0. DOCID:16767 SCORE: 0.00227080088635617
DOCNO: 1793396
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: F McDermott F
AFFILIATION: Monash University, Alfred Hospital, Prahran, Victoria.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Australian family physician.
COUNTRY: AUSTRALIA
TITLE: Risk factors in breast cancer.
PUBDATE: 19911001
Risk factors are identified in less than 25 per cent of women who develop invasive breast cancer. The risk factors include a family history of breast cancer in a first degree family relative, late menopause, nulliparity, a first full term pregnancy after the age of 35 years, increasing age, P2 and DY mammographic parenchymal patterns, increasing dosage of non contraceptive oestrogens, mammary dysplasia associated with epithelial proliferation, a previous invasive breast carcinoma and carcinoma in situ.


1. DOCID:17833 SCORE: 0.00217931657843973
DOCNO: 2056566
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Kidney Transplantation
QUALIFIER: surgery
QUALIFIER: methods
QUALIFIER: surgery
AUTHOR: T J Kinahan TJ
AUTHOR: M G McLoughlin MG
AUTHOR: A D Manson AD
AFFILIATION: Department of Surgery (Urology), Vancouver General Hospital, British Columbia, Canada.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Radical prostatectomy for localized prostatic carcinoma in the renal transplant patient.
PUBDATE: 19910701
Three renal transplant patients had prostatic carcinoma after transurethral prostatectomy at 2 weeks, 2 months and 12 years following transplantation. One patient had stage A1 disease, while 2 had stage A2 prostatic carcinoma. All patients underwent radical retropubic prostatectomy and pelvic lymph node dissection. All patients had residual cancer in the radical prostatectomy specimen but none had nodal or capsular involvement. The surgical technique and rationale for management are discussed.


2. DOCID:18727 SCORE: 0.00196881794429999
DOCNO: 1557848
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: pathology
QUALIFIER: ultrasonography
QUALIFIER: pathology
QUALIFIER: ultrasonography
AUTHOR: H Miyashita H
AUTHOR: P Troncoso P
AUTHOR: R J Babaian RJ
AFFILIATION: Department of Urology, University of Texas M.D. Anderson Cancer Center, Houston.
PUBTYPE: Journal Article
JOURNALTITLE: Urology.
COUNTRY: UNITED STATES
TITLE: BCG-induced granulomatous prostatitis: a comparative ultrasound and pathologic study.
PUBDATE: 19920401
We analyzed the ultrasound findings and the information obtained from serial whole-mount cross-section histologic examination of the prostates from 6 patients with bacillus Calmette-Guérin (BCG)-induced granulomatous prostatitis. Similarities to prostate cancer included a hypoechoic pattern on ultrasound, multifocality, and a propensity for a peripheral zone location. BCG-induced granulomatous prostatitis cannot be distinguished from cancer by ultrasonography. We suggest performing an ultrasound examination prior to starting BCG immunotherapy as a baseline for future reference to aid in the clinical diagnosis of BCG-induced granulomatous prostatitis.


3. DOCID:19726 SCORE: 0.00183850866279878
DOCNO: 2166300
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: G Bongiorni G
AUTHOR: V Marchisio V
AUTHOR: S Bragaja S
AFFILIATION: Servizio di Radiologia, Ospedale Civile, Villafranca, VR.
PUBTYPE: Journal Article
JOURNALTITLE: La Radiologia medica.
COUNTRY: ITALY
TITLE: [Comedocarcinoma: a tumor histotype to be reevaluated]
PUBDATE: 19900601
The authors report their experience with clinical mammography in the study of breast cancers, stressing the importance of comedocarcinoma, to date considered an histotype with low incidence (5%). Of late, however, a major increase has been observed in the incidence of this tumoral histotype (14%) which is now ranking second in the overall breast-cancer incidence rate. The diagnostic accuracy of mammography in our series of cases was approximately 85%. A special emphasis is put on structurally dense breast as an intrinsic factor limiting mammographic accuracy. The influence of the histotype on these results is reported. The differential diagnosis with ductal carcinoma is discussed after an anatomo-pathologic review.


4. DOCID:19511 SCORE: 0.00181700495406901
DOCNO: 2011963
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: Y Tomita Y
AUTHOR: T Nishiyama T
AUTHOR: S Sato S
AUTHOR: M Fujiwara M
AFFILIATION: Department of Urology, Niigata University School of Medicine.
PUBTYPE: Journal Article
JOURNALTITLE: Hinyokika kiyo. Acta urologica Japonica.
COUNTRY: JAPAN
TITLE: [Expression of transferrin receptor on transitional cell cancer]
PUBDATE: 19910101
We examined the expression of transferrin receptor (TR) in transitional cell cancer (TCC) immunohistologically, to clarify its implication in tumor malignancy. Forty eight out of 51 tumors expressed TR while TR was not detected on the normal transitional epithelium of renal pelvis, ureter and urinary bladder. In general, a higher grade and more invasive TCC expressed TR more frequently and more intensely. Furthermore, recurrent tumors treated with transurethral resection significantly more frequently expressed TR than the initial tumor. These results indicate that the detection of TR on the tumor cells is useful for estimating the degree of their malignancy.


5. DOCID:19666 SCORE: 0.00174935775956912
DOCNO: 1341249
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Fluorescence
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: A M Kluftinger AM
AUTHOR: N L Davis NL
AUTHOR: N F Quenville NF
AUTHOR: S Lam S
AUTHOR: J Hung J
AUTHOR: B Palcic B
AFFILIATION: Department of Surgery, Vancouver General Hospital, British Columbia, Canada.
PUBTYPE: Journal Article
JOURNALTITLE: Surgical oncology.
COUNTRY: ENGLAND
TITLE: Detection of squamous cell cancer and pre-cancerous lesions by imaging of tissue autofluorescence in the hamster cheek pouch model.
PUBDATE: 19920401
Early detection of invasive and pre-invasive neoplasms of the aerodigestive tract will ultimately improve the management of patients with these lesions. This paper describes the use of quantitative fluorescence imaging of early squamous cell carcinomas in an animal model. Dysplasia, carcinoma in situ and invasive cancers were imaged exploiting tumour autofluorescence. Mapped biopsies were obtained from areas imaged determining a sensitivity of 100% and specificity of 80%. Autofluorescence imaging is an excellent method of detecting neoplasms of the aerodigestive tract.


6. DOCID:18031 SCORE: 0.00170157340682977
DOCNO: 8309605
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: M Erba M
AUTHOR: M Boneschi M
AUTHOR: S Miani S
AUTHOR: D Eusebio D
AUTHOR: E M Bortolani EM
AFFILIATION: Istituto di Chirurgia Generale e Cardiovascolare, Università degli Studi di Milano.
PUBTYPE: Journal Article
JOURNALTITLE: Minerva chirurgica.
COUNTRY: ITALY
TITLE: [Biliary lithiasis and carcinoma of the gallbladder]
PUBDATE: 19931001
Gallstones are a major risk factor for gallbladder cancer, but only few patients with stone experience develop this tumor. To examine this relationship, twenty-one patients with gallbladder cancer referred to our Institute over a 26-year period were studied. The tumor was most common in older females (95.2%) (median age 69.2 years). Seventy-six percent of patients had gallstones. The cell type in 57.1% of patients was adenocarcinoma. The prognosis is poor, the median survival time was 6.7 months.


7. DOCID:18101 SCORE: 0.00170157268946527
DOCNO: 1689207
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Physician's Role
DESCRIPTOR: Role
DESCRIPTOR: Surgery
QUALIFIER: surgery
AUTHOR: C M Balch CM
AFFILIATION: Department of General Surgery, University of Texas, M.D. Anderson Cancer Center, Houston 77030.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: The surgeon's expanded role in cancer care.
PUBDATE: 19900201
T expaanded role of the surgeon now integrates a range of multi-modality treatment options that address both local and regional and systemic disease control. This decision-making process requires an understanding of the natural history of cancer and those prognostic factors that predict the risk of clinically occult regional metastases and distant metastases. The goal in managing the surgical patient with cancer is a full implementation of multi-disciplinary cancer care to provide the highest quality of care with the maximum rehabilitation at the lowest possible cost.


8. DOCID:18769 SCORE: 0.00164699732872564
DOCNO: 7692283
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mutagenesis
QUALIFIER: toxicity
QUALIFIER: etiology
QUALIFIER: toxicity
AUTHOR: H S Rosenkranz HS
AFFILIATION: Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15261.
PUBTYPE: Journal Article
JOURNALTITLE: Mutation research.
COUNTRY: NETHERLANDS
TITLE: Revisiting the role of mutagenesis in the induction of lung cancers in rats by diesel emissions.
PUBDATE: 19931001
Recent studies have reported the induction of lung tumors in rats chronically exposed to levels of diesel-engine emissions which interfered with lung clearance. The present analysis suggests that the mutagenic substances (e.g. dinitropyrenes, polycyclic aromatic hydrocarbons) present in diesel particulates are not major contributors to rat-lung carcinogenesis. The cancers presumably result from lung "overloading" and the ensuing inflammatory response. In the absence of additional data, this putative mechanism of diesel-caused cancer cannot be extrapolated to other species at risk from exposure to diesel emissions.


9. DOCID:17099 SCORE: 0.00159343643412225
DOCNO: 8210778
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Human Genome Project
QUALIFIER: genetics
AUTHOR: T L Bassford TL
AUTHOR: L Hauck L
AFFILIATION: Department of Family and Community Medicine, College of Medicine, University of Arizona, Tucson.
PUBTYPE: Journal Article
JOURNALTITLE: Seminars in oncology nursing.
COUNTRY: UNITED STATES
TITLE: Human Genome Project and cancer: the ethical implications for clinical practice.
PUBDATE: 19930801
The Human Genome Project has far-reaching implications for the entire spectrum of cancer care. An understanding of fundamental gene biology clarifies the role of genetics in cancer causation. The scientific advances of genetic screening for cancers have also given rise to problems such as employment and insurance discrimination, adverse psychosocial effects, and the ethical dilemma of "to screen or not to screen."


10. DOCID:19442 SCORE: 0.00143543103210256
DOCNO: 2321331
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Stents
DESCRIPTOR: Ureter
AUTHOR: K P Killeen KP
AUTHOR: W Bihrle W
AFFILIATION: Department of Urology, Lahey Clinic Medical Center, Burlington, Massachusetts.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Urology.
COUNTRY: UNITED STATES
TITLE: Ureteroscopic removal of retained ureteral Double-J stents.
PUBDATE: 19900401
At the Lahey Clinic Medical Center, Double-J stents are placed primarily for management of patients with calculi. They are used before extracorporeal shock-wave lithotripsy (ESWL) of large renal calculi or bilateral ESWL treatments and after ureteroscopic instrumentation or removal of calculi. They are also used for palliative urinary diversion for patients with ureteral obstruction secondary to pelvic cancer. Fluoroscopy with C-arm guidance is the standard radiologic technique employed for manipulation of all calculi and insertion of stents. Results have been good with the use of these stents, but in 3 patients the rigid ureteroscope was required to remove a retained Double-J stent.


11. DOCID:18977 SCORE: 0.00142424208460698
DOCNO: 1997199
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemistry
QUALIFIER: analysis
AUTHOR: S C Phan SC
AUTHOR: M Morotomi M
AUTHOR: J G Guillem JG
AUTHOR: P LoGerfo P
AUTHOR: I B Weinstein IB
AFFILIATION: Department of Medicine, Columbia University, New York, New York 10032.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Decreased levels of 1,2-sn-diacylglycerol in human colon tumors.
PUBDATE: 19910301
We have found that in 15 of 15 primary human colon tumors there was a significant decrease (by about 40%) in the levels of diacylglycerol when compared to paired adjacent normal mucosa samples. Assays on the same samples indicated that this decrease was seen both in tumors that did and did not display mutations in codon 12 of c-K-ras. These results, taken together with previous studies on protein kinase C, suggest that the protein kinase C signal transduction pathway is suppressed in human colon cancer.


12. DOCID:19319 SCORE: 0.00139202049888889
DOCNO: 1843111
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: radiotherapy
AUTHOR: S M Devine SM
AUTHOR: E E Vokes EE
AUTHOR: R R Weichselbaum RR
AFFILIATION: Department of Medicine, Pritzker School of Medicine, University of Chicago Medical Center, IL 60637.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in oncology.
COUNTRY: UNITED STATES
TITLE: Chemotherapeutic and biologic radiation enhancement.
PUBDATE: 19911201
The main objectives of concomitant chemoradiotherapy are to increase local tumor control, decrease the incidence of distant metastases, and improve survival. In addition, concomitant therapy may reduce long-term cancer therapy morbidity either by reducing the need for radical surgery or by permitting the use of lower radiation doses. This article briefly summarizes the rationale for concomitant chemoradiotherapy and summarizes the most recent clinical experience for selected solid tumors. In addition, recent data that suggest additive or synergistic interaction between radiation and certain biologic response modifiers such as tumor necrosis factor and interferon are reviewed.


13. DOCID:17943 SCORE: 0.0013567658527708
DOCNO: 1897954
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: cytology
QUALIFIER: metabolism
QUALIFIER: pharmacology
AUTHOR: D Boscoboinik D
AUTHOR: A Szewczyk A
AUTHOR: A Azzi A
AFFILIATION: Institut für Biochemie und Molekularbiologie, Universität Bern, Switzerland.
PUBTYPE: Journal Article
JOURNALTITLE: Archives of biochemistry and biophysics.
COUNTRY: UNITED STATES
TITLE: Alpha-tocopherol (vitamin E) regulates vascular smooth muscle cell proliferation and protein kinase C activity.
PUBDATE: 19910401
Alpha-Tocopherol (vitamin E) protects against free radical damage, which has been implicated in aging, cancer initiation, and atherosclerosis. We have found that physiological concentrations of alpha-tocopherol specifically inhibited aorta smooth muscle cell (VSMC, line A7r5) proliferation and protein kinase C (PKC) activity. Other water and lipid soluble antioxidants were inactive. alpha-Tocopherol inhibition of PKC and of VSMC proliferation may represent a physiological mechanism, relevant to the onset of diseased states such as atherosclerosis.


14. DOCID:19136 SCORE: 0.00134892395505594
DOCNO: 1662596
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: prevention & control
QUALIFIER: antagonists & inhibitors
AUTHOR: D V Spicer DV
AUTHOR: D Shoupe D
AUTHOR: M C Pike MC
AFFILIATION: Department of Medicine, University of Southern California School of Medicine.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Contraception.
COUNTRY: UNITED STATES
TITLE: GnRH agonists as contraceptive agents: predicted significantly reduced risk of breast cancer.
PUBDATE: 19910901
Gonadotrophin-releasing hormone agonists (GnRHAs) were investigated as contraceptive agents from the late 1970's to the mid-1980's. They were abandoned as they appeared to offer no advantage over conventional combination-type oral contraceptives (COCs). This conclusion appears to be incorrect. We propose here a contraceptive regimen of a depot formulation of a GnRHA plus add-back estrogen and intermittent progestogen. The dose of add-back sex-steroids is substantially less than that in COCs; this reduction in sex-steroids should lead to a major reduction in lifetime breast cancer occurrence.