0. DOCID:31395 SCORE: 0.00385002455588906
DOCNO: 15112573
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Venous Thrombosis
QUALIFIER: complications
AUTHOR: Anna Falanga A
AUTHOR: Alfonso Vignoli A
AFFILIATION: Department of Hematology-Oncology, Ospedali Riuniti di Bergamo, Bergamo, Italy. annafalanga@yahoo.com
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Eksperimentalʹnai︠a︡ onkologii︠a︡.
COUNTRY: Ukraine
TITLE: Venous thromboembolism in oncology.
PUBDATE: 20040301
Thromboembolic events represent well-recognised complications of neoplastic disease contributing, in a significant manner, to the morbidity and mortality from cancer. The close relationship between the activation of blood coagulation and tumor growth is known since 1865, when Armand Trousseau first described the clinical association between primary or idiopathic venous thromboembolism and an underlying occult malignancy. However, only in the last decades significant advances in this field have been achieved, both on the comprehension of the complex interactions between the tumor and the hemostatic system, and on the prophylaxis and therapy of the thromboembolic manifestations in cancer patients.


1. DOCID:30180 SCORE: 0.00369565442746629
DOCNO: 14751092
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: Eric J Lentsch EJ
AFFILIATION: Division of Otolaryngology-Head and Neck Surgery, University of Louisville, Myers Hall, Louisville, KY 40292, USA. ejlent01@louisville.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current oncology reports.
COUNTRY: United States
TITLE: Management of cervical metastasis.
PUBDATE: 20040301
Cervical metastasis from head and neck cancer is a common occurrence. Despite improvements in diagnostic modalities and treatment options, survival in this group of patients has not changed appreciably over the past few decades. Cervical metastasis portends a poor prognosis and also presents a diagnostic and treatment dilemma for the head and neck oncologist. This article reviews the current state of the art in the diagnosis and treatment of this difficult group of patients and the literature on the topic.


2. DOCID:28339 SCORE: 0.00328880131551454
DOCNO: 14998485
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: immunology
QUALIFIER: physiology
QUALIFIER: immunology
QUALIFIER: metabolism
AUTHOR: Ana M Gamero AM
AUTHOR: Howard A Young HA
AUTHOR: Robert H Wiltrout RH
AFFILIATION: Laboratory of Experimental Immunology, National Cancer Institute, Center for Cancer Research, Frederick, MD 21702, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer cell.
COUNTRY: United States
TITLE: Inactivation of Stat3 in tumor cells: releasing a brake on immune responses against cancer?
PUBDATE: 20040201
A model of immune evasion mediated by tumors expressing constitutively activated Stat3 was recently proposed in Nature Medicine by Wang et al., suggesting opportunities for a new therapeutic approach for cancer.


3. DOCID:27723 SCORE: 0.00308969172930824
DOCNO: 15616627
OWNER: NLM
STATUS: PubMed-not-MEDLINE
AUTHOR: A Cases A
AFFILIATION: Department of Nephrology, Hospital Clínic, Barcelona, Spain.
PUBTYPE: Journal Article
JOURNALTITLE: Drug news & perspectives.
COUNTRY: Spain
TITLE: Recent advances in hypertension research and management.
PUBDATE: 19980801
At the 17th Scientific Meeting of the International Society of Hypertension (Amsterdam, June 7-11, 1998), clinicians and scientists from all over the world exchanged the results of latest research on the pathophysiology, prevention and management of hypertension. Progress in two key areas of basic research was presented at the meeting: ion channels and experimental genetics. In the clinical arena, a number of large, long-term studies were presented on topics that included risk factors of cardiovascular events in male hypertensives; antihypertensive therapy and the risk of cancer; and antihypertensive therapy in dementia. A population-wide approach was stressed as essential in a session on diet intervention and hypertension in the 21st century.


4. DOCID:27295 SCORE: 0.00307780529699003
DOCNO: 10363960
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: prevention & control
QUALIFIER: utilization
QUALIFIER: statistics & numerical data
QUALIFIER: statistics & numerical data
PUBTYPE: Journal Article
JOURNALTITLE: MMWR. Morbidity and mortality weekly report.
COUNTRY: UNITED STATES
TITLE: Patients' reports of counseling on mammography screening by health-care providers--North Carolina, 1997.
PUBDATE: 19990501
Regular mammography screening combined with timely and appropriate treatment can reduce mortality from breast cancer by 30% in women aged 50-69 years and 16% in women aged 40-49 years. A physician's recommendation has been strongly associated with a patient having a mammogram. This report analyzes data collected during 1997 in North Carolina as part of the Behavioral Risk Factor Surveillance System (BRFSS), which indicated that 23% of women aged > or =40 years who had had a routine physical examination during the 2 years preceding the survey did not recall having a discussion about mammography with a health-care provider.


5. DOCID:27506 SCORE: 0.00287762378877288
DOCNO: 9735127
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Lymph Node Excision
DESCRIPTOR: Lymphatic Metastasis
DESCRIPTOR: Thyroidectomy
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: H Chen H
AUTHOR: R Udelsman R
AFFILIATION: Division of Surgical Oncology, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Surgical oncology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Papillary thyroid carcinoma: justification for total thyroidectomy and management of lymph node metastases.
PUBDATE: 19981001
Papillary thyroid carcinoma (PTC) is the most common epithelial thyroid tumor and comprises approximately 80% of all thyroid cancers. In this article, the authors discuss the data showing that total thyroidectomy is the treatment of choice of clinically significant PTC, and review an algorithm for the management of lymph node metastases. Although the prognosis for patients with PTC is generally good, appropriate surgical management (total thyroidectomy plus 131I and life-long TSH suppression) can further reduce recurrence and cancer death rates significantly.


6. DOCID:26144 SCORE: 0.00270857578452313
DOCNO: 10869101
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: D W Lamson DW
AUTHOR: M S Brignall MS
AFFILIATION: Bastyr University - Kenmore, WA, USA. davisl@seanet.com
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Alternative medicine review : a journal of clinical therapeutic.
COUNTRY: UNITED STATES
TITLE: Antioxidants and cancer, part 3: quercetin.
PUBDATE: 20000601
Quercetin is a flavonoid molecule ubiquitous in nature. A number of its actions make it a potential anti-cancer agent, including cell cycle regulation, interaction with type II estrogen binding sites, and tyrosine kinase inhibition. Quercetin appears to be associated with little toxicity when administered orally or intravenously. Much in vitro and some preliminary animal and human data indicate quercetin inhibits tumor growth. More research is needed to elucidate the absorption of oral doses and the magnitude of the anti-cancer effect.


7. DOCID:30880 SCORE: 0.00264069070739798
DOCNO: 11839240
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: trends
QUALIFIER: trends
AUTHOR: Jack G M Jagwe JG
AUTHOR: David Barnard D
AFFILIATION: Senior Advisor on National Policy and Advocacy on Pain Control, Hospice Uganda, Uganda.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of palliative medicine.
COUNTRY: United States
TITLE: The introduction of palliative care in Uganda.
PUBDATE: 20020201
Hospice Uganda was established in Kampala, September 27, 1993. Since then the hospice has served over 3,000 patients with cancer, and referrals of patients with HIV/AIDS are increasing steadily. The concepts of hospice and palliative care are well accepted in Uganda, but the delivery of services has been severely constrained by limited resources. Possibilities for growth, both in service provision and education of health professionals, were improved significantly with the incorporation of palliative care objectives into the Ministry of Health 5-year strategic plan.


8. DOCID:30878 SCORE: 0.00264068210829994
DOCNO: 11906280
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: agonists
QUALIFIER: chemistry
QUALIFIER: pharmacology
AUTHOR: Ulrich Schopfer U
AUTHOR: Philippe Schoeffter P
AUTHOR: Serge F Bischoff SF
AUTHOR: Joachim Nozulak J
AUTHOR: Dominik Feuerbach D
AUTHOR: Philipp Floersheim P
PUBTYPE: Letter
JOURNALTITLE: Journal of medicinal chemistry.
COUNTRY: United States
TITLE: Toward selective ERbeta agonists for central nervous system disorders: synthesis and characterization of aryl benzthiophenes.
PUBDATE: 20020301
In an effort to identify selective ligands for the estrogen receptor subtype ERbeta, a series of aryl benzthiophenes was synthesized. In a radioligand binding assay and reporter gene assays in HeLa and SH-SY5Y cells, compounds were characterized as ERbeta-selective agonists. By targeting ERbeta in the brain, these compounds could lead to drugs able to separate the beneficial effects of estrogens on mood, learning, and memory from side effects such as the stimulation of endometrial and breast cancer.


9. DOCID:27589 SCORE: 0.00255531119228448
DOCNO: 10391016
AUTHOR: D A Cooper DA
AUTHOR: A L Eldridge AL
AUTHOR: J C Peters JC
AFFILIATION: Department of Regulatory and Clinical Development, Food and Beverage Products, Procter & Gamble Company, Cincinnati, OH 45224-1703, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nutrition reviews.
COUNTRY: UNITED STATES
TITLE: Dietary carotenoids and lung cancer: a review of recent research.
PUBDATE: 19990501
Several hundred carotenoid research studies have been published since 1996, when two major intervention trials showed a lack of protective effect of beta-carotene supplements against lung cancer. Recent epidemiologic studies continue to show an association between high dietary intake of beta-carotene and lower risk of lung cancer. New research is attempting to clarify the apparently contradictory results of intervention and epidemiologic studies. Promising areas of investigation include characterizing biologic activities of carotenoids and gaining further insight into whether they may serve primarily as markers for a healthy lifestyle or diet.


10. DOCID:29392 SCORE: 0.00253003544588964
DOCNO: 12044696
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiography
QUALIFIER: radiography
QUALIFIER: radiography
QUALIFIER: radiography
AUTHOR: Basak Kumbasar B
AFFILIATION: Department of Radiology, Istanbul Faculty of Medicine, Istanbul University, 34390 Capa, Istanbul, Turkey. bkumbasar@hotmail.com
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: European journal of radiology.
COUNTRY: Ireland
TITLE: Carcinoma of esophagus: radiologic diagnosis and staging.
PUBDATE: 20020601
Esophageal carcinoma is an uncommon malignancy accounting for approximately 7% of gastrointestinal tract cancers and 1% of all cancers. Esophageal cancer still remains one of the most lethal of all cancers. Since a multimodality approach is presently used to treat esophageal cancer, early radiologic diagnosis and accurate tumor staging are essential to direct therapy toward cure or palliation. This article presents a review of radiologic diagnosis and staging of esophageal cancer.


11. DOCID:26603 SCORE: 0.00251632386031549
DOCNO: 10206304
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genes, myc
DESCRIPTOR: Polymorphism, Restriction Fragment Length
QUALIFIER: genetics
AUTHOR: M J Ejarque MJ
AUTHOR: M Vicente M
AUTHOR: M Bernués M
AUTHOR: A Oliver A
AUTHOR: J Vicente J
AUTHOR: G Capellá G
AUTHOR: F Lluís F
AUTHOR: G Chéchile G
AFFILIATION: Urology Service, Fundació Puigvert, Barcelona, Spain.
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: SCOTLAND
TITLE: Restriction fragment length polymorphism of the L-myc gene is not a prognostic factor in bladder cancer patients.
PUBDATE: 19990401
The L-myc restriction fragment length polymorphism has been suggested to be of prognostic significance in some types of primary tumours. We examined the prognostic and susceptibility significance of the L-myc genotype in a group of 98 bladder cancer patients. The L-myc genotype did not correlate with any pathologic parameter and does not offer any clinical utility in patients with bladder cancer.


12. DOCID:30977 SCORE: 0.00244483471415062
DOCNO: 12778133
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: Jesus Perez-Losada J
AUTHOR: Allan Balmain A
AFFILIATION: UCSF Comprehensive Cancer Center, 2340 Sutter Street, San Francisco, California 94143, USA. jperez-losada@cc.ucsf.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nature reviews. Cancer.
COUNTRY: England
TITLE: Stem-cell hierarchy in skin cancer.
PUBDATE: 20030601
Tumour architecture mimics many of the features of normal tissues, with a cellular hierarchy that regulates the balance between cell renewal and cell death. Although many tumours contain cells with the characteristics of stem cells, the identity of the normal cells that acquire the first genetic hits leading to initiation of carcinogenesis has remained elusive. Identification of the primary cell of origin of cancers and the mechanisms that influence cell-fate decisions will be crucial for the development of novel non-toxic therapies that influence tumour-cell behaviour.


13. DOCID:31011 SCORE: 0.00239370023303153
DOCNO: 15629272
AUTHOR: Dheerendra Prasad D
AUTHOR: David Schiff D
AFFILIATION: Department of Radiation Oncology, University of Virginia, Charlottesville, VA, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The lancet oncology.
COUNTRY: England
TITLE: Malignant spinal-cord compression.
PUBDATE: 20050101
Malignant spinal-cord compression (MSCC) is a common complication of cancer and has a substantial negative effect on quality of life and survival. Despite widespread availability of good diagnostic technology, studies indicate that most patients are diagnosed only after they become unable to walk. We review the epidemiology, pathophysiology, and clinical features of MSCC. Clinical trials have informed the optimum management of MSCC, and we review the role of corticosteroids, radiotherapy, and surgery in the management of patients. We also emphasise advances in radiation delivery and the results of a randomised trial that supported aggressive debulking in patients with MSCC.


14. DOCID:31010 SCORE: 0.00239369583054501
DOCNO: 16178559
OWNER: NLM
STATUS: PubMed-not-MEDLINE
QUALIFIER: antagonists & inhibitors
QUALIFIER: antagonists & inhibitors
QUALIFIER: chemical synthesis
QUALIFIER: pharmacology
QUALIFIER: chemistry
QUALIFIER: pharmacology
AUTHOR: Mijoon Lee M
AUTHOR: M Margarida Bernardo MM
AUTHOR: Samy O Meroueh SO
AUTHOR: Stephen Brown S
AUTHOR: Rafael Fridman R
AUTHOR: Shahriar Mobashery S
AFFILIATION: Department of Chemistry and Biochemistry and the Walther Cancer Research Center, University of Notre Dame, Notre Dame, Indiana 46556, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Organic letters.
COUNTRY: United States
TITLE: Synthesis of chiral 2-(4-phenoxyphenylsulfonylmethyl)thiiranes as selective gelatinase inhibitors.
PUBDATE: 20050901
[reactions: see text] Compound 1, 2-(4-phenoxyphenylsulfonylmethyl)thiirane, is a selective inhibitor of gelatinases, which is showing high promise in studies of animal models for cancer metastasis and stroke. The (R)-1 and (S)-1 enantiomers of compound 1 were each synthesized in this study and were shown to be equally active in inhibition of gelatinases.