0. DOCID:3562 SCORE: 0.0087787700234855
DOCNO: 558345
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: diagnosis
AUTHOR: M Fleisher M
AUTHOR: H Grabstald H
AUTHOR: W F Whitmore WF
AUTHOR: C M Pinsky CM
AUTHOR: H F Oettgen HF
AUTHOR: M K Schwartz MK
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: The clinical utility of plasma and urinary carcinoembryonic antigen in patients with genitourinary disease.
PUBDATE: 19770501
Carcinoembryonic antigen was measured in the urine and plasma of 108 patients with several types and various stages of genitourinary cancer. The value of the carcinoembryonic antigen assay as an early indicator of neoplastic disease was evaluated and a correlation was made between the extent of disease and the concentration of urinary and plasma carcinoembryonic antigen. Patients were classified according to stage of tumor involvement as follows: no evidence of disease, non-malignant disease, non-invasive disease, no known metastasis, regional metastasis and disseminated metastasis. The urinary carcinoembryonic antigen levels more closely paralleled the extent of disease than did the plasma carcinoembryonic antigen levels in patients with bladder cancer. Neither urinary nor plasma carcinoembryonic antigen levels were useful in assessing the extent of disease in patients with prostatic or testicular cancer. Studies related to microbiological interference in the carcinoembryonic antigen assay indicated that bacterial counts up to 10(5) organisms per ml. did not interfere. Cytological studies indicated that the presence of white blood cells, atypical cells and malignant cells could result in elevated urinary carcinoembryonic antigen levels.

1. DOCID:3903 SCORE: 0.00699495568658177
DOCNO: 12259609
OWNER: PIP
STATUS: MEDLINE
DESCRIPTOR: Age Factors
DESCRIPTOR: Androgens
DESCRIPTOR: Estrogens
DESCRIPTOR: Men
DESCRIPTOR: Menopause
DESCRIPTOR: Psychology
DESCRIPTOR: Sexual Behavior
DESCRIPTOR: Women
AUTHOR: R B Greenblatt RB
AUTHOR: R Witherington R
AUTHOR: I B Sipahioglu IB
PUBTYPE: Journal Article
JOURNALTITLE: Drug therapy.
COUNTRY: United States
TITLE: Hormones for improved sexuality in the male and female climacteric.
PUBDATE: 19760901
In the perimenopausal period, estrogen falls to 1/3 or 1/2 of the levels found in premenopausal women, serum and urinary gonadotropins rise 6- to 10-fold, and the vaginal mucosa undergoes regressive changes; this state is referred to as the menopausal syndrome. Similarly, aging men often experience psychosexual and physical problems. Testosterone levels fall while estrogen rises. Gonadotropin levels do not rise if any spermatogenic function remains. Estrogen replacement therapy for women may simulate proliferation of the endometrium which might evolve into neoplasia. Estrogen-androgen (EA) preparations have been most acceptable and effective. Hormones implanted sc at 6-month intervals have been effective, particularly in women who have undergone hysterectomy. A potent oral progestogen should be given for 5-7 days at monthly intervals to induce orderly withddrawal symptoms. For men, androgens may exacerbate the growth of a cancer already present. Androgens for the male climacteric have given beneficial results when taken in adequate dosage; but in younger men who complain of impotence favorable results have not often been obtained. While other factors play important roles, testosterone is a true aphrodisiac for both men and women. For frigidity in women psycchogenic factors are often more important. For men under age 50 psychogenic block may also be a most important factor.

2. DOCID:31345 SCORE: 0.00493894905082033
DOCNO: 16392666
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analogs & derivatives
QUALIFIER: chemistry
AUTHOR: Rui Liu R
AUTHOR: Cheng-Bin Cui CB
AUTHOR: Lin Duan L
AUTHOR: Qian-Qun Gu QQ
AUTHOR: Wei-Ming Zhu WM
AFFILIATION: Key Laboratory of Marine Drugs, Chinese Ministry of Education, PR China.
PUBTYPE: Journal Article
JOURNALTITLE: Archives of pharmacal research.
COUNTRY: Korea (South)
TITLE: Potent in vitro anticancer activity of metacycloprodigiosin and undecylprodigiosin from a sponge-derived actinomycete Saccharopolyspora sp. nov.
PUBDATE: 20051201
Bioassay-guided fractionation of CHCl3 extract from the fermentation broth of a sponge Mycale plumose-derived actinomycete Saccharopolyspora sp. nov., led to the isolation of two known prodigiosin analogs--metacycloprodigiosin (1) and undecylprodigiosin (2). These compounds exhibited significant cytotoxic activities against five cancer cell lines: P388, HL60, A-549, BEL-7402, and SPCA4. This is the first report on the significant cytotoxicity of metacycloprodigiosin (1) against human cancer cell lines.

3. DOCID:31156 SCORE: 0.00493725395208573
DOCNO: 16274621
OWNER: NLM
STATUS: In-Data-Review
AUTHOR: Ke Qiang Chen KQ
AUTHOR: Pablo Iribarren P
AUTHOR: Wang Hua Gong WH
AUTHOR: Ji Ming Wang JM
AFFILIATION: School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 201101, China.
PUBTYPE: Journal Article
JOURNALTITLE: Cellular & molecular immunology.
COUNTRY: China
TITLE: The Essential Role of Phosphoinositide 3-Kinases (PI3Ks) in Regulating Pro-Inflammatory Responses and the Progression of Cancer.
PUBDATE: 20050801
Phosphoinositide 3-Kinases (PI3Ks) are proteins coupled to a variety of cell surface receptors and play a key role in signal transduction cascade regulating fundamental cellular functions such as transcription, proliferation, and survival. PI3Ks also are important in disease processes such as inflammation and cancer. The aim of this review is to outline current understandings of the PI3K family, mechanism of their activation, their role in inflammatory responses and the development of malignant tumors.

4. DOCID:6845 SCORE: 0.00469478430643957
DOCNO: 455241
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antigen-Antibody Complex
DESCRIPTOR: Complement System Proteins
QUALIFIER: immunology
AUTHOR: H Biran H
AUTHOR: G M Mavligit GM
AUTHOR: J L Moake JL
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Receptor sites for complement and for immune complexes on human nonhemopoietic tumor cells.
PUBDATE: 19790701
Tumor cells in primary cultures derived from 11 untreated nonhemopoietic cancer patients were reacted with specifically coated sheep erythrocytes. Rosette formation between tumor and indicator cells was assessed, Eight of the primary cultures reacted positively with both IgG-coated (EAIgG) and with IgM-human complement coated (EAIgMC or EAIgMC 4,3) sheep erythrocytes. EAIgG rosette formation in positive cultures ranged from 25 to 85%, and for EAIgMC/EAIgMC 4,3 reactivity ranged between 22--95%. Rosette formation with E (uncoated) and EAIgM was negligible. These findings suggest that human nonhemopoietic tumor cells may carry on their surface receptor sites for an IgG component of immune complexes and for human complement. These receptor sites may be important in the host-tumor relationship.

5. DOCID:2615 SCORE: 0.00469343739131181
DOCNO: 1173080
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: A F Hoge AF
AUTHOR: M T Shaw MT
AUTHOR: R H Bottomley RH
AUTHOR: J M Hartsuck JM
PUBTYPE: Journal Article
JOURNALTITLE: JAMA : the journal of the American Medical Association.
COUNTRY: UNITED STATES
TITLE: Therapeutic regimens in advanced breast cancer.
PUBDATE: 19750301
A retrospective study of the methods of treatment in 98 patients with advanced breast cancer over the past five years showed striking differences in remission rates, duration of remissions, and overall survival according to the method of treatment. Adrenalectomy and oophorectomy produced remissions in 58% of patients, with a median duration of 22 months. Survival curves were impressive and favored the surgically ablated group, who had a median survival of 32 months. Sixty-seven percent of responders continue to survive at four years. Chemotherapy with single agents produced remissions in 30% of patients, having a median duration of nine months. Additive endocrine therapy produced 33% to 36% remission rates, with median durations of 12 to 16 months. Responses were more frequent and longer lasting in older patients. Radiotherapy, when used without supplemental therapy, resulted in good local control, but a short median survival of 7.5 months.

6. DOCID:27466 SCORE: 0.00449137281980727
DOCNO: 10858954
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Cycle Proteins
DESCRIPTOR: Enzyme Inhibitors
DESCRIPTOR: Tumor Suppressor Proteins
QUALIFIER: antagonists & inhibitors
QUALIFIER: physiology
AUTHOR: C Desdouets C
AUTHOR: C Bréchot C
AFFILIATION: Inserm U370, Paris, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Pathologie-biologie.
COUNTRY: FRANCE
TITLE: p27: a pleiotropic regulator of cellular phenotype and a target for cell cycle dysregulation in cancer.
PUBDATE: 20000401
The eukaryotic cell cycle is regulated by the sequential activation of cyclin-dependent kinases (CDKs). CDK activation is regulated by phosphorylation of the catalytic subunit, by binding to activating (cyclins) and inactivating subunits (cyclin-dependent kinase inhibitor). In this review, we will focus on the role of the cyclin-dependent kinase inhibitor p27 which has been recently the subject of extensive work. This negative regulator of cell growth indeed illustrates the pleiotropic biological effects of such molecules in both normal and cancer cells and the complexity of the regulatory mechanisms involved.

7. DOCID:7814 SCORE: 0.00437383824356702
DOCNO: 7365390
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: M Hakama M
AUTHOR: R West R
PUBTYPE: Journal Article
JOURNALTITLE: Journal of epidemiology and community health.
COUNTRY: ENGLAND
TITLE: Cervical cancer in Finland and South Wales: implications of end results data on the natural history.
PUBDATE: 19800301
The population-based cancer registry data on patients with cervical cancer in Finland and South Wales in 1960--69 were analysed for survival. Patients with carcinoma-in-situ experienced essentially the normal life expectancy. Those with invasive carcinoma experienced 75% of normal post-registration life expectancy in Finland but only 45% in South Wales. The difference was due to higher frequency and to better survival of patients with localised carcinoma in Finland, which was attributed to the fact that in Wales the mean age of the population is higher than that in Finland, and also to the longer delya in Wales from first symptoms to diagnosis among women with localised cancer. The differences in mean age by clinical stage and in survival combined with the duration of symptoms support the hypothesis that speed of tumour growth is a major determinant of clinical stage at diagnosis.

8. DOCID:6775 SCORE: 0.00432469107255674
DOCNO: 379835
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: K Wurster K
AUTHOR: W Rapp W
PUBTYPE: Journal Article
JOURNALTITLE: Pathology, research and practice.
COUNTRY: GERMANY, WEST
TITLE: Histological and immunohistological studies on gastric mucosa. I. The presence of CEA in dysplastic surface epithelium.
PUBDATE: 19790101
Surface and foveolar gastric cells (SE) of 74 gastric resection specimens were studied by classical and indirect immunoenzyme histology. Immunoadsorbed CEA-antibodies reacting only with the specific determinant of of the CEA molecule were applied. The following SE types with different CEA distribution patterns were observed: Type SE-O, no CEA, normal neutral mucosubstances (MCS); type SE-A, CEA present in the lower half of the SE, important decrease of MCS, mild cell dysplasia by conventional criteria; type SE-B, CEA present in the total cell, absence of MCS, moderate until marked dysplasia; type SE-C, CEA present or decreased, absence of MCS, very important cell dysplasia resembling cancer cells. CEA proved to be useful as marker for the degree of SE dysplasia.

9. DOCID:11664 SCORE: 0.00419003929771242
DOCNO: 3986769
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Amplification
DESCRIPTOR: Oncogenes
QUALIFIER: genetics
AUTHOR: K A Graham KA
AUTHOR: C L Richardson CL
AUTHOR: M D Minden MD
AUTHOR: J M Trent JM
AUTHOR: R N Buick RN
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Varying degrees of amplification of the N-ras oncogene in the human breast cancer cell line MCF-7.
PUBDATE: 19850501
The oncogene N-ras has been found to be amplified (congruent to 20 copies) in the human breast carcinoma cell line MCF-7. The amplified sequences have been localized to a marker chromosome by in situ hybridization. Sublines of MCF-7, serially passaged in different laboratories, have marked variation in the degree of N-ras amplification. The differing degrees of amplification of N-ras are further evidence of heterogeneity within MCF-7 subclones. The phenomenon may not have general relevance for breast cancer, since other breast cancer cell lines and DNA from patient biopsies failed to show evidence of N-ras amplification.

10. DOCID:14667 SCORE: 0.00404803016760993
DOCNO: 2940540
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Electrons
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: J de Ranieri J
AUTHOR: H Crouet H
AUTHOR: C Levy C
AUTHOR: P Allain P
AUTHOR: J Bloquel J
AUTHOR: J Souloy J
AUTHOR: A Roussel A
AUTHOR: J S Abbatucci JS
PUBTYPE: Journal Article
JOURNALTITLE: Presse médicale (Paris, France : 1983)
COUNTRY: FRANCE
TITLE: [Intraoperative abdominopelvic radiotherapy by single dose electrons]
PUBDATE: 19860501
Thirty-four patients received, during laparotomy, a 15-20 Gy localized irradiation from a 10-13 MeV beam of electrons supplied by a linear accelerator and focalized by means of a localizer especially designed for this purpose. This technique is indicated for localized residual tumours of the pelvis and intra-operative irradiation of the lumbar aorta, as part of a chemo-radiotherapeutic programme in patients with advanced cancer of the cervix. It is too early to evaluate the medium-term results, but the technique is very well tolerated immediately.

11. DOCID:3973 SCORE: 0.00392537187126665
DOCNO: 558818
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Counseling
DESCRIPTOR: Family Planning Services
AUTHOR: A G Dawrant AG
PUBTYPE: Letter
JOURNALTITLE: Canadian Medical Association journal.
COUNTRY: CANADA
TITLE: Family planning and birth control counseling.
PUBDATE: 19770601
The following item appeared recently in our local newspaper: "The Federal Government plans to press the provinces to establish special abortion clinics that would also provide family planning services, Health Minister Marc Lalonde announced. The proposed clinics would combine abortion services with family planning and birth control counseling, cancer screening and other services related to the health of mothers, he said." It seems that the federal government is attempting to cover the bitter pill of a therapeutic abortion clinic with the sugar coating of family planning and contraceptive counseling. Family planning and contraceptive counseling is an important part of the day-to-day work of the great majority of family physicians and gynecologists, and I urge all physicians who are opposed to Mr. Lalonde's proposal to contact their Members of Parliament and their representatives in the provincial legislatures. Let us urge the Canadian Medical Association to make it clear that the appropriate setting for contraceptive counseling and related services should be the office of the family physician or gynecologist. The time has come for the association to take a more aggressive approach in the field of family planning and birth control counseling and, at the same time, actively discourage government involvement in this important area of preventive medicine. Further, let us make it clear that the whole question of therapeutic abortions and abortion clinics is to be regarded as distinct from family planning and contraceptive counseling.

12. DOCID:25523 SCORE: 0.00391775820121356
DOCNO: 11282273
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: secondary
QUALIFIER: metabolism
AUTHOR: J Fujimoto J
AUTHOR: H Sakaguchi H
AUTHOR: I Aoki I
AUTHOR: S Khatun S
AUTHOR: H Toyoki H
AUTHOR: T Tamaya T
AFFILIATION: Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasa-machi, 500-8705, Gifu City, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Journal of steroid biochemistry and molecular biology.
COUNTRY: England
TITLE: Steroid receptors and metastatic potential in endometrial cancers.
PUBDATE: 20001201
The relative overexpression of estrogen receptor (ER)-alpha exon 5 splicing variant, the disrupted synchronization of ER-beta and ER-alpha expressions, and the suppression of progesterone receptor (PR) form A expression as a transcriptional repressor might be related to metastatic potential of uterine endometrial cancers, leading to poor patient prognosis related to estrogen refractoriness.

13. DOCID:7462 SCORE: 0.0038504001453043
DOCNO: 6155790
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: Y K Wu YK
AUTHOR: P T Chen PT
AUTHOR: J P Fang JP
AUTHOR: S S Lin SS
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: Surgical treatment of esophageal carcinoma.
PUBDATE: 19800601
Recent progress in the surgical treatment of carcinoma of the esophagus has changed the pessimistic outlook for this malignancy. With reasonably early diagnosis, it is feasible to achieve a resectability rate of 75 to 85 percent, an operative mortality of about 5 percent and a 5 year survival rate of about 30 percent. With careful selection of patients for operation and proper use of radiation and other adjunctive therapy, even more encouraging results are possible. Efforts for further improvement may be directed toward early diagnosis, refinement in operative technique and better pre- and postoperative care. The use of microsurgery and the development of mechanical suture apparatus in esophageal reconstruction after resection may further improve surgical treatment of cancer of the esophagus. Thoracic surgeons still have the responsibility to improve the management of the nonresectable cases of carcinoma of the esophagus.

14. DOCID:7281 SCORE: 0.0037819704751588
DOCNO: 746597
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: Z Paszko Z
AUTHOR: H Padzik H
AUTHOR: M Dabska M
AUTHOR: F Pienkowska F
PUBTYPE: Journal Article
JOURNALTITLE: Tumori.
COUNTRY: ITALY
TITLE: Estrogen receptor in human breast cancer in relation to tumor morphology and endocrine therapy.
PUBDATE: 19781001
The presence of estrogen receptors (ER) was determined in 111 human breast cancer specimens. In 61% of the tumors, specific estrogen binding was found and in 39% of the tumors ER was absent. In 69 tumors no correlation was found between the histological grading of the tumor and the level of ER. The values of ER in tumors from patients over 50 years of age were usually much higher than those for patients under 50 years of age. Different methods of endocrine therapy were applied in 20 patients. In 10 of 15 patients with ER positive tumors, endocrine therapy resulted in remission. Only 1 of 5 patients with ER negative tumors responded with remission. It is concluded that estimation of ER in tumor tissue is helpful in the selection of patients for endocrine therapy.