0. DOCID:31345 SCORE: 0.00493894905082033
DOCNO: 16392666
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analogs & derivatives
QUALIFIER: chemistry
AUTHOR: Rui Liu R
AUTHOR: Cheng-Bin Cui CB
AUTHOR: Lin Duan L
AUTHOR: Qian-Qun Gu QQ
AUTHOR: Wei-Ming Zhu WM
AFFILIATION: Key Laboratory of Marine Drugs, Chinese Ministry of Education, PR China.
PUBTYPE: Journal Article
JOURNALTITLE: Archives of pharmacal research.
COUNTRY: Korea (South)
TITLE: Potent in vitro anticancer activity of metacycloprodigiosin and undecylprodigiosin from a sponge-derived actinomycete Saccharopolyspora sp. nov.
PUBDATE: 20051201
Bioassay-guided fractionation of CHCl3 extract from the fermentation broth of a sponge Mycale plumose-derived actinomycete Saccharopolyspora sp. nov., led to the isolation of two known prodigiosin analogs--metacycloprodigiosin (1) and undecylprodigiosin (2). These compounds exhibited significant cytotoxic activities against five cancer cell lines: P388, HL60, A-549, BEL-7402, and SPCA4. This is the first report on the significant cytotoxicity of metacycloprodigiosin (1) against human cancer cell lines.

1. DOCID:31156 SCORE: 0.00493725395208573
DOCNO: 16274621
OWNER: NLM
STATUS: In-Data-Review
AUTHOR: Ke Qiang Chen KQ
AUTHOR: Pablo Iribarren P
AUTHOR: Wang Hua Gong WH
AUTHOR: Ji Ming Wang JM
AFFILIATION: School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 201101, China.
PUBTYPE: Journal Article
JOURNALTITLE: Cellular & molecular immunology.
COUNTRY: China
TITLE: The Essential Role of Phosphoinositide 3-Kinases (PI3Ks) in Regulating Pro-Inflammatory Responses and the Progression of Cancer.
PUBDATE: 20050801
Phosphoinositide 3-Kinases (PI3Ks) are proteins coupled to a variety of cell surface receptors and play a key role in signal transduction cascade regulating fundamental cellular functions such as transcription, proliferation, and survival. PI3Ks also are important in disease processes such as inflammation and cancer. The aim of this review is to outline current understandings of the PI3K family, mechanism of their activation, their role in inflammatory responses and the development of malignant tumors.

2. DOCID:27466 SCORE: 0.00449137281980727
DOCNO: 10858954
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Cycle Proteins
DESCRIPTOR: Enzyme Inhibitors
DESCRIPTOR: Tumor Suppressor Proteins
QUALIFIER: antagonists & inhibitors
QUALIFIER: physiology
AUTHOR: C Desdouets C
AUTHOR: C Bréchot C
AFFILIATION: Inserm U370, Paris, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Pathologie-biologie.
COUNTRY: FRANCE
TITLE: p27: a pleiotropic regulator of cellular phenotype and a target for cell cycle dysregulation in cancer.
PUBDATE: 20000401
The eukaryotic cell cycle is regulated by the sequential activation of cyclin-dependent kinases (CDKs). CDK activation is regulated by phosphorylation of the catalytic subunit, by binding to activating (cyclins) and inactivating subunits (cyclin-dependent kinase inhibitor). In this review, we will focus on the role of the cyclin-dependent kinase inhibitor p27 which has been recently the subject of extensive work. This negative regulator of cell growth indeed illustrates the pleiotropic biological effects of such molecules in both normal and cancer cells and the complexity of the regulatory mechanisms involved.

3. DOCID:25523 SCORE: 0.00391775820121356
DOCNO: 11282273
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: secondary
QUALIFIER: metabolism
AUTHOR: J Fujimoto J
AUTHOR: H Sakaguchi H
AUTHOR: I Aoki I
AUTHOR: S Khatun S
AUTHOR: H Toyoki H
AUTHOR: T Tamaya T
AFFILIATION: Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasa-machi, 500-8705, Gifu City, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Journal of steroid biochemistry and molecular biology.
COUNTRY: England
TITLE: Steroid receptors and metastatic potential in endometrial cancers.
PUBDATE: 20001201
The relative overexpression of estrogen receptor (ER)-alpha exon 5 splicing variant, the disrupted synchronization of ER-beta and ER-alpha expressions, and the suppression of progesterone receptor (PR) form A expression as a transcriptional repressor might be related to metastatic potential of uterine endometrial cancers, leading to poor patient prognosis related to estrogen refractoriness.

4. DOCID:26713 SCORE: 0.00374041493548874
DOCNO: 10562762
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Obesity
DESCRIPTOR: Weight Loss
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Drug and therapeutics bulletin.
COUNTRY: ENGLAND
TITLE: Why and how should adults lose weight?
PUBDATE: 19981201
Being overweight increases the risk of developing many common diseases including type-2 diabetes mellitus, hypertension, coronary heart disease, gallstones and various cancers of the gastrointestinal and urogenital tracts. It can also cause or exacerbate osteoarthritis, breathlessness, heartburn, sleep apnoea, venous thromboembolism and psychological distress, particularly anxiety and depression. It makes anaesthesia and surgery more hazardous, and in pregnancy increases the risks associated with childbirth. Being overweight can also complicate day-to-day social functioning such as negotiating seats on public transport or purchasing clothes. In this article, we review the evidence that weight loss is beneficial and how this might be achieved using lifestyle changes, drug therapy, or surgery.

5. DOCID:26642 SCORE: 0.00374041148936889
DOCNO: 11504627
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Expression Regulation
DESCRIPTOR: Oxidative Stress
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: A S Lee AS
AFFILIATION: University of Southern California/Norris Comprehensive Cancer Center, Dept of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089-9176, USA. amylee@hsc.usc.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Trends in biochemical sciences.
COUNTRY: England
TITLE: The glucose-regulated proteins: stress induction and clinical applications.
PUBDATE: 20010801
A protective mechanism used by cells to adapt to stress of the endoplasmic reticulum (ER) is the induction of members of the glucose-regulated protein (Grp) family. The induction of mammalian Grp proteins in response to ER stress involves a complex network of regulators and novel mechanisms. The elucidation of Grp function and regulation opens up new therapeutic approaches to diseases associated with ER stress and cancer.

6. DOCID:16627 SCORE: 0.00364689064027003
DOCNO: 1597271
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: B Caniels B
AUTHOR: W Hammans W
AFFILIATION: Institut für Klinische Genetik und Zytologie, Akademisches Lehrkrankenhaus GH Essen.
PUBTYPE: Journal Article
JOURNALTITLE: Geburtshilfe und Frauenheilkunde.
COUNTRY: GERMANY
TITLE: [CIN and pregnancy, a 20-year retrospect]
PUBDATE: 19920301
This is a report on CIN associated with pregnancy in a review over the last 20 years. Biological tumour behaviour, diagnostic problems and therapy are discussed in 100 cases of preinvasive and invasive lesions of the cervix. It is pointed out that low acceptance of early detection measures in association with late pregnancy planning may contribute to an increase of invasive cancer in pregnancy.

7. DOCID:26430 SCORE: 0.00361587663468681
DOCNO: 9835759
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: M Rørth M
AUTHOR: H H Storm HH
AFFILIATION: Onkologisk klinik, Rigshospitalet, København.
PUBTYPE: Journal Article
JOURNALTITLE: Nordisk medicin.
COUNTRY: SWEDEN
TITLE: [Treatment of cancer patients in the Nordic countries]
PUBDATE: 19981101
A recent analysis of epidemiological data from the Nordic Cancer Registries revealed that the prognosis of several groups of cancer patients in Denmark is inferior to that of the other countries. These differences have evolved during the last 20-30 years. The prognosis of cancer patients in the Nordic countries is reasonably good compared to other European countries and to the black community in the United States while the white community in the US has a better prognosis with regard to most of the cancer diseases. It is speculated that these differences reflect differences in resources allocated to cancer treatment.

8. DOCID:26559 SCORE: 0.00353789076662495
DOCNO: 11564312
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Parenteral Nutrition, Total
QUALIFIER: etiology
QUALIFIER: diet therapy
AUTHOR: A Shadaba A
AUTHOR: J Paine J
AUTHOR: R Adlard R
AUTHOR: M Dilkes M
AFFILIATION: Department of Otolaryngology and Head/Surgery, St Bartholomew's Hospital, London, UK.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of laryngology and otology.
COUNTRY: England
TITLE: Re-feeding syndrome.
PUBDATE: 20010901
The effect of a therapeutically administered high calorie diet in a severely malnourished patient is discussed in this case report. In patients with advanced head and neck cancer prolonged periods of malnutrition prior to admission are frequently encountered. This case report highlights the need to constantly monitor the electrolyte and vitamin levels during the early stages of instituting enteral or parenteral nutrition. By vigilant monitoring and a high index of suspicion re-feeding syndrome or severe hypophosphataemia and its associated complications can be avoided.

9. DOCID:26543 SCORE: 0.00352901495323165
DOCNO: 10817498
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Polymorphism, Genetic
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: G Liu G
AUTHOR: P Ghadirian P
AUTHOR: D Vesprini D
AUTHOR: N Hamel N
AUTHOR: A J Paradis AJ
AUTHOR: G Lal G
AUTHOR: S Gallinger S
AUTHOR: S A Narod SA
AUTHOR: W D Foulkes WD
AFFILIATION: Centre for Research in Women's Health, Women's College Hospital, University of Toronto, Canada.
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: SCOTLAND
TITLE: Polymorphisms in GSTM1, GSTT1 and CYP1A1 and risk of pancreatic adenocarcinoma.
PUBDATE: 20000501
A prospective study of 149 unselected incident cases of pancreatic adenocarcinoma and 146 ethnically-matched controls found no associations between GSTM1 (adjusted odds ratio (AOR) 1.14), GSTT1 (AOR: 1.19) and CYP1A1 (AOR: 1.08) polymorphisms and pancreatic cancer susceptibility. Smoking and drinking status did not affect results. These polymorphisms do not appear to be important gene modifiers in pancreatic cancer.

10. DOCID:22388 SCORE: 0.00352122227147568
DOCNO: 7554509
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Health Behavior
QUALIFIER: prevention & control
AUTHOR: J S Rossi JS
AUTHOR: L M Blais LM
AUTHOR: C A Redding CA
AUTHOR: M A Weinstock MA
AFFILIATION: Department of Psychology, University of Rhode Island, Kingston, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Dermatologic clinics.
COUNTRY: UNITED STATES
TITLE: Preventing skin cancer through behavior change. Implications for interventions.
PUBDATE: 19950701
Sun exposure is the only major causative factor for skin cancer for which prevention is feasible. Both individual and community-based interventions have been effective in changing sun exposure knowledge and attitudes but generally have not been effective in changing behaviors. An integrative model of behavior change is described that has been successful in changing behavior across a wide range of health conditions. This model holds promise for developing a rational public health approach to skin cancer prevention based on sound behavioral science.

11. DOCID:22416 SCORE: 0.00352122092672893
DOCNO: 8091052
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: L Perey L
AUTHOR: S Leyvraz S
AFFILIATION: Centre pluridisciplinaire d'oncologie, Lausanne.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Schweizerische Rundschau für Medizin Praxis = Revue suisse de médecine Praxis.
COUNTRY: SWITZERLAND
TITLE: [Primary and adjuvant treatment of breast cancer: an update]
PUBDATE: 19940801
Several articles covering treatment of mammary carcinoma in situ and invading mammary cancer have been published recently. This article delivers a short description of the clinical picture and the treatment of a noninvasive tumor as well as of the mainly conservative primary treatment of invasive carcinoma in common use since 20 years. Systemic adjuvant treatment is discussed in the context of results from a meta-analysis publishes two years ago in 'Lancet'. Finally, various directives for the execution of an adjuvant treatment are given that are offered today outside of a study protocol.

12. DOCID:17896 SCORE: 0.00336528407586771
DOCNO: 2278511
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
QUALIFIER: drug effects
AUTHOR: S Erber S
AUTHOR: H Birnböck H
AUTHOR: E von Angerer E
AFFILIATION: Institut für Pharmazie, Universität Regensburg.
PUBTYPE: Journal Article
JOURNALTITLE: Archiv der Pharmazie.
COUNTRY: GERMANY
TITLE: Synthesis and biological properties of a 1-(6-aziridinylhexyl)-2-phenylindole, a potential fluorescence label for estrogen receptors.
PUBDATE: 19900801
2-Phenylindole derivative 8, linked to aziridine by a hexamethylene spacer group, was synthesized and tested. It binds to the estrogen receptor with an RBA-value of 4.0 (estradiol = 100). In vitro, it shows a selective cytostatic activity in hormone-dependent MCF-7 breast cancer cells (41% T/C at 10(-6) M). In vivo, it exerts a strong estrogenic effect. The binding to the estrogen receptor is largely reversible.

13. DOCID:18909 SCORE: 0.00334229796545248
DOCNO: 2195801
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Seeding
DESCRIPTOR: Tissue Donors
QUALIFIER: pathology
QUALIFIER: physiopathology
QUALIFIER: pathology
AUTHOR: K Lucius K
AUTHOR: H Oesterwitz H
AUTHOR: P Müller P
AUTHOR: W Blank W
AUTHOR: G May G
AFFILIATION: Urologische Klinik, Krankenhauses in Friedrichshain, Berlin.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Zeitschrift für Urologie und Nephrologie.
COUNTRY: GERMANY, EAST
TITLE: [Transplantation of the kidneys of donors with cancer--personal experiences and review of the literature]
PUBDATE: 19900201
From 1980 to 1988 more than 1,549 organ donors were harvested, 125 of them (8%) died from cancer--116 brain tumors and 9 donors with extracerebral cancer. In 3 donors suffering from extracerebral cancer 5 kidneys were transplanted. All transplants functioned well without tumor signs up to 21 months after grafting. However, because of tumor recurrence in nearly 50% of the cases described in the literature generally organs from donors suffering from extracerebral cancer should not transplanted if possible.

14. DOCID:18923 SCORE: 0.00334229256669497
DOCNO: 8222585
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: therapy
AUTHOR: I D Hay ID
AUTHOR: G G Klee GG
AFFILIATION: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Clinics in laboratory medicine.
COUNTRY: UNITED STATES
TITLE: Thyroid cancer diagnosis and management.
PUBDATE: 19930901
This article provides an overview of the classification of thyroid carcinoma into well-differentiated forms (papillary and follicular) as well as the rare Hurthle cell, medullary, and anaplastic forms. The characteristics, relative frequency, and mortality rates of each form of thyroid cancer are summarized. The roles of history, physical examination, blood tests, such as thyroid function test, thyroglobulin (htg), calcitonin and CEA, radionuclide and ultrasound imaging, and fine-needle aspirates are outlined for the diagnosis and management of thyroid cancer. An algorithmic diagram of the monitoring procedures for long-term management of various forms of thyroid cancer is presented.