0. DOCID:2953 SCORE: 0.00507118445103282
DOCNO: 875870
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: H Langhammer H
AUTHOR: R Sintermann R
AUTHOR: K Kempken K
AUTHOR: G Hör G
AUTHOR: H W Pabst HW
AUTHOR: M Fendl M
PUBTYPE: Journal Article
JOURNALTITLE: Medizinische Klinik (1947)
COUNTRY: GERMANY, WEST
TITLE: [Diagnosis of skeletal metastases in prostatic cancer using gamma camera (author's transl)]
PUBDATE: 19770501
On 170 patients with histologically proven carcinoma of the prostate scintigraphic studies of the skeleton using gamma camera and follow-up examinations were performed and compared with x-ray as well as serum alkaline and acid phosphatase. Osseous metastases in 47% had no radiological evidence and were only scintigraphically detectable. Positive scans were registered in 48% of the patients with prostatic cancer, 20% of them were positive due to metastases and 28% were false positive caused by osteoarthrotic and arthritic changes, sporadically by post-traumatic lesions and in 3 cases by Paget's disease. At the time of the initial diagnosis of prostatic cancer 21% of 159 patients studied scintigraphically had radiological or scan evidence of osseous metastases. Analyses corresponding stages of tumor revealed an unequivocal dependance of the frequency of metastases upon the extent of the primary tumor. The successful treatment is characterized by the decreased uptake of radioactivity primarily accumulated in skeletal metastases.

1. DOCID:3507 SCORE: 0.0043648026370809
DOCNO: 884670
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Receptors, Estrogen
DESCRIPTOR: Receptors, Progesterone
QUALIFIER: metabolism
AUTHOR: S Hirohashi S
AUTHOR: Y Shimosato Y
AUTHOR: T Kameya T
AUTHOR: K Nagai K
AUTHOR: R Tsunematsu R
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Hormone dependency of a serially transplantable human breast cancer (Br-10) in nude mice.
PUBDATE: 19770901
The human breast cancer (Br-10) serially transplanted to nude mice (BALB/c-nu/nu) grew well in female mice but very slowly or not at all in untreated male mice and female mice treated with 1 mg of testosterone i.m. twice a week. The growth in female mice was arrested by ovariectomy, and that in male mice was accelerated by 0.1 mg of estradiol i.m. once a week. Tumors in female and estrogenized male mice retained the original histology of duct carcinoma. Tumors in ovariectomized female, androgenized female, and male mice consisted of cells with smaller and more uniform nuclei, forming markedly dilated lumina in the first group and arranged in lobular patterns in the latter two groups. High-affinity 8 S and 4 S estrogen receptors were present in tumors transplanted to female nude mice, but no progesterone receptors were detected. These results provide experimental evidence for the hormone dependency of a human breast cancer in vivo and strongly suggest the important role of estrogen and androgen in the growth regulation of some estrogen receptor-positive human breast cancers.

2. DOCID:3727 SCORE: 0.00435646683357351
DOCNO: 975061
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: enzymology
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: enzymology
AUTHOR: K Miki K
AUTHOR: T Oda T
AUTHOR: H Suzuki H
AUTHOR: S Iino S
AUTHOR: H Niwa H
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Alkaline phosphatase isoenzymes in intestinal metaplasia and carcinoma of the stomach.
PUBDATE: 19761101
The enzymological and immunological properties of alkaline phosphatase (ALP) isoenzymes in intestinal metaplasia and gastric carcinoma tissues were compared with those of purified human intestinal, placental, and hepatic ALP's to speculate the gene expression of gastric cancer cells. The results were as follows: Intestinal metaplasia was found in 21 of 23 cases (91%) of gastric cancer, whereas normal gastric mucosa had no ALP activity. ALP extracted from the mucosa of intestinal metaplasia was identical with intestinal ALP as to enzymological and immunological properties. ALP obtained from gastric carcinoma tissues of 23 patients was separated into 3 bands (ALPa, ALPb, and ALPc) by polyacrylamide-gel disc electrophoresis. Ten cases showed ALPa only, 4 cases showed ALPa and ALPb, 5 cases showed ALPa and ALPc, and the other 4 cases showed ALPa, ALPb, ALPc, respectively. It was concluded that ALPa was similar in its enzymological and immunological properties to hepatic-type ALP, ALPb was similar to placental-type ALP, and ALPc was similar to intestinal-type ALP, ALPb probably originates from the cancer cell itself. As for the other enzymes, ALPa and ALPc, further investigation should be made to determine whether they come from the cancer cell itself or not.

3. DOCID:3232 SCORE: 0.00419450257097492
DOCNO: 200572
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: J P Lamelin JP
AUTHOR: R Ellouz R
AUTHOR: G De Thé G
AUTHOR: J P Revillard JP
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: Lymphocyte subpopulations and mitogenic responses in nasopharyngeal carcinoma, prior to and after radiotherapy.
PUBDATE: 19771101
Eighteen patients with nasopharyngeal carcinoma (NPC) were compared to matched controls, before or after cobalt therapy, for the ability of their peripheral blood lymphocytes to: (1) form E and EAC rosettes and (2) mount a proliferative response with PHA, Con A and ALG. A slight decrease in the percentage of E rosettes and a moderate hyporesponsiveness to PHA and Con A were observed before treatment. The statistical significance of these alterations was borderline. Within the group of treated patients a much greater depression, including the response to ALG, was found, although a few long-term survivors responded to mitogens as well as the controls. These findings stress the difficulty of interpreting the results of a longitudinal study of cell-mediated immunity, specific or non-specific, in cancer patients. Finally, by comparing the proliferative response to the three mitogens before and after radiotherapy, it is suggested that their differential effect on these responses might be used in man, as it was in mice, to delineate lymphocyte subpopulations.

4. DOCID:3181 SCORE: 0.00410375782431947
DOCNO: 833858
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Beauty Culture
QUALIFIER: chemically induced
QUALIFIER: chemically induced
AUTHOR: J Garfinkel J
AUTHOR: S Selvin S
AUTHOR: S M Brown SM
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Brief communication: Possible increased risk of lung cancer among beauticians.
PUBDATE: 19770101
Death certificates of residents of Alameda County, California (1958-1962) with any mention of cancer were examined to determine the risk of cancer among beauticians. Twenty-four female beauticians were found among 3,460 adult females who died with cancer; four female beauticians were found in a sample of 1,000 females who died from causes other than cancer. The case and control certificates were matched for age and race. The resulting odds ratio (i.e., approximate relative risk of a cancer death) was slightly elevated (1.73) but was not statistically significant. Although a possible increase in the risk of cancer was found for several organ sites, the increase in risk for lung cancer was most striking. Analysis of pairs of death certificates, in which female controls dying of causes other than cancer were matched to female lung cancer cases for age, race, and date of death, yielded an odds ratio of 6.0. This finding suggested that the risk of lung cancer may be substantially increased among female beauticians.

5. DOCID:2355 SCORE: 0.00394009244668009
DOCNO: 140095
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Laparotomy
AUTHOR: V Jalůvka V
PUBTYPE: Journal Article
JOURNALTITLE: Geburtshilfe und Frauenheilkunde.
COUNTRY: GERMANY, WEST
TITLE: [Exploratory laparotomies in geriatric-gynaecological patients (author's transl)]
PUBDATE: 19770401
In 17 gynaecological departments of West-Berlin hospitals, 2940 laparotomies were done between 1960 and 1969 in women of at least 60 years of age, of which 331 (10,9%) were exploratory. Of these the postoperative mortality was 39,2% (130 cases). The fatal cases could be divided into 120 women suffering from inoperable malignant tumors, 7 from sigmoid diverticulitis and 3 from chromical gynaecological inflammatory tumors. The frequency of such critical exploratory laparotomies could be lowered partly by intensifying cancer routine check-up by specialists by more complex diagnostic measures before the operations and by fewer adhesiotomies in cases of chronical inflammatory complaints. Most important, however, seems to be the well indicated application of laparoscopy under conditions that allow consecutive laparotomy if necessary. It is thought that to an experienced surgeon the diagnostic value of laparoscopy is almost equal to that of laparotomy. It therefore can be considered a true alternative.

6. DOCID:31395 SCORE: 0.00385002455588906
DOCNO: 15112573
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Venous Thrombosis
QUALIFIER: complications
AUTHOR: Anna Falanga A
AUTHOR: Alfonso Vignoli A
AFFILIATION: Department of Hematology-Oncology, Ospedali Riuniti di Bergamo, Bergamo, Italy. annafalanga@yahoo.com
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Eksperimentalʹnai︠a︡ onkologii︠a︡.
COUNTRY: Ukraine
TITLE: Venous thromboembolism in oncology.
PUBDATE: 20040301
Thromboembolic events represent well-recognised complications of neoplastic disease contributing, in a significant manner, to the morbidity and mortality from cancer. The close relationship between the activation of blood coagulation and tumor growth is known since 1865, when Armand Trousseau first described the clinical association between primary or idiopathic venous thromboembolism and an underlying occult malignancy. However, only in the last decades significant advances in this field have been achieved, both on the comprehension of the complex interactions between the tumor and the hemostatic system, and on the prophylaxis and therapy of the thromboembolic manifestations in cancer patients.

7. DOCID:3998 SCORE: 0.00371253895009152
DOCNO: 1184240
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antibodies, Neoplasm
DESCRIPTOR: Antibody Formation
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: S Canevari S
AUTHOR: G Fossati G
AUTHOR: G Della Porta G
AUTHOR: G P Balzarini GP
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: Humoral cytotoxicity in melanoma patients and its correlation with the extent and course of the disease.
PUBDATE: 19751101
Complement-dependent cytotoxicity against melanoma cells was demonstrated with a microassay in sera from melanoma patients. The response was tumor-specific and histologic type-specific since 16 out of 52 (30%) melanoma patient sera taken before surgery reacted against melanoma cells, whereas 3 out of 43 (7%) control sera, collected from patients with unrelated tumors and from cancer-free individuals, were positive. The serum activity correlated with the clinical stage of the disease since it was detected in 15 out of 40 patients with stage I and II tumors and in 1 of the 12 patients in stage III. Twelve melanoma patients, clinically tumor-free for to 4 years after surgery, showed no humoral cytotoxicity. A follow-up study of 13 melanoma patients revealed that the cytotoxicity appeared 7-10 days after radical removal of the tumor and that it disappeared if there was no recurrence. The histologic type-specificity was further tested by assaying sera from 16 melanoma and 10 breast-cancer patients simultaneously on both melanoma and breast-cancer cells; a positive reaction was observed in 6 cases of melanoma and in 5 of breast cancer on homologous cells only, in 1 case on the opposite type of cells, and in 3 cases on both types of tumor cells.

8. DOCID:30180 SCORE: 0.00369565442746629
DOCNO: 14751092
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: Eric J Lentsch EJ
AFFILIATION: Division of Otolaryngology-Head and Neck Surgery, University of Louisville, Myers Hall, Louisville, KY 40292, USA. ejlent01@louisville.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current oncology reports.
COUNTRY: United States
TITLE: Management of cervical metastasis.
PUBDATE: 20040301
Cervical metastasis from head and neck cancer is a common occurrence. Despite improvements in diagnostic modalities and treatment options, survival in this group of patients has not changed appreciably over the past few decades. Cervical metastasis portends a poor prognosis and also presents a diagnostic and treatment dilemma for the head and neck oncologist. This article reviews the current state of the art in the diagnosis and treatment of this difficult group of patients and the literature on the topic.

9. DOCID:11941 SCORE: 0.0036501672262141
DOCNO: 7077060
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: T L Fabry TL
AUTHOR: A Frankel A
AUTHOR: J D Waye JD
PUBTYPE: Journal Article
JOURNALTITLE: Journal of clinical gastroenterology.
COUNTRY: UNITED STATES
TITLE: Gastric polyps.
PUBDATE: 19820201
We suggest an approach to patients with gastric polyps, based on a study of 73 patients seen at this institution over a 5-year period. There were 40 cases of adenomatous and 20 cases of hamartomatous polyps. Differentiation between these two groups of polyps was not possible on the basis of clinical presentation, laboratory data, radiological, or endoscopic appearance. Differentiation was possible only on histologic examination of a totally resected specimen. In this series, only the adenomatous polyps were associated with gastric cancers in five patients. Since the malignancy either preceded or followed the recognition of adenomatous polyps, it is important to establish an early definite histological diagnosis. Patients with known adenomatous polyps should be followed closely for the development of gastric carcinoma, even after the polyps have been removed.

10. DOCID:7525 SCORE: 0.00355643114530627
DOCNO: 7355726
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: instrumentation
QUALIFIER: analysis
AUTHOR: J F Mazur JF
AUTHOR: G E Podolak GE
AUTHOR: B T Heitke BT
PUBTYPE: Journal Article
JOURNALTITLE: American Industrial Hygiene Association journal.
COUNTRY: UNITED STATES
TITLE: Use of a GC concentrator to improve analysis of low levels of airborne hydrazine and unsymmetrical dimethylhydrazine.
PUBDATE: 19800101
New findings from animal studies indicate that there is a serious cancer risk associated with exposures to hydrazines. In June, 1978, NIOSH announced more restrictive occupational exposure levels for these compounds. Adherence to these limits requires improved analytical methodology. This paper describes a modified method for monitoring hydrazine and unsymmetrical dimethylhydrazine in atmospheric samples below the ceiling concentrations recommended by NIOSH. The method utilizes a GC concentrator for which a "trap" (ventable GC precolumn) was prepared and tested. Using this trap, up to 40 microL sample injections (injections much too large for conventional GC work) are effectively chromatographed. Presented are data on the overall efficiency of the method for airborne hydrazine and unsymmetrical dimethylhydrazine in the concentration ranges of 0.02 - 0.67 mg/m3 and 0.04 - 1.04 mg/m3, respectively.

11. DOCID:10881 SCORE: 0.00347466150294851
DOCNO: 6323872
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: H Fleming H
AUTHOR: R Blumenthal R
AUTHOR: E Gurpide E
PUBTYPE: Journal Article
JOURNALTITLE: Journal of steroid biochemistry.
COUNTRY: ENGLAND
TITLE: Characteristics of cyclic nucleotide dependent regulation of cytoplasmic E2 binders in cultured endometrial and breast cells.
PUBDATE: 19840101
Estradiol binding levels have previously been shown to be increased or decreased by the addition of of cGMP or cAMP respectively to cellular homogenates prepared from human endometrial tissue or from the endometrial cell line HEC 1. Similar cyclic nucleotide dependent effects have now been demonstrated in homogenates prepared from a second endometrial cell line, HEC 50, and from two breast cancer cell lines, CG-5 and T47D. It was previously shown that ATP and Mg2+ are necessary for the generation or inactivation of E2 binding sites. The present study demonstrates that the concentration of K+ and of dithiothreitol can also affect these reactions.

12. DOCID:17526 SCORE: 0.00338573868031531
DOCNO: 1333812
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
AUTHOR: B McCormick B
AFFILIATION: Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in oncology.
COUNTRY: UNITED STATES
TITLE: Radiation therapy for breast cancer.
PUBDATE: 19921201
Now that the radiation literature for breast cancer is well established in terms of both local control and survival endpoints, especially for invasive breast cancer, recent reports focus on refining selection criteria of patients for treatment and on minimizing complications and maximizing cosmetic effects. The optimal treatment of patients with ductal carcinoma in situ remains a controversial issue, and the optimal sequencing of adjuvant chemotherapy and primary radiation in patients with breast-conserving surgery is emerging as a topic requiring further study.

13. DOCID:28339 SCORE: 0.00328880131551454
DOCNO: 14998485
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: immunology
QUALIFIER: physiology
QUALIFIER: immunology
QUALIFIER: metabolism
AUTHOR: Ana M Gamero AM
AUTHOR: Howard A Young HA
AUTHOR: Robert H Wiltrout RH
AFFILIATION: Laboratory of Experimental Immunology, National Cancer Institute, Center for Cancer Research, Frederick, MD 21702, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer cell.
COUNTRY: United States
TITLE: Inactivation of Stat3 in tumor cells: releasing a brake on immune responses against cancer?
PUBDATE: 20040201
A model of immune evasion mediated by tumors expressing constitutively activated Stat3 was recently proposed in Nature Medicine by Wang et al., suggesting opportunities for a new therapeutic approach for cancer.

14. DOCID:3368 SCORE: 0.00327722944418089
DOCNO: 922658
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammography
QUALIFIER: radiography
AUTHOR: R L Egan RL
AUTHOR: R C Mosteller RC
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Breast cancer mammography patterns.
PUBDATE: 19771101
Mammography studies, from 1963 through 1972, on 5,918 women over age 30 years with 327 breast cancer on initial studies, were prospectively categorized on a scale of 1 to 4 of increasing amounts of fibroglandular tissue. Approximately 60% of the cancers occurred in classes 1 and 2 breasts, about one-third of the patients, while 40% of the cancer were in the remaining two-thirds, comprising classes 3 and 4. There were 54 cancers that developed in breast that previously were free of symptoms, clinical signs, and x-ray abnormality. Up to 36 months one cancer was found in class 1, while 26 cancers were detected in class 4 breasts; two cancers developed in class 2 and seven in class 3. Cancers developing 38 to 88 months after normal examination had an incidence of 0.23% in combined classes 1 and 2 and an incidence of 0.21% in classes 3 and 4. Dense fibroglandular tissue delays detection of breast cancer by mammography. Apparent increase in cancer risk in such breasts is due to this delay. More than a 3-year follow-up is required to assess the life history of breast cancer by mammography.