0. DOCID:3562 SCORE: 0.0087787700234855
DOCNO: 558345
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: diagnosis
AUTHOR: M Fleisher M
AUTHOR: H Grabstald H
AUTHOR: W F Whitmore WF
AUTHOR: C M Pinsky CM
AUTHOR: H F Oettgen HF
AUTHOR: M K Schwartz MK
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: The clinical utility of plasma and urinary carcinoembryonic antigen in patients with genitourinary disease.
PUBDATE: 19770501
Carcinoembryonic antigen was measured in the urine and plasma of 108 patients with several types and various stages of genitourinary cancer. The value of the carcinoembryonic antigen assay as an early indicator of neoplastic disease was evaluated and a correlation was made between the extent of disease and the concentration of urinary and plasma carcinoembryonic antigen. Patients were classified according to stage of tumor involvement as follows: no evidence of disease, non-malignant disease, non-invasive disease, no known metastasis, regional metastasis and disseminated metastasis. The urinary carcinoembryonic antigen levels more closely paralleled the extent of disease than did the plasma carcinoembryonic antigen levels in patients with bladder cancer. Neither urinary nor plasma carcinoembryonic antigen levels were useful in assessing the extent of disease in patients with prostatic or testicular cancer. Studies related to microbiological interference in the carcinoembryonic antigen assay indicated that bacterial counts up to 10(5) organisms per ml. did not interfere. Cytological studies indicated that the presence of white blood cells, atypical cells and malignant cells could result in elevated urinary carcinoembryonic antigen levels.

1. DOCID:3903 SCORE: 0.00699495568658177
DOCNO: 12259609
OWNER: PIP
STATUS: MEDLINE
DESCRIPTOR: Age Factors
DESCRIPTOR: Androgens
DESCRIPTOR: Estrogens
DESCRIPTOR: Men
DESCRIPTOR: Menopause
DESCRIPTOR: Psychology
DESCRIPTOR: Sexual Behavior
DESCRIPTOR: Women
AUTHOR: R B Greenblatt RB
AUTHOR: R Witherington R
AUTHOR: I B Sipahioglu IB
PUBTYPE: Journal Article
JOURNALTITLE: Drug therapy.
COUNTRY: United States
TITLE: Hormones for improved sexuality in the male and female climacteric.
PUBDATE: 19760901
In the perimenopausal period, estrogen falls to 1/3 or 1/2 of the levels found in premenopausal women, serum and urinary gonadotropins rise 6- to 10-fold, and the vaginal mucosa undergoes regressive changes; this state is referred to as the menopausal syndrome. Similarly, aging men often experience psychosexual and physical problems. Testosterone levels fall while estrogen rises. Gonadotropin levels do not rise if any spermatogenic function remains. Estrogen replacement therapy for women may simulate proliferation of the endometrium which might evolve into neoplasia. Estrogen-androgen (EA) preparations have been most acceptable and effective. Hormones implanted sc at 6-month intervals have been effective, particularly in women who have undergone hysterectomy. A potent oral progestogen should be given for 5-7 days at monthly intervals to induce orderly withddrawal symptoms. For men, androgens may exacerbate the growth of a cancer already present. Androgens for the male climacteric have given beneficial results when taken in adequate dosage; but in younger men who complain of impotence favorable results have not often been obtained. While other factors play important roles, testosterone is a true aphrodisiac for both men and women. For frigidity in women psycchogenic factors are often more important. For men under age 50 psychogenic block may also be a most important factor.

2. DOCID:6845 SCORE: 0.00469478430643957
DOCNO: 455241
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antigen-Antibody Complex
DESCRIPTOR: Complement System Proteins
QUALIFIER: immunology
AUTHOR: H Biran H
AUTHOR: G M Mavligit GM
AUTHOR: J L Moake JL
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Receptor sites for complement and for immune complexes on human nonhemopoietic tumor cells.
PUBDATE: 19790701
Tumor cells in primary cultures derived from 11 untreated nonhemopoietic cancer patients were reacted with specifically coated sheep erythrocytes. Rosette formation between tumor and indicator cells was assessed, Eight of the primary cultures reacted positively with both IgG-coated (EAIgG) and with IgM-human complement coated (EAIgMC or EAIgMC 4,3) sheep erythrocytes. EAIgG rosette formation in positive cultures ranged from 25 to 85%, and for EAIgMC/EAIgMC 4,3 reactivity ranged between 22--95%. Rosette formation with E (uncoated) and EAIgM was negligible. These findings suggest that human nonhemopoietic tumor cells may carry on their surface receptor sites for an IgG component of immune complexes and for human complement. These receptor sites may be important in the host-tumor relationship.

3. DOCID:2615 SCORE: 0.00469343739131181
DOCNO: 1173080
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: A F Hoge AF
AUTHOR: M T Shaw MT
AUTHOR: R H Bottomley RH
AUTHOR: J M Hartsuck JM
PUBTYPE: Journal Article
JOURNALTITLE: JAMA : the journal of the American Medical Association.
COUNTRY: UNITED STATES
TITLE: Therapeutic regimens in advanced breast cancer.
PUBDATE: 19750301
A retrospective study of the methods of treatment in 98 patients with advanced breast cancer over the past five years showed striking differences in remission rates, duration of remissions, and overall survival according to the method of treatment. Adrenalectomy and oophorectomy produced remissions in 58% of patients, with a median duration of 22 months. Survival curves were impressive and favored the surgically ablated group, who had a median survival of 32 months. Sixty-seven percent of responders continue to survive at four years. Chemotherapy with single agents produced remissions in 30% of patients, having a median duration of nine months. Additive endocrine therapy produced 33% to 36% remission rates, with median durations of 12 to 16 months. Responses were more frequent and longer lasting in older patients. Radiotherapy, when used without supplemental therapy, resulted in good local control, but a short median survival of 7.5 months.

4. DOCID:7814 SCORE: 0.00437383824356702
DOCNO: 7365390
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: M Hakama M
AUTHOR: R West R
PUBTYPE: Journal Article
JOURNALTITLE: Journal of epidemiology and community health.
COUNTRY: ENGLAND
TITLE: Cervical cancer in Finland and South Wales: implications of end results data on the natural history.
PUBDATE: 19800301
The population-based cancer registry data on patients with cervical cancer in Finland and South Wales in 1960--69 were analysed for survival. Patients with carcinoma-in-situ experienced essentially the normal life expectancy. Those with invasive carcinoma experienced 75% of normal post-registration life expectancy in Finland but only 45% in South Wales. The difference was due to higher frequency and to better survival of patients with localised carcinoma in Finland, which was attributed to the fact that in Wales the mean age of the population is higher than that in Finland, and also to the longer delya in Wales from first symptoms to diagnosis among women with localised cancer. The differences in mean age by clinical stage and in survival combined with the duration of symptoms support the hypothesis that speed of tumour growth is a major determinant of clinical stage at diagnosis.

5. DOCID:6775 SCORE: 0.00432469107255674
DOCNO: 379835
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: K Wurster K
AUTHOR: W Rapp W
PUBTYPE: Journal Article
JOURNALTITLE: Pathology, research and practice.
COUNTRY: GERMANY, WEST
TITLE: Histological and immunohistological studies on gastric mucosa. I. The presence of CEA in dysplastic surface epithelium.
PUBDATE: 19790101
Surface and foveolar gastric cells (SE) of 74 gastric resection specimens were studied by classical and indirect immunoenzyme histology. Immunoadsorbed CEA-antibodies reacting only with the specific determinant of of the CEA molecule were applied. The following SE types with different CEA distribution patterns were observed: Type SE-O, no CEA, normal neutral mucosubstances (MCS); type SE-A, CEA present in the lower half of the SE, important decrease of MCS, mild cell dysplasia by conventional criteria; type SE-B, CEA present in the total cell, absence of MCS, moderate until marked dysplasia; type SE-C, CEA present or decreased, absence of MCS, very important cell dysplasia resembling cancer cells. CEA proved to be useful as marker for the degree of SE dysplasia.

6. DOCID:3973 SCORE: 0.00392537187126665
DOCNO: 558818
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Counseling
DESCRIPTOR: Family Planning Services
AUTHOR: A G Dawrant AG
PUBTYPE: Letter
JOURNALTITLE: Canadian Medical Association journal.
COUNTRY: CANADA
TITLE: Family planning and birth control counseling.
PUBDATE: 19770601
The following item appeared recently in our local newspaper: "The Federal Government plans to press the provinces to establish special abortion clinics that would also provide family planning services, Health Minister Marc Lalonde announced. The proposed clinics would combine abortion services with family planning and birth control counseling, cancer screening and other services related to the health of mothers, he said." It seems that the federal government is attempting to cover the bitter pill of a therapeutic abortion clinic with the sugar coating of family planning and contraceptive counseling. Family planning and contraceptive counseling is an important part of the day-to-day work of the great majority of family physicians and gynecologists, and I urge all physicians who are opposed to Mr. Lalonde's proposal to contact their Members of Parliament and their representatives in the provincial legislatures. Let us urge the Canadian Medical Association to make it clear that the appropriate setting for contraceptive counseling and related services should be the office of the family physician or gynecologist. The time has come for the association to take a more aggressive approach in the field of family planning and birth control counseling and, at the same time, actively discourage government involvement in this important area of preventive medicine. Further, let us make it clear that the whole question of therapeutic abortions and abortion clinics is to be regarded as distinct from family planning and contraceptive counseling.

7. DOCID:7462 SCORE: 0.0038504001453043
DOCNO: 6155790
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: Y K Wu YK
AUTHOR: P T Chen PT
AUTHOR: J P Fang JP
AUTHOR: S S Lin SS
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: Surgical treatment of esophageal carcinoma.
PUBDATE: 19800601
Recent progress in the surgical treatment of carcinoma of the esophagus has changed the pessimistic outlook for this malignancy. With reasonably early diagnosis, it is feasible to achieve a resectability rate of 75 to 85 percent, an operative mortality of about 5 percent and a 5 year survival rate of about 30 percent. With careful selection of patients for operation and proper use of radiation and other adjunctive therapy, even more encouraging results are possible. Efforts for further improvement may be directed toward early diagnosis, refinement in operative technique and better pre- and postoperative care. The use of microsurgery and the development of mechanical suture apparatus in esophageal reconstruction after resection may further improve surgical treatment of cancer of the esophagus. Thoracic surgeons still have the responsibility to improve the management of the nonresectable cases of carcinoma of the esophagus.

8. DOCID:7281 SCORE: 0.0037819704751588
DOCNO: 746597
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: Z Paszko Z
AUTHOR: H Padzik H
AUTHOR: M Dabska M
AUTHOR: F Pienkowska F
PUBTYPE: Journal Article
JOURNALTITLE: Tumori.
COUNTRY: ITALY
TITLE: Estrogen receptor in human breast cancer in relation to tumor morphology and endocrine therapy.
PUBDATE: 19781001
The presence of estrogen receptors (ER) was determined in 111 human breast cancer specimens. In 61% of the tumors, specific estrogen binding was found and in 39% of the tumors ER was absent. In 69 tumors no correlation was found between the histological grading of the tumor and the level of ER. The values of ER in tumors from patients over 50 years of age were usually much higher than those for patients under 50 years of age. Different methods of endocrine therapy were applied in 20 patients. In 10 of 15 patients with ER positive tumors, endocrine therapy resulted in remission. Only 1 of 5 patients with ER negative tumors responded with remission. It is concluded that estimation of ER in tumor tissue is helpful in the selection of patients for endocrine therapy.

9. DOCID:1708 SCORE: 0.00376029501706354
DOCNO: 1048489
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Colostomy
DESCRIPTOR: Ileostomy
DESCRIPTOR: Information Services
DESCRIPTOR: Patient Education
DESCRIPTOR: Urinary Diversion
AUTHOR: M E Yahle ME
PUBTYPE: Journal Article
JOURNALTITLE: The Nursing clinics of North America.
COUNTRY: UNITED STATES
TITLE: An ostomy information clinic. A community resource.
PUBDATE: 19760901
This article has included some facets of discussions that take place at the Ostomy Information Clinic in Milwaukee. All types of ostomates attend one or more clinics to obtain information and help with management of their ostomies. Topics explored are management of drainage, odor control, use of the cone irrigation, digestion, nutrition and diet, and travel tips. In addition to ostomates, nurses often attend the clinics with or without their patients. Consultation is also provided to the Visiting Nurses' Association and local hospital nursing staffs. I would like to encourage other nurses to consider conducting ostomy information clinics in conjunction with the American Cancer Society. Not only is there a great need, but it is a personally rewarding and satisfactory experience.

10. DOCID:2412 SCORE: 0.00367060436407311
DOCNO: 819136
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: A W Cheever AW
AUTHOR: R E Kuntz RE
AUTHOR: J A Moore JA
AUTHOR: T C Huang TC
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Proliferative epithelial lesions of the urinary bladder in cynomolgus monkeys (Macaca fascicularis) infected with Schistosoma intercalatum.
PUBDATE: 19760801
Five cynomolgus monkeys (Macaca fascicularis) were infected with Schistosoma intercalatum, a helminth that is morphologically similar to Schistosoma haematobium. Infections were readily established and remained active until the monkeys were sacrificed 21 to 84 weeks after exposure. Although the schistosomes were located predominantly in mesenteric and hepatic portal venules, schistosome eggs were found in the bladders of 3 monkeys. Nodules of atypical epithelial cells interpreted as superficially infiltrating undifferentiated bladder carcinomas were found in one monkey 23 weeks after infection. These sessile tumors differ strikingly from the well-differentiated, papillary transitional cell tumors previously reported from several species of experimental animals infected with S. haematobium. The tumors are also dissimilar to the squamous cell bladder tumors associated with S. haematobium infection in man but may nonetheless be useful for investigations of schistosomal bladder cancer.

11. DOCID:1506 SCORE: 0.00366654026854905
DOCNO: 195711
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: adverse effects
QUALIFIER: etiology
AUTHOR: P Cole P
AUTHOR: D Cramer D
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Diet and cancer of endocrine target organs.
PUBDATE: 19770701
The role of diet in the etiology of cancer of the breast and endometrium is considered. Geographic variation in rates, effects of migration, consequences of exogenous hormone use, and other epidemiologic factors are reviewed. Cancer of the endometrium is related to diet probably through simple caloric excess. The excess is reflected in obesity and the consequent overproduction of estrone, a natural but carcinogenic human estrogen. Diet may also influence breast cancer risk somewhat through the same mechanism. But this mechanism probably would not explain a large proportion of the disease. It is possible that, in addition, some specific dietary factor, for example, saturated fat, is causally related to breast cancer. Such a relationship would probably be mediated through an endocrine mechanism.

12. DOCID:7542 SCORE: 0.00348976037428063
DOCNO: 220925
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: K Y Yeung KY
AUTHOR: D J Haidak DJ
AUTHOR: J A Brown JA
AUTHOR: D Anderson D
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Archives of internal medicine.
COUNTRY: UNITED STATES
TITLE: Metastasis-induced acute pancreatitis in small cell bronchogenic carcinoma.
PUBDATE: 19790501
Despite frequent metastatic involvement of the pancreas at postmortem examination in patients with small cell lung cancer, clinically observed pancreatitis due to metastatic pancreatic tumor rarely has been reported. This communication describes three cases of clinical acute pancreatitis occurring in a consecutive series of 40 patients with oat cell lung cancer. This complication may appear either as the initial manifestation of the neoplasm or during a recrudescent phase of the malignant growth. The diagnosis should be suspected in the presence of the clinical, laboratory, and radiologic features of acute pancreatitis in patients with known small cell carcinoma of the lung, especially if there is evidence of progression of the neoplastic disease elsewhere and no response to conservative medical management. Aggressive treatment with polychemotherapy can produce rapid clinical improvement and useful prolongation of survival.

13. DOCID:6989 SCORE: 0.00339904010213614
DOCNO: 7470623
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Blood Coagulation
QUALIFIER: blood
AUTHOR: M Colucci M
AUTHOR: R Giavazzi R
AUTHOR: G Alessandri G
AUTHOR: N Semeraro N
AUTHOR: A Mantovani A
AUTHOR: M B Donati MB
PUBTYPE: Journal Article
JOURNALTITLE: Blood.
COUNTRY: UNITED STATES
TITLE: Procoagulant activity of sarcoma sublines with different metastatic potential.
PUBDATE: 19810401
It has been suggested that cancer cell procoagulant activity influences metastasis formation by promoting fibrin deposition around tumors. We have investigated the procoagulant activity of various tumor cell sublines with different metastatic capacity derived from metastatic nodules of a murine fibrosarcoma. All the cells tested possessed a marked thromboplastin-like activity; they were, however, heterogeneous as regards the degree of procoagulant activity; the two cell lines with virtually no metastatic capacity showed 6--8 times higher procoagulant activity than the cells from the parent line; in contrast, the procoagulant activity of the two sublines with higher metastatic capacity did not differ significantly from that of the parent line. These findings support the hypothesis that fibrin is part of a defence reaction against cancer cell invasiveness.

14. DOCID:7946 SCORE: 0.00333271554529042
DOCNO: 7205706
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Attitude of Health Personnel
DESCRIPTOR: Internship and Residency
QUALIFIER: psychology
QUALIFIER: psychology
AUTHOR: J Kaye J
AUTHOR: M Appel M
AUTHOR: R Joseph R
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of psychology.
COUNTRY: UNITED STATES
TITLE: Attitudes of medical students and residents toward cancer.
PUBDATE: 19810101
Attitudes toward cancer and heart disease were evaluated in 99 freshmen medical students, 76 seniors, and 66 residents using the Cancer Attitude Survey and a Semantic Differential test. The Survey revealed a rise in positive attitudes towards patients' inner resources to cope with serious illness and toward personal immortality and a rise in negative attitudes toward early diagnosis of cancer as students progressed in their training. The Semantic Differential test demonstrated more negative attitudes toward cancer than heart disease in all groups (freshman, seniors, and residents in medicine, psychiatry, or surgery). The seniors had the most positive attitudes toward cancer and freshman the least positive attitudes. The residents had more positive attitudes than the freshmen but less positive attitudes than the seniors. The residents in psychiatry had more positive attitudes than the residents in medicine, who had more positive attitudes than the residents in surgery.