947 SCORE: 0.00285880782073024
DOCNO: 12073121
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Buttocks
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: pathology
AUTHOR: Ik Yang I
AUTHOR: Curtis W Hayes CW
AUTHOR: J Sybil Biermann JS
AFFILIATION: Department of Radiology, University of Michigan Health Systems, Ann Arbor, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Skeletal radiology.
COUNTRY: Germany
TITLE: Calcific tendinitis of the gluteus medius tendon with bone marrow edema mimicking metastatic disease.
PUBDATE: 20020601
A case of calcific tendinitis of the gluteus medius is presented. This report describes a patient with a history of breast cancer who had the combination of amorphous calcifications in the gluteus medius tendon and the MR finding of conspicuous bone marrow edema in the adjacent greater trochanter, prompting concern for metastatic disease. We present images from radiography, bone scanning, CT, and MR imaging. The unusual combination of findings in these studies should be considered conclusive for calcific tendinitis, and should not be confused with malignancy.


3. DOCID:26843 SCORE: 0.00262554986202171
DOCNO: 11057328
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Taxoids
QUALIFIER: drug therapy
QUALIFIER: pharmacology
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: analogs & derivatives
AUTHOR: K Daido K
AUTHOR: K Arita K
AUTHOR: N Ohashi N
AUTHOR: K Nakamura K
AFFILIATION: Dept. of Respiratory Disease, Hiroshima Red Cross Hospital.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [A case of docetaxel-resistant lung cancer effectively treated with chemotherapy of gemcitabine and vinorelbine]
PUBDATE: 20001001
We report a NSCLC patient effectively treated with anti-cancer agents on an outpatient basis despite chemotherapy with carboplatin and docetaxel, he relapsed after achieving a transient response. Combination chemotherapy with gemcitabine and vinorelbine administered every three weeks in an outpatient clinic caused the lung cancer volume to reduce remarkably. This regimen was well tolerated and suitable for outpatients. Its usefulness as a second line chemotherapy in the treatment of NSCLC should be investigated.


4. DOCID:27293 SCORE: 0.00245860152215008
DOCNO: 10400552
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: European Continental Ancestry Group
QUALIFIER: epidemiology
AUTHOR: N D Pharris-Ciurej ND
AUTHOR: L S Cook LS
AUTHOR: N S Weiss NS
AFFILIATION: Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
PUBTYPE: Journal Article
JOURNALTITLE: American journal of epidemiology.
COUNTRY: UNITED STATES
TITLE: Incidence of testicular cancer in the United States: has the epidemic begun to abate?
PUBDATE: 19990701
In response to a report that testicular cancer incidence in non-Hispanic White males in Los Angeles county had fallen in the 1990s, particularly in young men, the authors analyzed data collected by the Surveillance, Epidemiology, and End Results (SEER) program from 1973 to 1995. While the incidence rate of testicular cancer in US White males ages 15-64 years did stabilize in the first half of the 1990s, after a number of years of a steady increase, there was no indication of an actual decline.


5. DOCID:31598 SCORE: 0.00230998348135791
DOCNO: 16382037
OWNER: NLM
STATUS: In-Process
AUTHOR: Patrick A Everley PA
AUTHOR: Bruce R Zetter BR
AFFILIATION: Department of Surgery, Children's Hospital / Harvard Medical School, Boston, Massachusetts 02115, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Annals of the New York Academy of Sciences.
COUNTRY: United States
TITLE: Proteomics in tumor progression and metastasis.
PUBDATE: 20051101
With the ultimate goal of systematically identifying and characterizing proteins within an organism, the field of proteomics has generated much excitement in the past few years. Coupled with mass spectrometry, various quantitative and functional techniques are now available that allow for large-scale analyses of proteins implicated in cancer. New techniques are just now being applied to identifying the temporal changes in protein levels associated with tumor development. This review will focus on the use and promise of proteomic technologies as they apply to the study of tumor progression and metastasis.


6. DOCID:31506 SCORE: 0.00230998238944532
DOCNO: 15756269
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: microbiology
QUALIFIER: complications
QUALIFIER: pathogenicity
QUALIFIER: epidemiology
QUALIFIER: microbiology
AUTHOR: A Shin A
AUTHOR: H R Shin HR
AUTHOR: D Kang D
AUTHOR: S K Park SK
AUTHOR: C-S Kim CS
AUTHOR: K-Y Yoo KY
AFFILIATION: Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-799, Republic of Korea.
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: England
TITLE: A nested case-control study of the association of Helicobacter pylori infection with gastric adenocarcinoma in Korea.
PUBDATE: 20050401
In a nested case-control study of 86 cases of gastric adenocarcinoma in relation to Helicobacter pylori infection in the Korean Multi-center Cancer Cohort, the H. pylori IgG seropositivity was 83.7% and that of the 344 matched controls was 80.8%, with a matched odds ratio for H. pylori infection of 1.06 (95% CI, 0.80-1.40).


7. DOCID:30061 SCORE: 0.00229990369396913
DOCNO: 15191008
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: therapeutic use
QUALIFIER: analogs & derivatives
QUALIFIER: drug therapy
QUALIFIER: virology
QUALIFIER: drug therapy
QUALIFIER: virology
QUALIFIER: chemically induced
AUTHOR: M E Melisko ME
AUTHOR: R Fox R
AUTHOR: A Venook A
AFFILIATION: Comprehensive Cancer Center, University of California, San Francisco, California 94115, USA. mmelisko@medicine.ucsf.edu
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Clinical oncology (Royal College of Radiologists (Great Britain))
COUNTRY: England
TITLE: Reactivation of hepatitis C virus after chemotherapy for colon cancer.
PUBDATE: 20040501
Hepatitis C virus (HCV) infection often goes undiagnosed in asymptomatic carriers, but may become clinically relevant during periods of immunosuppression or severe illness. We report the clinical course of HCV reactivation in a patient receiving chemotherapy for metastatic colon cancer. We also review other reports showing the significance of HCV infection in patients being treated with chemotherapy.


8. DOCID:29982 SCORE: 0.00198764060672833
DOCNO: 14764990
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: biosynthesis
AUTHOR: Arun Singh A
AUTHOR: William D Figg WD
AFFILIATION: Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer biology & therapy.
COUNTRY: United States
TITLE: Upregulation of the androgen receptor during prostate cancer progression.
PUBDATE: 20040301
The androgen receptor is one of the central factors in mediating prostate cancer progression and is an important target for treatment. Several possible mechanisms have been put forth as to how it promotes this process. In the January 2004 issue of Nature Medicine, Chen et al. report that the androgen receptor is consistently upregulated as hormone sensitive prostate cancer changes to a hormone refractory state. They also show that this change is intricately involved during the development of resistance to androgen ablation therapy.


9. DOCID:27610 SCORE: 0.00194908882831869
DOCNO: 9773039
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: pathology
QUALIFIER: secondary
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: secondary
AUTHOR: J P Ferroir JP
AUTHOR: J Cadranel J
AUTHOR: A Khalil A
AUTHOR: C Lebreton C
AUTHOR: S Contant S
AUTHOR: B Milleron B
AFFILIATION: Service de Neurologie, Hôpital Tenon, Paris.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Revue neurologique.
COUNTRY: FRANCE
TITLE: [Intramedullary metastases of bronchogenic carcinoma. Two cases]
PUBDATE: 19980201
Intramedullary metastases are uncommon. We report two cases in patients with small cell bronchogenic cancer. The clinical diagnosis was supported by T1 magnetic resonance imaging after gadolinium injection. A unique medullary metastasis associated with other metastatic localizations was observed in the first patient and multiple intramedullary metastases alone in the second. These secondary intramedullary localizations were highly sensitive to chemotherapy after the first monthly cure in the first patient and after the third in the second patient. We emphasize the importance of chemotherapy in such cases, usually associated with focal radiotherapy.


10. DOCID:25073 SCORE: 0.0019377229764864
DOCNO: 10937726
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: immunology
AUTHOR: J H Chen JH
AUTHOR: F Zou F
AUTHOR: N D Wang ND
AUTHOR: S W Xie SW
AUTHOR: X Zhang X
AFFILIATION: Ministry of Education Key Lab of Bioorganic Chemistry & Molecular Engineering, Department of Chemistry, Peking University, Beijing, PR China. jhchem@chemms.chem.pku.edu.cn
PUBTYPE: Journal Article
JOURNALTITLE: Bioorganic & medicinal chemistry letters.
COUNTRY: ENGLAND
TITLE: Production and application of LPA polyclonal antibody.
PUBDATE: 20000801
By using colloidal gold as a hapten carrier, a kind of antibody against lysophosphatidic acid (LPA) was developed and used to successfully detect 500 ng/mL LPA in dot immunogold filtration assay. Such application of the LPA antibody could offer us a way to diagnose ovarian cancer at its early stage.


11. DOCID:29265 SCORE: 0.00182235421693348
DOCNO: 12360192
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: physiology
AUTHOR: Gary Thomas G
AFFILIATION: Vollum Institute, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA. thomasg@ohsu.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nature reviews. Molecular cell biology.
COUNTRY: England
TITLE: Furin at the cutting edge: from protein traffic to embryogenesis and disease.
PUBDATE: 20021001
Furin catalyses a simple biochemical reaction--the proteolytic maturation of proprotein substrates in the secretory pathway. But the simplicity of this reaction belies furin's broad and important roles in homeostasis, as well as in diseases ranging from Alzheimer's disease and cancer to anthrax and Ebola fever. This review summarizes various features of furin--its structural and enzymatic properties, intracellular localization, trafficking, substrates, and roles in vivo.


12. DOCID:26931 SCORE: 0.00181226682864315
DOCNO: 11073026
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chemotherapy, Adjuvant
DESCRIPTOR: Patient Acceptance of Health Care
QUALIFIER: complications
QUALIFIER: drug therapy
QUALIFIER: complications
AUTHOR: M Colleoni M
AUTHOR: M Mandala M
AUTHOR: G Peruzzotti G
AUTHOR: C Robertson C
AUTHOR: A Bredart A
AUTHOR: A Goldhirsch A
PUBTYPE: Letter
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Depression and degree of acceptance of adjuvant cytotoxic drugs.
PUBDATE: 20001001
An interaction between psychological attitude and outcome in early-stage breast cancer has been postulated, with a possible explanation related to the presumed tendency of depressed patients to be less proactive in obtaining health care. We report on the degree of acceptance of adjuvant chemotherapy in patients with breast cancer who have concomitant depression. Only 20 (51.3%) of the study group accepted and received the proposed chemotherapy compared with 75 (92.2%) of the control group (p<0.0001). Treatment of depression might be essential for tailoring adjuvant treatments with chemotherapy.


13. DOCID:31524 SCORE: 0.0017144220738233
DOCNO: 15150596
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: mortality
QUALIFIER: surgery
QUALIFIER: analysis
AUTHOR: K Canna K
AUTHOR: D C McMillan DC
AUTHOR: R F McKee RF
AUTHOR: A-M McNicol AM
AUTHOR: P G Horgan PG
AUTHOR: C S McArdle CS
AFFILIATION: University Department of Surgery, Glasgow Royal Infirmary, Alexandra Parade, Glasgow G31 2ER, Scotland, UK.
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: England
TITLE: Evaluation of a cumulative prognostic score based on the systemic inflammatory response in patients undergoing potentially curative surgery for colorectal cancer.
PUBDATE: 20040501
The value of combining Dukes' stage and C-reactive protein to form a cumulative prognostic score was assessed in 147 patients undergoing potentially curative resection for colorectal cancer. The cancer-specific survival rates at 3 years for patients with a cumulative prognostic score of 0, 1 and 2 were 100, 77 and 40%, respectively (HR 4.76, 2.78-8.15, P<0.001).


14. DOCID:27850 SCORE: 0.00169866354696428
DOCNO: 9738588
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: physiology
AUTHOR: D G Kirsch DG
AUTHOR: M B Kastan MB
AFFILIATION: Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
COUNTRY: UNITED STATES
TITLE: Tumor-suppressor p53: implications for tumor development and prognosis.
PUBDATE: 19980901
The p53 protein plays a central role in modulating cellular responses to cytotoxic stresses by contributing to both cell-cycle arrest and programmed cell death. Loss of p53 function during tumorigenesis can lead to inappropriate cell growth, increased cell survival, and genetic instability. p53 gene mutations occur in approximately half of all malignancies from a wide range of human tumors. In some tumor types, these p53 mutations are associated with poor prognosis and treatment failure. Based on these insights, new approaches are being developed to prevent, diagnose, and treat cancer.