0. DOCID:17526 SCORE: 0.00338573868031531
DOCNO: 1333812
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
AUTHOR: B McCormick B
AFFILIATION: Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in oncology.
COUNTRY: UNITED STATES
TITLE: Radiation therapy for breast cancer.
PUBDATE: 19921201
Now that the radiation literature for breast cancer is well established in terms of both local control and survival endpoints, especially for invasive breast cancer, recent reports focus on refining selection criteria of patients for treatment and on minimizing complications and maximizing cosmetic effects. The optimal treatment of patients with ductal carcinoma in situ remains a controversial issue, and the optimal sequencing of adjuvant chemotherapy and primary radiation in patients with breast-conserving surgery is emerging as a topic requiring further study.


1. DOCID:18967 SCORE: 0.00316155117485501
DOCNO: 1891857
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hyperthermia, Induced
DESCRIPTOR: Microwaves
QUALIFIER: therapeutic use
QUALIFIER: therapy
AUTHOR: V A Chernyĭ VA
AUTHOR: K A Galakhin KA
AUTHOR: E A Kolesnik EA
AUTHOR: O I Morgunova OI
PUBTYPE: Journal Article
JOURNALTITLE: Vrachebnoe delo.
COUNTRY: USSR
TITLE: [Endolymphatic polychemotherapy with local UHF hyperthermia in the surgical treatment of rectal neoplasms]
PUBDATE: 19910601
To reduce the risk of intraoperative metastases and increasing ablastic principles in radical surgical treatment of patients with cancer of the rectum the authors developed a scheme of preoperative treatment including endolymphatic polychemotherapy and UHF-hyperthermia. 5-fluorouracil and platidiam were used in the treatment of 30 patients with different histological types of adenocarcinomas of the rectum (grade III-IV). After treatment the viable epithelial component in the tumour was 26.5% as compared with 44.8% in the control. The effect of treatment was favourable both objectively and subjectively. The treatment was well tolerated.


2. DOCID:17161 SCORE: 0.00311897230583645
DOCNO: 1341778
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: R Gómez R
AUTHOR: E Oyarzún E
AUTHOR: A Cortínez A
AUTHOR: N Barrena N
AUTHOR: L Massardo L
AUTHOR: R Wild R
AFFILIATION: Departamento de Obstetricia y Ginecología, Pontificia Universidad Católica de Chile.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Revista médica de Chile.
COUNTRY: CHILE
TITLE: [Ovarian cancer and dermatomyositis. A clinical case]
PUBDATE: 19921001
Dermatomyositis (DM) is associated to malignant neoplasia in up to one third of the cases. Not considering breast neoplasia, ovarian cancer is the malignancy most frequently associated with DM in women. This study shows the evolution and outcome of a case of this association managed in our unit. The principal features of similar cases reported in the literature are summarized.


3. DOCID:18856 SCORE: 0.00297824650905271
DOCNO: 8402103
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: adverse effects
QUALIFIER: adverse effects
AUTHOR: A J Park AJ
AUTHOR: R J Black RJ
AUTHOR: A C Watson AC
AFFILIATION: Department of Plastic Surgery, St John's Hospital, Livingston, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The British journal of surgery.
COUNTRY: ENGLAND
TITLE: Silicone gel breast implants, breast cancer and connective tissue disorders.
PUBDATE: 19930901
Recent worldwide media speculation that silicone gel-filled breast implants may be linked to an increased incidence of breast and other cancers, and connective tissue disease (particularly systemic sclerosis) has caused concern to the medical profession and public alike. Until carefully controlled studies have been performed to prove the safety of these implants, the US Food and Drug Administration has restricted their use to research and breast reconstruction. Research has so far failed to prove a causative relationship between silicone implants and cancer or connective tissue disorders.


4. DOCID:18170 SCORE: 0.00294133351517395
DOCNO: 8244395
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosomes, Human, Pair 3
QUALIFIER: genetics
QUALIFIER: enzymology
AUTHOR: S S Li SS
AUTHOR: F S Sharief FS
AFFILIATION: Laboratory of Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709.
PUBTYPE: Journal Article
JOURNALTITLE: Genomics.
COUNTRY: UNITED STATES
TITLE: The prostatic acid phosphatase (ACPP) gene is localized to human chromosome 3q21-q23.
PUBDATE: 19930901
Human prostatic acid phosphatase (ACPP) has been used as a diagnostic marker for prostate cancer. It is synthesized under androgen regulation and secreted by the epithelial cells of the prostate gland. We have confirmed the previous assignment of the ACPP gene to chromosome 3 by probing a panel of 25 human-Chinese hamster somatic cell hybrids, and we have further localized the ACPP gene to chromosome 3q21-q23 by fluorescence in situ hybridization.


5. DOCID:18430 SCORE: 0.00279036153777591
DOCNO: 1807796
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: epidemiology
AUTHOR: P T Nmadu PT
AUTHOR: O A Mabogunje OA
AFFILIATION: Department of Surgery, Ahmadu Bellow University Hospital, Zaria, Nigeria.
PUBTYPE: Journal Article
JOURNALTITLE: The Central African journal of medicine.
COUNTRY: ZIMBABWE
TITLE: The risk of cancer in endemic multinodular goitre.
PUBDATE: 19910801
From 1971 to 1985 at the Ahmadu Bello University Hospital, Zaria, 245 patients with multinodular goitre were operated upon mostly for cosmesis. Clinically unsuspected malignancy was present in 50 (20 pc) of the resected specimens of which 26 were follicular and 20 papillary. This pattern conforms with the reports from other African Zones of endemic goitre where the frequency of cancer is lower in the clinically solitary nodular goitre. Thus, the management strategy ought to regard the multinodular goitre as pre-malignant and operations should be performed earlier on this account.


6. DOCID:18986 SCORE: 0.00272675507215285
DOCNO: 1698531
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: diagnostic use
AUTHOR: L Krogerus L
AUTHOR: L C Andersson LC
AFFILIATION: Department of Pathology, University of Helsinki, Finland.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Different lectin-binding patterns in primary breast cancers and their metastases.
PUBDATE: 19901001
The expression of glycoconjugates in primary tumors and their metastases in 18 consecutive cases of metastasized breast cancer was studied by use of lectin histochemistry. Paraffin sections were stained with a panel of seven fluorochrome-labeled lectins with defined sugar specificities. The study revealed variation in the lectin binding patterns of individual cancers. In the primary tumors the lectin reactivity was diversified, whereas in their respective metastases it was rather homogeneous. This finding indicates that there is intratumoral heterogeneity in the primary cancers, whereas the selected subclones of malignant cells with restricted glycoconjugate expression seem to give rise to metastases.


7. DOCID:19111 SCORE: 0.00265269524213962
DOCNO: 1459723
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: genetics
AUTHOR: G W Dyke GW
AUTHOR: J L Craven JL
AUTHOR: R Hall R
AUTHOR: R C Garner RC
AFFILIATION: Dept. of Biology, University of York, UK.
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: UNITED STATES
TITLE: Smoking-related DNA adducts in human gastric cancers.
PUBDATE: 19921201
DNA was extracted from the tumour tissue of 26 patients (18 smokers, 8 non-smokers) undergoing surgery for gastric cancer, and analyzed for the presence of DNA adducts by the 32P-post-labelling method. Adducts were detected in all samples tested, and adduct levels ranged from 2 adducts/10(8) nucleotides to 60 adducts/10(8) nucleotides. In male subjects, adduct levels were significantly greater in the DNA of smokers than in that of non-smokers. These results support epidemiological data suggesting that smoking is a risk factor for gastric cancer.


8. DOCID:19820 SCORE: 0.00253009179347616
DOCNO: 1864298
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immune Tolerance
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: complications
AUTHOR: A G Maiche AG
AFFILIATION: Department of Radiotherapy and Oncology, Helsinki University Central Hospital, Finland.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
COUNTRY: GERMANY
TITLE: Use of quinolones in the immunocompromised host.
PUBDATE: 19910401
Immune deficiency generally leads to infections. Cancer chemotherapy, medical interventions and various investigational procedures are important factors in the development of infection. In recent decades, there has been a major change in most cancer centers in the etiology of bacterial infections occurring in the immunocompromised host, most infections now being caused by gram-positive organisms. This might be partly due to prophylactic use of agents effective against gram-negative bacteria. The quinolones are now widely used in the treatment of serious infections of the immunocompromised patient. Prophylaxis with quinolones is also practised in cancer centers.


9. DOCID:19888 SCORE: 0.00249265280668066
DOCNO: 1618599
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: W K Amery WK
AUTHOR: J P Bruynseels JP
AFFILIATION: Janssen Research Foundation, Beerse, Belgium.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: International journal of immunopharmacology.
COUNTRY: ENGLAND
TITLE: Levamisole, the story and the lessons.
PUBDATE: 19920401
The history of the use of levamisole in man is summarized, from its start as an anthelmintic in the early sixties, through its world-wide recognition as an immunotropic agent especially in the seventies and early eighties, and its return to clinical prominence in 1989-90 as an effective adjuvant treatment for operable colon cancer. The knowledge accumulated from experimental tumour models and from clinical use in various types of cancer, supplemented with the recent evidence obtained from large-scale controlled trials in resectable colon cancer is reviewed. It is speculated that we may not have seen the end of levamisole story yet; also, the role of serendipidity in drug research is emphasized.


10. DOCID:18801 SCORE: 0.00242433955738317
DOCNO: 1734875
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: drug effects
QUALIFIER: pharmacology
QUALIFIER: metabolism
AUTHOR: S Noguchi S
AUTHOR: Y Kubota Y
AUTHOR: T Shuin T
AUTHOR: E Ito E
AUTHOR: H Inoue H
AUTHOR: T Yoshioka T
AFFILIATION: Department of Urology, Yokohama City University, School of Medicine, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Biochemical and biophysical research communications.
COUNTRY: UNITED STATES
TITLE: Effect of extracellular phosphatidylinositol on c-myc gene-expressed human renal cancer cell line.
PUBDATE: 19920101
Effect of exogenously added soybean phosphatidylinositol on c-myc gene expressed and unexpressed human cancer cell lines was investigated. When phosphatidylinositol liposomes were introduced into culture media, viability of c-myc unexpressed cells was reduced, while that of c-myc expressed cells was not. Death of c-myc unexpressed cells by phosphatidylinositol liposomes was found to be caused by abnormally accumulated intracellular Ca2+, and it seemed to be related to reduction of protein kinase C activity.


11. DOCID:19814 SCORE: 0.00233083346287634
DOCNO: 1933158
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: J Vicente J
AUTHOR: M P Laguna MP
AUTHOR: D Duarte D
AUTHOR: F Algaba F
AUTHOR: G Chéchile G
AFFILIATION: Department of Urology, Fundación Puigvert, Barcelona, Spain.
PUBTYPE: Journal Article
JOURNALTITLE: British journal of urology.
COUNTRY: ENGLAND
TITLE: Carcinoma in situ as a prognostic factor for G3pT1 bladder tumours.
PUBDATE: 19911001
G3pT1 bladder cancer has traditionally been regarded as a superficial tumour with a high risk of progression. We have studied 37 patients with initial G3pT1 bladder tumours treated between January 1981 and December 1985. They were divided into 2 groups according to the association with carcinoma in situ (Cis) at the time of diagnosis. Clinical behaviour was analysed at 5 years. The first group (without Cis) showed progression and recurrence rates similar to those of low grade, low stage bladder tumours. The second group (with Cis) had a similar rate of recurrence but their progression rate was 65%.


12. DOCID:19313 SCORE: 0.00231335262826639
DOCNO: 1582886
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: analogs & derivatives
QUALIFIER: methods
AUTHOR: S Hoshi S
AUTHOR: S Orikasa S
AUTHOR: M Kuwahara M
AUTHOR: K Suzuki K
AUTHOR: S Shirai S
AUTHOR: K Yoshikawa K
AUTHOR: M Nose M
AFFILIATION: Department of Urology, Tohoku University School of Medicine, Sendai.
PUBTYPE: Journal Article
JOURNALTITLE: Japanese journal of cancer research : Gann.
COUNTRY: JAPAN
TITLE: Shock wave and THP-adriamycin for treatment of rabbit's bladder cancer.
PUBDATE: 19920301
Focused high-energy shock waves (6,000 to 10,000 shots) were targeted under ultrasound guidance onto implanted urinary bladder cancer in rabbits to elucidate its effect. Although only focal necrosis of the tumor was seen following 6,000 to 10,000 shots daily for 3 days or following chemotherapy (THP-adriamycin) alone, almost total tumor necrosis was observed following a combined shock-wave therapy for one day and THP-adriamycin administration, demonstrating an additive and/or synergetic effect on rabbit urinary bladder cancer.


13. DOCID:18649 SCORE: 0.00231005584297681
DOCNO: 1314683
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: S A Holmes SA
AUTHOR: T J Christmas TJ
AUTHOR: R S Kirby RS
AUTHOR: W F Hendry WF
AFFILIATION: Department of Urology, St Bartholomew's Hospital, London.
PUBTYPE: Journal Article
JOURNALTITLE: British journal of urology.
COUNTRY: ENGLAND
TITLE: Cystectomy and substitution enterocystoplasty: alternative primary treatment for T2/3 bladder cancer.
PUBDATE: 19920301
The optimal treatment for invasive bladder cancer remains controversial. Although external beam radiotherapy is able to eradicate the disease in a number of patients, the difficulty is selecting those who will respond. Those who do develop a local recurrence will require a salvage cystectomy combined with urinary diversion. The results of performing cystectomy and bladder reconstruction as a primary procedure are presented and the concept of combining this with chemotherapy as an alternative strategy for the management of bladder cancer is discussed.


14. DOCID:17545 SCORE: 0.00228198651446765
DOCNO: 2057397
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: nursing
QUALIFIER: methods
AUTHOR: A C Yeomans AC
AUTHOR: J B Washington JB
AFFILIATION: Division of Medicine, University of Texas M.D. Anderson Cancer Center, Houston.
PUBTYPE: Journal Article
JOURNALTITLE: Oncology nursing forum.
COUNTRY: UNITED STATES
TITLE: Occult primary malignancies.
PUBDATE: 19910401
Occult primary malignancies (OPMs) are the eighth most common cancer in the United States. Generally, the prognosis is poor, with survival usually lasting two to four months from the time of diagnosis. The primary tumor will never be found in more than half of the patients, even after an exhaustive diagnostic workup and eventual autopsy. The majority of these tumors are metastatic at the time of diagnosis; therefore, therapy is palliative. Nursing implications include providing symptom management, psychological support, and patient education.