0. DOCID:23959 SCORE: 0.00315438316465281
DOCNO: 7600136
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Helicobacter pylori
QUALIFIER: etiology
QUALIFIER: complications
QUALIFIER: etiology
QUALIFIER: etiology
AUTHOR: S Eidt S
AUTHOR: M Stolte M
AFFILIATION: Institute of Pathology, University of Cologne, Germany.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: European journal of gastroenterology & hepatology.
COUNTRY: ENGLAND
TITLE: The significance of Helicobacter pylori in relation to gastric cancer and lymphoma.
PUBDATE: 19950401
The evidence linking Helicobacter pylori and non-cardia gastric adenocarcinoma is accumulating. Patterns of strain specificities and host factors that increase epithelial proliferation and have implications for mutagenic effects are evolving. The decision by the World Health Organization and the International Agency for Research on Cancer to classify H. pylori as a 'definite' carcinogen, however, represents a milestone in the association of H. pylori with gastric carcinogenesis. The importance of H. pylori in gastric lymphoma has been underscored by the finding that H. pylori eradication can induce complete regression in low-grade mucosa-associated lymphoid tissue lymphomas, at least in the early stages of development.


1. DOCID:20250 SCORE: 0.00278987709114149
DOCNO: 8862710
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Taxoids
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: analogs & derivatives
AUTHOR: J P Armand JP
AFFILIATION: Department of Medicine, Institut Gustave-Roussy, Villejuif, Paris, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Anti-cancer drugs.
COUNTRY: ENGLAND
TITLE: The clinical rationale for developing docetaxel (Taxotere).
PUBDATE: 19960801
Clinical empiricism has recognized resistant breast cancer as a privileged target for docetaxel (Taxotere). This worldwide registration will offer medical oncologists the opportunity to develop new indications for docetaxel. Pharmacokinetics, preclinical optimal combination and clinical practice will constitute the rationale for the future development of docetaxel.


2. DOCID:22643 SCORE: 0.00262309324165023
DOCNO: 8965365
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: K Sugino K
AUTHOR: K Ito K
AFFILIATION: Ito Hospital.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: JAPAN
TITLE: [Thyroid microcarcinoma]
PUBDATE: 19960501
The term "early cancer of the thyroid" is not clearly defined. Recently, microcarcinoma of the thyroid, less than 10 mm, has been frequently detected and in Ito Hospital smaller papillary carcinoma has increased in these 10 years. As rate of microcarcinoma found in autopsy cases were reported 10-28.4% in Japan, all of thyroid microcarcinoma are not thought to be developed clinically. In our hospital, papillary microcarcinoma diagnosed preoperatively underwent lobectomy with modified neck dissection in principle. Lymph node metastases were found in 65% of patients with papillary microcarcinoma. Further studies and discussion concerned whether thyroid microcarcinoma should be treated and how it should be treated, is necessary.


3. DOCID:22465 SCORE: 0.00254923375704502
DOCNO: 9457985
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: methods
QUALIFIER: surgery
QUALIFIER: adverse effects
QUALIFIER: chemically induced
QUALIFIER: therapy
AUTHOR: T Römer T
AFFILIATION: Department of Obstetrics and Gynecology, Ernst-Moritz-Arndt-University of Greifswald, Germany.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.
COUNTRY: IRELAND
TITLE: Successful treatment of recurrent uterine bleeding during tamoxifen therapy by endometrial ablation.
PUBDATE: 19950401
Recurrent bleeding occurred in a premenopausal breast cancer woman during tamoxifen therapy. This bleeding required three curettages. Atypical hyperplasia and carcinoma were excluded, and the patient was prepared for endometrial ablation with two GnRH agonist injections. An endometrial ablation using the roller ball technique was carried out without complications. Tamoxifen therapy was continued postoperatively. During 24 months' follow-up the patient experienced no bleeding and no endometrium was seen by sonography.


4. DOCID:23750 SCORE: 0.00246404586745631
DOCNO: 8608062
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: economics
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: J A Glaspy JA
AFFILIATION: Department of Medicine, UCLA School of Medicine, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncology (Williston Park, N.Y.)
COUNTRY: UNITED STATES
TITLE: Economic outcomes associated with the use of hematopoietic growth factors.
PUBDATE: 19951101
The myeloid growth factors G-CSF and GM-CSF have had an impact on the supportive care of cancer patients as well as on the strategies utilized in chemotherapy dose intensification. Therapy with these factors has not been associated with improvements in survival, and hence an examination of their effects on economic outcomes is central to rational decision making regarding their use. Erythropoietin therapy has been shown to decrease transfusion requirements in anemic cancer patients undergoing chemotherapy and to improve the quality of life in responding patients. The available data on the economic outcomes associated with the use of these three factors in oncology practice are reviewed.


5. DOCID:23944 SCORE: 0.00235665887606139
DOCNO: 8597089
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: pharmacology
AUTHOR: S Agrawal S
AUTHOR: P K Rustagi PK
AUTHOR: D R Shaw DR
AFFILIATION: Hybridon, Inc., Worcester, MA 01605, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Toxicology letters.
COUNTRY: NETHERLANDS
TITLE: Novel enzymatic and immunological responses to oligonucleotides.
PUBDATE: 19951201
Oligonucleotide phosphorothioates (PS-oligos) are being studied as antisense agents for viral infection and cancer. In preclinical studies, PS-oligos produced dose-dependent changes in heart rate and blood pressure and significantly reduced serum hemolytic complement, which could be avoided by slowing infusion rates. Here, in vitro PS-oligo treatment of either human, rhesus monkey or guinea pig serum reduced hemolytic complement and further inhibited in vitro coagulation when added to whole blood or citrated plasma. These effects were dependent upon both oligonucleotide dose and structure. Oligonucleotides having identical sequences but containing methylphosphonates (Chimeric), 2'-O-methyl ribonucleosides (Hybrid) or 3' hairpin loop (Self-stabilized) had altered effects on complement and coagulation in vitro.


6. DOCID:22466 SCORE: 0.00235393047821406
DOCNO: 10154406
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Clinical Trials
QUALIFIER: therapy
QUALIFIER: legislation & jurisprudence
QUALIFIER: economics
PUBTYPE: Journal Article
JOURNALTITLE: Federal register.
COUNTRY: UNITED STATES
TITLE: Cancer treatment clinical trials--DoD. Notice of demonstration project.
PUBDATE: 19960101
This notice is to advise interested parties of a demonstration project in which the DoD will expand a current demonstration for breast cancer treatment clinical trials to include all cancer treatment clinical trials under approved National Institutes of Health, National Cancer Institute (NCI) clinical trials. Participation in these clinical trials will improve accessing to promising cancer therapies for CHAMPUS eligible beneficiaries when their conditions meet protocol eligibility criteria. DoD financing of these procedures will assist in meeting clinical trial goals and arrival at conclusions regarding the safety and efficacy of emerging therapies in the treatment of cancer. This demonstration project is under the authority of 10 U.S.C. 1092.


7. DOCID:22787 SCORE: 0.00234613166505591
DOCNO: 9048863
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cystectomy
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: M A Ghoneim MA
AFFILIATION: Department of Urology, University of Mansoura, Egypt.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: The Urologic clinics of North America.
COUNTRY: UNITED STATES
TITLE: Orthotopic bladder substitution in women following cystectomy for bladder cancer.
PUBDATE: 19970201
The feasibility of orthotopic substitution of the bladder after cystectomy for cancer has been realized. One must be careful about two potential drawbacks that may appear. Cases must be selected carefully and followed up to ensure that the adoption of such a procedure does not increase the risk of local recurrences. In the long term, if overcontinence proves to be a problem among a significant proportion of such cases, the logic of and the need for orthotopic substitution are lost. One then has to reconsider that intermittent catheterization of a continent cutaneous stoma provides a better alternative.


8. DOCID:22444 SCORE: 0.00225150028981825
DOCNO: 8970599
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: J M Jenrette JM
AFFILIATION: Department of Radiation Oncology, Medical University of South Carolina, Charleston 29425, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in oncology.
COUNTRY: UNITED STATES
TITLE: Malignant melanoma: the role of radiation therapy revisited.
PUBDATE: 19961201
In a multidisciplinary approach to the treatment of malignant melanoma, the role of radiation therapy is often relegated to one of minor importance. There is a supporting body of scientific literature that shows a relative radioresistance of melanoma when compared with other malignancies. Others have disputed the notion of resistance and have recommended radiation in a number of clinical settings including not only palliation but also in the primary management of melanoma. This article reviews the current and historical literature to better define the current role of radiation in a multidisciplinary approach for cancer management.


9. DOCID:21663 SCORE: 0.00214397819734103
DOCNO: 9340233
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: methods
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: H P Bruch HP
AUTHOR: G Kolbert G
AFFILIATION: Chirurgische Klinik, Medizinischen Universität zu Lübeck.
PUBTYPE: Journal Article
JOURNALTITLE: Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen.
COUNTRY: GERMANY
TITLE: [Results of deep rectum resection and intersphincteric rectum excision]
PUBDATE: 19970701
Low resection and intersphincteric extirpation of rectal cancer in the distal third of the rectum has become an accepted sphincter-saving method. From December 1990 to December 1994, 42 patients (17 women and 25 men) with a mean age of 67.2 years had a low resection or extirpation of the rectum at our institution. Eighteen patients received a transanal sutured anastomosis, 24 a stapler anastomosis. We had a lethality rate of 2.5% and a anastomotic insufficiency rate of 14%.


10. DOCID:21424 SCORE: 0.00195615375338738
DOCNO: 9424328
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: enzymology
QUALIFIER: metabolism
AUTHOR: B Floriańczyk B
AUTHOR: K Pasternak K
AUTHOR: L Grzybowska L
AUTHOR: J Peszyński J
AFFILIATION: Katedry i Zakładu Chemii Fizjologicznej Akademii Medycznej w Lublinie.
PUBTYPE: Journal Article
JOURNALTITLE: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
COUNTRY: POLAND
TITLE: [Activity of isocitrate dehydrogenase in breast cancer]
PUBDATE: 19970601
The activity of isocitrate dehydrogenase (ICDH) was studied in the tissue of breast cancer and in the blood serum of the women suffering from this neoplasm. The comparative material was the physiological tissue of mammae and blood serum of the healthy women. The activity of ICDH in neoplasm tissue was more higher than in physiological tissue. In the blood serum of ill patients activity of this enzyme was higher than in control serums too.


11. DOCID:23263 SCORE: 0.00194531199385892
DOCNO: 7557724
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiopathology
QUALIFIER: prevention & control
QUALIFIER: methods
AUTHOR: M Glajchen M
AUTHOR: D Blum D
AUTHOR: K Calder K
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Health & social work.
COUNTRY: UNITED STATES
TITLE: Cancer pain management and the role of social work: barriers and interventions.
PUBDATE: 19950801
Quality of life has become increasingly important in the management of cancer, because patients with the disease are surviving longer. Although effective therapies exist, more than half of all cancer patients suffer unrelieved pain during illness and treatment. Undertreated and unnecessary pain represents a failure of the multidisciplinary team, including the social worker, to respond appropriately to the needs of cancer patients. This article increases social workers' awareness of the prevalence of cancer-related pain, identifies the barriers that undermine effective pain relief, and develops a model for social work intervention. Skills such as communication, assessment, problem solving, and psychological support are explored in detail.


12. DOCID:23298 SCORE: 0.00194530956478267
DOCNO: 11363236
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
PUBTYPE: Newspaper Article
JOURNALTITLE: AIDS alert.
COUNTRY: UNITED STATES
TITLE: New treatment for KS offers options for therapy.
PUBDATE: 19960201
Researchers are still divided as to whether Kaposi's sarcoma (KS), the most common HIV infection complication, is a true cancer or a skin disease resulting from an unknown infectious agent. A comparative trial for KS treatments indicates that Doxil may be more effective than the current standard of care for widespread systemic disease. More studies are necessary before drug superiority can be determined. Doxil is being promoted as superior due to its longer circulating half-life of approximately 50 hours compared to 10 minutes for free (non-liposome) doxorubicin. Detractors question whether the drug's longer half-life allows it to penetrate the tumor. Variations in trial protocols and response assessment indicate further problems in the Doxil trial.


13. DOCID:23307 SCORE: 0.00178356696031878
DOCNO: 9354957
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: injuries
QUALIFIER: surgery
QUALIFIER: adverse effects
QUALIFIER: etiology
QUALIFIER: secondary
AUTHOR: N Ohguchi N
AUTHOR: N Sakaida N
AUTHOR: A Okamura A
AUTHOR: S Kawakita S
AUTHOR: H Kawamura H
AUTHOR: T Matsuda T
AFFILIATION: Department of Urology, Kansai Medical University, Moriguchi, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: International journal of urology : official journal of the Japanese Urological Association.
COUNTRY: JAPAN
TITLE: Extravesical tumor implantation caused by perforation during transurethral resection of a bladder tumor: a case report.
PUBDATE: 19970901
We report a case of invasive bladder cancer in which cancer dissemination occurred through a perforation of the vesical wall during transurethral resection of the tumor. A radical cystectomy was performed 1 month later and several clusters of viable cancer cells were histologically identified in a fibrous foreign body granuloma in the paravesicular adipose tissue of the lymphadenectomy specimen. The patient received adjuvant chemotherapy, but developed right inguinal lymph node metastasis 21 months after cystectomy.


14. DOCID:22473 SCORE: 0.00176913185725734
DOCNO: 7553521
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mutation
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: A Robinson A
PUBTYPE: Journal Article
JOURNALTITLE: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.
COUNTRY: CANADA
TITLE: Mouse models and breast cancer.
PUBDATE: 19951001
With his colleagues at McMaster University in Hamilton, Ont., molecular biologist Dr. William J. Muller has developed strains of transgenic mice to study the roles of certain genes in the development of mammary epithelial cancer. Genes of particular interest include neu, which codes for a growth factor receptor, and c-src, one of the first oncogenes ever described. The outcome of this work is a better understanding of how breast cancer starts and of the prognosis for patients with certain forms of the disease. It is expected that murine models will also be used to test the efficacy of new therapies for breast cancer.