0. DOCID:30498 SCORE: 0.0028699470228185
DOCNO: 15773200
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: M S Aapro MS
AFFILIATION: IMO, Clinique de Genolier, 1272 Genolier. maapro@genolier.net
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Revue médicale suisse.
COUNTRY: Switzerland
TITLE: [Medical oncology]
PUBDATE: 20050101
Progresses in medical oncology seem to be speeding up. New drugs developed these last years have been submitted to comparative trials, and many results lead us to expect improvements in the treatment of patients with solid tumors. Unquestionable in some cancer types, these progresses unfortunately sometimes remain marginal in other fields. Survival benefits are not always well established and, confronted with the exploding costs of medicine, the physician might tend to refrain from using some promising drugs. This review is summarizing results of the most important trials, while trying to present data in a context useful to the clinician.

1. DOCID:29186 SCORE: 0.00278504711287501
DOCNO: 15899635
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: Pascal Eschwege P
AFFILIATION: Service d'Urologie, Hôpital Bicêtre, Faculté de Médecine, Paris-Sud.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Bulletin du cancer.
COUNTRY: France
TITLE: [Cyclooxygenase 2 inhibitors and urologic and gynaecologic cancers]
PUBDATE: 20040501
PGE2 is one of the most important prostaglandin involved in the oncogenesis. PGE2 is found at high concentration level in the most of epithelial cancer. Urologic and gynaecologic cancer express the enzyme which are at the origin of PGE2: cyclooxygenase 2. Cox2 inhibitors present anticancer properties demonstrated in wide varieties of cellular and animal models. Human applications are currently tested in many clinical trials for bladder, prostate and uterine carcinomas.

2. DOCID:31797 SCORE: 0.00248175816333223
DOCNO: 12972703
AUTHOR: C Friedrich C
AUTHOR: G Kolb G
AUTHOR: U Wedding U
AUTHOR: L Pientka L
AFFILIATION: Medizinisch-Geriatrische Klinik, Universitätsklinik, Marienhospital Herne, Germany. christoph.friedrich@ruhr-uni-bochum.de
PUBTYPE: Journal Article
JOURNALTITLE: Onkologie.
COUNTRY: Switzerland
TITLE: Comprehensive geriatric assessment in the elderly cancer patient.
PUBDATE: 20030801
The proportion of older cancer patients is increasing due to demographic and disease-specific reasons. However, this group of patients is severely underrepresented in research and clinical therapy. Limitation in physical and functional capacity with considerable interindividual heterogeneity remains one of the important problems in the treatment decision process. One approach to this problem is the use of a Comprehensive Geriatric Assessment (CGA) to describe and classify these deficits with high validity and reliability. The different domains of CGA are described with special respect to the instruments applied, as CGA has also a key role in the decision process.

3. DOCID:30968 SCORE: 0.00239349188051883
DOCNO: 14605452
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: J Lehmann J
AUTHOR: M Retz M
AUTHOR: M Hack M
AUTHOR: S Siemer S
AUTHOR: M Stöckle M
AFFILIATION: Klinik für Urologie und Kinderurologie, Universität des Saarlandes, Homburg, Deutschland.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Onkologie.
COUNTRY: Switzerland
TITLE: [Systemic chemotherapy for transitional cell carcinoma of the urothelium]
PUBDATE: 20031001
Moderate activity of systemic chemotherapy for advanced urothelial cancer has been reported for more than 30 years. Only with the advent of potent combination therapy in the mid eighties of the past century clinically significant response rates as well as prolonged survival has been documented. This review summarizes seven Phase-III trials of systemic chemotherapy for advanced urothelial carcinoma as well as results from adjuvant and neoadjuvant Phase-III trials for muscle-invasive bladder cancer including the most recent reports.

4. DOCID:28700 SCORE: 0.0023574077335153
DOCNO: 12001989
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Apoptosis
QUALIFIER: pathology
AUTHOR: Frederik H Igney FH
AUTHOR: Peter H Krammer PH
AFFILIATION: Tumor Immunology Program, German Cancer Research Center (DKFZ), Heidelberg.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nature reviews. Cancer.
COUNTRY: England
TITLE: Death and anti-death: tumour resistance to apoptosis.
PUBDATE: 20020401
Every cell in a multicellular organism has the potential to die by apoptosis, but tumour cells often have faulty apoptotic pathways. These defects not only increase tumour mass, but also render the tumour resistant to therapy. So, what are the molecular mechanisms of tumour resistance to apoptosis and how can we use this knowledge to resensitize tumour cells to cancer therapy?

5. DOCID:28512 SCORE: 0.00235732449139475
DOCNO: 12690647
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: Patrick Y Wen PY
AUTHOR: David Schiff D
AFFILIATION: Division of Neuro-Oncology, Department of Neurology, Brigham and Women's Hospital, 75 Francis St. Boston, MA 02115, USA. pwen@partners.org
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Neurologic clinics.
COUNTRY: United States
TITLE: Neurologic complications of solid tumors.
PUBDATE: 20030201
This article reviews the neurologic complications of the most common solid tumors, including lung, breast, gastrointestinal, genitourinary, gynecologic, head and neck cancers, melanoma and sarcomas. As systemic therapy improves for many of these tumors, patients are surviving longer and the incidence of neurologic complications is increasing.

6. DOCID:29150 SCORE: 0.00233948744563455
DOCNO: 12470902
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: DNA Methylation
QUALIFIER: genetics
QUALIFIER: metabolism
QUALIFIER: genetics
QUALIFIER: metabolism
AUTHOR: Yasuhito Yuasa Y
AFFILIATION: Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. yuasa.monc@tmd.ac.jp
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Mechanisms of ageing and development.
COUNTRY: Ireland
TITLE: DNA methylation in cancer and ageing.
PUBDATE: 20021101
Epigenetic gene silencing through DNA methylation is now clearly thought to be one of the important steps in the mechanism underlying tumourigenesis. The methylation of several genes increases with age in normal tissues such as the colon. Methylation related to cancer and ageing may lead to new biomarkers and therapeutic concepts for cancer.

7. DOCID:31313 SCORE: 0.00229541461238227
DOCNO: 12440163
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Maxillofacial Prosthesis Implantation
DESCRIPTOR: Palatal Obturators
DESCRIPTOR: Reconstructive Surgical Procedures
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: Kengo Nishimoto K
AUTHOR: Mituaki Iwamoto M
AUTHOR: Atuko Karaki A
AUTHOR: Yasuhiro Nishi Y
AUTHOR: Yasuhiko Morita Y
AUTHOR: Yuichi Kurono Y
AFFILIATION: Department of Otolaryngology, Faculty of Medicine, Kagoshima University, Kagoshima.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Nippon Jibiinkoka Gakkai kaiho.
COUNTRY: Japan
TITLE: [Application of prosthetic replacement for bilateral maxillectomy defect]
PUBDATE: 20021001
A 59-year-old woman with large hard palate cancer underwent surgical resection. We constructed a maxillary prosthesis to be connected to the patient's mandibular denture. Bilateral maxillectomy resulted in total loss of the hard palate and bilateral alveolar and partial loss of the soft palate. A obturator prosthesis was prepared beforehand to fit the surgical cavity. The patient recovered functional speech and swallowing at a relatively early stage, achieving satisfactory cosmetic results.

8. DOCID:30156 SCORE: 0.00229020521048056
DOCNO: 15806096
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: toxicity
QUALIFIER: etiology
AUTHOR: Alistair J Lax AJ
AFFILIATION: Department of Microbiology, Dental Institute, King's College London, Floor 28 Guy's Tower, Guy's Hospital, London SE1 9RT, UK. alistair.lax@kcl.ac.uk
PUBTYPE: Journal Article
JOURNALTITLE: Nature reviews. Microbiology.
COUNTRY: England
TITLE: Opinion: Bacterial toxins and cancer--a case to answer?
PUBDATE: 20050401
Since the discovery that Helicobacter pylori infection leads to gastric cancer, other chronic bacterial infections have been shown to cause cancer. The bacterial and host molecular mechanisms remain unclear. However, many bacteria that cause persistent infections produce toxins that specifically disrupt cellular signalling to perturb the regulation of cell growth or to induce inflammation. Other bacterial toxins directly damage DNA. Such toxins mimic carcinogens and tumour promoters and might represent a paradigm for bacterially induced carcinogenesis.

9. DOCID:28599 SCORE: 0.00226176405017584
DOCNO: 15043405
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: isolation & purification
QUALIFIER: chemistry
QUALIFIER: chemistry
AUTHOR: Ali A H El-Gamal AA
AUTHOR: Shang-Kwei Wang SK
AUTHOR: Chang-Yih Duh CY
AFFILIATION: Department of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of natural products.
COUNTRY: United States
TITLE: New diterpenoids from Viburnum awabuki.
PUBDATE: 20040301
Eight new vibsane-type diterpenoids, vibsanins P-W (1-8), were isolated from the methanol extracts of the leaves and twigs of Viburnum awabuki. The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

10. DOCID:30295 SCORE: 0.00224684675146547
DOCNO: 12624825
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Phytotherapy
DESCRIPTOR: Vernonia
QUALIFIER: pharmacology
QUALIFIER: pharmacology
QUALIFIER: pharmacology
AUTHOR: J L Koul JL
AUTHOR: S Koul S
AUTHOR: C Singh C
AUTHOR: S C Taneja SC
AUTHOR: M Shanmugavel M
AUTHOR: H Kampasi H
AUTHOR: A K Saxena AK
AUTHOR: G N Qazi GN
PUBTYPE: Letter
JOURNALTITLE: Planta medica.
COUNTRY: Germany
TITLE: In vitro cytotoxic elemanolides from Vernonia lasiopus.
PUBDATE: 20030201
Two new elemanolides, epivernodalol and lasiopulide, were isolated after chromatographic separation of the alcoholic extract of the dried aerial parts of the Vernonia lasiopus. These elemanolides are new C-10 epimers of the sesquiterpene lactones vernodalol and demethylacroylated vernodalol isolated from other species of Vernonia. Both elemanolides showed in vitro cytotoxicity against human cancer cell lines in culture. This is the first report of isolation and cytotoxic activity of the two elemanolides from V. lasiopus.

11. DOCID:29449 SCORE: 0.00223527455572223
DOCNO: 12360278
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: Theresa M Allen TM
AFFILIATION: Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada T6G 2H7. terry.allen@ualberta.ca
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nature reviews. Cancer.
COUNTRY: England
TITLE: Ligand-targeted therapeutics in anticancer therapy.
PUBDATE: 20021001
Cytotoxic chemotherapy or radiotherapy of cancer is limited by serious, sometimes life-threatening, side effects that arise from toxicities to sensitive normal cells because the therapies are not selective for malignant cells. So how can selectivity be improved? One strategy is to couple the therapeutics to antibodies or other ligands that recognize tumour-associated antigens. This increases the exposure of the malignant cells, and reduces the exposure of normal cells, to the ligand-targeted therapeutics.

12. DOCID:30529 SCORE: 0.00212367909271659
DOCNO: 12838303
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: statistics & numerical data
AUTHOR: L K Smith LK
AUTHOR: P C Lambert PC
AUTHOR: D R Jones DR
AFFILIATION: Department of Epidemiology and Public Health, University of Leicester, 22-28 Princess Road West, Leicester LE1 6TP, UK. lksl@le.ac.uk
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: England
TITLE: Up-to-date estimates of long-term cancer survival in England and Wales.
PUBDATE: 20030701
Cancer survival in England and Wales has improved over the last 30 years. However, cohort survival estimates delay recognition of these improvements. Here we show that period survival estimates, based on survival in a recent time period, suggest a more optimistic pattern for England and Wales than cohort-based measures for most cancers.British Journal of Cancer (2003) 89, 74-76. doi:10.1038/sj.bjc.6600976 www.bjcancer.com

13. DOCID:30940 SCORE: 0.00210340556562787
DOCNO: 15348996
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: trends
AUTHOR: Charlie C Pan CC
AUTHOR: James A Hayman JA
AFFILIATION: Department of Radiation Oncology, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA. cpan@umich.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society.
COUNTRY: United States
TITLE: Recent advances in radiation oncology.
PUBDATE: 20040901
The field of radiation oncology has experienced dramatic progress in recent years. Advances in areas of tumor delineation, treatment planning, delivery, and verification allow modern radiotherapy to deliver high doses with great accuracy, less patient morbidity, and in a highly individualized manner. A good understanding of what can be achieved with modern radiotherapy is important in ensuring an effective multidisciplinary approach to the management of cancer and other benign, yet rapidly proliferating, lesions.

14. DOCID:31364 SCORE: 0.00208904007994085
DOCNO: 16175183
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Body Height
DESCRIPTOR: Body Mass Index
QUALIFIER: epidemiology
QUALIFIER: pathology
AUTHOR: T Bjørge T
AUTHOR: S Tretli S
AUTHOR: A Engeland A
AFFILIATION: Department of Public Health and Primary Health Care, Section for Epidemiology and Medical Statistics, University of Bergen, Norway. tone.bjorge@isf.uib.no
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: England
TITLE: Height and body mass index in relation to cancer of the small intestine in two million Norwegian men and women.
PUBDATE: 20051001
The present study aimed at exploring the relations between body mass index (BMI, (weight in kilograms)/(height in meters)(2)) and stature and cancer of the small intestine (1162 cases) in a large Norwegian cohort (of two million) with measured height and weight. Elevated BMI in males and increasing height in both sexes were associated with a moderately increased risk of cancer of the small intestine.