0. DOCID:17526 SCORE: 0.00338573868031531
DOCNO: 1333812
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
AUTHOR: B McCormick B
AFFILIATION: Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in oncology.
COUNTRY: UNITED STATES
TITLE: Radiation therapy for breast cancer.
PUBDATE: 19921201
Now that the radiation literature for breast cancer is well established in terms of both local control and survival endpoints, especially for invasive breast cancer, recent reports focus on refining selection criteria of patients for treatment and on minimizing complications and maximizing cosmetic effects. The optimal treatment of patients with ductal carcinoma in situ remains a controversial issue, and the optimal sequencing of adjuvant chemotherapy and primary radiation in patients with breast-conserving surgery is emerging as a topic requiring further study.


1. DOCID:18967 SCORE: 0.00316155117485501
DOCNO: 1891857
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hyperthermia, Induced
DESCRIPTOR: Microwaves
QUALIFIER: therapeutic use
QUALIFIER: therapy
AUTHOR: V A Chernyĭ VA
AUTHOR: K A Galakhin KA
AUTHOR: E A Kolesnik EA
AUTHOR: O I Morgunova OI
PUBTYPE: Journal Article
JOURNALTITLE: Vrachebnoe delo.
COUNTRY: USSR
TITLE: [Endolymphatic polychemotherapy with local UHF hyperthermia in the surgical treatment of rectal neoplasms]
PUBDATE: 19910601
To reduce the risk of intraoperative metastases and increasing ablastic principles in radical surgical treatment of patients with cancer of the rectum the authors developed a scheme of preoperative treatment including endolymphatic polychemotherapy and UHF-hyperthermia. 5-fluorouracil and platidiam were used in the treatment of 30 patients with different histological types of adenocarcinomas of the rectum (grade III-IV). After treatment the viable epithelial component in the tumour was 26.5% as compared with 44.8% in the control. The effect of treatment was favourable both objectively and subjectively. The treatment was well tolerated.


2. DOCID:17161 SCORE: 0.00311897230583645
DOCNO: 1341778
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: R Gómez R
AUTHOR: E Oyarzún E
AUTHOR: A Cortínez A
AUTHOR: N Barrena N
AUTHOR: L Massardo L
AUTHOR: R Wild R
AFFILIATION: Departamento de Obstetricia y Ginecología, Pontificia Universidad Católica de Chile.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Revista médica de Chile.
COUNTRY: CHILE
TITLE: [Ovarian cancer and dermatomyositis. A clinical case]
PUBDATE: 19921001
Dermatomyositis (DM) is associated to malignant neoplasia in up to one third of the cases. Not considering breast neoplasia, ovarian cancer is the malignancy most frequently associated with DM in women. This study shows the evolution and outcome of a case of this association managed in our unit. The principal features of similar cases reported in the literature are summarized.


3. DOCID:21756 SCORE: 0.00300160235496145
DOCNO: 9136458
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
AUTHOR: N G Huilgol NG
AUTHOR: M M Khan MM
AUTHOR: R Puniyani R
AFFILIATION: Division of Radiation Oncology, Dr. Balabhai Nanavati Hospital & Medical Center, Bombay.
PUBTYPE: Clinical Trial
PUBTYPE: Controlled Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Indian journal of cancer.
COUNTRY: INDIA
TITLE: Capillary perfusion--a study in two groups of radiated patients for cancer of head and neck.
PUBDATE: 19950601
Laser Doppler velocitometry is novel non-invasive technique to assess cutaneous microcirculation. Patients undergoing radiation therapy for head and neck cancer with convention and accelerated fraction action were evaluated under normal condition before and after radiation. A total of 70 sites in group A (conventional fractionation) and 35 sites in group B (accelerated fractionation were evaluated. Increase in perfusion was noted in patients undergoing radiation with accelerated fractionation.


4. DOCID:18856 SCORE: 0.00297824650905271
DOCNO: 8402103
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: adverse effects
QUALIFIER: adverse effects
AUTHOR: A J Park AJ
AUTHOR: R J Black RJ
AUTHOR: A C Watson AC
AFFILIATION: Department of Plastic Surgery, St John's Hospital, Livingston, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The British journal of surgery.
COUNTRY: ENGLAND
TITLE: Silicone gel breast implants, breast cancer and connective tissue disorders.
PUBDATE: 19930901
Recent worldwide media speculation that silicone gel-filled breast implants may be linked to an increased incidence of breast and other cancers, and connective tissue disease (particularly systemic sclerosis) has caused concern to the medical profession and public alike. Until carefully controlled studies have been performed to prove the safety of these implants, the US Food and Drug Administration has restricted their use to research and breast reconstruction. Research has so far failed to prove a causative relationship between silicone implants and cancer or connective tissue disorders.


5. DOCID:18170 SCORE: 0.00294133351517395
DOCNO: 8244395
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosomes, Human, Pair 3
QUALIFIER: genetics
QUALIFIER: enzymology
AUTHOR: S S Li SS
AUTHOR: F S Sharief FS
AFFILIATION: Laboratory of Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709.
PUBTYPE: Journal Article
JOURNALTITLE: Genomics.
COUNTRY: UNITED STATES
TITLE: The prostatic acid phosphatase (ACPP) gene is localized to human chromosome 3q21-q23.
PUBDATE: 19930901
Human prostatic acid phosphatase (ACPP) has been used as a diagnostic marker for prostate cancer. It is synthesized under androgen regulation and secreted by the epithelial cells of the prostate gland. We have confirmed the previous assignment of the ACPP gene to chromosome 3 by probing a panel of 25 human-Chinese hamster somatic cell hybrids, and we have further localized the ACPP gene to chromosome 3q21-q23 by fluorescence in situ hybridization.


6. DOCID:18430 SCORE: 0.00279036153777591
DOCNO: 1807796
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: epidemiology
AUTHOR: P T Nmadu PT
AUTHOR: O A Mabogunje OA
AFFILIATION: Department of Surgery, Ahmadu Bellow University Hospital, Zaria, Nigeria.
PUBTYPE: Journal Article
JOURNALTITLE: The Central African journal of medicine.
COUNTRY: ZIMBABWE
TITLE: The risk of cancer in endemic multinodular goitre.
PUBDATE: 19910801
From 1971 to 1985 at the Ahmadu Bello University Hospital, Zaria, 245 patients with multinodular goitre were operated upon mostly for cosmesis. Clinically unsuspected malignancy was present in 50 (20 pc) of the resected specimens of which 26 were follicular and 20 papillary. This pattern conforms with the reports from other African Zones of endemic goitre where the frequency of cancer is lower in the clinically solitary nodular goitre. Thus, the management strategy ought to regard the multinodular goitre as pre-malignant and operations should be performed earlier on this account.


7. DOCID:18986 SCORE: 0.00272675507215285
DOCNO: 1698531
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: diagnostic use
AUTHOR: L Krogerus L
AUTHOR: L C Andersson LC
AFFILIATION: Department of Pathology, University of Helsinki, Finland.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Different lectin-binding patterns in primary breast cancers and their metastases.
PUBDATE: 19901001
The expression of glycoconjugates in primary tumors and their metastases in 18 consecutive cases of metastasized breast cancer was studied by use of lectin histochemistry. Paraffin sections were stained with a panel of seven fluorochrome-labeled lectins with defined sugar specificities. The study revealed variation in the lectin binding patterns of individual cancers. In the primary tumors the lectin reactivity was diversified, whereas in their respective metastases it was rather homogeneous. This finding indicates that there is intratumoral heterogeneity in the primary cancers, whereas the selected subclones of malignant cells with restricted glycoconjugate expression seem to give rise to metastases.


8. DOCID:19111 SCORE: 0.00265269524213962
DOCNO: 1459723
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: genetics
AUTHOR: G W Dyke GW
AUTHOR: J L Craven JL
AUTHOR: R Hall R
AUTHOR: R C Garner RC
AFFILIATION: Dept. of Biology, University of York, UK.
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: UNITED STATES
TITLE: Smoking-related DNA adducts in human gastric cancers.
PUBDATE: 19921201
DNA was extracted from the tumour tissue of 26 patients (18 smokers, 8 non-smokers) undergoing surgery for gastric cancer, and analyzed for the presence of DNA adducts by the 32P-post-labelling method. Adducts were detected in all samples tested, and adduct levels ranged from 2 adducts/10(8) nucleotides to 60 adducts/10(8) nucleotides. In male subjects, adduct levels were significantly greater in the DNA of smokers than in that of non-smokers. These results support epidemiological data suggesting that smoking is a risk factor for gastric cancer.


9. DOCID:23630 SCORE: 0.00256107479477434
DOCNO: 8825571
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: veterinary
QUALIFIER: veterinary
QUALIFIER: surgery
QUALIFIER: therapy
QUALIFIER: veterinary
QUALIFIER: veterinary
AUTHOR: E G MacEwen EG
AUTHOR: I D Kurzman ID
AFFILIATION: Department of Medical Sciences, University of Wisconsin, Madison 53706, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Veterinary clinics of North America. Small animal practice.
COUNTRY: UNITED STATES
TITLE: Canine osteosarcoma: amputation and chemoimmunotherapy.
PUBDATE: 19960101
Canine osteosarcoma is a highly metastatic cancer commonly seen in large breed dogs. At the time of diagnosis, approximately 90% to 95% of the dogs have established micrometastases. Dogs undergoing amputation alone have a median survival time of 3 to 4 months. Amputation followed by cisplatin chemotherapy increases median survival times to 9 to 11 months. When dogs are treated with amputation and cisplatin, followed by immunotherapy (with liposome-encapsulated muramyl tripeptide phosphatidylethanolamine), median survival times increase to 14.4 months, the longest reported median survival time for dogs with osteosarcoma treated by amputation and any form of adjuvant therapy.


10. DOCID:22575 SCORE: 0.00254010779188935
DOCNO: 7731639
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Breast Neoplasms
DESCRIPTOR: Carcinoma in Situ
DESCRIPTOR: Carcinoma, Ductal, Breast
AUTHOR: M J Silverstein MJ
AFFILIATION: Breast Center, Van Nuys, California, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Obstetrics and gynecology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Noninvasive breast cancer. The dilemma of the 1990s.
PUBDATE: 19941201
The most profound impact in the field of breast cancer during the last 15 years has been the development and acceptance of screening mammography: a test capable of finding nonpalpable cancer years before it would have become clinically evident. Many of these nonpalpable lesions are noninvasive; many of them are not even real cancers. The spectrum of treatment for noninvasive breast cancer runs from nothing more than excisional biopsy to bilateral mastectomy. No wonder noninvasive breast cancer is one of the most confusing problems in oncology today, for both patients and physicians.


11. DOCID:19820 SCORE: 0.00253009179347616
DOCNO: 1864298
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immune Tolerance
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: complications
AUTHOR: A G Maiche AG
AFFILIATION: Department of Radiotherapy and Oncology, Helsinki University Central Hospital, Finland.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
COUNTRY: GERMANY
TITLE: Use of quinolones in the immunocompromised host.
PUBDATE: 19910401
Immune deficiency generally leads to infections. Cancer chemotherapy, medical interventions and various investigational procedures are important factors in the development of infection. In recent decades, there has been a major change in most cancer centers in the etiology of bacterial infections occurring in the immunocompromised host, most infections now being caused by gram-positive organisms. This might be partly due to prophylactic use of agents effective against gram-negative bacteria. The quinolones are now widely used in the treatment of serious infections of the immunocompromised patient. Prophylaxis with quinolones is also practised in cancer centers.


12. DOCID:19888 SCORE: 0.00249265280668066
DOCNO: 1618599
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: W K Amery WK
AUTHOR: J P Bruynseels JP
AFFILIATION: Janssen Research Foundation, Beerse, Belgium.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: International journal of immunopharmacology.
COUNTRY: ENGLAND
TITLE: Levamisole, the story and the lessons.
PUBDATE: 19920401
The history of the use of levamisole in man is summarized, from its start as an anthelmintic in the early sixties, through its world-wide recognition as an immunotropic agent especially in the seventies and early eighties, and its return to clinical prominence in 1989-90 as an effective adjuvant treatment for operable colon cancer. The knowledge accumulated from experimental tumour models and from clinical use in various types of cancer, supplemented with the recent evidence obtained from large-scale controlled trials in resectable colon cancer is reviewed. It is speculated that we may not have seen the end of levamisole story yet; also, the role of serendipidity in drug research is emphasized.


13. DOCID:18801 SCORE: 0.00242433955738317
DOCNO: 1734875
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: drug effects
QUALIFIER: pharmacology
QUALIFIER: metabolism
AUTHOR: S Noguchi S
AUTHOR: Y Kubota Y
AUTHOR: T Shuin T
AUTHOR: E Ito E
AUTHOR: H Inoue H
AUTHOR: T Yoshioka T
AFFILIATION: Department of Urology, Yokohama City University, School of Medicine, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Biochemical and biophysical research communications.
COUNTRY: UNITED STATES
TITLE: Effect of extracellular phosphatidylinositol on c-myc gene-expressed human renal cancer cell line.
PUBDATE: 19920101
Effect of exogenously added soybean phosphatidylinositol on c-myc gene expressed and unexpressed human cancer cell lines was investigated. When phosphatidylinositol liposomes were introduced into culture media, viability of c-myc unexpressed cells was reduced, while that of c-myc expressed cells was not. Death of c-myc unexpressed cells by phosphatidylinositol liposomes was found to be caused by abnormally accumulated intracellular Ca2+, and it seemed to be related to reduction of protein kinase C activity.


14. DOCID:23664 SCORE: 0.00241929106014584
DOCNO: 7600538
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: DNA Damage
DESCRIPTOR: Oxidative Stress
QUALIFIER: toxicity
QUALIFIER: toxicity
AUTHOR: H Wiseman H
AUTHOR: H Kaur H
AUTHOR: B Halliwell B
AFFILIATION: Department of Nutrition and Dietetics, King's College London, Kensington, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer letters.
COUNTRY: IRELAND
TITLE: DNA damage and cancer: measurement and mechanism.
PUBDATE: 19950601
There is currently great interest in the possible role of reactive nitrogen species and reactive oxygen species in causing DNA damage that leads to cancer. It appears likely that certain reactive oxygen species can act as complete carcinogens. However, the development of human cancer will depend on other factors such as the extent of DNA damage, antioxidant levels and DNA repair systems. The true picture will only be seen if we have reliable and sensitive techniques for the measurement of DNA damage. In this article we outline various methods for measuring DNA damage base, with special emphasis on HPLC and GC-MS based systems.