0. DOCID:7525 SCORE: 0.00355643114530627
DOCNO: 7355726
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: instrumentation
QUALIFIER: analysis
AUTHOR: J F Mazur JF
AUTHOR: G E Podolak GE
AUTHOR: B T Heitke BT
PUBTYPE: Journal Article
JOURNALTITLE: American Industrial Hygiene Association journal.
COUNTRY: UNITED STATES
TITLE: Use of a GC concentrator to improve analysis of low levels of airborne hydrazine and unsymmetrical dimethylhydrazine.
PUBDATE: 19800101
New findings from animal studies indicate that there is a serious cancer risk associated with exposures to hydrazines. In June, 1978, NIOSH announced more restrictive occupational exposure levels for these compounds. Adherence to these limits requires improved analytical methodology. This paper describes a modified method for monitoring hydrazine and unsymmetrical dimethylhydrazine in atmospheric samples below the ceiling concentrations recommended by NIOSH. The method utilizes a GC concentrator for which a "trap" (ventable GC precolumn) was prepared and tested. Using this trap, up to 40 microL sample injections (injections much too large for conventional GC work) are effectively chromatographed. Presented are data on the overall efficiency of the method for airborne hydrazine and unsymmetrical dimethylhydrazine in the concentration ranges of 0.02 - 0.67 mg/m3 and 0.04 - 1.04 mg/m3, respectively.


1. DOCID:7419 SCORE: 0.00325012298767431
DOCNO: 384260
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Maternal-Fetal Exchange
QUALIFIER: administration & dosage
QUALIFIER: drug effects
QUALIFIER: etiology
AUTHOR: L Tomatis L
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: National Cancer Institute monograph.
COUNTRY: UNITED STATES
TITLE: Prenatal exposure to chemical carcinogens and its effect on subsequent generations.
PUBDATE: 19790501
That exposure of pregnant animals to chemical carcinogens results in the occurrence of tumors in the progeny is well documented. Evidence has been accumulated on at least 38 chemicals pertaining to different chemical groups. The experimental evidence was followed by observations in humans regarding the increased risk of cancer in daughters of women who received stilbestrol during pregnancy. Additional experimental evidence is accumulating on the possibility that exposure during pregnancy results in an increased incidence of tumors for more than one generation of untreated descendants. Studies done on mice with DMBA and on rats with MNU and ENU showed that exposure to the carcinogens during pregnancy resulted in a high incidence of tumors in animals of the first generation and in an increased incidence of tumors at specific sites in untreated animals of the second and third generations.


2. DOCID:7068 SCORE: 0.00322748154799314
DOCNO: 432325
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: J Conley J
AUTHOR: D C Baker DC
PUBTYPE: Journal Article
JOURNALTITLE: Plastic and reconstructive surgery.
COUNTRY: UNITED STATES
TITLE: Hypoglossal-facial nerve anastomosis for reinnervation of the paralyzed face.
PUBDATE: 19790101
The hypoglossal-facial nerve crossover is a valuable surgical procedure for the treatment of certain types of facial paralysis. It is most effective when used as an integral part of a primary ablative operation for the treatment of cancer in this region. In the treatment of long-standing facial paralysis, its application requires an intact peripheral facial nerve system and some functioning mimetic muscles with an obliterated proximal facial nerve segment. It is recognized that other procedures are available for repair in patients who meet essentially these same criteria. The disadvantages are minimal intraoral crippling, mass movements of the face and, in some instances, hypertonia of the face. The advantages are improved facial tone, protection of the eye, intentional facial movements controlled by the tongue, and movements associated with physiological functions of the tongue.


3. DOCID:7954 SCORE: 0.00299994789989271
DOCNO: 7415839
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: etiology
QUALIFIER: etiology
AUTHOR: T Okumura T
AUTHOR: M Okada M
AUTHOR: M Tsuji M
AUTHOR: A Inoue A
AUTHOR: Y Ochiai Y
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Acta pathologica japonica.
COUNTRY: JAPAN
TITLE: Mesothelioma with lung cancer complicating asbestosis.
PUBDATE: 19800701
The patient had been employed in an asbestos factory for four years from the age of 16. Five years ago, she complained of sputum and cough, and she was treated for chronic bronchitis. From March, 1977, when she was 53 years old, hydrothorax and ascites increased, her weight decreased and she was hospitalized for cachexia. The clinical diagnosis of malignant diffuse mesothelioma was made on the presence of atypical cells in the effusions. Atypical cells showed a positive colloidal iron staining test and positive hyaluronidase digestion test. Asbestos bodies were found in the sputum. The patient died on February 1978. Postmortem confirmed asbestosia and mesothelioma which was scattered over the pleura, pericardial sac, diaphragma, peritoneum and pancreas. In addition, bronchiolo-alveolar cell type lung cancer was found localized in the lower lobe of the left lung. The electron beam diffraction disclosed the asbestos as amosite (brown asbestos).


4. DOCID:7267 SCORE: 0.00273807332482557
DOCNO: 527268
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: classification
AUTHOR: B Petrini B
AUTHOR: J Wasserman J
AUTHOR: H Blomgren H
AUTHOR: E Baral E
AUTHOR: L E Strender LE
AUTHOR: A Wallgren A
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Clinical and experimental immunology.
COUNTRY: ENGLAND
TITLE: Blood lymphocyte subpopulations in breast cancer patients following post-operative adjuvant chemotherapy or radiotherapy.
PUBDATE: 19791101
The peripheral lymphocyte population was examined in sixty-five randomized breast cancer patients before and after post-operative adjuvant cyclic chemotherapy or local radiation therapy. During 10 months of chemotherapy total lymphocyte and T cell counts were reduced to 70% and non-T cells to about 50% of pretreatment values. The population of T cells was unaltered whereas the proportion of non-T cells was significantly reduced at the end of the period. Immediately after radiotherapy total lymphocyte and T cell counts were reduced to 30%, and non-T cells to 15% of pretreatment values. During 10 months' observation total lymphocyte and T cell counts increased to 70%, and non-T cells to 50--60% of pretreatment values.


5. DOCID:7878 SCORE: 0.00273711590499285
DOCNO: 6171375
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ultrasonography
QUALIFIER: diagnosis
AUTHOR: P J Brooman PJ
AUTHOR: G J Griffiths GJ
AUTHOR: E Roberts E
AUTHOR: W B Peeling WB
AUTHOR: K Evans K
PUBTYPE: Journal Article
JOURNALTITLE: Clinical radiology.
COUNTRY: ENGLAND
TITLE: Per rectal ultrasound in the investigation of prostatic disease.
PUBDATE: 19811101
Primary prostatic disease is usually assessed by digital palpation of the prostate. This method lacks objectivity and has been shown to be inaccurate, especially in the staging of primary prostatic cancer. This paper describes the investigation of 200 subjects using per rectal ultrasound. Of 70 patients with histological evidence of carcinoma of the prostate, 96% were correctly diagnosed ultrasonically and 87% correctly diagnosed by digital palpation. Of the 37 patients with ultrasonic evidence of a capsular breach, only 65% were diagnosed as such by digital palpation. A study of 10 cadaver specimens confirmed the accuracy of per rectal ultrasound as a technique for staging primary prostatic cancer . The ultrasonic appearances of the prostate, seminal vesicles and bladder base are described. Per rectal ultrasound is acceptable to patients, and its use is recommended in all cases where accurate assessment of primary prostatic cancer is required.


6. DOCID:7171 SCORE: 0.00245014710885983
DOCNO: 480647
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
AUTHOR: J S Cooper JS
AUTHOR: L W Davis LW
AUTHOR: J J Diamond JJ
AUTHOR: J Sedransk J
AUTHOR: R F Curley RF
PUBTYPE: Journal Article
JOURNALTITLE: JAMA : the journal of the American Medical Association.
COUNTRY: UNITED STATES
TITLE: Evaluation of carcinoma of the uterine cervix before radiotherapy.
PUBDATE: 19791101
In 1974 the Patterns of Care Study began a prospective nationwide survey of radiotherapeutic cancer care in the United States. Cancer of the uterine cervix was one of the diseases surveyed. Pretreatment evaluation data were collected from 170 randomly chosen radiation therapy facilities. The frequency of use of tests in workup varied substantially according, for example, to the severity of disease and the availability of tests. For carcinoma of the uterine cervix, we found that the following tests were used routinely: physical examination, including taking a history; complete blood cell count; serum chemistry analysis; chest roentgenogram; and intravenous pyelogram. Frequent but not routine tests included dilation and curettage and evaluation of the involvement of the bladder and rectum. Other test were used infrequently.


7. DOCID:7269 SCORE: 0.0023313835991099
DOCNO: 228573
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: chemically induced
QUALIFIER: chemically induced
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: W Weiss W
AUTHOR: R L Moser RL
AUTHOR: O Auerbach O
PUBTYPE: Journal Article
JOURNALTITLE: The American review of respiratory disease.
COUNTRY: UNITED STATES
TITLE: Lung cancer in chloromethyl ether workers.
PUBDATE: 19791101
During the period from 1948 to 71, some workers in a chemical plant were exposed to chloromethyl ethers in varying degrees and for varying durations. A historical cohort study of 1,446 male production employees from 1960 through 1975 showed both an increased risk of lung cancer as compared to that in the general population among 465 exposed workers and a dose-response relationship. Significantly increased risk occurred only among men with moderate and heavy chemical exposure. Smoking habit could account for some of the cases of lung cancer that developed in men with light chemical exposure and for cases among unexposed workers. Microscopic sections of most of the lung cancers were reviewed, and the results suggested that small-cell carcinoma was a specific response to inhalation of chloromethyl ethers.


8. DOCID:7181 SCORE: 0.00219619428722489
DOCNO: 84883
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analogs & derivatives
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: M Kajiyama M
AUTHOR: M Dohjyo M
AUTHOR: A Ohno A
AUTHOR: K Nagasaka K
AUTHOR: M Yamaguma M
AUTHOR: T Okabe T
AUTHOR: S Terasaka S
PUBTYPE: Journal Article
JOURNALTITLE: The Japanese journal of antibiotics.
COUNTRY: JAPAN
TITLE: [Clinical effects of NK 631, a new bleomycin derivative, in treatment of oral cancer (author's transl)]
PUBDATE: 19790101
We used only NK 631, a new bleomycin derivative, for 10 cases of primary oral cancer, and obtained following results. (1) Anti-cancer effects were immediate and as follow: remarkably good in 1 case, efficacious in 8 cases, and none in 1 case. (2) In clinical examination, peripheral blood, function of kidney, liver, etc. were normal. But attention must be payed to blood gas. (3) Loss of hair, stomatitis and exanthema were noticed as side effects more clearly than regular bleomycin, but no fever. As the result of the above, NK 631 is better than regular bleomycin in anti-cancer effect and activity, but more attention should be payed to the side effect.


9. DOCID:7036 SCORE: 0.00216822708510496
DOCNO: 7196088
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: H W Farr HW
PUBTYPE: Journal Article
JOURNALTITLE: Seminars in oncology.
COUNTRY: UNITED STATES
TITLE: Soft part sarcomas of the head and neck.
PUBDATE: 19810601
During the 28-yr-period from 1949-1977, 285 patients with sarcoma of the head and neck region were seen and treated at Memorial Cancer Center. Two hundred forty-two cases were determinate, and none was lost to follow-up study. The determinate and absolute 5-yr cure rate was 32%. More than 50% of the cases were seen in children (8 cases were congenital) and were almost universally anaplastic and prone to generalized metastasis with fatal outcome. Combined modalities of radical surgery, postoperative radiotherapy, and chemotherapy over a prolonged period have markedly altered the prognosis of these tumors. Soft part sarcomas are an unusual group of tumors with a common fibrosarcomatous background. The qualified pathologist can identify quite accurately the different histologic entities and their varying grade, a point of great significance as to clinical course and treatment.


10. DOCID:7000 SCORE: 0.00215980524277164
DOCNO: 7373947
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: E C Holmes EC
PUBTYPE: Journal Article
JOURNALTITLE: The Japanese journal of surgery.
COUNTRY: JAPAN
TITLE: BCG immunotherapy of lung cancer.
PUBDATE: 19800301
Thirty-three patients have undergone BCG intralesional injection into pulmonary tumors. Six received the injection by way of the bronchoscope and 27 were injected percutaneously under fluoroscopic control. The toxicity of this treatment is closely related to PPD reactivity. PPD-negative patients have little fever and malaise. However patients with strongly positive PPD reactions have extensive and prolonged fever. Twenty-six of the 27 patients injected with BCG underwent pulmonary resection. There were no significant postoperative complications. Histologically BCG induces a granulomatous inflammatory reaction, and in the patients who are PPD-positive there is extensive plasma-cell infiltration and de novo germinal center formation within the tumor. Eighty-five percent of the patients with bronchogenic carcinoma and 58 percent of the patients with metastatic cancer are alive and well at a median follow-up of 16 months following pulmonary resection.


11. DOCID:7733 SCORE: 0.00211607452681965
DOCNO: 736631
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Migration Inhibition
DESCRIPTOR: Immunity, Cellular
QUALIFIER: immunology
AUTHOR: U D Koenig UD
PUBTYPE: Journal Article
JOURNALTITLE: Archives of gynecology.
COUNTRY: GERMANY, WEST
TITLE: [Cell mediated immunity in cervical cancer patients: evaluation by in vitro leukocyte-migration-inhibition-assay (author's transl)]
PUBDATE: 19781201
Cellular mediated immune reactions (CMI) against tumour associated antigens are the demonstration of an interrelationship between tumour and tumour host. They are related to the stage and prognosis of the disease. 41 patients with cervical cancer were tested by leukocyte-migration-inhibition test. Cryostat sections of 10 micron of the tumour-tissue, gained by excision or curettage and histologically defined, were taken as tumour antigens. The test was performed in Sykes-Moore-Chamber as so-called one-way-test with the lymphocytes/leukocytes and macrophagen of the tumour patient. Reactions against autologous and homologous tumour tissue and against recall antigens (tuberculin and varidase) were tested. There was no overall diminution of cellular mediated immune reactions. CMI was demonstrated in 69.7% (inhibition in 30.3%, stimulation in 39.4%) in the autologous and in 51.3% in the homologous system (21.6% inhibition, 29.7% stimulation).


12. DOCID:7713 SCORE: 0.00210923349324254
DOCNO: 7400867
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mortality
DESCRIPTOR: Printing
QUALIFIER: chemically induced
AUTHOR: A Paganini-Hill A
AUTHOR: E Glazer E
AUTHOR: B E Henderson BE
AUTHOR: R K Ross RK
PUBTYPE: Journal Article
JOURNALTITLE: Journal of occupational medicine. : official publication of the Industrial Medical Association.
COUNTRY: UNITED STATES
TITLE: Cause-specific mortality among newspaper web pressmen.
PUBDATE: 19800801
A mortality study of 1,361 newspaper web pressmen who were members of the Los Angeles Pressmen's Union for at least one year -- between 1949 and 1965 -- was conducted. Vital status as of December 31, 1978, was determined for 1,261 (91%), and death certificates were obtained for 344 of the 354 decedents. Using a modified life-table technique, cause-specific mortality among the pressmen was compared to that in the United States white male population. Overall mortality was similar to that expected. Analysis of the cancer mortality by site showed no significant differences between observed and expected except for leukemia (7 observed vs. 2.8 expected) and kidney cancer (5 observed vs. 1.6 expected). A significant excess of deaths due to cirrhosis of the liver (17 observed vs. 8.3 expected) was also observed.


13. DOCID:5354 SCORE: 0.00207774479091696
DOCNO: 205000
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: D G Harvey DG
AUTHOR: R E Fechner RE
PUBTYPE: Journal Article
JOURNALTITLE: Southern medical journal.
COUNTRY: UNITED STATES
TITLE: Atypical lobular and papillary lesions of the breast: a follow-up study of 30 cases.
PUBDATE: 19780401
Sections from 879 consecutive breast biopsies performed for clinically and grossly benign disease between 1962 and 1966 were reviewed. Twenty-four cases of undiagnosed lobular carcinoma in situ or atypical lobular hyperplasia and six cases of intraductal papillary carcinoma were found. Only one patient later developed invasive carcinoma, an infiltrating lobular carcinoma in the ipsilateral breast, which was diagnosed seven years after the biopsy containing lobular carcinoma in situ. Invasive cancers have not been found in other patients who have a median follow-up period of eight years.


14. DOCID:7389 SCORE: 0.00207545061485968
DOCNO: 650696
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Cycle
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: methods
AUTHOR: T Okagaki T
AUTHOR: M Izuo M
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Correction of modal DNA values obtained by microspectrophotometry and tests for their shifts.
PUBDATE: 19780601
The technical problems in the application of statistical analyses of the nuclear DNA contents measured by plug or two-wavelength Feulgen microspectrophotometry were discussed. The skewness of the nuclear DNA content unimodally distributed in a cluster could be corrected by logarithmic transformation. A mean value of the logarithmically transformed DNA contents was a more logical characterization of cancer than a graphically obtained mode of nontransformed values. Equations were derived to estimate the number of cells in the G1- and S-phases of mitotic cycles contained within the cluster and to estimate the correction factor of the mean of transformed values of cells in the G1-phase. Thus statistical tests for a shift in the nuclear DNA content of the cells in question in the G1-phase from that of control cells were made possible.