0. DOCID:22012 SCORE: 0.00357643084251198
DOCNO: 8652450
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: drug effects
QUALIFIER: pharmacology
QUALIFIER: pharmacology
AUTHOR: K Kawamoto K
AFFILIATION: Kansai Medical University Depertment of Neurosurgery, Osaka, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Human cell : official journal of Human Cell Research Society.
COUNTRY: JAPAN
TITLE: [Flow cytometric analysis of cell cycle for the action mechanism of antineoplastic agents]
PUBDATE: 19950901
Cell kinetics of cancers have been described in books, texts and other reports, but the correlation with action mechanism of antineoplastic agents has rarely been mentioned in the literature. The action mechanism of the antineoplastic agents such as interferon, ACNU and cisplatin was analyzed with use of propidium iodide and BrdU double staining by flow cytometer. Interferon showed S phase accumulation, ACNU and cisplatin blocked the stage of G(2)M phase. Flow cytometry was useful for the analysis of cell kinetics.


1. DOCID:23155 SCORE: 0.00305884864365039
DOCNO: 8689512
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: biosynthesis
AUTHOR: K Nishimura K
AUTHOR: M Higashino M
AUTHOR: T Hara T
AUTHOR: T Oka T
AFFILIATION: Department of Urology, Minoh City Hospital, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: International journal of urology : official journal of the Japanese Urological Association.
COUNTRY: JAPAN
TITLE: Bladder cancer producing granulocyte colony-stimulating factor: a case report.
PUBDATE: 19960301
A rare case of bladder cancer producing granulocyte colony-stimulating factor (G-CSF) is reported. A 63-year-old man with a progressive, grade 3 transitional cell bladder carcinoma, showed marked leukocytosis (maximum 181,800/mm3) and an elevated serum G-CSF to 131.7 pg/mL. After radical cystectomy and neoadjuvant chemotherapy, the tumor recurred locally. Immunohistochemical examination with monoclonal antibody specific for G-CSF revealed positive staining in the local recurrent tumor. To our knowledge, there have been only seven cases reported of bladder cancer producing G-CSF.


2. DOCID:23530 SCORE: 0.00291537626713191
DOCNO: 8946611
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: N Harpaz N
AUTHOR: I C Talbot IC
AFFILIATION: Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in diagnostic pathology.
COUNTRY: UNITED STATES
TITLE: Colorectal cancer in idiopathic inflammatory bowel disease.
PUBDATE: 19961101
The development of colorectal cancer is the most serious long-term problem faced by patients with extensive ulcerative colitis and Crohn's colitis, with an incidence 20-fold higher and an average age of onset 20 years younger than colorectal cancer in the general population. This report summarizes the epidemiology, pathology, and recent advances in the molecular pathogenesis of colorectal cancer in inflammatory bowel disease and of its acknowledged precursor, mucosal dysplasia. It also reviews the rationale behind the use of endoscopic surveillance for dysplasia as a means of reducing cancer mortality, as well as some of the issues involved in its effective implementation.


3. DOCID:23695 SCORE: 0.00291304394909283
DOCNO: 8113901
AUTHOR: T Misaki T
AUTHOR: R Takeuchi R
AUTHOR: S Miyamoto S
AUTHOR: K Kasagi K
AUTHOR: Y Matsui Y
AUTHOR: J Konishi J
AFFILIATION: Department of Nuclear Medicine, School of Medicine, Kyoto University, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
COUNTRY: UNITED STATES
TITLE: Radioiodine uptake by squamous-cell carcinoma of the lung.
PUBDATE: 19940301
A patient with a history of total thyroidectomy for papillary carcinoma showed a solitary hot spot in the chest on post-therapy radioiodine imaging. Subsequent evaluation demonstrated that this lesion was a primary squamous-cell lung cancer. Our case illustrates a rare but important differential diagnosis from lung metastasis of thyroid cancer in 131I scintigraphy. Alternatively, this "aberrant uptake" might be a rather common phenomenon for lung neoplasms, although the underlying mechanism is not yet known. Future experimental studies might lead to a new application of radioiodine imaging in pulmonary oncology.


4. DOCID:23029 SCORE: 0.00267479815707853
DOCNO: 7912881
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: H Kuroda H
AUTHOR: Y Yasunaga Y
AUTHOR: H Takatera H
AUTHOR: H Fujioka H
AUTHOR: A Ohnishi A
AUTHOR: M Tsujimoto M
AFFILIATION: Department of Urology, Osaka Police Hospital.
PUBTYPE: Journal Article
JOURNALTITLE: Hinyokika kiyo. Acta urologica Japonica.
COUNTRY: JAPAN
TITLE: [Growth fractions of bladder cancer determined by proliferating cell nuclear antigen immunostaining]
PUBDATE: 19940501
Immunohistochemical staining of proliferating cell nuclear antigen (PCNA) can be performed on conventionally fixed and processed tissue. We applied anti-PCNA monoclonal antibodies to transurethrally resected bladder cancer specimens. The labelling index (LI) of PCNA increased with tumor grade and that of the invasive tumor group was higher than that of the non-invasive tumor group. Especially in large tumors, there was intratumoral variation of labelled cell distribution, which may represent tumor heterogeneity. These findings suggest that PCNA might be a useful marker for bladder cancer proliferation.


5. DOCID:23123 SCORE: 0.00258063386001427
DOCNO: 9207316
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: therapy
QUALIFIER: analogs & derivatives
QUALIFIER: therapy
QUALIFIER: administration & dosage
QUALIFIER: antagonists & inhibitors
AUTHOR: A Gregor A
AFFILIATION: Department of Clinical Oncology, University of Edinburgh, Scotland.
PUBTYPE: Clinical Trial
PUBTYPE: Clinical Trial, Phase I
PUBTYPE: Journal Article
JOURNALTITLE: Seminars in oncology.
COUNTRY: UNITED STATES
TITLE: Gemcitabine plus radiotherapy for non-small cell lung cancer.
PUBDATE: 19970601
Radiosensitization promises to improve local control in patients with locally advanced non-small cell lung cancer (NSCLC). The nucleoside analogue gemcitabine, which is not only a potent radiosensitizer but also has significant antitumor activity in this disease, is an important candidate for such a strategy. This report describes the design of a clinical phase I study for treatment of patients with locally advanced NSCLC using gemcitabine and radiotherapy. It also discusses some of the practical constraints that must be taken into consideration when evaluating this type of combined modality strategy in the clinic.


6. DOCID:23276 SCORE: 0.00253604914673016
DOCNO: 7818356
AUTHOR: W A Fry WA
AUTHOR: A Siddiqui A
AUTHOR: J M Pensler JM
AUTHOR: H Mostafavi H
AFFILIATION: Department of Surgery, Evanston Hospital, Northwestern University Medical School, Illinois.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Annals of thoracic surgery.
COUNTRY: UNITED STATES
TITLE: Thoracoscopic implantation of cancer with a fatal outcome.
PUBDATE: 19950101
A case is presented in which an indeterminate lung lesion was extracted through an accessory incision during a video-assisted thoracic surgical lung biopsy. The lesion was malignant, and a completion lobectomy was performed. An incisional recurrence developed 5 months later, and this was treated with a wide chest wall resection and reconstruction. However, there was a second massive chest wall recurrence that proved fatal. We believe that tumor seeding to the chest wall occurred at thoracoscopy. To prevent such tumor seeding, thoracoscopic biopsy specimens should be removed in some sort of receptacle when cancer is suspected.


7. DOCID:21882 SCORE: 0.00250081930610711
DOCNO: 7575291
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: ethnology
AUTHOR: T Alagaratnam T
AFFILIATION: University of Hong Kong Department of Surgery, Queen Mary Hospital.
PUBTYPE: Journal Article
JOURNALTITLE: The Australian and New Zealand journal of surgery.
COUNTRY: AUSTRALIA
TITLE: The presentation of breast cancer in an Oriental community.
PUBDATE: 19950901
A retrospective study was made of the presentation of breast cancer in Chinese women who were treated at the University Surgical Unit, Hong Kong, over a 20 year period (1971-90). Only 6% of patients presented with tumours less than 2 cm. Nearly half the patients presented with advanced disease. There was no tendency towards earlier presentation in the latter half of the study period. An increase in the number of patients treated for breast cancer was observed; the increase being seen mainly in postmenopausal women.


8. DOCID:22179 SCORE: 0.00238880431837845
DOCNO: 9431768
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: prevention & control
AUTHOR: P R Silverman PR
PUBTYPE: Journal Article
JOURNALTITLE: Delaware medical journal.
COUNTRY: UNITED STATES
TITLE: Observations about cancer and implications for cancer control in Delaware.
PUBDATE: 19971201
Cancer is a provocative disease, made more so in Delaware because of our high cancer mortality rates. Information made available to the public is often insufficient to form a balanced perspective about the causes of cancer and appropriate interventions. Four observations are offered to guide communication and to consider in the development of cancer-related public health programs. These are: (1) focusing on our cancer mortality rank obscures important information; (2) four sites are responsible for most of the cancer in Delaware; (3) cancer intervention are based on common sense; and (4) there are limitations to what can be done to control cancer.


9. DOCID:21065 SCORE: 0.00234301098758718
DOCNO: 9278928
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Models, Genetic
DESCRIPTOR: Mutation
AUTHOR: J A Morris JA
AFFILIATION: Royal Lancaster Infirmary, UK.
PUBTYPE: Journal Article
JOURNALTITLE: Medical hypotheses.
COUNTRY: ENGLAND
TITLE: Genetic control of redundant systems.
PUBDATE: 19970801
Concepts from information theory are used to develop a model in which genes control highly redundant systems. One consequence is that mutations interact synergistically and there will be selection against zygotes which have several mutations in any one system. This could explain why total mutational load in the human genome remains constant even though there are several new mutations per generation. This model has implications for fertility, polygenic disease and cancer. It also explains a fundamental biological problem concerning the advantage of sexual over asexual reproduction.


10. DOCID:23076 SCORE: 0.00227951231704389
DOCNO: 8532980
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Life Tables
DESCRIPTOR: Models, Statistical
DESCRIPTOR: Mortality
QUALIFIER: statistics & numerical data
QUALIFIER: statistics & numerical data
AUTHOR: P Congdon P
AFFILIATION: Department of Geography, Queen Mary and Westfield College, London, U.K.
PUBTYPE: Journal Article
JOURNALTITLE: Statistics in medicine.
COUNTRY: ENGLAND
TITLE: Modelling frailty in area mortality.
PUBDATE: 19950901
This paper investigates the impact on area life tables of the specification of unobserved frailty. Frailty specification may affect both the regression effects of area and individual level covariates, and lead to changes in the value of summary mortality parameters, such as life expectancy. The paper also investigates how frailty affects life tables for specific causes of death, especially lung cancer and heart disease. Implications for choice between different model specifications, both in terms of age dependence and frailty, are discussed. The focus is on registered deaths recorded by age, birthplace and by small area within a borough of Greater London.


11. DOCID:21875 SCORE: 0.0022654622665204
DOCNO: 8547395
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: pathology
AUTHOR: K Hoskins K
AUTHOR: B L Weber BL
AFFILIATION: University of Pennsylvania, Philadelphia, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in oncology.
COUNTRY: UNITED STATES
TITLE: Recent advances in breast cancer biology.
PUBDATE: 19951101
Breast cancer represents a significant worldwide public health problem as well as an excellent model system for examining many aspects of tumor biology and genetics. As the understanding of the biology of breast cancer expands, this new knowledge can be put to use in efforts to diagnose, treat, and prevent breast cancer. In this review we highlight recent advances in breast cancer biology in the areas of genetics, immunobiology, and molecular biology, with particular emphasis on tumor-suppressor genes, minimal disease detection, growth factor receptors, cell cycle regulators, and mediators of apoptosis.


12. DOCID:23786 SCORE: 0.00219385548358457
DOCNO: 8047739
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Bayes Theorem
DESCRIPTOR: Chromosome Deletion
DESCRIPTOR: Models, Genetic
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: M A Newton MA
AUTHOR: S Q Wu SQ
AUTHOR: C A Reznikoff CA
AFFILIATION: Department of Biostatistics, University of Wisconsin-Madison 53792.
PUBTYPE: Journal Article
JOURNALTITLE: Statistics in medicine.
COUNTRY: ENGLAND
TITLE: Assessing the significance of chromosome-loss data: where are suppressor genes for bladder cancer?
PUBDATE: 19940401
Cytogenetic analysis reveals alterations of chromosome structure (losses, gains, and rearrangements of genetic material) in bladder cancer cells generated using an in vitro/in vivo transformation system. To predict possible locations of bladder cancer suppressor genes, we performed a robust Bayesian analysis of the chromosome-loss data. We postulated a simple stochastic model to describe chromosome loss during tumour progression. Posterior computations are enabled by a dynamic simulation algorithm. Ordered by decreasing posterior probability of putatively harbouring a suppressor gene, we observe significant losses on chromosomes 3, 18, 13, 10, 11, and y.


13. DOCID:23591 SCORE: 0.00216511332162319
DOCNO: 7944483
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: A Wakui A
AFFILIATION: Miyagi Cancer Center, Natori, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Chemotherapy of scirrhous gastric cancer]
PUBDATE: 19941001
Cancer chemotherapy plays a central role in the treatment of recurrent or unresectable scirrhous gastric cancers classified mainly as Borrmann type 4. Though we have no specifically effective drugs for scirrhous gastric cancer, 5-FU and its derivative, MMC, anthracyclines, CDDP, CQ and ACNU are known to be relatively effective single agents against this tumor. In an attempt to enhance the effect of single agents, several combined chemotherapy regimens have been devised and tested. These regimens included 5-FU + MMC, UFT + MMC, UFT + CDDP, MTX.5-FU, FAM, FAP, EAP and ELF regimen. At present, combined therapies using 5-FU and MTX or CDDP may be the most attractive of these combined regimens.


14. DOCID:23541 SCORE: 0.00216510137824068
DOCNO: 8790320
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: H Yaziji H
AUTHOR: W L Broghamer WL
AFFILIATION: Department of Pathology, University of Louisville Hospital, Louisville, Ky, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Southern medical journal.
COUNTRY: UNITED STATES
TITLE: Primary small cell undifferentiated carcinoma of the rectum associated with ulcerative colitis.
PUBDATE: 19960901
Primary small cell undifferentiated carcinomas (SCUCs) are unusual tumors of the colon and rectum. Histologically, these lesions represent a spectrum of neuroendocrine differentiation, with oat cell carcinoma being the most primitive subtype and carcinoid tumors being the most differentiated. This observation is supported by immunohistochemical and ultrastructural findings. We report a case of SCUC of the rectum in a patient with ulcerative colitis. To date, there have been only two reported cases of primary SCUC associated with ulcerative colitis. Recent theories of tumorigenesis attribute most colorectal cancers to a single, pluripotential mucosal stem cell, regardless of the tumor's histologic type.