0. DOCID:7381 SCORE: 0.00380148467146802
DOCNO: 717271
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: metabolism
AUTHOR: E R Eichner ER
AUTHOR: C R McDonald CR
AUTHOR: V L Dickson VL
PUBTYPE: Journal Article
JOURNALTITLE: The American journal of clinical nutrition.
COUNTRY: UNITED STATES
TITLE: Elevated serum levels of unsaturated folate binding protein: clinical correlates in a general hospital population.
PUBDATE: 19781101
We measured the capactiy of unsaturated folate binding protein to bind 3H-pteroylglutamic acid (UFBC) in serums from 489 general hospital patients. Of the patients 20% had mild-to-moderate elevations in UFBC (250 to 500 pg/ml), but only 6% had marked elevations (greater than 650 pg/ml), which correlated with metastatic cancer, active granulomatous disease, and especially with liver disease. The poor correlation of serum UFBC with folate status of the patient suggests that in many instances the elevated serum UFBC is neither the consequence nor the cause of folate deficiency. Although the role of folate binding protein remains unknown, it may be primarily an intracellular protein that is released into the serum as an index of activity of liver cells, granulocytes, and perhaps certain cancer cells.


1. DOCID:6879 SCORE: 0.00318038610868272
DOCNO: 7442196
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Speech
DESCRIPTOR: Speech Acoustics
QUALIFIER: physiopathology
AUTHOR: T Murry T
AUTHOR: E T Doherty ET
PUBTYPE: Journal Article
JOURNALTITLE: Journal of speech and hearing research.
COUNTRY: UNITED STATES
TITLE: Selected acoustic characteristics of pathologic and normal speakers.
PUBDATE: 19800601
The purpose of this study was to determine if measures of speaking fundamental frequency and its perturbation could be useful in differentiating talkers with no known vocal pathology and talkers with cancer of the larynx. Ten male subjects, five with a diagnosed malignancy of the larynx and five with normal voice, produced speech samples from which five voice production measures were obtained: the average speaking fundamental frequency (SFF), SFF variability during the reading of a sentence, the fo of a sustained vowel and a percent and magnitude jitter value. The perturbation factors, both directional and magnitudinal, during sustained vowels were found to be significant in discriminating normal talkers from those with laryngeal cancer. The speaking fundamental frequency and its variability during the reading of a sentence improved the discriminant function.


2. DOCID:3896 SCORE: 0.0031511091785644
DOCNO: 1192433
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Precancerous Conditions
QUALIFIER: pathology
QUALIFIER: etiology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: K Toyoshima K
AUTHOR: J Leighton J
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Bladder calculi and urothelial hyperplasia with papillomatosis in the rat following insertion of chalk powder in the bladder cavity with subsequent trauma of the bladder wall.
PUBDATE: 19751201
A suspension of chalk powder was injected into the cavity of the urinary bladder of Fischer 344 rats. Three weeks later rats were divided into 4 major groups and were given a submucosal injection. One group received a suspension of viable Chapman 4909 tumor cells, the 2nd group received a suspension of frozen-killed 4909 tumor cells, the 3rd group received a suspension of normal rat spleen cells, and the 4th group received cell-free fresh tissue culture medium. After 3 additional weeks urolithiasis was recognized in each experimental group. The incidence of calculi in the groups as listed above was 14 of 17, 6 of 11, 6 of 11, and 2 of 15, respectively. In control studies inocula consisted of tumor alone, i.e., without chalk powder. Inoculation of the 4909 rat bladder cancer cell line into the lumen of urinary bladders of rats did not result in any calculi after 3 weeks but did produce intramural tumor nodules and hyperplastic changes in adjacent host urothelium in 2 of 10 rats. The tumor inoculated in the submucosa of the bladder produced calculi and papillomas in 2 of 7 rats, and it produced intramural tumor nodules with adjacent hyperplasia of urothelium in all 7 rats.


3. DOCID:10894 SCORE: 0.00310170881072735
DOCNO: 6410105
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
AUTHOR: M Abe M
AUTHOR: M Takahashi M
AUTHOR: K Ono K
AUTHOR: Y Dodo Y
AUTHOR: M Hiraoka M
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Intraoperative radiotherapy for locally advanced refractory cancer]
PUBDATE: 19830501
Clinical results of intraoperative radiotherapy (IOR) in carcinoma of the stomach and prostate, and malignant soft tissue tumors are reported. The 5-year survival rate was found to be increased by IOR in stages II-IV gastric cancer. From the analysis of the clinical results of prostatic cancer, a single dose of 3,500 rad was considered to be a potential curative dose for the tumor less than 3 cm in diameter. The local recurrence rate of patients with malignant soft tissue tumors who received a single dose ranging from 3,000 to 4,500 rad was 5.9 and the 5-year survival rate was 64.6%.


4. DOCID:11680 SCORE: 0.00298828475605901
DOCNO: 6468285
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: G J Röth GJ
AUTHOR: E Schirner E
AUTHOR: O P Hornstein OP
AUTHOR: M Simon M
PUBTYPE: Journal Article
JOURNALTITLE: Deutsche medizinische Wochenschrift (1946)
COUNTRY: GERMANY, WEST
TITLE: [Precancerous conditions and carcinomas of the lower lip. Coincidence with leukoplakia and carcinomas of the oral cavity and larynx]
PUBDATE: 19840801
In a prospective study of 102 patients with pre-neoplasia and/or manifest squamous-cell carcinoma of the lower lip the synchronous occurrence of intra-oral, pharyngeal or laryngeal leukoplakia and carcinoma was assessed. There was a coincidence rate of almost 15% leukoplakias, including individual carcinomas. This high coincidence is probably due to a combination of various "risk profiles" in patients with threatened or manifest lower-lip cancer. Chronic exposure to sunlight, especially in the presence of a genetic disposition, is the most important risk factor in lower-lip cancer and its preceding stages, while chronic alcoholism and smoking abuse have little etiological significance.


5. DOCID:6865 SCORE: 0.00284825193584826
DOCNO: 7309279
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: H G Kwa HG
AUTHOR: F Cleton F
AUTHOR: R D Bulbrook RD
AUTHOR: D Y Wang DY
AUTHOR: J L Hayward JL
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: Plasma prolactin levels and breast cancer: relation to parity, weight and height, and age at first birth.
PUBDATE: 19810701
Plasma prolactin has been measured in over 3,500 women volunteers from a normal population. In premenopausal women there was a significant decrease in prolactin levels with increasing parity. However, this effect was transitory since plasma prolactin concentration rose with increasing time after the birth of the last child. There were no significant differences in prolactin levels with respect to height and weight, although overweight compared to underweight women had approximately 15% more plasma prolactin. If prolactin is a carcinogen, then these results are in keeping with the epidemiological findings that multiparity affords protection and that age at last delivery is a risk factor in the development of breast cancer.


6. DOCID:1189 SCORE: 0.00258202034869509
DOCNO: 1008991
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Leukocyte Count
DESCRIPTOR: Lymphocytes
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: C R Franks CR
AUTHOR: Y Williams Y
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Prognostic value of peripheral lymphocyte count in hormone therapy of advanced breast cancer.
PUBDATE: 19761201
Peripheral lymphocyte counts were performed on 41 patients with advanced breast cancer, before starting treatment with oestrogens or androgens. Patients were seen at monthly intervals, and the response to treatment was independently assessed, using the criteria of the British Breast Group. In the patients treated with oestrogens and androgens, the successful responders were found to have significantly higher pre-treatment peripheral lymphocyte counts than the intermediate responders and failures. It is suggested that pre-treatment peripheral lymphocyte counts may have a prognostic value in assessing potential response to hormone therapy in patients with breast cancer.


7. DOCID:9109 SCORE: 0.00256538673069854
DOCNO: 6837865
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: D Tong D
AUTHOR: A H Russell AH
AUTHOR: L E Dawson LE
AUTHOR: W Wisbeck W
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: Second laparotomy for proximal colon cancer. Sites of recurrence and implications for adjuvant therapy.
PUBDATE: 19830301
Sixty-four patients with primary adenocarcinomas of the colon proximal to the peritoneal reflection underwent exploratory laparotomy at the time of first recurrence of their cancers. Local recurrence, retroperitoneal lymph node metastases, parenchymal liver metastases, and diffuse peritoneal seeding were identified as frequent components of the overall pattern of recurrence. The significance of these findings has been discussed herein, relative to refinements of operative technique and selection of appropriate adjuvant therapy.


8. DOCID:9880 SCORE: 0.00248506848162321
DOCNO: 6319654
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: H F Hull HF
AUTHOR: J D Blumhagen JD
AUTHOR: D Benjamin D
AUTHOR: L Corey L
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of pediatrics.
COUNTRY: UNITED STATES
TITLE: Herpes simplex viral pneumonitis in childhood.
PUBDATE: 19840201
We report two cases of herpes simplex pneumonia in children. One patient had Down syndrome, and the other was immunosuppressed by cancer therapy. Both had interstitial pneumonitis with nonspecific physical, radiographic, and laboratory findings, and both died. The diagnosis of herpes simplex pneumonia was made by isolation of herpes simplex virus from autopsy lung cultures as well as by demonstration of antigen in the tissue with an immunoperoxidase procedure. Inasmuch as herpes simplex pneumonia is a potentially treatable infection, early virologic studies are recommended in immunocompromised children with progressive pneumonitis of undetermined cause.


9. DOCID:3705 SCORE: 0.00247984298213518
DOCNO: 414402
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: prevention & control
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
AUTHOR: D Byar D
AUTHOR: C Blackard C
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Urology.
COUNTRY: UNITED STATES
TITLE: Comparisons of placebo, pyridoxine, and topical thiotepa in preventing recurrence of stage I bladder cancer.
PUBDATE: 19771201
Animal studies have shown that metabolites of tryptophan can cause bladder cancer, and human observations reveal an appreciable incidence of abnormalities of tryptophan metabolism in patients with bladder cancer. It has been suggested that pyridoxine (vitamin B6) may correct this abnormality and prevent recurrences of superficial bladder cancers. Intravesical instillation of thiotepa has been used for more than fifteen years in the treatment of superficial bladder cancer, but no controlled trials have been done. We report here a prospective clinical trial of 121 patients with Stage I bladder cancer randomized to placebo, pyridoxine, or intravesical thiotepa. The percentages of patients with recurrences over the period of study were 60.4, 46.9, and 47.4 for the three groups, respectively, and did not differ significantly. However, if patients having recurrences during the first ten months or followed up less than ten months were excluded, pyridoxine was significantly better than placebo (P = 0.03). Thiotepa significantly reduced the recurrence rate compared with placebo (P = 0.016) or pyridoxine (P = 0.015). These results suggest that a new trial of pyridoxine should be undertaken in which the tryptophan metabolites are measured and that further study of intravesical instillation of chemotherapeutic agents is warranted.


10. DOCID:2529 SCORE: 0.00247784997504117
DOCNO: 49475
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: microbiology
QUALIFIER: genetics
AUTHOR: E Bone E
AUTHOR: B S Drasar BS
AUTHOR: M J Hill MJ
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Gut bacteria and their metabolic activities in familiar polyposis.
PUBDATE: 19750501
Earlier work had suggested that patients with large-bowel cancer can be characterized by carriage of clostridia capable of dehydrogenating the nucleus of steroids and by high faecal bile-acid concentrations. Familial polyposis is an inherited disease which untreated, will progress to cancer of the large bowel, and those affected might be expected to have these metabolic characteristics. However, enviromental factors seem to play no part in polyposis. Investigation of as yet unaffected children of known polyposis patients revealed that the gut flora of half of them did not degrade cholesterol in vivo andnor did flora from patients in whom polyposis had already been diagnosed. The reason for this is unknown, but if the same patients develop polyposis (i.e., they carry the abnormal gene) we would have a simple diagnostic test which could replace the continuing follow-up now required for the siblings and children of patients with polyposis.


11. DOCID:6414 SCORE: 0.00246463713820319
DOCNO: 7471471
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: enzymology
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: A A Keshgegian AA
PUBTYPE: Journal Article
JOURNALTITLE: Clinica chimica acta; international journal of clinical chemistry.
COUNTRY: NETHERLANDS
TITLE: No relationship between lactate dehydrogenase and estrogen receptor levels in clinical human breast cancer.
PUBDATE: 19801201
The level of lactate dehydrogenase has been reported to increase in a human breast cancer cell line as a result of estrogen action [4]. This finding suggests that lactate dehydrogenase may be useful in clinical human breast cancer as a marker for intactness of the estrogen receptor pathway and for probability of response to hormonal therapy. In 97 hunan breast cancer specimens submitted for estrogen receptor analysis, the level of lactate dehydrogenase varied from 0.19 to 3.3 I.U. per mg of extractable protein and bore no relation with either the presence of estrogen receptor or its level. It thus appears that lactate dehydrogenase is not a useful marker for endocrine responsiveness in clinical breast tumors.


12. DOCID:3245 SCORE: 0.00245831205337075
DOCNO: 128842
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunity
QUALIFIER: immunology
QUALIFIER: surgery
AUTHOR: J A Roth JA
AUTHOR: S H Golub SH
AUTHOR: E A Grimm EA
AUTHOR: F R Eilber FR
AUTHOR: D L Morton DL
PUBTYPE: Journal Article
JOURNALTITLE: Surgery.
COUNTRY: UNITED STATES
TITLE: Effects of operation on immune response in cancer patients: sequential evaluation of in vitro lymphocyte function.
PUBDATE: 19760101
The effect of operation on in vitro lymphocyte function in 35 cancer patients was studied. Lymphocyte proliferative responses to phytohemagglutinin (PHA), poke-weed mitogen (PWM), and concanavalin A (Con A) were measured by 3H-thymidine incorporation. Sheep red blood cell (SRBC) rosette formation also was quantitated. These tests were performed preoperatively and at 24 hours, one week, and 4 weeks postoperatively. Intra-abdominal and intrathoracic procedures, transfusions, and longer operating times depressed the lymphocyte proliferative response. However, an increased lymphocyte proliferative response was noted in sarcoma patients 24 hours postoperatively, possibly as a result of lowered tumor burden. Several of these changes still were evident 4 weeks after operation. Rosette formation also decreased significantly 24 hours postoperatively in patients who had intrathoracic or intra-abdominal procedures, but returned to preoperative levels after one week. In general, operation appears to cause transient depression of lymphocyte function in some cancer patients. However, lymphocyte function returns to normal by the fourth postoperative week in most patients.


13. DOCID:3584 SCORE: 0.00243976298655628
DOCNO: 338105
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: therapeutic use
QUALIFIER: prevention & control
QUALIFIER: surgery
AUTHOR: I Taylor I
AUTHOR: P Brooman P
AUTHOR: J T Rowling JT
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: British medical journal.
COUNTRY: ENGLAND
TITLE: Adjuvant liver perfusion in colorectal cancer: initial results of a clinical trial.
PUBDATE: 19771101
Fifty consecutive patients with colorectal cancer but no evidence of secondary deposits in the liver were included in an ongoing controlled clinical trial of adjuvant liver perfusion aimed at reducing the incidence of hepatic metastases. All patients had their primary tumour resected in the standard way. Twenty-six of the patients served as controls, and 24 received fluorouracil, 1 g daily, as a continuous infusion into the portal venous system during the first seven days after operation. The patients were matched for age, sex, and site and stage of the disease. The immediate postoperative mortality and morbidity did not differ significantly between the two groups. During the follow-up period (mean duration 15.5 months), however, six deaths occurred in the control group and only one in the perfusion group. At necropsy four of the controls had multiple liver metastases. Two of the surviving controls developed evidence of liver metastases, and two had a local recurrence. No patient in the perfusion group developed evidence of hepatic metastases. These initial results suggest that adjuvant portal venous perfusion with fluorouracil may reduce the incidence of liver metastases in colorectal cancer.


14. DOCID:6556 SCORE: 0.00243433609486042
DOCNO: 371803
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: F Cabanillas F
AUTHOR: G P Bodey GP
AUTHOR: M A Burgess MA
AUTHOR: E J Freireich EJ
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Cancer treatment reports.
COUNTRY: UNITED STATES
TITLE: Results of a phase II study of maytansine in patients with breast carcinoma and melanoma.
PUBDATE: 19790301
During the phase I study of maytansine at our institution, some activity was observed against breast carcinoma and melanoma. A phase II study was thus initiated to more thoroughly investigate the activity of this drug against these two tumors. In 33 evaluable patients with melanoma, no complete or partial responses were observed. Twenty-one evaluable patients with breast cancer were entered and only one response (partial) was seen. The toxicity was similar to that observed in the phase I study and consisted mainly of diarrhea, paresthesias, phlebitis, and flu-like symptoms. Myelosuppression was infrequent and was short-lived when it occurred.