0. DOCID:30774 SCORE: 0.00499344580281483
DOCNO: 11890096
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: drug therapy
QUALIFIER: genetics
AUTHOR: Tetsuya Mitsudomi T
AFFILIATION: Department of Thoracic Surgery, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan. mitsudom@leo.bekkoame.ne.jp
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: Japan
TITLE: Molecular lesions as targets for diagnosis and therapy of lung cancer.
PUBDATE: 20020201
Alteration of the p53 tumor suppressor gene is one of the most frequently seen molecular lesions in human lung cancer. It is of importance to integrate translational science into clinical practice. In our laboratory, we are in search for clinical utility of p53 gene alterations in management of patients with lung cancer. Here, we would like to discuss p53 alterations as a prognostic factor for lung cancer patients or as a predictor of chemosensitivity.

1. DOCID:30185 SCORE: 0.00499344441803905
DOCNO: 14612484
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: history
AUTHOR: Marcia L Meldrum ML
AFFILIATION: Department of History, University of California-Los Angeles, Los Angeles 90095-1473, USA. mlynnmel@earthlink.net
PUBTYPE: Historical Article
PUBTYPE: Journal Article
JOURNALTITLE: JAMA : the journal of the American Medical Association.
COUNTRY: United States
TITLE: A capsule history of pain management.
PUBDATE: 20031101
Pain is a complex clinical problem. Assessment depends on verbal report, and the patient's physical perceptions may be modified by cognitive and affective factors. The salience of pain as a problem in its own right has grown since 1945 and new therapeutic alternatives have developed from research and from new theoretical perspectives. This short historical review of the highlights of the history of pain management gives particular emphasis to the 20th century and to chronic and cancer pain.

2. DOCID:30402 SCORE: 0.00354833038604926
DOCNO: 14520433
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Bone Marrow Transplantation
DESCRIPTOR: Hematopoietic Stem Cell Transplantation
QUALIFIER: adverse effects
QUALIFIER: chemically induced
QUALIFIER: therapy
AUTHOR: C Palmieri C
AUTHOR: R Gillmore R
AUTHOR: A Menzies-Gow A
AUTHOR: S Fishpool S
AUTHOR: D Robinson D
AUTHOR: R Shaw R
AUTHOR: R C Coombes RC
AFFILIATION: Department of Medical Oncology, Charing Cross Hospital, Fulham Palace Road, London, UK. c.palmieri@ic.ac.uk
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Bone marrow transplantation.
COUNTRY: England
TITLE: Resolution of late-onset asthma following high-dose chemotherapy.
PUBDATE: 20031001
We describe a patient with moderately severe (British Thorax Society Step IV/V) asthma requiring regular inhaled and oral corticosteroids to control symptoms who experienced resolution of her asthma following high-dose chemotherapy and autologous stem cell transplantation for breast cancer. As far as the authors are aware this is the first reported case.

3. DOCID:30278 SCORE: 0.002651528310941
DOCNO: 14763146
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: Jacques Bosq J
AUTHOR: Frédérique Penault-Llorca F
AUTHOR: Jean-Claude Sabourin JC
AFFILIATION: Département de pathologie, Institut Gustave-Roussy, rue Camille-Desmoulins, 94805 Villejuif. bosq@igr.fr
PUBTYPE: Journal Article
JOURNALTITLE: Bulletin du cancer.
COUNTRY: France
TITLE: [Expression of epidermal growth factor receptor and its ligands in other malignant tumor pathologies]
PUBDATE: 20031101
The aim of this review was to describe expression of epithelial growth factor receptor (EGFR) and of its ligands in a panel of tumours (which are not specified elsewhere in this special issue of Bulletin du Cancer): squamous cell carcinomas, adenocarcinomas, sarcomas, brain and germ line tumours. The role of EGFR and its ligands in the carcinogenesis and the progression of these tumours, as well as the relevance of targeting EGFR.

4. DOCID:29998 SCORE: 0.00251641208437825
DOCNO: 12879794
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: etiology
QUALIFIER: epidemiology
QUALIFIER: etiology
AUTHOR: Annie Sasco A
AFFILIATION: Centre international de recherche sur le cancer Unité d'épidémiologie pour la prévention du cancer et Institut national de la santé et de la recherche médicale 69372 Lyon. sasco@iarc.fr
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: La Revue du praticien.
COUNTRY: France
TITLE: [Epidemiology of lung carcinoma]
PUBDATE: 20030401
Lung cancer is the most common cancer in the world, either in terms of incidence or mortality, and it is still increasing in particular in the developing world and among women. The vast majority of lung cancers are due to tobacco smoking and therefore primary prevention through efficient tobacco control is possible. Occupational carcinogens are also recognised and the role of environmental exposures remains to be defined.

5. DOCID:30969 SCORE: 0.00239355205968118
DOCNO: 14584403
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Vaginal Smears
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: Deborah A Simon DA
AUTHOR: Elizabeth Dimitrievich E
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: South Dakota journal of medicine.
COUNTRY: United States
TITLE: Case report: detection of an advanced ovarian malignancy by cervical cytology.
PUBDATE: 20031001
There are currently no recommended screening tests for the early detection of ovarian cancer. Ovarian malignancies are most often discovered on bimanual exam at advanced stages, resulting in a high mortality from this disease. While the Papanicolaou (Pap) smear is not a reliable screen for the detection of ovarian cancer, abnormal cytology may be the initial indicator of ovarian malignancy. This is a case report of an invasive serous adenocarcinoma of the ovary that was discovered as the result of a clinical work-up for abnormal cytology reported on a Pap smear.

6. DOCID:30749 SCORE: 0.00219044561520406
DOCNO: 12901942
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: antagonists & inhibitors
AUTHOR: Paul A Marks PA
AUTHOR: Thomas Miller T
AUTHOR: Victoria M Richon VM
AFFILIATION: Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. munroed@mskcc.org
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in pharmacology.
COUNTRY: England
TITLE: Histone deacetylases.
PUBDATE: 20030801
Post-translational modification of the histones of chromatin has a fundamental role in regulating gene expression. Enzymes involved in these epigenetic events include histone deacetylases (class I and class II), which can be inhibited by a structurally diverse group of small molecules. These histone deacetylase inhibitors induce growth arrest, differentiation and/or apoptosis of cancer cells in vitro and in vivo. Results of clinical trials with several of these agents have indicated that they are well tolerated at doses that have anti-tumour activity.

7. DOCID:31879 SCORE: 0.00213226870875498
DOCNO: 15706282
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Drug Therapy
DESCRIPTOR: Pharmaceutical Preparations
AUTHOR: Daniel A Hussar DA
AFFILIATION: Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, PA, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nursing.
COUNTRY: United States
TITLE: New drugs 05, part I.
PUBDATE: 20050201
In this article, you'll learn about nine new drugs, including: Prussian blue, which could protect people from radiation exposure following an act of biochemical terrorism. Bevacizumab, a new monoclonal antibody and the first angiogenesis inhibitor for colorectal cancer. Cinacalcet HCl, the first calcimimetic drug for treating hyperparathyroidism. Unless otherwise specified, the information in the following summaries applies to adults, not children. Consult the package insert for information about each drug's safety during pregnancy and breast-feeding. Also consult the package insert, a pharmacist, or a comprehensive drug reference for more details on precautions, drug interactions, and adverse reactions for all these drugs.

8. DOCID:28646 SCORE: 0.002043126561488
DOCNO: 15052182
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Lumbar Vertebrae
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: A Salem A
AUTHOR: N Mnif N
AUTHOR: M Karray M
AUTHOR: L Kribi L
AUTHOR: T Ellouze T
AUTHOR: R Hamza R
AFFILIATION: EPS Charles-Nicolle, boulevard du 9-Avril, 1006 Tunis, Tunisie.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal de gynécologie, obstétrique et biologie de la reproduction.
COUNTRY: France
TITLE: [Double location of breast and spine tuberculosis. A case report]
PUBDATE: 20040401
We describe the case of a 38-year-old woman with breast tuberculosis associated with a second localization in the lumber spine. These features simulated breast cancer with vertebral metastasis. Clinical and imaging findings are described herein.

9. DOCID:28192 SCORE: 0.00195812672012618
DOCNO: 12717523
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genetic Heterogeneity
QUALIFIER: genetics
AUTHOR: L A Sheklakova LA
AUTHOR: V D Kallinikova VD
AUTHOR: L P Karpenko LP
AFFILIATION: M. V. Lomonosov Moscow State University.
PUBTYPE: Journal Article
JOURNALTITLE: Bulletin of experimental biology and medicine.
COUNTRY: United States
TITLE: Genetic heterogeneity of Trypanosoma cruzi and its direct anticancer effect in cultured human tumor cells.
PUBDATE: 20030101
The direct inhibitory effect of Trypanosoma cruzi epimastigote lysates on in vitro cultured human breast cancer MCF-7 cells differs in various genetic groups and cloned subgroups of Trypanosoma.

10. DOCID:29028 SCORE: 0.00195249073064019
DOCNO: 12095922
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Culture
DESCRIPTOR: Recovery of Function
QUALIFIER: psychology
AUTHOR: Anna Barbera A
AUTHOR: Lina Prosa L
AFFILIATION: Associazione Arlenika, Progetto Amazzone, Palermo, Italy.
PUBTYPE: Journal Article
JOURNALTITLE: Annals of the New York Academy of Sciences.
COUNTRY: United States
TITLE: The Amazon Project: helping the patient to become an instrument of her own recovery.
PUBDATE: 20020601
The Amazon Project combines science, myth, and theater to explore problems linked to cancer and its surgical management in women from a social, political, and cultural point of view. This Project is concerned with change in the hope that one day it will be possible to discuss, along with the Science of Medicine, the Science of Patients as well.

11. DOCID:29379 SCORE: 0.0019463945240477
DOCNO: 12825923
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nuclear Proteins
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
QUALIFIER: analogs & derivatives
QUALIFIER: chemical synthesis
AUTHOR: Srinivas K Kumar SK
AUTHOR: Erin Hager E
AUTHOR: Catherine Pettit C
AUTHOR: Hallur Gurulingappa H
AUTHOR: Nancy E Davidson NE
AUTHOR: Saeed R Khan SR
AFFILIATION: Division of Experimental Therapeutics, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of medicinal chemistry.
COUNTRY: United States
TITLE: Design, synthesis, and evaluation of novel boronic-chalcone derivatives as antitumor agents.
PUBDATE: 20030701
A series of boronic-chalcone derivatives were synthesized and tested for antitumor activity against human breast cancer cell lines. The results show the boronic-chalcones are more toxic to breast cancer cells compared to normal breast cells than other known chalcones.

12. DOCID:31092 SCORE: 0.00194334741523502
DOCNO: 12944993
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ultrasonography, Doppler, Color
QUALIFIER: ultrasonography
AUTHOR: Koji Okihara K
AUTHOR: Osamu Ukimura O
AUTHOR: Yoichi Mizutani Y
AUTHOR: Akihiro Kawauchi A
AUTHOR: Masahiro Nakao M
AUTHOR: Tsuneharu Miki T
AFFILIATION: Department of Urology, Kyoto Prefectural University of Medicine, Kawarama-chi-Hirokoji, Kyoto, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Drugs of today (Barcelona, Spain : 1998)
COUNTRY: Spain
TITLE: Prostate cancer detection using power Doppler imaging.
PUBDATE: 20030601
Various preliminary and reassessment articles focusing on power Doppler imaging to detect prostate cancer have studied the potential of this powerful tool. By identifying abnormal vascular flow, power Doppler imaging can enhance prostate cancer detection. However, according to recent articles, the applications for biopsy-guided power Doppler imaging targeting the intermediate serum prostate-specific antigen range has some limitations. Three-dimensional reconstruction of power Doppler imaging is a promising technique to improve cancer detection.

13. DOCID:31132 SCORE: 0.00194334566397682
DOCNO: 16296803
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: chemistry
QUALIFIER: chemistry
QUALIFIER: therapeutic use
AUTHOR: Amin I Kassis AI
AFFILIATION: Harvard Medical School, Department of Radiology, Boston, MA 02115, USA. amin_kassis@hms.harvard.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Expert opinion on drug delivery.
COUNTRY: England
TITLE: Radiotargeting agents for cancer therapy.
PUBDATE: 20051101
Although the general radiobiological principles underlying external beam therapy and radionuclide therapy are the same, there are significant differences in the radiobiological effects observed in mammalian cells. In external beam therapy and brachytherapy, emissions are composed of photons, whereas in radionuclide therapy, the radiations of interest are particulate. This article will explore the special features that characterise the biological effects consequent to the traversal of charged particles through mammalian cells. In addition, it will highlight what has been learned when these radionuclides and targeting radiopharmaceuticals are used to treat cancers.

14. DOCID:31150 SCORE: 0.00194334473144375
DOCNO: 16309305
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemistry
QUALIFIER: pharmacology
QUALIFIER: isolation & purification
AUTHOR: Omar E Christian OE
AUTHOR: Jennifer Compton J
AUTHOR: Keisha R Christian KR
AUTHOR: Susan L Mooberry SL
AUTHOR: Fredrick A Valeriote FA
AUTHOR: Phillip Crews P
AFFILIATION: Department of Chemistry and Biochemistry and Institute for Marine Sciences, University of California, Santa Cruz, California 95064, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of natural products.
COUNTRY: United States
TITLE: Using jasplakinolide to turn on pathways that enable the isolation of new chaetoglobosins from Phomospis asparagi.
PUBDATE: 20051101
The isolation and structure elucidation of three new secondary metabolites, chaetoglobosin-510 (1), -540 (2), and -542 (3), are described. These compounds were produced by cultures of the marine-derived fungus Phomopsis asparagi, challenged with the known F-actin inhibitor jasplakinolide. Chaetoglobosin-542 (3) displayed antimicrofilament activity and was cytotoxic toward murine colon and leukemia cancer cell lines.