0. DOCID:7381 SCORE: 0.00380148467146802
DOCNO: 717271
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: metabolism
AUTHOR: E R Eichner ER
AUTHOR: C R McDonald CR
AUTHOR: V L Dickson VL
PUBTYPE: Journal Article
JOURNALTITLE: The American journal of clinical nutrition.
COUNTRY: UNITED STATES
TITLE: Elevated serum levels of unsaturated folate binding protein: clinical correlates in a general hospital population.
PUBDATE: 19781101
We measured the capactiy of unsaturated folate binding protein to bind 3H-pteroylglutamic acid (UFBC) in serums from 489 general hospital patients. Of the patients 20% had mild-to-moderate elevations in UFBC (250 to 500 pg/ml), but only 6% had marked elevations (greater than 650 pg/ml), which correlated with metastatic cancer, active granulomatous disease, and especially with liver disease. The poor correlation of serum UFBC with folate status of the patient suggests that in many instances the elevated serum UFBC is neither the consequence nor the cause of folate deficiency. Although the role of folate binding protein remains unknown, it may be primarily an intracellular protein that is released into the serum as an index of activity of liver cells, granulocytes, and perhaps certain cancer cells.


1. DOCID:6879 SCORE: 0.00318038610868272
DOCNO: 7442196
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Speech
DESCRIPTOR: Speech Acoustics
QUALIFIER: physiopathology
AUTHOR: T Murry T
AUTHOR: E T Doherty ET
PUBTYPE: Journal Article
JOURNALTITLE: Journal of speech and hearing research.
COUNTRY: UNITED STATES
TITLE: Selected acoustic characteristics of pathologic and normal speakers.
PUBDATE: 19800601
The purpose of this study was to determine if measures of speaking fundamental frequency and its perturbation could be useful in differentiating talkers with no known vocal pathology and talkers with cancer of the larynx. Ten male subjects, five with a diagnosed malignancy of the larynx and five with normal voice, produced speech samples from which five voice production measures were obtained: the average speaking fundamental frequency (SFF), SFF variability during the reading of a sentence, the fo of a sustained vowel and a percent and magnitude jitter value. The perturbation factors, both directional and magnitudinal, during sustained vowels were found to be significant in discriminating normal talkers from those with laryngeal cancer. The speaking fundamental frequency and its variability during the reading of a sentence improved the discriminant function.


2. DOCID:3896 SCORE: 0.0031511091785644
DOCNO: 1192433
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Precancerous Conditions
QUALIFIER: pathology
QUALIFIER: etiology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: K Toyoshima K
AUTHOR: J Leighton J
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Bladder calculi and urothelial hyperplasia with papillomatosis in the rat following insertion of chalk powder in the bladder cavity with subsequent trauma of the bladder wall.
PUBDATE: 19751201
A suspension of chalk powder was injected into the cavity of the urinary bladder of Fischer 344 rats. Three weeks later rats were divided into 4 major groups and were given a submucosal injection. One group received a suspension of viable Chapman 4909 tumor cells, the 2nd group received a suspension of frozen-killed 4909 tumor cells, the 3rd group received a suspension of normal rat spleen cells, and the 4th group received cell-free fresh tissue culture medium. After 3 additional weeks urolithiasis was recognized in each experimental group. The incidence of calculi in the groups as listed above was 14 of 17, 6 of 11, 6 of 11, and 2 of 15, respectively. In control studies inocula consisted of tumor alone, i.e., without chalk powder. Inoculation of the 4909 rat bladder cancer cell line into the lumen of urinary bladders of rats did not result in any calculi after 3 weeks but did produce intramural tumor nodules and hyperplastic changes in adjacent host urothelium in 2 of 10 rats. The tumor inoculated in the submucosa of the bladder produced calculi and papillomas in 2 of 7 rats, and it produced intramural tumor nodules with adjacent hyperplasia of urothelium in all 7 rats.


3. DOCID:6865 SCORE: 0.00284825193584826
DOCNO: 7309279
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: H G Kwa HG
AUTHOR: F Cleton F
AUTHOR: R D Bulbrook RD
AUTHOR: D Y Wang DY
AUTHOR: J L Hayward JL
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: Plasma prolactin levels and breast cancer: relation to parity, weight and height, and age at first birth.
PUBDATE: 19810701
Plasma prolactin has been measured in over 3,500 women volunteers from a normal population. In premenopausal women there was a significant decrease in prolactin levels with increasing parity. However, this effect was transitory since plasma prolactin concentration rose with increasing time after the birth of the last child. There were no significant differences in prolactin levels with respect to height and weight, although overweight compared to underweight women had approximately 15% more plasma prolactin. If prolactin is a carcinogen, then these results are in keeping with the epidemiological findings that multiparity affords protection and that age at last delivery is a risk factor in the development of breast cancer.


4. DOCID:1189 SCORE: 0.00258202034869509
DOCNO: 1008991
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Leukocyte Count
DESCRIPTOR: Lymphocytes
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: C R Franks CR
AUTHOR: Y Williams Y
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Prognostic value of peripheral lymphocyte count in hormone therapy of advanced breast cancer.
PUBDATE: 19761201
Peripheral lymphocyte counts were performed on 41 patients with advanced breast cancer, before starting treatment with oestrogens or androgens. Patients were seen at monthly intervals, and the response to treatment was independently assessed, using the criteria of the British Breast Group. In the patients treated with oestrogens and androgens, the successful responders were found to have significantly higher pre-treatment peripheral lymphocyte counts than the intermediate responders and failures. It is suggested that pre-treatment peripheral lymphocyte counts may have a prognostic value in assessing potential response to hormone therapy in patients with breast cancer.


5. DOCID:3705 SCORE: 0.00247984298213518
DOCNO: 414402
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: prevention & control
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
AUTHOR: D Byar D
AUTHOR: C Blackard C
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Urology.
COUNTRY: UNITED STATES
TITLE: Comparisons of placebo, pyridoxine, and topical thiotepa in preventing recurrence of stage I bladder cancer.
PUBDATE: 19771201
Animal studies have shown that metabolites of tryptophan can cause bladder cancer, and human observations reveal an appreciable incidence of abnormalities of tryptophan metabolism in patients with bladder cancer. It has been suggested that pyridoxine (vitamin B6) may correct this abnormality and prevent recurrences of superficial bladder cancers. Intravesical instillation of thiotepa has been used for more than fifteen years in the treatment of superficial bladder cancer, but no controlled trials have been done. We report here a prospective clinical trial of 121 patients with Stage I bladder cancer randomized to placebo, pyridoxine, or intravesical thiotepa. The percentages of patients with recurrences over the period of study were 60.4, 46.9, and 47.4 for the three groups, respectively, and did not differ significantly. However, if patients having recurrences during the first ten months or followed up less than ten months were excluded, pyridoxine was significantly better than placebo (P = 0.03). Thiotepa significantly reduced the recurrence rate compared with placebo (P = 0.016) or pyridoxine (P = 0.015). These results suggest that a new trial of pyridoxine should be undertaken in which the tryptophan metabolites are measured and that further study of intravesical instillation of chemotherapeutic agents is warranted.


6. DOCID:2529 SCORE: 0.00247784997504117
DOCNO: 49475
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: microbiology
QUALIFIER: genetics
AUTHOR: E Bone E
AUTHOR: B S Drasar BS
AUTHOR: M J Hill MJ
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Gut bacteria and their metabolic activities in familiar polyposis.
PUBDATE: 19750501
Earlier work had suggested that patients with large-bowel cancer can be characterized by carriage of clostridia capable of dehydrogenating the nucleus of steroids and by high faecal bile-acid concentrations. Familial polyposis is an inherited disease which untreated, will progress to cancer of the large bowel, and those affected might be expected to have these metabolic characteristics. However, enviromental factors seem to play no part in polyposis. Investigation of as yet unaffected children of known polyposis patients revealed that the gut flora of half of them did not degrade cholesterol in vivo andnor did flora from patients in whom polyposis had already been diagnosed. The reason for this is unknown, but if the same patients develop polyposis (i.e., they carry the abnormal gene) we would have a simple diagnostic test which could replace the continuing follow-up now required for the siblings and children of patients with polyposis.


7. DOCID:6414 SCORE: 0.00246463713820319
DOCNO: 7471471
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: enzymology
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: A A Keshgegian AA
PUBTYPE: Journal Article
JOURNALTITLE: Clinica chimica acta; international journal of clinical chemistry.
COUNTRY: NETHERLANDS
TITLE: No relationship between lactate dehydrogenase and estrogen receptor levels in clinical human breast cancer.
PUBDATE: 19801201
The level of lactate dehydrogenase has been reported to increase in a human breast cancer cell line as a result of estrogen action [4]. This finding suggests that lactate dehydrogenase may be useful in clinical human breast cancer as a marker for intactness of the estrogen receptor pathway and for probability of response to hormonal therapy. In 97 hunan breast cancer specimens submitted for estrogen receptor analysis, the level of lactate dehydrogenase varied from 0.19 to 3.3 I.U. per mg of extractable protein and bore no relation with either the presence of estrogen receptor or its level. It thus appears that lactate dehydrogenase is not a useful marker for endocrine responsiveness in clinical breast tumors.


8. DOCID:3245 SCORE: 0.00245831205337075
DOCNO: 128842
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunity
QUALIFIER: immunology
QUALIFIER: surgery
AUTHOR: J A Roth JA
AUTHOR: S H Golub SH
AUTHOR: E A Grimm EA
AUTHOR: F R Eilber FR
AUTHOR: D L Morton DL
PUBTYPE: Journal Article
JOURNALTITLE: Surgery.
COUNTRY: UNITED STATES
TITLE: Effects of operation on immune response in cancer patients: sequential evaluation of in vitro lymphocyte function.
PUBDATE: 19760101
The effect of operation on in vitro lymphocyte function in 35 cancer patients was studied. Lymphocyte proliferative responses to phytohemagglutinin (PHA), poke-weed mitogen (PWM), and concanavalin A (Con A) were measured by 3H-thymidine incorporation. Sheep red blood cell (SRBC) rosette formation also was quantitated. These tests were performed preoperatively and at 24 hours, one week, and 4 weeks postoperatively. Intra-abdominal and intrathoracic procedures, transfusions, and longer operating times depressed the lymphocyte proliferative response. However, an increased lymphocyte proliferative response was noted in sarcoma patients 24 hours postoperatively, possibly as a result of lowered tumor burden. Several of these changes still were evident 4 weeks after operation. Rosette formation also decreased significantly 24 hours postoperatively in patients who had intrathoracic or intra-abdominal procedures, but returned to preoperative levels after one week. In general, operation appears to cause transient depression of lymphocyte function in some cancer patients. However, lymphocyte function returns to normal by the fourth postoperative week in most patients.


9. DOCID:3584 SCORE: 0.00243976298655628
DOCNO: 338105
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: therapeutic use
QUALIFIER: prevention & control
QUALIFIER: surgery
AUTHOR: I Taylor I
AUTHOR: P Brooman P
AUTHOR: J T Rowling JT
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: British medical journal.
COUNTRY: ENGLAND
TITLE: Adjuvant liver perfusion in colorectal cancer: initial results of a clinical trial.
PUBDATE: 19771101
Fifty consecutive patients with colorectal cancer but no evidence of secondary deposits in the liver were included in an ongoing controlled clinical trial of adjuvant liver perfusion aimed at reducing the incidence of hepatic metastases. All patients had their primary tumour resected in the standard way. Twenty-six of the patients served as controls, and 24 received fluorouracil, 1 g daily, as a continuous infusion into the portal venous system during the first seven days after operation. The patients were matched for age, sex, and site and stage of the disease. The immediate postoperative mortality and morbidity did not differ significantly between the two groups. During the follow-up period (mean duration 15.5 months), however, six deaths occurred in the control group and only one in the perfusion group. At necropsy four of the controls had multiple liver metastases. Two of the surviving controls developed evidence of liver metastases, and two had a local recurrence. No patient in the perfusion group developed evidence of hepatic metastases. These initial results suggest that adjuvant portal venous perfusion with fluorouracil may reduce the incidence of liver metastases in colorectal cancer.


10. DOCID:6556 SCORE: 0.00243433609486042
DOCNO: 371803
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: F Cabanillas F
AUTHOR: G P Bodey GP
AUTHOR: M A Burgess MA
AUTHOR: E J Freireich EJ
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Cancer treatment reports.
COUNTRY: UNITED STATES
TITLE: Results of a phase II study of maytansine in patients with breast carcinoma and melanoma.
PUBDATE: 19790301
During the phase I study of maytansine at our institution, some activity was observed against breast carcinoma and melanoma. A phase II study was thus initiated to more thoroughly investigate the activity of this drug against these two tumors. In 33 evaluable patients with melanoma, no complete or partial responses were observed. Twenty-one evaluable patients with breast cancer were entered and only one response (partial) was seen. The toxicity was similar to that observed in the phase I study and consisted mainly of diarrhea, paresthesias, phlebitis, and flu-like symptoms. Myelosuppression was infrequent and was short-lived when it occurred.


11. DOCID:6190 SCORE: 0.00243154797388068
DOCNO: 6778106
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Tomography, X-Ray Computed
QUALIFIER: radiography
QUALIFIER: radiography
AUTHOR: T Araki T
AUTHOR: Y Itai Y
AUTHOR: A Tasaka A
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: AJR. American journal of roentgenology.
COUNTRY: UNITED STATES
TITLE: CT of choledochal cyst.
PUBDATE: 19801001
Ten preoperative cases of choledochal cyst and five patients who had had complications after surgical treatment for their choledochal cysts were studied to evaluate the accuracy of computed tomography (CT) in the diagnosis of this malformation and its complications. Choledochal cysts were accurately diagnosed by CT in seven and suggested in three of the 10 preoperative patients. CT provided the correct diagnosis in all six patients with intrahepatic involvement. The CT pattern of congenital dilatation of the intrahepatic ducts was strikingly different from that of an acquired obstructive one. CT was also effective in the postoperative follow-up patients. In addition, within this group of 15 patients, three choledochal cyst cancers were detected.


12. DOCID:3961 SCORE: 0.00242581491613524
DOCNO: 1026759
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Breast Neoplasms
DESCRIPTOR: Pregnancy Complications
AUTHOR: M Dargent M
AUTHOR: M Mayer M
AUTHOR: J Lansac J
AUTHOR: J L Carret JL
PUBTYPE: Journal Article
JOURNALTITLE: Journal de gynécologie, obstétrique et biologie de la reproduction.
COUNTRY: FRANCE
TITLE: [Breast cancer and pregnancy. Apropos of 96 cases followed for 3 and 1/2 years at the Centre Léon Bérard, Lyons]
PUBDATE: 19760901
96 cases where cancer of the breast and pregnancy were associated have been studied at the Léon Bérard Centre of Lyon with a follow-up of at least 3 years. Those patients who had a malignant tumour of the breast, which was treated, and then became pregnant (19 cases) were not made any worse (79 per cent survival in 5 years). This was quite independent of the outcome of the pregnancy. On the other hand, those women (54 cases) in which the cancer was discovered and treated during pregnancy had a far worse prognosis (20 per cent survival in 5 years). This prognosis was made worse by the discovery of the cancer in the third trimester of the pregnancy, and by the presence of lymph node involvement, by termination of pregnancy and by weaning. When malignant tumours were discovered during breast-feeding or weaning (23 cases) the prognosis was equally bad (23 per cent survival in 3 years). The authors discuss the frequency of the association of cancer of the breast and pregnancy, as well as the different factors in the prognosis. They attempt to outline the management that should be carried out in the light of recent publications on this subject.


13. DOCID:3817 SCORE: 0.00229966009154712
DOCNO: 300876
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ultraviolet Rays
QUALIFIER: immunology
AUTHOR: M S Fisher MS
AUTHOR: M L Kripke ML
PUBTYPE: Journal Article
JOURNALTITLE: Proceedings of the National Academy of Sciences of the United States of America.
COUNTRY: UNITED STATES
TITLE: Systemic alteration induced in mice by ultraviolet light irradiation and its relationship to ultraviolet carcinogenesis.
PUBDATE: 19770401
Chronic irradiation of mice with ultraviolet (UV) light produces a systemic alteration of an immunologic nature. This alteration is detectable in mice long before primary skin cancers induced by UV light begin to appear. The alteration results in the failure of UV-irradiated mice to reject highly antigenic, transplanted UV-induced tumors that are rejected by unirradiated syngeneic recipients. The immunologic aspect of this systemic alteration was demonstrated by transferring lymphoid cells from UV-irradiated mice to lethally x-irradiated recipients. These recipeints were unable to resist a later challenge with a syngeneic UV-induced tumor, whereas those given lymphoid cells from normal donors were resistant to tumor growth. Parabiosis of normal mice with UV-irradiated mice, followed by tumor challenge of both parabionts with a UV-induced tumor, resulted in the growth of the challenge tumors in both UV-irradiated and unirradiated mice. Splenic lymphocytes from tumor-implanted UV-treated mice were not cytotoxic in vitro against UV-induced tumors, whereas under identical conditions cells from tumor-implanted, unirradiated mice were highly cytotoxic. Our findings suggest that repeated UV irradiation can circumvent an immunologic mechanism that might otherwise destroy nascent UV-induced primary tumors that are strongly antigenic.


14. DOCID:6206 SCORE: 0.00229772315958268
DOCNO: 498025
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: H Kodama H
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Modification of muscle-preserving radical mastectomy.
PUBDATE: 19791001
A technical improvement of the muscle-preserving radical mastectomy for breast cancer is presented. In this procedure, the Sulcus interpectoralis, located between clavicular and sternocostal parts of the pectoralis major muscle, is split bluntly and spread apart. Then, the pectoralis minor muscle is severed near its attachment to the coracoid process and an axillary dissection is thereby easily and thoroughly accomplished. The effectiveness of lymph node dissection by this method was ascertained when the number of the lymph nodes removed by this procedure was compared with that removed by the conventional muscle preserving mastectomy (Madden's operation) and the radical mastectomy. Ninety-three patients treated by this operation have shown a satisfactory cosmetic appearance and a good prognosis when compared with patients treated by the standard radical mastectomy.