0. DOCID:3649 SCORE: 0.00319464924258222
DOCNO: 163141
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiography
AUTHOR: H Grossman H
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: The evaluation of abdominal masses in children with emphasis on noninvasive methods. A roentgenographic approach.
PUBDATE: 19750301
Intravenous urography with total body opacification, and tomography as required, often give the most information toward evaluating abdominal masses in children. Ultrasonography is a noninvasive procedure which defines normal structures and differentiates cystic and solid tumors. The combination of these studies gives sufficient information about renal tumors to plan for possible surgery. Arteriography is not necessary for the diagnosis of Wilms' tumor, nor its surgical or medical management. Pseudotumor of the kidney is due to focal cortical hyperplasia. It can be diagnosed by nephrotomography, renal arteriography or renal scanning. The latter method is most accurate and has the lowest morbidity. Aortography is advisable in the evaluation of a patient with pheochromocytoma in an attempt to locate multiple tumors. Determining the extent of abdominal neuroblastoma by angiography and lymphangiography does not appear to influence the mode of therapy, not the survival rate; therefore, invasive diagnostic procedures do not appear to be indicated in neuroblastoma. Angiography is necessary in the evaluation of liver cancer. If one lobe is determined to be free of disease, lobectomy is a possible cure. Splenic cysts and choledochal cysts can be diagnosed by noninvasive methods such as ultrasonography or radioisotope scanning. Arteriography and percutaneous opacification are not necessary to make these diagnoses.


1. DOCID:5317 SCORE: 0.00304643277021827
DOCNO: 6174068
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
AUTHOR: B Windeyer B
PUBTYPE: Journal Article
JOURNALTITLE: Annals of the Academy of Medicine, Singapore.
COUNTRY: SINGAPORE
TITLE: Therapeutic radiology -- a review.
PUBDATE: 19810701
Radiotherapy has played an important role in the curative and palliative treatment of cancer and should continue to do so in the future. As the radiotherapist is concerned with the overall management of the cancer patient, he should be a well trained clinician. Notable advances and improvements in apparatus have taken place recently. Better treatment planning, new forms of after loading techniques, neutron therapy, hyperthermia and other interesting developments are also discussed. With these advances, problems of radiological protection are reviewed and recommendations made from time to time by the International Commission and Radiological Protection to ensure the safety of both staff and patients.


2. DOCID:1939 SCORE: 0.00269856415583485
DOCNO: 324083
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
AUTHOR: D Zoedler D
AUTHOR: G Limbacher G
PUBTYPE: Journal Article
JOURNALTITLE: Der Urologe. Ausg. A.
COUNTRY: GERMANY, WEST
TITLE: [Report of 100 total prostatectomies (author's transl)]
PUBDATE: 19770301
A total retropubic prostatectomy is an exact, clearly defined operation, which, in our hands, has been extensively standardized: it lasts an average of 1 1/2 h, results in relatively little blood loss-in only 20% of the cases is one or more units of whole blood utilized-and is accompanied by complications that are kept within tolerable boundaries. Complete enuresis can be avoided by using a particular stitching technique for the outlet of the bladder. A considerable incontinence occurred in only one patient, who during the day was temporarily forced to wear a Cunningham clamp. In the postoperative stationary phase, mortality was 2%. A radical prostatectomy makes complete recovery from cancer of the prostate possible without mutilation and without aggravating functional injuries. It has, therefore, a secure place in the surgical therapy of cancer.


3. DOCID:1530 SCORE: 0.00250684166046271
DOCNO: 1115531
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Carcinogens
QUALIFIER: toxicity
QUALIFIER: chemically induced
AUTHOR: M Kuschner M
AUTHOR: S Laskin S
AUTHOR: R T Drew RT
AUTHOR: V Cappiello V
AUTHOR: N Nelson N
PUBTYPE: Journal Article
JOURNALTITLE: Archives of environmental health.
COUNTRY: UNITED STATES
TITLE: Inhalation carcinogenicity of alpha halo ethers. III. Lifetime and limited period inhalation studies with bis(chloromethyl)ether at 0.1 ppm.
PUBDATE: 19750201
Rats and hamsters were exposed to 0.1 ppm bis(chloromethyl)ether (BCME) six hours per day, five days per week throughout their lifetime. Additional groups of rats were given 10, 20, 40, 60, 80, and 100 exposures to 0.1 ppm BCME and then held until death. Forty cancers originating in the respiratory tract were found in the 200 rats involved in these studies. These included 14 cancers of the lung and 26 cancers of the nasal cavity. They occurred in dose-related fashion. A single undifferentiated carcinoma of the lung was seen in a hamster.


4. DOCID:3059 SCORE: 0.00233751763323494
DOCNO: 922013
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Daunorubicin
AUTHOR: S Neidle S
AUTHOR: G Taylor G
PUBTYPE: Journal Article
JOURNALTITLE: Biochimica et biophysica acta.
COUNTRY: NETHERLANDS
TITLE: Nucleic acid binding drugs. Part IV. The crystal structure of the anti-cancer agent daunomycin.
PUBDATE: 19771201
The crystal structure has been determined of the anti-cancer drug daunomycin, as the hydrochloride monohydrate pyridine salt. The overall structure, previously determined by X-ray analysis of an N-bromoacetyl derivative (Anguili, R., Foresti, E., Riva Di Sanserverino, L., Isaacs, N.W., Kennard, O., Motherwell, W.D.S., Wampler, D.L. and Arcamone, F. (1971) Nat. New Biol. 234, 78-80) has been confirmed, although substantial conformational differences are observed. The conformation described here is very similar to that found for the related drug carminomycin I (Wani, M.C., Taylor, H.L., Wall, M.E., McPhaill, A.T. and Onan, K.D. (1975) J. Am. Chem. Soc. 97, 5955-5956; Pettit, G.R., Einck, J.J., Herald, C.L., Ode, R.H. Von Dreele, R.B., Brown, P., Brazhnikova, M.G. and Gause, G.F. (1975) J. Am. Chem. Soc. 97, 7387-7388); it is suggested that this represents a significantly stable molecular conformation; an intramolecular C(7)...O(9) hydrogen bond is invoked to account for this. This conformation is likely to be at least close to that of daunomycin when bound to DNA.


5. DOCID:7340 SCORE: 0.00214642380533141
DOCNO: 580557
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: etiology
AUTHOR: S Warren S
AUTHOR: C E Brown CE
PUBTYPE: Journal Article
JOURNALTITLE: Archives of pathology & laboratory medicine.
COUNTRY: UNITED STATES
TITLE: Mammary and other tumors as a response to radiation and multiple stresses.
PUBDATE: 19780501
Parabiosis of paired NEDH rats and subsequent irradiation of one produced multiple stresses, particularly altered hormonal milieu. Benign mammary tumors developed in 8.6% of the control pairs, 12.7% of the shielded partners, and 19.7% of the irradiated rats. Mammary cancers developed in 5% of control pairs, 14.2% of the shielded partners, and 11.9% of the irradiated rats. With increased amounts of prolactin, the rate was 50% in shielded partner, 10% in the irradiated rats. Mesenchymal sarcoma develop at the anastomosis in parabiont rats. Their incidence rate in single controls is 3.1%, in parabiont control pairs 12.5%, in pairs with one partner irradiated 16.6%, and with both irradiated 23.1%. The incidence rate in other parts was increased threefold over controls in the irradiated partners. Radiation appears to be the dominant factor in both mammary and anastomotic tumors.


6. DOCID:6091 SCORE: 0.00212554707921186
DOCNO: 7226076
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: analysis
AUTHOR: B W Børjesson BW
AUTHOR: G A Sarfaty GA
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Estradiol receptors in subpopulations of breast cancer cells isolated from human primary tumors.
PUBDATE: 19810401
Cancer cells isolated from biopsy specimens from seven women with primary breast cancer were analyzed for estradiol receptors. The cells were separated into subpopulations using the techniques of velocity centrifugation, buoyant density centrifugation, and density gradient electrophoresis. It was found that only large breast cancer cells (with diameters between 10.1-18.5 micrometers) concentrate tritiated estradiol. The total population of cancer cells has diameters between 5.6-18.5 micrometers, and the proportion of large cancer cells from different tumors varies from 8-59% of the total population. It is suggested that clinical regression following endocrine ablation is related to the proportion of large cancer cells and to the concentration of estradiol receptors in these cells.


7. DOCID:6154 SCORE: 0.00209068522835917
DOCNO: 472833
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: etiology
AUTHOR: S Hanowell S
AUTHOR: D E Lees DE
AUTHOR: T MacNamara T
PUBTYPE: Journal Article
JOURNALTITLE: Southern medical journal.
COUNTRY: UNITED STATES
TITLE: Auriculotemporal syndrome after combined modality therapy for cancer.
PUBDATE: 19790901
Auriculotemporal syndrome frequently follows trauma to the auriculotemporal nerve, a branch of the mandibular nerve. Classic symptoms are gustatory sweating and hyperemia, with pain occurring in less than 10% of cases. We have treated six patients for a variant of auriculotemporal syndrome following combined modality therapy for head and neck cancers. Unique was the presence of pain and the absence of gustatory sweating in all cases. The combination of radical surgery, chemotherapy, and irradiation obscured the "textbook" presentation, leading to initial misdiagnosis. Long-term relief (one year) from this atypical presentation of auriculotemporal syndrome was afforded by a simple mandibular nerve block, a technic that is of no sustained therapeutic benefit in the classic cases.


8. DOCID:1962 SCORE: 0.00205074329258213
DOCNO: 576889
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: adverse effects
QUALIFIER: etiology
AUTHOR: F S Greenspan FS
PUBTYPE: Journal Article
JOURNALTITLE: JAMA : the journal of the American Medical Association.
COUNTRY: UNITED STATES
TITLE: Radiation exposure and thyroid cancer.
PUBDATE: 19770501
There are abundant experimental and clinical data to associate radiation exposure and thyroid cancer. The incidence of thyroid cancer increases with increasing doses of thyroidal radiation from 6.5 rads to 1,500 rads, but higher doses tend to destroy the gland and are associated with hypothyroidism rather than cancer. The peak occurrence of thyroid tumors is between five and 30 years after exposure, but a person may develop thyroid tumors as long as 50 years after irradiation. Multiple thyroidal lesions or disorders, including adenomas, thyroditis, and hypothyroidism as well as malignant neoplasms, can occur after radiation exposure. It is imperative, therefore, to study carefully all patients with a history of radiation exposure to the gland and to observe them carefully for life. Suggestions are made for the management of thyroid disease in these patients.


9. DOCID:5809 SCORE: 0.00200105486208572
DOCNO: 112181
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Parenteral Nutrition
QUALIFIER: therapy
AUTHOR: I D Johnston ID
PUBTYPE: Journal Article
JOURNALTITLE: Journal of human nutrition.
COUNTRY: ENGLAND
TITLE: Parenteral nutrition in the cancer patient.
PUBDATE: 19790601
The nutritional state of patients with malignant disease must be assessed at the beginning of treatment. Nutritional supplements, given either orally or intravenously, enable patients to tolerate larger doses of chemotherapy and radiotherapy and the clinical response may be enhanced by nutritional support. Crystalline L aminoacids and glucose are the main nutrients used intravenously and fat emulsions are required in prolonged parenteral nutrition. Hypophosphataemia related to glucose administration and infection related to access to the circulation are the main complications, both of which are preventable. Total parenteral nutrition alone will not improve the results of cancer treatment significantly but its careful use in association with surgery, radiation therapy and chemotherapy can be most valuable.


10. DOCID:3349 SCORE: 0.00187604468728857
DOCNO: 991105
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: C A Presant CA
AUTHOR: C Klahr C
AUTHOR: J Olander J
AUTHOR: D Gatewood D
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Amphotericin B plus 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU-NSC no. 409962) in advanced cancer. Phase I and preliminary phase II results.
PUBDATE: 19761101
Twenty-one patients with advanced metastatic cancer received amphotericin B (AmB) plus BNUC in a Phase I chemotherapy trial. Of 11 patients with measurable metastases from bronchogenic carcinoma, five had partial antitumor responses lasting 1.5 to 12+ months, and one had objective improvement. Only two of six patients with other types of tumors had objective improvement of short duration. No consistent evidence of immunologic stimulation was observed in eight patients studied. These results suggest that amphotericin B may increase the therapeutic ratio of BCNU, and further trials of this new concept in chemotherapy of advanced tumors are in progress. The dose-limiting toxicity was myelosuppression, usually thrombocytopenia. No enhancement of BCNU toxicity by the addition of AmB was observed. The recommended dose for future studies is: AmB, 7.5 mg/m2 on day 1, 15 mg/m2 on day 1, 30 mg/m2 on days 3 and 4; plus BCNU, 250 mg/m3 on day 4. The regimen is repeated every 6 to 8 weeks.


11. DOCID:2849 SCORE: 0.0018626611533466
DOCNO: 950862
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Laryngeal Neoplasms
DESCRIPTOR: Lymphoma
AUTHOR: H A Anderson HA
AUTHOR: R H Maisel RH
AUTHOR: R W Cantrell RW
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Laryngoscope.
COUNTRY: UNITED STATES
TITLE: Isolated laryngeal lymphoma.
PUBDATE: 19760801
Isolated laryngeal lymphoma is a rare occurrence. We found a total of 14 previously reported cases. These plus ouradditional case are reviewed in order to make recommendations for diagnosis, therapy,a nd follow-up. Histologic classification and clinical staging of lymphomas have limited usefulness, because the tumor can change cell type during the clinical course of the disease. Once histologic proof of the tumor exists, adequate evaluation consists of physical examination to detect adenopathy elsewhere, bone marrow biopsy, urinalysis, blood uric acid levels, liver biopsy, and liver and kidney function tests. The search must continue in the chest by X-ray, the retroperitoneal nodes by lymphangiography and the abdomonal visera by contrast radiography. Radiation therapy is the best initial treatment for isolated laryngeal lymphoma. If the tumor does not respond to irradiation, then operation to remove the lesion is required. This tumor has a tendency to recur at distant sites many years later. As with all cancer patients life-long follow-up is required.


12. DOCID:5721 SCORE: 0.00182672486809112
DOCNO: 7382092
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Recurrence, Local
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: A Sohrabi A
AUTHOR: J Sandoz J
AUTHOR: J S Spratt JS
AUTHOR: H C Polk HC
PUBTYPE: Journal Article
JOURNALTITLE: JAMA : the journal of the American Medical Association.
COUNTRY: UNITED STATES
TITLE: Recurrence of breast cancer. Obesity, tumor size, and axillary lymph node metastases.
PUBDATE: 19800701
Substantially different conclusions have been reached by several studies about relationships between mammary cancer and obesity. We studied retrospectively 106 consecutive patients who underwent mastectomy for breast cancer. We found no association between obesity per se and the frequency or time of recurrence. Our sample did reaffirm that recurrence of breast cancer is related to tumor size and nodal status. Obesity was similarly related to tumor size and nodal status. However, we could not confirm prior findings that obese patients with pathologically similar breast tumors had a poor prognosis.


13. DOCID:3532 SCORE: 0.00182584330505176
DOCNO: 60156
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: W R Vogler WR
AUTHOR: D S Miller DS
AUTHOR: J W Keller JW
PUBTYPE: Journal Article
JOURNALTITLE: Blood.
COUNTRY: UNITED STATES
TITLE: 5-Azacytidine (NSC 102816): a new drug for the treatment of myeloblastic leukemia.
PUBDATE: 19760901
The pyrimidine analog, 5-azacytidine (NSC 102816), was administered by continuous intravenous infusion in Ringer's lactate in increasing doses to sets of patients with metastatic cancer to establish a dose sufficient to produce mild toxicity. Twenty-one patients (23 trials) were treated with doses of 50-200 mg/sq/m/day for 5 days every 2-4 wk. Nausea and vomiting were moderate and easily preventable. Doses of 100-200 mg/sq/m for 5 days every 14 days produced granulocytopenia, usually after two courses. Less toxicity was observed when courses were given every 21-28 days. Forty-five patients with previously treated and refractory acute myeloblastic leukemia were treated. The majority received doses of 150 mg/sq m for 5 days every 2 wk. Eleven (24%) complete remissions and four partial remissions were observed. The number of courses to achieve remission averaged three and required an average of 59 days. Nine patients with blastic crisis of chronic myeloblastic leukemia and four with refractory acute lymphoblastic leukemia failed to respond. 5-Azacytidine administered by continuous infusion is well tolerated and is an active compound in acute myeloblastic leukemia.


14. DOCID:6369 SCORE: 0.00176190718784441
DOCNO: 7399944
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
AUTHOR: M Jekic M
PUBTYPE: Journal Article
JOURNALTITLE: Helvetica chirurgica acta.
COUNTRY: SWITZERLAND
TITLE: [Superficial cancer of the stomach in our hospital]
PUBDATE: 19800201
Gastric cancer remains difficult to cure except in its superficial spreading stage, that is when it is mucosal or submucosal without any lymph node involvement. Its detection rate should reach 20% of all cancers. Three anatomical types are described: the malignant polyp, the muco-erosive cancer and the ulcero-cancer. The most efficient radiological procedure is fibroscopy rather than radiology: it permits biopsy and brush cytology, two procedures which yield 95% of positive diagnosis. The most frequent precancerous lesion seems to be chronic gastritis and especially gland dysplasia. Early detection may be made easier by defining a poor risk population: gastric ulcer, polyadenoma, partial gastrectomy going back to more than fifteen years, and dyspeptic patients in whom biopsy discovers atrophic gastritis. Such a population should be regularly followed up.