0. DOCID:30774 SCORE: 0.00499344580281483
DOCNO: 11890096
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: drug therapy
QUALIFIER: genetics
AUTHOR: Tetsuya Mitsudomi T
AFFILIATION: Department of Thoracic Surgery, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan. mitsudom@leo.bekkoame.ne.jp
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: Japan
TITLE: Molecular lesions as targets for diagnosis and therapy of lung cancer.
PUBDATE: 20020201
Alteration of the p53 tumor suppressor gene is one of the most frequently seen molecular lesions in human lung cancer. It is of importance to integrate translational science into clinical practice. In our laboratory, we are in search for clinical utility of p53 gene alterations in management of patients with lung cancer. Here, we would like to discuss p53 alterations as a prognostic factor for lung cancer patients or as a predictor of chemosensitivity.

1. DOCID:30185 SCORE: 0.00499344441803905
DOCNO: 14612484
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: history
AUTHOR: Marcia L Meldrum ML
AFFILIATION: Department of History, University of California-Los Angeles, Los Angeles 90095-1473, USA. mlynnmel@earthlink.net
PUBTYPE: Historical Article
PUBTYPE: Journal Article
JOURNALTITLE: JAMA : the journal of the American Medical Association.
COUNTRY: United States
TITLE: A capsule history of pain management.
PUBDATE: 20031101
Pain is a complex clinical problem. Assessment depends on verbal report, and the patient's physical perceptions may be modified by cognitive and affective factors. The salience of pain as a problem in its own right has grown since 1945 and new therapeutic alternatives have developed from research and from new theoretical perspectives. This short historical review of the highlights of the history of pain management gives particular emphasis to the 20th century and to chronic and cancer pain.

2. DOCID:30402 SCORE: 0.00354833038604926
DOCNO: 14520433
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Bone Marrow Transplantation
DESCRIPTOR: Hematopoietic Stem Cell Transplantation
QUALIFIER: adverse effects
QUALIFIER: chemically induced
QUALIFIER: therapy
AUTHOR: C Palmieri C
AUTHOR: R Gillmore R
AUTHOR: A Menzies-Gow A
AUTHOR: S Fishpool S
AUTHOR: D Robinson D
AUTHOR: R Shaw R
AUTHOR: R C Coombes RC
AFFILIATION: Department of Medical Oncology, Charing Cross Hospital, Fulham Palace Road, London, UK. c.palmieri@ic.ac.uk
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Bone marrow transplantation.
COUNTRY: England
TITLE: Resolution of late-onset asthma following high-dose chemotherapy.
PUBDATE: 20031001
We describe a patient with moderately severe (British Thorax Society Step IV/V) asthma requiring regular inhaled and oral corticosteroids to control symptoms who experienced resolution of her asthma following high-dose chemotherapy and autologous stem cell transplantation for breast cancer. As far as the authors are aware this is the first reported case.

3. DOCID:23959 SCORE: 0.00315438316465281
DOCNO: 7600136
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Helicobacter pylori
QUALIFIER: etiology
QUALIFIER: complications
QUALIFIER: etiology
QUALIFIER: etiology
AUTHOR: S Eidt S
AUTHOR: M Stolte M
AFFILIATION: Institute of Pathology, University of Cologne, Germany.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: European journal of gastroenterology & hepatology.
COUNTRY: ENGLAND
TITLE: The significance of Helicobacter pylori in relation to gastric cancer and lymphoma.
PUBDATE: 19950401
The evidence linking Helicobacter pylori and non-cardia gastric adenocarcinoma is accumulating. Patterns of strain specificities and host factors that increase epithelial proliferation and have implications for mutagenic effects are evolving. The decision by the World Health Organization and the International Agency for Research on Cancer to classify H. pylori as a 'definite' carcinogen, however, represents a milestone in the association of H. pylori with gastric carcinogenesis. The importance of H. pylori in gastric lymphoma has been underscored by the finding that H. pylori eradication can induce complete regression in low-grade mucosa-associated lymphoid tissue lymphomas, at least in the early stages of development.

4. DOCID:20250 SCORE: 0.00278987709114149
DOCNO: 8862710
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Taxoids
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: analogs & derivatives
AUTHOR: J P Armand JP
AFFILIATION: Department of Medicine, Institut Gustave-Roussy, Villejuif, Paris, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Anti-cancer drugs.
COUNTRY: ENGLAND
TITLE: The clinical rationale for developing docetaxel (Taxotere).
PUBDATE: 19960801
Clinical empiricism has recognized resistant breast cancer as a privileged target for docetaxel (Taxotere). This worldwide registration will offer medical oncologists the opportunity to develop new indications for docetaxel. Pharmacokinetics, preclinical optimal combination and clinical practice will constitute the rationale for the future development of docetaxel.

5. DOCID:30278 SCORE: 0.002651528310941
DOCNO: 14763146
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: Jacques Bosq J
AUTHOR: Frédérique Penault-Llorca F
AUTHOR: Jean-Claude Sabourin JC
AFFILIATION: Département de pathologie, Institut Gustave-Roussy, rue Camille-Desmoulins, 94805 Villejuif. bosq@igr.fr
PUBTYPE: Journal Article
JOURNALTITLE: Bulletin du cancer.
COUNTRY: France
TITLE: [Expression of epidermal growth factor receptor and its ligands in other malignant tumor pathologies]
PUBDATE: 20031101
The aim of this review was to describe expression of epithelial growth factor receptor (EGFR) and of its ligands in a panel of tumours (which are not specified elsewhere in this special issue of Bulletin du Cancer): squamous cell carcinomas, adenocarcinomas, sarcomas, brain and germ line tumours. The role of EGFR and its ligands in the carcinogenesis and the progression of these tumours, as well as the relevance of targeting EGFR.

6. DOCID:22643 SCORE: 0.00262309324165023
DOCNO: 8965365
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: K Sugino K
AUTHOR: K Ito K
AFFILIATION: Ito Hospital.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: JAPAN
TITLE: [Thyroid microcarcinoma]
PUBDATE: 19960501
The term "early cancer of the thyroid" is not clearly defined. Recently, microcarcinoma of the thyroid, less than 10 mm, has been frequently detected and in Ito Hospital smaller papillary carcinoma has increased in these 10 years. As rate of microcarcinoma found in autopsy cases were reported 10-28.4% in Japan, all of thyroid microcarcinoma are not thought to be developed clinically. In our hospital, papillary microcarcinoma diagnosed preoperatively underwent lobectomy with modified neck dissection in principle. Lymph node metastases were found in 65% of patients with papillary microcarcinoma. Further studies and discussion concerned whether thyroid microcarcinoma should be treated and how it should be treated, is necessary.

7. DOCID:25737 SCORE: 0.00258194996596751
DOCNO: 11176226
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Education, Medical, Graduate
QUALIFIER: surgery
AUTHOR: J W Orr JW
AUTHOR: P Y Roland PY
AUTHOR: P J Orr PJ
AUTHOR: D D Bolen DD
AUTHOR: S L Hutcheson SL
AFFILIATION: Gynecologic Oncology and Gynecologic Cancer Research, Lee Cancer Care, Lee Memorial Hospital, Fort Myers, Florida 33901, USA. James.Orr@LeeMemorial.ORG
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in obstetrics & gynecology.
COUNTRY: England
TITLE: Subspecialty training: does it affect the outcome of women treated for a gynecologic malignancy?
PUBDATE: 20010201
A review of available direct and indirect scientific reports strongly suggests that subspecialty training increases the likelihood that the appropriate surgical procedure will be completed in women operated on for gynecologic cancer. It is likely that specialty care lessens the costs associated with diagnosis, treatment and surveillance, and frequently improves survival.

8. DOCID:27196 SCORE: 0.00256187905603389
DOCNO: 10580865
AUTHOR: A W Lee AW
AUTHOR: W M Sze WM
AUTHOR: J F Fowler JF
AUTHOR: R Chappell R
AUTHOR: S F Leung SF
AUTHOR: P Teo P
AFFILIATION: Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong, People's Republic of China.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
COUNTRY: IRELAND
TITLE: Caution on the use of altered fractionation for nasopharyngeal carcinoma.
PUBDATE: 19990901
Randomized trials and overviews on the value of altered fractionation for head and neck cancers are reviewed. Attention is drawn to the unexpectedly high incidence of temporal lobe necrosis incurred in patients with nasopharyngeal carcinoma. Preliminary analyses suggest that incomplete repair is likely to be the major factor, even a 6-h interfraction interval may be inadequate if substantial volumes of nervous tissues are included within the target volume.

9. DOCID:22465 SCORE: 0.00254923375704502
DOCNO: 9457985
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: methods
QUALIFIER: surgery
QUALIFIER: adverse effects
QUALIFIER: chemically induced
QUALIFIER: therapy
AUTHOR: T Römer T
AFFILIATION: Department of Obstetrics and Gynecology, Ernst-Moritz-Arndt-University of Greifswald, Germany.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.
COUNTRY: IRELAND
TITLE: Successful treatment of recurrent uterine bleeding during tamoxifen therapy by endometrial ablation.
PUBDATE: 19950401
Recurrent bleeding occurred in a premenopausal breast cancer woman during tamoxifen therapy. This bleeding required three curettages. Atypical hyperplasia and carcinoma were excluded, and the patient was prepared for endometrial ablation with two GnRH agonist injections. An endometrial ablation using the roller ball technique was carried out without complications. Tamoxifen therapy was continued postoperatively. During 24 months' follow-up the patient experienced no bleeding and no endometrium was seen by sonography.

10. DOCID:29998 SCORE: 0.00251641208437825
DOCNO: 12879794
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: etiology
QUALIFIER: epidemiology
QUALIFIER: etiology
AUTHOR: Annie Sasco A
AFFILIATION: Centre international de recherche sur le cancer Unité d'épidémiologie pour la prévention du cancer et Institut national de la santé et de la recherche médicale 69372 Lyon. sasco@iarc.fr
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: La Revue du praticien.
COUNTRY: France
TITLE: [Epidemiology of lung carcinoma]
PUBDATE: 20030401
Lung cancer is the most common cancer in the world, either in terms of incidence or mortality, and it is still increasing in particular in the developing world and among women. The vast majority of lung cancers are due to tobacco smoking and therefore primary prevention through efficient tobacco control is possible. Occupational carcinogens are also recognised and the role of environmental exposures remains to be defined.

11. DOCID:23750 SCORE: 0.00246404586745631
DOCNO: 8608062
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: economics
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: J A Glaspy JA
AFFILIATION: Department of Medicine, UCLA School of Medicine, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncology (Williston Park, N.Y.)
COUNTRY: UNITED STATES
TITLE: Economic outcomes associated with the use of hematopoietic growth factors.
PUBDATE: 19951101
The myeloid growth factors G-CSF and GM-CSF have had an impact on the supportive care of cancer patients as well as on the strategies utilized in chemotherapy dose intensification. Therapy with these factors has not been associated with improvements in survival, and hence an examination of their effects on economic outcomes is central to rational decision making regarding their use. Erythropoietin therapy has been shown to decrease transfusion requirements in anemic cancer patients undergoing chemotherapy and to improve the quality of life in responding patients. The available data on the economic outcomes associated with the use of these three factors in oncology practice are reviewed.

12. DOCID:30969 SCORE: 0.00239355205968118
DOCNO: 14584403
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Vaginal Smears
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: Deborah A Simon DA
AUTHOR: Elizabeth Dimitrievich E
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: South Dakota journal of medicine.
COUNTRY: United States
TITLE: Case report: detection of an advanced ovarian malignancy by cervical cytology.
PUBDATE: 20031001
There are currently no recommended screening tests for the early detection of ovarian cancer. Ovarian malignancies are most often discovered on bimanual exam at advanced stages, resulting in a high mortality from this disease. While the Papanicolaou (Pap) smear is not a reliable screen for the detection of ovarian cancer, abnormal cytology may be the initial indicator of ovarian malignancy. This is a case report of an invasive serous adenocarcinoma of the ovary that was discovered as the result of a clinical work-up for abnormal cytology reported on a Pap smear.

13. DOCID:26569 SCORE: 0.00236312403712832
DOCNO: 11292948
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: C Casali C
AUTHOR: A Stefani A
AUTHOR: M Paci M
AUTHOR: U Morandi U
AUTHOR: R Lodi R
AFFILIATION: Department of Cardio-Thoracic Surgery, University of Modena and Reggio Emilia, Modena, Italy.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of cardiovascular surgery.
COUNTRY: Italy
TITLE: Surgical management of solitary pulmonary nodules. An unexpected lucky case.
PUBDATE: 20010401
The case of a 63-year-old woman with a solitary pulmonary nodule (SPN) is reported. Surgical wedge resection revealed an hamartoma. Digital examination of the lung parenchyma showed an unexpected (not previously visualized by thoracic imaging) second nodule that intraoperative frozen examination revealed an adenocarcinoma. The operation was completed with a right upper lobectomy and complete lymphoadenectomy. The authors recommend an early open surgical procedure for any SPNs with risk factors for developing lung cancer.

14. DOCID:23944 SCORE: 0.00235665887606139
DOCNO: 8597089
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: pharmacology
AUTHOR: S Agrawal S
AUTHOR: P K Rustagi PK
AUTHOR: D R Shaw DR
AFFILIATION: Hybridon, Inc., Worcester, MA 01605, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Toxicology letters.
COUNTRY: NETHERLANDS
TITLE: Novel enzymatic and immunological responses to oligonucleotides.
PUBDATE: 19951201
Oligonucleotide phosphorothioates (PS-oligos) are being studied as antisense agents for viral infection and cancer. In preclinical studies, PS-oligos produced dose-dependent changes in heart rate and blood pressure and significantly reduced serum hemolytic complement, which could be avoided by slowing infusion rates. Here, in vitro PS-oligo treatment of either human, rhesus monkey or guinea pig serum reduced hemolytic complement and further inhibited in vitro coagulation when added to whole blood or citrated plasma. These effects were dependent upon both oligonucleotide dose and structure. Oligonucleotides having identical sequences but containing methylphosphonates (Chimeric), 2'-O-methyl ribonucleosides (Hybrid) or 3' hairpin loop (Self-stabilized) had altered effects on complement and coagulation in vitro.