0. DOCID:26678 SCORE: 0.00262952119721404
DOCNO: 10505166
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: B Abboud B
AUTHOR: B Tabchy B
AUTHOR: S Jambart S
AUTHOR: W A Hamad WA
AUTHOR: P Farah P
AFFILIATION: Department of General Surgery, Hôtel Dieu de France, Beirut, Lebanon.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of laryngology and otology.
COUNTRY: ENGLAND
TITLE: Benign disease of the thyroid gland and vocal fold paralysis.
PUBDATE: 19990501
Development of vocal fold paralysis in the presence of thyroid disease is strongly indicative of thyroid cancer, and requires surgical exploration. At the same time, vocal fold paralysis does not relieve the surgeon of his obligation to identify and preserve the recurrent laryngeal nerves, since the cause of the paralysis may be a benign disease, with a fair chance of functional recovery after surgery. We hereby report a case of recurrent laryngeal nerve palsy secondary to a multinodular goitre.

1. DOCID:25591 SCORE: 0.00257111383882182
DOCNO: 11228404
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
AUTHOR: A N Houghton AN
AUTHOR: J S Gold JS
AUTHOR: N E Blachere NE
AFFILIATION: Memorial Sloan-Kettering Cancer Center and Weill Medical School of Cornell University, 1275 York Avenue, New York, NY 10021, USA. a-houghton@ski.mskcc.org
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in immunology.
COUNTRY: England
TITLE: Immunity against cancer: lessons learned from melanoma.
PUBDATE: 20010401
Most major advances in human cancer immunology and immunotherapy have come from studies in melanoma. We are beginning to understand the immune repertoire of T cells and antibodies that are active against melanoma, with recent glimpses of the CD4(+) T cell repertoire. The view of what the immune system can see is extending to mutations and parts of the genome that are normally invisible.

2. DOCID:25206 SCORE: 0.00255659989392277
DOCNO: 9739758
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Repressor Proteins
DESCRIPTOR: Trans-Activation (Genetics)
QUALIFIER: physiology
QUALIFIER: physiology
AUTHOR: L Rapp L
AUTHOR: J J Chen JJ
AFFILIATION: Department of Dermatology, New England Medical Center, Boston, MA, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Biochimica et biophysica acta.
COUNTRY: NETHERLANDS
TITLE: The papillomavirus E6 proteins.
PUBDATE: 19980801
Specific types of human papillomaviruses (HPV) are strongly associated with the development of cervical cancer. The E6 gene from cancer-related HPVs has exhibited functions in tumorigenesis, regulation of transcription, telomerase, and apoptosis. Cancer-related HPVs E6 proteins bind the tumor suppressor p53 and promotes its degradation through an ubiquitin-dependent pathway. Several additional cellular E6-binding proteins have recently been identified and implicated in playing roles in p53-independent functions of E6.

3. DOCID:26833 SCORE: 0.00247854331600814
DOCNO: 11908366
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: J J Sciubba JJ
AFFILIATION: Dental and Oral Medicine, Johns Hopkins Medical Center, Baltimore, Maryland, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)
COUNTRY: United States
TITLE: Oral precancer and cancer: etiology, clinical presentation, diagnosis, and management.
PUBDATE: 20001001
Oral and oropharyngeal cancers represent 3% of all cancers in the United States annually, with nearly 50% of people diagnosed with oral and oropharyngeal cancers dying as a result of the disease. Because the dental practitioner is in an ideal position for recognizing any abnormality of the oral mucosa, he or she is involved in the battle against oral cancer by helping establish the diagnosis at an early stage. This article presents the clinical appearance, explains the origins, and describes steps for the management of oral precancer and cancer.

4. DOCID:26967 SCORE: 0.00247571169252047
DOCNO: 11249682
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Liposomes
QUALIFIER: administration & dosage
AUTHOR: G Gregoriadis G
AFFILIATION: Centre for Drug Delivery Research, School of Pharmacy, University of London, 29-39 Brunswick Square, London, WCIN 1AX, UK. Gregoriadis@cua.ulsop.ac.uk
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in molecular therapeutics.
COUNTRY: England
TITLE: DNA vaccines: a role for liposomes.
PUBDATE: 19990201
Vaccination with attenuated or killed microbes, purified or recombinant subunit proteins and synthetic peptides is often hampered by toxicity, the presence of infectious agents, weak immune responses and prohibiting costs, especially in the developing world. Such problems may be circumvented by genetic immunization, which, by the use of plasmid DNA encoding antigens from bacteria, viruses, protozoa and cancers leads to protective humoral and cell-mediated immunity. This review deals with the background and progress made so far with DNA vaccines and evaluates the role of liposomes in their optimization.

5. DOCID:26985 SCORE: 0.00242012859318354
DOCNO: 9811028
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Surgical Flaps
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: K Sasaki K
AUTHOR: M Nozaki M
AUTHOR: H Nakazawa H
AUTHOR: Y Kikuchi Y
AUTHOR: T Huang T
AFFILIATION: Department of Plastic and Reconstructive Surgery at Tokyo Women's Medical College, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Plastic and reconstructive surgery.
COUNTRY: UNITED STATES
TITLE: Reconstruction of a large abdominal wall defect using combined free tensor fasciae latae musculocutaneous flap and anterolateral thigh flap.
PUBDATE: 19981101
A large abdominal wall defect was reconstructed with the use of a flap combining the tensor fasciae latae musculocutaneous flap and the anterolateral thigh flap in four individuals who had undergone extensive abdominal wall resection because of cancer. The flap was harvested as a single combined composite flap and was transferred to the recipient site by means of microvascular surgery. Morbidity was minimal and the outcome was satisfactory in all instances.

6. DOCID:24357 SCORE: 0.00227048858831561
DOCNO: 9927973
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: F R Miller FR
AUTHOR: J L Netterville JL
AFFILIATION: Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
PUBTYPE: Journal Article
JOURNALTITLE: The Medical clinics of North America.
COUNTRY: UNITED STATES
TITLE: Surgical management of thyroid and parathyroid disorders.
PUBDATE: 19990101
This article begins with a discussion of thyroid anatomy and physiology and then proceeds with an in-depth study of the area of focus, thyroid and parathyroid disorders, including thyroid nodules and cancer, multinodular goiter, and hyperparathyroidism. Complications of thyroid and parathyroid surgery are discussed.

7. DOCID:25612 SCORE: 0.00225823668543888
DOCNO: 10344155
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: R Włodarczyk R
AUTHOR: M Sobolewski M
AUTHOR: G Wojtas G
AFFILIATION: Wojskowego Szpitala Gruźlicy i Chorób Płuc w Otwocku.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
COUNTRY: POLAND
TITLE: [Role of oxygen free radicals in the pathogenesis of lung diseases]
PUBDATE: 19990101
The authors have tried to compose the characteristics of the free radicals and their role in the pathogenesis od various diseases. They show up both the ways the free radicals appear and the biochemical compounds negating their toxic effects. They stress the meaning of the dynamic equilibrium between them, and asses its value in the lung cancer pathogenesis. They also quote the examples of the medicines, which work towards neutralizing the free radicals.

8. DOCID:26023 SCORE: 0.00219234353912447
DOCNO: 11738785
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: J Ortega-Carnicer J
AUTHOR: J Benezet J
AUTHOR: L Porras L
AFFILIATION: Intensive Care Unit, Hospital Alarcos, Av. Pío XII s/n., Los Alisos 10, 13002, Ciudad Real, Spain.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Resuscitation.
COUNTRY: Ireland
TITLE: Lung cancer presenting as cardiac tamponade associated with transmural myocardial ischaemia.
PUBDATE: 20011201
Cardiac tamponade due to carcinomatous pericarditis is a life-threatening complication of malignancy and is uncommon as its initial manifestation [Chest 88 (1985) 70; Cancer 45 (1980) 1697; J Am Med Assoc 257 (1987) 1088]. A case of lung cancer presenting with cardiac tamponade associated with transient ST-segment elevation and life-threatening arrhythmias is presented. To our knowledge, this is the first reported case of transmural myocardial ischaemia related to malignancy.

9. DOCID:27406 SCORE: 0.00214505319394807
DOCNO: 9608315
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: pharmacology
AUTHOR: L S Simon LS
AFFILIATION: Beth Israel Deaconess Medical Center, Department of Medical Education, Boston, MA 02215, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in rheumatology.
COUNTRY: UNITED STATES
TITLE: Biology and toxic effects of nonsteroidal anti-inflammatory drugs.
PUBDATE: 19980501
Nonsteroidal anti-inflammatory drugs (NSAIDs) continue to be important therapeutically. The development of drugs that are highly COX-2 selective has led to interesting new findings about their effects and potential toxic reactions. This year there were interesting observations about the effects of individual NSAIDs on the gastrointestinal mucosa, risk factors for sustaining an NSAID-induced gastric or duodenal ulcer, and there has been progress in further understanding what may or may not work to prevent a toxic reaction. Furthermore, information has been gathered about the effects of NSAIDs on colorectal polyps and the development of cancers.

10. DOCID:26486 SCORE: 0.00210635460426595
DOCNO: 11030077
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: isolation & purification
QUALIFIER: epidemiology
AUTHOR: K Haruma K
AFFILIATION: First Department of Internal Medicine, Hiroshima University School of Medicine, Japan. kharuma@mcai.med.hiroshima-u-ac.jp
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gastroenterology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Trend toward a reduced prevalence of Helicobacter pylori infection, chronic gastritis, and gastric cancer in Japan.
PUBDATE: 20000901
It is speculated that declines in H. pylori infection and gastritis over the past few decades may lead to a decline in gastric cancer in Japan, supplemented by excellent procedures for the early detection of gastric cancer. Because H. pylori infection rarely is acquired in adult life, once it is eradicated, reinfection would not be expected in adult patients. It seems likely that adequate treatment of H. pylori infection would provide long-term protection against gastric cancer.

11. DOCID:27097 SCORE: 0.00208134325067934
DOCNO: 9648240
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: analogs & derivatives
QUALIFIER: drug effects
AUTHOR: M Sazuka M
AUTHOR: M Isemura M
AUTHOR: S Isemura S
AFFILIATION: School of Food and Nutritional Sciences, University of Shizuoka, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Bioscience, biotechnology, and biochemistry.
COUNTRY: JAPAN
TITLE: Interaction between the carboxyl-terminal heparin-binding domain of fibronectin and (-)-epigallocatechin gallate.
PUBDATE: 19980501
We have previously reported that (-)-epigallocatechin gallate (EGCg) inhibited lung carcinoma cell adhesion to fibronectin (FN) and demonstrated its interaction with FN. In the present work, we studied the interaction between thermolysin fragments of FN and EGCg. An amino acid sequence analysis of the fragment bound by EGCg-agarose provided its identification as a carboxyl-terminal heparin-binding domain. Thus, the inhibition of cancer cell adhesion to FN by EGCg is not caused by its direct binding to the cell-binding domain containing an Arg-Gly-Asp-sequence.

12. DOCID:27294 SCORE: 0.00205713451829661
DOCNO: 10367879
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: T E Read TE
AUTHOR: I J Kodner IJ
AFFILIATION: Section of Colon and Rectal Surgery, Washington University School of Medicine, St Louis, MO, USA. readt@msnotes.wustl.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Archives of surgery (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Proctectomy and coloanal anastomosis for rectal cancer.
PUBDATE: 19990601
Fueled by a greater understanding of pelvic physiology along with an improved comprehension of rectal cancer spread, we are now able to offer most patients restoration of intestinal continuity following oncologic proctectomy. Coloanal or ultralow colorectal anastomosis can be performed in most patients with midrectal cancers, provided that anal sphincter function is not impaired preoperatively. Functional results may be improved by construction of a colonic pouch with pouch-anal anastomosis. Temporary fecal diversion, usually with a diverting loop ileostomy, may be prudent, especially in patients undergoing neoadjuvant chemoradiation.

13. DOCID:26824 SCORE: 0.00204805718013226
DOCNO: 11410198
AUTHOR: F Levi F
AUTHOR: C La Vecchia C
AUTHOR: P Boyle P
AUTHOR: F Lucchini F
AUTHOR: E Negri E
PUBTYPE: Letter
JOURNALTITLE: Lancet.
COUNTRY: England
TITLE: Western and eastern European trends in testicular cancer mortality.
PUBDATE: 20010601
Testicular cancer is curable if treated appropriately. We used national mortality data to compare specific death rates from the disorder in western and eastern Europe, the USA, and Japan. Testicular cancer mortality rates have fallen by about 70% in the USA and western Europe since the 1970s. In eastern Europe, however, death rates from testicular cancer have been declining only since the late 1980s, and at a much slower rate than that recorded elsewhere (about 20%). Consequently, many avoidable deaths, mainly in young adults, are still occurring in eastern Europe. Available effective treatment strategies for testicular cancer must be implemented in these countries.

14. DOCID:25109 SCORE: 0.00202398212524027
DOCNO: 11691893
AUTHOR: D R Camidge DR
AFFILIATION: Department of Oncology, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK. drcamidge@talk21.com
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the Royal Society of Medicine.
COUNTRY: England
TITLE: The causes of dysphagia in carcinoma of the lung.
PUBDATE: 20011101
Dysphagia occurs in only a small percentage of patients with lung cancer, but the frequency of this cancer means that large numbers are affected. Non-quantitative analysis of a large Scottish series of lung cancer cases indicates the following eight broad categories of dysphagia according to underlying mechanisms: mediastinal disease; cervical lymphadenopathy; brainstem lesions; gastrointestinal tract metastases; associated systemic disorders; second primaries; oropharyngeal and oesophageal infections; and radiation-induced oesophageal toxicity.