0. DOCID:6845 SCORE: 0.00469478430643957
DOCNO: 455241
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antigen-Antibody Complex
DESCRIPTOR: Complement System Proteins
QUALIFIER: immunology
AUTHOR: H Biran H
AUTHOR: G M Mavligit GM
AUTHOR: J L Moake JL
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Receptor sites for complement and for immune complexes on human nonhemopoietic tumor cells.
PUBDATE: 19790701
Tumor cells in primary cultures derived from 11 untreated nonhemopoietic cancer patients were reacted with specifically coated sheep erythrocytes. Rosette formation between tumor and indicator cells was assessed, Eight of the primary cultures reacted positively with both IgG-coated (EAIgG) and with IgM-human complement coated (EAIgMC or EAIgMC 4,3) sheep erythrocytes. EAIgG rosette formation in positive cultures ranged from 25 to 85%, and for EAIgMC/EAIgMC 4,3 reactivity ranged between 22--95%. Rosette formation with E (uncoated) and EAIgM was negligible. These findings suggest that human nonhemopoietic tumor cells may carry on their surface receptor sites for an IgG component of immune complexes and for human complement. These receptor sites may be important in the host-tumor relationship.

1. DOCID:7814 SCORE: 0.00437383824356702
DOCNO: 7365390
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: M Hakama M
AUTHOR: R West R
PUBTYPE: Journal Article
JOURNALTITLE: Journal of epidemiology and community health.
COUNTRY: ENGLAND
TITLE: Cervical cancer in Finland and South Wales: implications of end results data on the natural history.
PUBDATE: 19800301
The population-based cancer registry data on patients with cervical cancer in Finland and South Wales in 1960--69 were analysed for survival. Patients with carcinoma-in-situ experienced essentially the normal life expectancy. Those with invasive carcinoma experienced 75% of normal post-registration life expectancy in Finland but only 45% in South Wales. The difference was due to higher frequency and to better survival of patients with localised carcinoma in Finland, which was attributed to the fact that in Wales the mean age of the population is higher than that in Finland, and also to the longer delya in Wales from first symptoms to diagnosis among women with localised cancer. The differences in mean age by clinical stage and in survival combined with the duration of symptoms support the hypothesis that speed of tumour growth is a major determinant of clinical stage at diagnosis.

2. DOCID:6775 SCORE: 0.00432469107255674
DOCNO: 379835
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: K Wurster K
AUTHOR: W Rapp W
PUBTYPE: Journal Article
JOURNALTITLE: Pathology, research and practice.
COUNTRY: GERMANY, WEST
TITLE: Histological and immunohistological studies on gastric mucosa. I. The presence of CEA in dysplastic surface epithelium.
PUBDATE: 19790101
Surface and foveolar gastric cells (SE) of 74 gastric resection specimens were studied by classical and indirect immunoenzyme histology. Immunoadsorbed CEA-antibodies reacting only with the specific determinant of of the CEA molecule were applied. The following SE types with different CEA distribution patterns were observed: Type SE-O, no CEA, normal neutral mucosubstances (MCS); type SE-A, CEA present in the lower half of the SE, important decrease of MCS, mild cell dysplasia by conventional criteria; type SE-B, CEA present in the total cell, absence of MCS, moderate until marked dysplasia; type SE-C, CEA present or decreased, absence of MCS, very important cell dysplasia resembling cancer cells. CEA proved to be useful as marker for the degree of SE dysplasia.

3. DOCID:7462 SCORE: 0.0038504001453043
DOCNO: 6155790
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: Y K Wu YK
AUTHOR: P T Chen PT
AUTHOR: J P Fang JP
AUTHOR: S S Lin SS
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: Surgical treatment of esophageal carcinoma.
PUBDATE: 19800601
Recent progress in the surgical treatment of carcinoma of the esophagus has changed the pessimistic outlook for this malignancy. With reasonably early diagnosis, it is feasible to achieve a resectability rate of 75 to 85 percent, an operative mortality of about 5 percent and a 5 year survival rate of about 30 percent. With careful selection of patients for operation and proper use of radiation and other adjunctive therapy, even more encouraging results are possible. Efforts for further improvement may be directed toward early diagnosis, refinement in operative technique and better pre- and postoperative care. The use of microsurgery and the development of mechanical suture apparatus in esophageal reconstruction after resection may further improve surgical treatment of cancer of the esophagus. Thoracic surgeons still have the responsibility to improve the management of the nonresectable cases of carcinoma of the esophagus.

4. DOCID:7281 SCORE: 0.0037819704751588
DOCNO: 746597
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: Z Paszko Z
AUTHOR: H Padzik H
AUTHOR: M Dabska M
AUTHOR: F Pienkowska F
PUBTYPE: Journal Article
JOURNALTITLE: Tumori.
COUNTRY: ITALY
TITLE: Estrogen receptor in human breast cancer in relation to tumor morphology and endocrine therapy.
PUBDATE: 19781001
The presence of estrogen receptors (ER) was determined in 111 human breast cancer specimens. In 61% of the tumors, specific estrogen binding was found and in 39% of the tumors ER was absent. In 69 tumors no correlation was found between the histological grading of the tumor and the level of ER. The values of ER in tumors from patients over 50 years of age were usually much higher than those for patients under 50 years of age. Different methods of endocrine therapy were applied in 20 patients. In 10 of 15 patients with ER positive tumors, endocrine therapy resulted in remission. Only 1 of 5 patients with ER negative tumors responded with remission. It is concluded that estimation of ER in tumor tissue is helpful in the selection of patients for endocrine therapy.

5. DOCID:7542 SCORE: 0.00348976037428063
DOCNO: 220925
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: K Y Yeung KY
AUTHOR: D J Haidak DJ
AUTHOR: J A Brown JA
AUTHOR: D Anderson D
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Archives of internal medicine.
COUNTRY: UNITED STATES
TITLE: Metastasis-induced acute pancreatitis in small cell bronchogenic carcinoma.
PUBDATE: 19790501
Despite frequent metastatic involvement of the pancreas at postmortem examination in patients with small cell lung cancer, clinically observed pancreatitis due to metastatic pancreatic tumor rarely has been reported. This communication describes three cases of clinical acute pancreatitis occurring in a consecutive series of 40 patients with oat cell lung cancer. This complication may appear either as the initial manifestation of the neoplasm or during a recrudescent phase of the malignant growth. The diagnosis should be suspected in the presence of the clinical, laboratory, and radiologic features of acute pancreatitis in patients with known small cell carcinoma of the lung, especially if there is evidence of progression of the neoplastic disease elsewhere and no response to conservative medical management. Aggressive treatment with polychemotherapy can produce rapid clinical improvement and useful prolongation of survival.

6. DOCID:6989 SCORE: 0.00339904010213614
DOCNO: 7470623
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Blood Coagulation
QUALIFIER: blood
AUTHOR: M Colucci M
AUTHOR: R Giavazzi R
AUTHOR: G Alessandri G
AUTHOR: N Semeraro N
AUTHOR: A Mantovani A
AUTHOR: M B Donati MB
PUBTYPE: Journal Article
JOURNALTITLE: Blood.
COUNTRY: UNITED STATES
TITLE: Procoagulant activity of sarcoma sublines with different metastatic potential.
PUBDATE: 19810401
It has been suggested that cancer cell procoagulant activity influences metastasis formation by promoting fibrin deposition around tumors. We have investigated the procoagulant activity of various tumor cell sublines with different metastatic capacity derived from metastatic nodules of a murine fibrosarcoma. All the cells tested possessed a marked thromboplastin-like activity; they were, however, heterogeneous as regards the degree of procoagulant activity; the two cell lines with virtually no metastatic capacity showed 6--8 times higher procoagulant activity than the cells from the parent line; in contrast, the procoagulant activity of the two sublines with higher metastatic capacity did not differ significantly from that of the parent line. These findings support the hypothesis that fibrin is part of a defence reaction against cancer cell invasiveness.

7. DOCID:7946 SCORE: 0.00333271554529042
DOCNO: 7205706
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Attitude of Health Personnel
DESCRIPTOR: Internship and Residency
QUALIFIER: psychology
QUALIFIER: psychology
AUTHOR: J Kaye J
AUTHOR: M Appel M
AUTHOR: R Joseph R
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of psychology.
COUNTRY: UNITED STATES
TITLE: Attitudes of medical students and residents toward cancer.
PUBDATE: 19810101
Attitudes toward cancer and heart disease were evaluated in 99 freshmen medical students, 76 seniors, and 66 residents using the Cancer Attitude Survey and a Semantic Differential test. The Survey revealed a rise in positive attitudes towards patients' inner resources to cope with serious illness and toward personal immortality and a rise in negative attitudes toward early diagnosis of cancer as students progressed in their training. The Semantic Differential test demonstrated more negative attitudes toward cancer than heart disease in all groups (freshman, seniors, and residents in medicine, psychiatry, or surgery). The seniors had the most positive attitudes toward cancer and freshman the least positive attitudes. The residents had more positive attitudes than the freshmen but less positive attitudes than the seniors. The residents in psychiatry had more positive attitudes than the residents in medicine, who had more positive attitudes than the residents in surgery.

8. DOCID:7872 SCORE: 0.00327019627038325
DOCNO: 98005
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiography
AUTHOR: M M Lindell MM
AUTHOR: B S Jing BS
AUTHOR: E P Fischer EP
AUTHOR: O M Guillamondegui OM
AUTHOR: S Wallace S
PUBTYPE: Journal Article
JOURNALTITLE: AJR. American journal of roentgenology.
COUNTRY: UNITED STATES
TITLE: Laryngocele.
PUBDATE: 19780801
Laryngocele occurs more commonly than the literature indicates. Until recently, most were diagnosed clinically in the symptomatic patient. Although laryngocele is usually asymptomatic, greater numbers are being diagnosed because more patients suspected of head and neck cancer are undergoing sophisticated diagnostic radiographic procedures. Of 2,068 patients studied at M.D. Anderson Hospital and Tumor Institute for suspected laryngeal or hypopharyngeal cancer, 87 (4.2%) had laryngoceles. Three types of laryngocele are recognized: internal, external, and combined. They may be congenital or acquired and occur at any age. The coexistence of carcinoma and laryngocele has been discussed often enough in the literature to suggest a direct relationship; however, this series yielded no substantive evidence to implicate laryngocele as a precursor of carcinoma. The radiographic procedures currently used which readily establish the presence of laryngoceles are lateral soft tissue radiography of the neck, anteroposterior tomography of the larynx, and contrast laryngography.

9. DOCID:7452 SCORE: 0.00325779184439747
DOCNO: 7053208
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: toxicity
QUALIFIER: chemically induced
QUALIFIER: chemically induced
QUALIFIER: pharmacology
AUTHOR: M Miyakawa M
AUTHOR: O Yoshida O
PUBTYPE: Journal Article
JOURNALTITLE: Gann = Gan.
COUNTRY: JAPAN
TITLE: Protective effects of DL-tryptophan on benzidine-induced hepatic tumor in mice.
PUBDATE: 19800401
This study was undertaken to evaluate the carcinogenic effect of benzidine on the urinary bladder of mice, and the effect of DL-tryptophan on the induction of bladder cancer. Benzidine plus DL-tryptophan or benzidine alone mixed with a commercial basal diet was fed to groups of ICR strain female mice for 20 weeks, after a glass bead had been inserted into the bladder. Control mice were fed the basal diet throughout the experimental period. All the surviving mice were killed 63 weeks after start of the study. Benzidine administered with or without DL-tryptophan did not induce tumors of the urinary bladder in these mice. Hepatomas developed in 34 of 41 mice (82.9%) fed benzidine and in 24 of 51 mice (47.1%) fed benzidine with tryptophan. DL-Tryptophan counteracted the effect of benzidine and significantly reduced the development of hepatomas.

10. DOCID:4995 SCORE: 0.00315823128784579
DOCNO: 6780330
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: diagnostic use
AUTHOR: K Kamijo K
AUTHOR: A Saito A
AUTHOR: A Yachi A
AUTHOR: T Wada T
PUBTYPE: Journal Article
JOURNALTITLE: Endocrinologia japonica.
COUNTRY: JAPAN
TITLE: Growth hormone response to thyrotropin-releasing hormone in cancer patients.
PUBDATE: 19800801
Plasma GH responses to TRH were investigated in 50 cancer patients. Out of 50 cancer patients, 33 were found to be responders. At 15, 30 and 60 min after TRH injection, the mean values GH for cancer patients was significantly higher than the corresponding value for normal controls and the base-line level following saline injection in cancer patients (p < 0.001). Our results suggests that a possible alteration of hypothalamic-pituitary function regulating GH secretion may occur in patients with cancer.

11. DOCID:7115 SCORE: 0.00307331410718067
DOCNO: 582429
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: analogs & derivatives
QUALIFIER: pharmacology
QUALIFIER: metabolism
AUTHOR: M Slavik M
PUBTYPE: Journal Article
JOURNALTITLE: Cancer treatment reports.
COUNTRY: UNITED STATES
TITLE: Changes in amino acid metabolism caused by 6-azauridine triacetate: relevance to cancer treatment.
PUBDATE: 19790601
6-Azauridine triacetate (6-AzUrd-TA) administration causes changes in amino acid metabolism both in experimental animals and in man. This effect is dose-related. Amino acid changes caused by 6-AzUrd-TA resemble those in inborn homocystinuria, beta-alaninemia, and hyperhistidinemia. Inhibition of certain enzymes using pyridoxal phosphate as a coenzyme appears to be the common denominator for these changes. There is supportive evidence suggesting that homocystinemia and thrombotic episodes, both caused by 6-AzUrd-TA, are related. These results also reveal that anticancer drugs other than amino acid analogs and amino acid-depleting enzymes may cause significant changes in amino acid metabolism. Their detection and correlation with the therapeutic or adverse effects can be used as an alternative method for studying the relevance of amino acid changes to the treatment of cancer.

12. DOCID:4559 SCORE: 0.00298085118590183
DOCNO: 439260
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Embolization, Therapeutic
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: therapy
AUTHOR: L Giuliani L
AUTHOR: G Carmignani G
AUTHOR: E Belgrano E
AUTHOR: P Puppo P
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Transcatheter arterial embolization in urological tumors: the use of isobutyl-2-cyanoacrylate.
PUBDATE: 19790501
Transcatheter arterial embolization is a useful technique to manage urological tumors. Herein we describe a new embolic material (isobutyl-2-cyanoacrylate) in 5 cases of renal cancer embolization and in 1 case of bilateral hypogastric embolization for bladder cancer hemorrhage. Isobutyl-2-cyanoacrylate provides a complete, distal and irreversible embolization, making it suitable material in cancer embolization.

13. DOCID:6981 SCORE: 0.00296768508569225
DOCNO: 7286916
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: G Franzin G
AUTHOR: P Novelli P
PUBTYPE: Journal Article
JOURNALTITLE: Histopathology.
COUNTRY: ENGLAND
TITLE: Gastritis cystica profunda.
PUBDATE: 19810901
Fourteen cases of gastritis cystica polyposa, four gastric adenomas and 25 "mature" erosions removed by diathermy at endoscopy were studied by light microscopy. Twenty surgical resections from gastric cancer patients and 18 gastric resections from gastroenterostomy patients previously operated upon for benign lesions were also studied. The mucosa showed consistent changes which were grouped as "gastritis cystica superficialis". Most surgical specimens, three out of 25 "mature" erosions, the four adenomas, and eight cases of gastritis cystica polyposa showed cystic gastric glands within the submucosa closely resembling the changes seen in colitis cystica profunda. Thus the term "gastritis cystica profunda" is proposed. It is suggested that ischaemia and chronic inflammation as well as the effects of surgery and presence of suture material have a role in the pathogenesis of gastritis cystica profunda. A correlation seems to exist between gastritis cystica profunda and gastric ulcer.

14. DOCID:5016 SCORE: 0.00272528285404251
DOCNO: 208182
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Breast Neoplasms
DESCRIPTOR: Carcinoma, Adenoid Cystic
AUTHOR: A Steinman A
AUTHOR: M Pepus M
AUTHOR: G McSwain G
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Southern medical journal.
COUNTRY: UNITED STATES
TITLE: Adenoid cystic carcinoma of the breast.
PUBDATE: 19780701
We have presented a case of adenoid cystic carcinoma of the breast and reviewed the literature, with emphasis on the behavior of this rare neoplasm and the fact that its prognosis appears to be more favorable than that of other more common histologic types of breast cancer. The accumulated information about adenoid cystic carcinoma of the breast that exists to date is insufficient to allow dogmatic statements, but one can conclude that total mastectomy seems to be the treatment of choice in selected cases.