0. DOCID:11941 SCORE: 0.0036501672262141
DOCNO: 7077060
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: T L Fabry TL
AUTHOR: A Frankel A
AUTHOR: J D Waye JD
PUBTYPE: Journal Article
JOURNALTITLE: Journal of clinical gastroenterology.
COUNTRY: UNITED STATES
TITLE: Gastric polyps.
PUBDATE: 19820201
We suggest an approach to patients with gastric polyps, based on a study of 73 patients seen at this institution over a 5-year period. There were 40 cases of adenomatous and 20 cases of hamartomatous polyps. Differentiation between these two groups of polyps was not possible on the basis of clinical presentation, laboratory data, radiological, or endoscopic appearance. Differentiation was possible only on histologic examination of a totally resected specimen. In this series, only the adenomatous polyps were associated with gastric cancers in five patients. Since the malignancy either preceded or followed the recognition of adenomatous polyps, it is important to establish an early definite histological diagnosis. Patients with known adenomatous polyps should be followed closely for the development of gastric carcinoma, even after the polyps have been removed.


1. DOCID:10881 SCORE: 0.00347466150294851
DOCNO: 6323872
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: H Fleming H
AUTHOR: R Blumenthal R
AUTHOR: E Gurpide E
PUBTYPE: Journal Article
JOURNALTITLE: Journal of steroid biochemistry.
COUNTRY: ENGLAND
TITLE: Characteristics of cyclic nucleotide dependent regulation of cytoplasmic E2 binders in cultured endometrial and breast cells.
PUBDATE: 19840101
Estradiol binding levels have previously been shown to be increased or decreased by the addition of of cGMP or cAMP respectively to cellular homogenates prepared from human endometrial tissue or from the endometrial cell line HEC 1. Similar cyclic nucleotide dependent effects have now been demonstrated in homogenates prepared from a second endometrial cell line, HEC 50, and from two breast cancer cell lines, CG-5 and T47D. It was previously shown that ATP and Mg2+ are necessary for the generation or inactivation of E2 binding sites. The present study demonstrates that the concentration of K+ and of dithiothreitol can also affect these reactions.


2. DOCID:11690 SCORE: 0.00306679603860673
DOCNO: 6231185
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: R Abele R
AUTHOR: E Kaplan E
AUTHOR: R Grossenbacher R
AUTHOR: H J Schmid HJ
AUTHOR: F Cavalli F
PUBTYPE: Journal Article
JOURNALTITLE: European journal of cancer & clinical oncology.
COUNTRY: ENGLAND
TITLE: Phase II study of doxifluridine in advanced squamous cell carcinoma of the head and neck.
PUBDATE: 19840301
We conducted a phase II trial with 5'-deoxy-5-fluoridine (doxifluridine) in advanced squamous cell carcinoma of the head and neck. The drug was given at the dose of 4 g/m2 daily X 5 every 3 weeks. Twenty eligible patients entered this trial, 12 being evaluable for response to doxifluridine. The majority of these patients received previous treatment for cancer. One complete and two partial remissions were observed (25%). Drug-induced toxicity consisted mainly of myelosuppression, mild nausea and vomiting, stomatitis and central nervous system side-effects. Other dosages or schedules for doxifluridine administration might be explored in poor-risk patients.


3. DOCID:11819 SCORE: 0.00273972049329066
DOCNO: 4014150
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: mortality
AUTHOR: R Brookmeyer R
AUTHOR: N Day N
AUTHOR: V Pompe-Kirn V
PUBTYPE: Journal Article
JOURNALTITLE: American journal of epidemiology.
COUNTRY: UNITED STATES
TITLE: Assessing the impact of additional follow-up in cohort studies.
PUBDATE: 19850401
An approach is described for predicting the statistical value of extending follow-up in a cohort study. A simple approximation to the expected number of new events of interest is given. The effect of these events on inferences for parameters such as a standardized mortality ratio is approached in two ways. The first concerns the probability of reversing the conclusion of a significance test. The second approach finds the plausible range of values for the standardized mortality ratio after further follow-up that are consistent with the currently available data. Each of these values is displayed together with the precision of the estimate. The methods are illustrated with results from the International Radiation Study of Cervical Cancer (IARC Scientific Publication No. 52, 1984).


4. DOCID:10497 SCORE: 0.00272209259556745
DOCNO: 6632211
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Bile Ducts, Intrahepatic
QUALIFIER: pathology
AUTHOR: M Kurashina M
AUTHOR: S Kozuka S
AUTHOR: N Nakashima N
AUTHOR: N Hirabayashi N
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Mode of spread of intrahepatic bile duct carcinoma]
PUBDATE: 19830901
To determine the area of surgical resection and the prognosis in patients with intrahepatic bile duct carcinoma, we studied the mode of spread of this cancer, using 27 autopsy and 4 lobectomized cases. In hilar carcinoma, there was lymphatic invasion to the extrahepatic bile duct before invation to the hepatic lobules. Scirrhous cancer spread more distantly toward the peripheral areas of the liver than non-scirrhous cancer. The occurrence of extrahepatic metastasis might involve the following factors; depth of infiltration, extent of venous invasion, intrahepatic metastasis, size of the main tumor, and number of hepatic segments invaded by the cancer.


5. DOCID:11379 SCORE: 0.00269233034147727
DOCNO: 6546732
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapy
AUTHOR: J Menczer J
AUTHOR: G Ben-Baruch G
AUTHOR: M Modan M
AUTHOR: J Brenner J
AUTHOR: H Brenner H
PUBTYPE: Journal Article
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: A comparison of postoperative radiotherapy with postoperative chemotherapy in stage II-IV ovarian cancer patients.
PUBDATE: 19840201
A retrospective comparison between 28 stage II-IV ovarian cancer patients who received postoperative abdominopelvic irradiation and 15 such patients who received postoperative cis-platinum, Adriamycin, and Cytoxan chemotherapy was made. In both treatment groups there was a trend for a longer progression-free interval and 3-year survival in patients with residual tumor masses of less than 2 cm in diameter. In these patients there was also a trend favoring radiotherapy. However, all differences were not significant. Criteria for the choice of either modality of postoperative therapy of ovarian cancer patients remain to be determined. Nevertheless, the efficacy of both modes of treatment does not differ greatly.


6. DOCID:11190 SCORE: 0.00262680230432416
DOCNO: 4071330
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: African Continental Ancestry Group
DESCRIPTOR: European Continental Ancestry Group
QUALIFIER: pathology
AUTHOR: R J Pegoraro RJ
AUTHOR: D Nirmul D
AUTHOR: J V Bryer JV
AUTHOR: J P Jordaan JP
AUTHOR: S M Joubert SM
PUBTYPE: Journal Article
JOURNALTITLE: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.
COUNTRY: SOUTH AFRICA
TITLE: Clinical patterns of presentation of breast cancer in women of different racial groups in South Africa.
PUBDATE: 19851101
The ages at presentation of white patients with breast cancer were found to be significantly higher than those of blacks, Indians and coloureds; 73% of white women fell into the postmenopausal group, in marked contrast to only 35% of Indians, while blacks and coloureds had similar proportions of pre- and post-menopausal patients. A significantly higher incidence of poorly differentiated tumours was seen in Indian and black patients. Blacks showed a significant tendency to present with more advanced disease, while whites were generally diagnosed at a much earlier stage.


7. DOCID:9222 SCORE: 0.00260133026249239
DOCNO: 3843375
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemically induced
QUALIFIER: chemically induced
AUTHOR: S K Hoar SK
AUTHOR: J Santodonato J
AUTHOR: T P Cameron TP
AUTHOR: M I Kelsey MI
PUBTYPE: Journal Article
JOURNALTITLE: Journal of occupational medicine. : official publication of the Industrial Medical Association.
COUNTRY: UNITED STATES
TITLE: Monographs on human exposures to chemicals in the workplace.
PUBDATE: 19850801
The National Cancer Institute has contracted with Syracuse Research Corporation to produce monographs on the potential hazards of human exposure to approximately 70 chemicals used in the workplace. The monographs include detailed exposure data for specific job categories, as well as summaries of chemical and physical data, animal and human toxicological studies, short-term assays, and epidemiologic data. The information is useful for identifying suitable populations for epidemiologic research.


8. DOCID:10697 SCORE: 0.00257840146456463
DOCNO: 6617281
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: secondary
AUTHOR: J R Jett JR
AUTHOR: C G Hollinger CG
AUTHOR: A R Zinsmeister AR
AUTHOR: P C Pairolero PC
PUBTYPE: Journal Article
JOURNALTITLE: Chest.
COUNTRY: UNITED STATES
TITLE: Pulmonary resection of metastatic renal cell carcinoma.
PUBDATE: 19831001
Over a ten-year period, 44 patients with known primary renal cell cancer underwent thoracotomy for pulmonary metastases. The median postthoracotomy survival for all patients was 33 months. The five-year survival was 27 percent. Postthoracotomy survival was significantly better in those patients with a disease free interval of greater than 24 months and patients with metastatic lesions greater than or equal to 3 cm. No difference in survival was detected in patients with one versus more than one lesion or in patients undergoing complete resection versus incomplete resection or biopsy only. Age, sex, grade of tumor, or location of the pulmonary metastasis had no influence on survival.


9. DOCID:11448 SCORE: 0.00233838463419359
DOCNO: 6523892
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: instrumentation
QUALIFIER: diagnosis
AUTHOR: W Mestwerdt W
AUTHOR: D Kranzfelder D
PUBTYPE: Journal Article
JOURNALTITLE: Wiener klinische Wochenschrift.
COUNTRY: AUSTRIA
TITLE: [Early diagnosis of endometrial cancer]
PUBDATE: 19841001
The increasing morbidity rate of endometrial carcinoma has prompted the development of methods of examination suitable for the detection of asymptomatic carcinoma of the endometrium. Commercially available instruments for collection of specimens from the uterine cavity employ washing, aspiration or curettage techniques. Under clinical testing conditions, these instruments have been shown to have a high cytomorphological accuracy, namely 80%. It has not yet been possible to reproduce this high level of accuracy under outpatient conditions. Hence, utilization of these techniques as screening methods in a cancer prevention programme for the early detection of endometrial cancer cannot be realized at the present time. Prerequisites for their use would be further technical improvements in instrumentation and a sufficient level of expertise in the assessment of endometrial smears by differential cytological techniques.


10. DOCID:9497 SCORE: 0.00233572769935445
DOCNO: 6491154
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: methods
AUTHOR: C E Mountford CE
AUTHOR: W B Mackinnon WB
AUTHOR: M Bloom M
AUTHOR: E E Burnell EE
AUTHOR: I C Smith IC
PUBTYPE: Journal Article
JOURNALTITLE: Journal of biochemical and biophysical methods.
COUNTRY: NETHERLANDS
TITLE: NMR methods for characterizing the state of the surfaces of complex mammalian cells.
PUBDATE: 19840901
It is shown that narrow 1H NMR resonances may be observed in cancer cells, and that these belong to fatty acyl chains of membrane lipids. A variety of NMR techniques such as Gaussian-Lorentzian deconvolution, and T1 and T2 measurements, may be used to subdivide these resonances further. The results of these various methods require that in the membrane structures the observed lipids tumble isotropically and sufficiently rapidly to give motionally narrowed 1H NMR lines.


11. DOCID:11500 SCORE: 0.00230535915332147
DOCNO: 7089642
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: T W Klamer TW
AUTHOR: M H Max MH
PUBTYPE: Journal Article
JOURNALTITLE: Southern medical journal.
COUNTRY: UNITED STATES
TITLE: Pancreatic carcinoma.
PUBDATE: 19820701
This retrospective review of 33 consecutive patients with cancer of the pancreas was undertaken to investigate epidemiologic factors, presenting symptoms, diagnostic methods, site and extent of cancer, treatment approaches, and survival data. The most frequent presenting complaint, reported by 23 patients (70%), was abdominal pain. Diagnosis was established by radiography or radionuclide scanning in 11 patients (33%). Nine patients (27%) were inoperable. One patient (3%) received resection in attempt for cure, 15 (46%) had palliative bypass procedures, and eight (25%) had laparotomy only. Eighteen patients (55%) received chemotherapy, with or without operation, and two (6%) had irradiation. The mean survival was 5.1 months. One third of the patients were dead a month after diagnosis. All patients died within 16 months of diagnosis, regardless of treatment method or extent of disease.


12. DOCID:11774 SCORE: 0.00215523721696006
DOCNO: 6611940
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: R V Mantravadi RV
AUTHOR: E J Liebner EJ
AUTHOR: R E Haas RE
AUTHOR: E M Skolnik EM
AUTHOR: E L Applebaum EL
PUBTYPE: Journal Article
JOURNALTITLE: Radiology.
COUNTRY: UNITED STATES
TITLE: Cancer of the glottis: prognostic factors in radiation therapy.
PUBDATE: 19831001
The authors conducted a multivariate analysis of the prognostic factors in 96 patients with early glottic cancer treated by radiation therapy. Of these, 73 had T1 and 23 had T2 tumor. The primary tumor was controlled in 82% of T1 and 74% of T2 lesions. Actuarial five-year survival rates were 87% for T1 and 74% for T2. Carcinoma of the anterior commissure associated with bilateral vocal cord involvement, subglottic tumor extension, persistent or recurrent laryngeal edema, and impaired cord mobility was found to adversely influence the prognosis. The data suggest that irradiation is the treatment of choice for glottic cancer limited to the vocal cords or with minimal extension to the anterior commissure or supraglottic larynx.


13. DOCID:10944 SCORE: 0.00214147540658598
DOCNO: 6727052
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: A Yaita A
AUTHOR: K Tohgi K
AUTHOR: H Kanamori H
AUTHOR: T Nakamura T
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Early esophageal cancer concomitant with leiomyoma of the esophagus--a case report]
PUBDATE: 19840501
Benign esophageal tumors concomitant with esophageal cancer are sometimes observed, however, it is rare that esophageal cancer is associated at the surface of the leiomyoma as a submucosal tumor. We report a 59-year-old man with a polypoid esophageal cancer. The polypoid tumor, 0.6 X 0.7 X 1.3 cm in size, was removed in 1976; histological findings showed that a large amount of the tumor was leiomyoma and that squamous cell cancer was associated at the surface of the leiomyoma. After polypectomy, he experienced recurrence and radical surgery was performed in 1981; histologically, the resected specimen showed early esophageal cancer.


14. DOCID:10848 SCORE: 0.00212211959257029
DOCNO: 7039579
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Titanium
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: D E Schuller DE
AUTHOR: J Bardach J
AUTHOR: C G Monteith CG
AUTHOR: M D Maves MD
PUBTYPE: Journal Article
JOURNALTITLE: Archives of otolaryngology (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Titanium tray mandibular reconstruction.
PUBDATE: 19820301
Mandibular reconstructions still present a difficult and challenging problem. Failures experienced in using rib or iliac bone grafts stimulated clinical and research activities in evaluating the following new techniques: composite myocutaneous bone flaps, bone transplants with microvascular anastomoses, and freeze-dried homografts. This article describes the usefulness of the titanium tray with or without cancellous iliac bone grafts for mandibular reconstruction. The series presented herein includes 12 patients who underwent mandibular reconstruction after trauma or ablative cancer surgery, No immediate or delayed extrusion of the titanium tray was observed with follow-up as long as eight years after surgery. Advantages and disadvantages of this technique will be discussed.