0. DOCID:31345 SCORE: 0.00493894905082033
DOCNO: 16392666
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analogs & derivatives
QUALIFIER: chemistry
AUTHOR: Rui Liu R
AUTHOR: Cheng-Bin Cui CB
AUTHOR: Lin Duan L
AUTHOR: Qian-Qun Gu QQ
AUTHOR: Wei-Ming Zhu WM
AFFILIATION: Key Laboratory of Marine Drugs, Chinese Ministry of Education, PR China.
PUBTYPE: Journal Article
JOURNALTITLE: Archives of pharmacal research.
COUNTRY: Korea (South)
TITLE: Potent in vitro anticancer activity of metacycloprodigiosin and undecylprodigiosin from a sponge-derived actinomycete Saccharopolyspora sp. nov.
PUBDATE: 20051201
Bioassay-guided fractionation of CHCl3 extract from the fermentation broth of a sponge Mycale plumose-derived actinomycete Saccharopolyspora sp. nov., led to the isolation of two known prodigiosin analogs--metacycloprodigiosin (1) and undecylprodigiosin (2). These compounds exhibited significant cytotoxic activities against five cancer cell lines: P388, HL60, A-549, BEL-7402, and SPCA4. This is the first report on the significant cytotoxicity of metacycloprodigiosin (1) against human cancer cell lines.

1. DOCID:31156 SCORE: 0.00493725395208573
DOCNO: 16274621
OWNER: NLM
STATUS: In-Data-Review
AUTHOR: Ke Qiang Chen KQ
AUTHOR: Pablo Iribarren P
AUTHOR: Wang Hua Gong WH
AUTHOR: Ji Ming Wang JM
AFFILIATION: School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 201101, China.
PUBTYPE: Journal Article
JOURNALTITLE: Cellular & molecular immunology.
COUNTRY: China
TITLE: The Essential Role of Phosphoinositide 3-Kinases (PI3Ks) in Regulating Pro-Inflammatory Responses and the Progression of Cancer.
PUBDATE: 20050801
Phosphoinositide 3-Kinases (PI3Ks) are proteins coupled to a variety of cell surface receptors and play a key role in signal transduction cascade regulating fundamental cellular functions such as transcription, proliferation, and survival. PI3Ks also are important in disease processes such as inflammation and cancer. The aim of this review is to outline current understandings of the PI3K family, mechanism of their activation, their role in inflammatory responses and the development of malignant tumors.

2. DOCID:27466 SCORE: 0.00449137281980727
DOCNO: 10858954
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Cycle Proteins
DESCRIPTOR: Enzyme Inhibitors
DESCRIPTOR: Tumor Suppressor Proteins
QUALIFIER: antagonists & inhibitors
QUALIFIER: physiology
AUTHOR: C Desdouets C
AUTHOR: C Bréchot C
AFFILIATION: Inserm U370, Paris, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Pathologie-biologie.
COUNTRY: FRANCE
TITLE: p27: a pleiotropic regulator of cellular phenotype and a target for cell cycle dysregulation in cancer.
PUBDATE: 20000401
The eukaryotic cell cycle is regulated by the sequential activation of cyclin-dependent kinases (CDKs). CDK activation is regulated by phosphorylation of the catalytic subunit, by binding to activating (cyclins) and inactivating subunits (cyclin-dependent kinase inhibitor). In this review, we will focus on the role of the cyclin-dependent kinase inhibitor p27 which has been recently the subject of extensive work. This negative regulator of cell growth indeed illustrates the pleiotropic biological effects of such molecules in both normal and cancer cells and the complexity of the regulatory mechanisms involved.

3. DOCID:25523 SCORE: 0.00391775820121356
DOCNO: 11282273
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: secondary
QUALIFIER: metabolism
AUTHOR: J Fujimoto J
AUTHOR: H Sakaguchi H
AUTHOR: I Aoki I
AUTHOR: S Khatun S
AUTHOR: H Toyoki H
AUTHOR: T Tamaya T
AFFILIATION: Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasa-machi, 500-8705, Gifu City, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Journal of steroid biochemistry and molecular biology.
COUNTRY: England
TITLE: Steroid receptors and metastatic potential in endometrial cancers.
PUBDATE: 20001201
The relative overexpression of estrogen receptor (ER)-alpha exon 5 splicing variant, the disrupted synchronization of ER-beta and ER-alpha expressions, and the suppression of progesterone receptor (PR) form A expression as a transcriptional repressor might be related to metastatic potential of uterine endometrial cancers, leading to poor patient prognosis related to estrogen refractoriness.

4. DOCID:26713 SCORE: 0.00374041493548874
DOCNO: 10562762
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Obesity
DESCRIPTOR: Weight Loss
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Drug and therapeutics bulletin.
COUNTRY: ENGLAND
TITLE: Why and how should adults lose weight?
PUBDATE: 19981201
Being overweight increases the risk of developing many common diseases including type-2 diabetes mellitus, hypertension, coronary heart disease, gallstones and various cancers of the gastrointestinal and urogenital tracts. It can also cause or exacerbate osteoarthritis, breathlessness, heartburn, sleep apnoea, venous thromboembolism and psychological distress, particularly anxiety and depression. It makes anaesthesia and surgery more hazardous, and in pregnancy increases the risks associated with childbirth. Being overweight can also complicate day-to-day social functioning such as negotiating seats on public transport or purchasing clothes. In this article, we review the evidence that weight loss is beneficial and how this might be achieved using lifestyle changes, drug therapy, or surgery.

5. DOCID:26642 SCORE: 0.00374041148936889
DOCNO: 11504627
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Expression Regulation
DESCRIPTOR: Oxidative Stress
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: A S Lee AS
AFFILIATION: University of Southern California/Norris Comprehensive Cancer Center, Dept of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089-9176, USA. amylee@hsc.usc.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Trends in biochemical sciences.
COUNTRY: England
TITLE: The glucose-regulated proteins: stress induction and clinical applications.
PUBDATE: 20010801
A protective mechanism used by cells to adapt to stress of the endoplasmic reticulum (ER) is the induction of members of the glucose-regulated protein (Grp) family. The induction of mammalian Grp proteins in response to ER stress involves a complex network of regulators and novel mechanisms. The elucidation of Grp function and regulation opens up new therapeutic approaches to diseases associated with ER stress and cancer.

6. DOCID:26430 SCORE: 0.00361587663468681
DOCNO: 9835759
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: M Rørth M
AUTHOR: H H Storm HH
AFFILIATION: Onkologisk klinik, Rigshospitalet, København.
PUBTYPE: Journal Article
JOURNALTITLE: Nordisk medicin.
COUNTRY: SWEDEN
TITLE: [Treatment of cancer patients in the Nordic countries]
PUBDATE: 19981101
A recent analysis of epidemiological data from the Nordic Cancer Registries revealed that the prognosis of several groups of cancer patients in Denmark is inferior to that of the other countries. These differences have evolved during the last 20-30 years. The prognosis of cancer patients in the Nordic countries is reasonably good compared to other European countries and to the black community in the United States while the white community in the US has a better prognosis with regard to most of the cancer diseases. It is speculated that these differences reflect differences in resources allocated to cancer treatment.

7. DOCID:26559 SCORE: 0.00353789076662495
DOCNO: 11564312
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Parenteral Nutrition, Total
QUALIFIER: etiology
QUALIFIER: diet therapy
AUTHOR: A Shadaba A
AUTHOR: J Paine J
AUTHOR: R Adlard R
AUTHOR: M Dilkes M
AFFILIATION: Department of Otolaryngology and Head/Surgery, St Bartholomew's Hospital, London, UK.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of laryngology and otology.
COUNTRY: England
TITLE: Re-feeding syndrome.
PUBDATE: 20010901
The effect of a therapeutically administered high calorie diet in a severely malnourished patient is discussed in this case report. In patients with advanced head and neck cancer prolonged periods of malnutrition prior to admission are frequently encountered. This case report highlights the need to constantly monitor the electrolyte and vitamin levels during the early stages of instituting enteral or parenteral nutrition. By vigilant monitoring and a high index of suspicion re-feeding syndrome or severe hypophosphataemia and its associated complications can be avoided.

8. DOCID:26543 SCORE: 0.00352901495323165
DOCNO: 10817498
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Polymorphism, Genetic
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: G Liu G
AUTHOR: P Ghadirian P
AUTHOR: D Vesprini D
AUTHOR: N Hamel N
AUTHOR: A J Paradis AJ
AUTHOR: G Lal G
AUTHOR: S Gallinger S
AUTHOR: S A Narod SA
AUTHOR: W D Foulkes WD
AFFILIATION: Centre for Research in Women's Health, Women's College Hospital, University of Toronto, Canada.
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: SCOTLAND
TITLE: Polymorphisms in GSTM1, GSTT1 and CYP1A1 and risk of pancreatic adenocarcinoma.
PUBDATE: 20000501
A prospective study of 149 unselected incident cases of pancreatic adenocarcinoma and 146 ethnically-matched controls found no associations between GSTM1 (adjusted odds ratio (AOR) 1.14), GSTT1 (AOR: 1.19) and CYP1A1 (AOR: 1.08) polymorphisms and pancreatic cancer susceptibility. Smoking and drinking status did not affect results. These polymorphisms do not appear to be important gene modifiers in pancreatic cancer.

9. DOCID:27659 SCORE: 0.00327590787782739
DOCNO: 11253593
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: therapy
QUALIFIER: pathology
QUALIFIER: therapy
AUTHOR: E A Rendina EA
AUTHOR: F Venuta F
AUTHOR: T De Giacomo T
AUTHOR: G Furio Coloni G
AFFILIATION: Department of Thoracic Surgery, Policlinico Umberto Io, University La Sapienza, Rome, Italy. erendina@tin.it
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Chest surgery clinics of North America.
COUNTRY: United States
TITLE: Stage IIIB non-small-cell lung cancer.
PUBDATE: 20010201
Highly selected patients with locally advanced non-small-cell lung cancer achieving cure do not contribute meaningfully to the overall prognosis of stage III. This finding is true particularly if clinicians rely on currently available therapeutic modalities (chemotherapy, radiation therapy, surgery) or refinements thereof. Understanding of the molecular biology continues to improve; it is more likely that in the new millenium, the real breakthroughs in staging and therapy for this high-risk, poor-prognosis group will come from the integration of molecular modalities in the clinical application.

10. DOCID:27746 SCORE: 0.00327590362190695
DOCNO: 17031151
OWNER: NLM
STATUS: In-Data-Review
AUTHOR: J A Vanderhoof JA
AUTHOR: R J Young RJ
AFFILIATION: Department of Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Current opinion in gastroenterology.
COUNTRY: United States
TITLE: The role of probiotics in the treatment of intestinal infections and inflammation.
PUBDATE: 20010101
Clinical studies have established that certain probiotics are useful in a variety of intestinal disorders, including viral diarrhea, antibiotic-associated diarrhea, Clostridium difficile-associated diarrhea, and traveler's diarrhea. Evolving data suggest that probiotics might be useful in the control of inflammatory diseases, treatment and prevention of allergic diseases, cancer prevention, and stimulation of the immune system, which may result in the reduction in respiratory disease. A review of current data regarding the most common probiotics is presented. It is important that probiotic use be directed by well-designed, placebo-controlled clinical studies published in peer-reviewed journals.

11. DOCID:29862 SCORE: 0.00308287117017039
DOCNO: 15935730
OWNER: NLM
STATUS: In-Process
AUTHOR: Beatriz M Carreno BM
AUTHOR: Laura L Carter LL
AUTHOR: Mary Collins M
AFFILIATION: Inflammation, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in pharmacology.
COUNTRY: England
TITLE: Therapeutic opportunities in the B7/CD28 family of ligands and receptors.
PUBDATE: 20050801
The CD28 and B7 protein families are critical regulators of immune responses and, in the past few years, several new family members have been identified. Preclinical studies exploring the role of members of the CD28 and B7 families support the targeting of these pathways for new therapeutic approaches. Indeed, recent Phase I clinical studies using agonists and antagonists of the CD28/CTLA-4/B7 pathway have shown promise in inflammatory diseases and cancer.

12. DOCID:31024 SCORE: 0.00308285665676592
DOCNO: 16474786
OWNER: NLM
STATUS: In-Process
AUTHOR: Fiona C Burkhard FC
AUTHOR: Martin Schumacher M
AUTHOR: Urs E Studer UE
AFFILIATION: Department of Urology at the University Hospital in Bern, Switzerland.
PUBTYPE: Journal Article
JOURNALTITLE: Nature clinical practice. Urology.
COUNTRY: United States
TITLE: The role of lymphadenectomy in prostate cancer.
PUBDATE: 20050701
It has been shown that an adequate lymphadenectomy for exact staging of prostate cancer consists of removal of all the tissue along the external iliac vein, in the obturator fossa and along the internal iliac artery. Morbidity associated with this procedure is low, if certain technical details are respected. This review discusses in detail the indications for lymphadenectomy and the extent of dissection, based on the localization of the positive nodes. The potential therapeutic impact of extended lymph node dissection in men with prostate cancer is also addressed.

13. DOCID:31187 SCORE: 0.0030793491137463
DOCNO: 15071997
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Adenocarcinoma
DESCRIPTOR: Rectal Neoplasms
QUALIFIER: therapeutic use
QUALIFIER: methods
AUTHOR: S V Peliukhovs'kyĭ SV
AUTHOR: A V Chornobaĭ AV
PUBTYPE: Journal Article
JOURNALTITLE: Klinichna khirurhiia / Ministerstvo okhorony zdorov'ia Ukraïny, Naukove tovarystvo khirurhiv Ukraïny.
COUNTRY: Ukraine
TITLE: [Experience of surgical treatment of rectal cancer with chemoradiation component on the first stage]
PUBDATE: 20040101
Experience of treatment of 14 patients with cancer recti, using chemoradiation impact on the tumor--endolymphatic polychemotherapy according to MFP (metotrexat, fluorouracyl cysplatin) schema and intense irradiation (summary focal dose 25 Gr) on the first stage with subsequent performance of surgical intervention in terms before 24 hours after completion of irradiation. The immediate results of treatment are estimated. There was not revealed the postoperative complications frequency enhancement. The anal sphincter function restoration was observed at the same terms as after performance of conventional surgical treatment.

14. DOCID:30308 SCORE: 0.00295199962703133
DOCNO: 12044009
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Molecular Biology
QUALIFIER: metabolism
AUTHOR: William C Hahn WC
AUTHOR: Robert A Weinberg RA
AFFILIATION: Whitehead Institute for Biomedical Research, Massachusetts 02142, USA. William_Hahn@dfci.harvard.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nature reviews. Cancer.
COUNTRY: England
TITLE: Modelling the molecular circuitry of cancer.
PUBDATE: 20020501
Cancer arises from a stepwise accumulation of genetic changes that liberates neoplastic cells from the homeostatic mechanisms that govern normal cell proliferation. In humans, at least four to six mutations are required to reach this state, but fewer seem to be required in mice. By rationalizing the shared and unique elements of human and mouse models of cancer, we should be able to identify the molecular circuits that function differently in humans and mice, and use this knowledge to improve existing models of cancer.