0. DOCID:17713 SCORE: 0.00314115097921228
DOCNO: 1556050
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: secondary
AUTHOR: P W Kantoff PW
AUTHOR: H I Scher HI
AFFILIATION: Department of Medicine, Dana-Farber Cancer Institute, Boston, Massachusetts.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hematology/oncology clinics of North America.
COUNTRY: ENGLAND
TITLE: Chemotherapy for metastatic bladder cancer.
PUBDATE: 19920201
Over the past decade, a large amount of information has been acquired regarding the use of chemotherapy for metastatic bladder cancer. Combination regimens including M-VAC and CMV have been developed that generate high response rates; however, the impact of chemotherapy on survival has been modest. The available data would strongly suggest that therapy needs to be improved, and therefore current regimens should not be considered the standards of care as much as the standards of comparison for improved future treatments.

1. DOCID:18267 SCORE: 0.00288834008256005
DOCNO: 1923245
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: E L Trimble EL
AUTHOR: P E Saigo PE
AUTHOR: G W Freeberg GW
AUTHOR: S C Rubin SC
AUTHOR: W J Hoskins WJ
AFFILIATION: Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Peritoneal sarcoidosis and elevated CA 125.
PUBDATE: 19911101
Although CA 125 is generally considered a serum marker of malignant tumors, it may be elevated in conditions characterized by peritoneal inflammation. We report a patient with known pulmonary sarcoidosis who presented with an adnexal mass and an elevated CA 125. At laparotomy, she was found to have miliary peritoneal disease simulating the appearance of metastatic cancer. Microscopic examination revealed a benign ovarian cyst and diffuse granulomatous disease similar to that present in the lung.

2. DOCID:17941 SCORE: 0.00279462602083513
DOCNO: 1756458
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosome Aberrations
DESCRIPTOR: Chromosomes, Human, Pair 14
DESCRIPTOR: Chromosomes, Human, Pair 7
QUALIFIER: genetics
AUTHOR: T L Kojis TL
AUTHOR: R A Gatti RA
AUTHOR: R S Sparkes RS
AFFILIATION: Jules Stein Eye Institute, Los Angeles, CA 90024-7008.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer genetics and cytogenetics.
COUNTRY: UNITED STATES
TITLE: The cytogenetics of ataxia telangiectasia.
PUBDATE: 19911001
Ataxia-telangiectasia (AT) is a heterogeneous autosomal recessive disorder marked by cerebellar ataxia, oculocutaneous telangiectases, hypersensitivity to ionizing radiation, immunodeficiency, and cancer susceptibility. AT is also a spontaneous chromosomal breakage syndrome, notable for tissue-specific cytogenetic changes and telomeric fusions. Molecular characterization of rearrangements specific to T-lymphocytes suggests that a DNA repair/processing defect is potentially responsible for the diverse array of chromosomal abnormalities observed in a variety of AT cell types.

3. DOCID:17242 SCORE: 0.00274295907608189
DOCNO: 2134503
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
AUTHOR: W Y Tan WY
AUTHOR: K P Singh KP
AFFILIATION: Department of Mathematical Sciences, Memphis State University, Tennessee 38152.
PUBTYPE: Journal Article
JOURNALTITLE: Mathematical biosciences.
COUNTRY: UNITED STATES
TITLE: A mixed model of carcinogenesis with applications to retinoblastoma.
PUBDATE: 19900301
This paper presents a mixed model of carcinogenesis and derives the incidence functions and the first four cumulants of the number of tumors. The model is then fitted to some retinoblastoma data from the SEER (Surveillance Epidemiology End Results) project of the National Cancer Institute for the years 1973-1982. In all the cases presented, the estimated incidence functions appear to fit the observed incidence curves quite well, suggesting the usefulness of the model.

4. DOCID:19943 SCORE: 0.00266909343588037
DOCNO: 7687966
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Laser Surgery
QUALIFIER: surgery
AUTHOR: C Garcia C
AUTHOR: T Collins T
AUTHOR: S Ide S
AUTHOR: L Herrera L
AUTHOR: H H Dosluoglu HH
AFFILIATION: Medical Center of Delaware, Wilmington.
PUBTYPE: Journal Article
JOURNALTITLE: Delaware medical journal.
COUNTRY: UNITED STATES
TITLE: Nd:YAG laser as a therapeutic option in the management of gastrointestinal cancer.
PUBDATE: 19930601
We report the use of ELT utilizing an Nd:YAG laser in a group of patients with cancer who represented a significant surgical risk. Effective palliation was achieved, with minimal morbidity, and the quality of life of most of our patients was preserved or enhanced, at a minimal physiologic cost. In carefully selected patients, ELT has proved to be a safe and highly effective procedure for the management of gastrointestinal cancers. It should be considered a valuable addition to the treatment armamentarium of the practicing clinician dealing with patients with advanced cancers or patients with significant medical conditions precluding surgical resection.

5. DOCID:19609 SCORE: 0.00261637819388329
DOCNO: 1874116
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nerve Block
QUALIFIER: physiopathology
QUALIFIER: surgery
AUTHOR: X X Yang XX
AFFILIATION: Affiliated First Hospital of Fujian Medical College, Fuzhou.
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua wai ke za zhi [Chinese journal of surgery].
COUNTRY: CHINA
TITLE: [Neural blockage of phenol-glycerine for cancer pain]
PUBDATE: 19910401
Neural blocking of phenol-glycerine was used for the treatment of cancer pain originated from the esophagus, stomach, liver, lung, rectum, ovary, nasopharynx, head and neck. According to the dose difference, 148 cases were divided into three groups of 7-10% 4-5 ml (30 cases), 15-20% 3-4 ml (70 cases), and 25% 2-2.5 ml (48 cases). The result observed among the three groups as good or fair was 46.7%, 80% and 89.6% respectively, however, complications occurred too within the rate of 13.3%, 34.3% and 14.6% respectively. It is indicated that 2.5 ml of 15-25% phenol-glycerine seems better.

6. DOCID:17867 SCORE: 0.00259868395567353
DOCNO: 1291468
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: blood
AUTHOR: P V Rao PV
AUTHOR: J G Ambekar JG
AFFILIATION: Department of Biochemistry, B.L.D.E.A's Medical College, Bijapur.
PUBTYPE: Journal Article
JOURNALTITLE: Indian journal of medical sciences.
COUNTRY: INDIA
TITLE: Evaluation of Ehrlich's test as screening test for cancer.
PUBDATE: 19921101
Ehrlich's test, serum mucoproproteins, phosphohexoisomerase (PHI), and lactate dehydrogenase (LDH) levels were studied in patients with cancer and age matched controls. All parameters studied were found to be significantly increased in cancer. Evaluation of Ehrlich's test, PHI and LDH for their validity as screening tests revealed that Ehrlich's test is better suited as a screening test for cancer. A positive correlation observed in the study between serum mucoproteins and Ehrlich's test strengthens the postulation that mucoproteins are responsible for the colour development in Ehrlich's test.

7. DOCID:19370 SCORE: 0.0025876300093482
DOCNO: 8511038
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genes, p53
DESCRIPTOR: Mutation
QUALIFIER: genetics
AUTHOR: T Soussi T
AUTHOR: T Leblanc T
AUTHOR: A Baruchel A
AUTHOR: G Schaison G
AFFILIATION: Unité de Génétique Moléculaire, Institut de Génétique Moléculaire, Unité INSERM 301, Paris, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nouvelle revue française d'hématologie.
COUNTRY: GERMANY
TITLE: Germline mutations of the p53 tumor-suppressor gene in cancer-prone families: a review.
PUBDATE: 19930201
Li-Fraumeni syndrome (LFS) is an autosomal dominant disorder that predisposes individuals to multiple forms of cancer including breast carcinoma, soft tissue sarcoma, osteosarcoma, leukemia and adrenocortical carcinoma. These diverse tumor types develop at unusually early ages. Analysis of the tumor suppressor gene p53 in family members with LFS have demonstrated that germline mutations in the p53 gene were present in most of the LFS family tested so far. Furthermore, germline p53 mutations were also found in cancer-prone individuals which were not indicative of the LFS.

8. DOCID:19227 SCORE: 0.0025595007247484
DOCNO: 1562981
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: L B Travis LB
AUTHOR: C L Gonzalez CL
AUTHOR: B F Hankey BF
AUTHOR: E S Jaffe ES
AFFILIATION: Division of Cancer Etiology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Hodgkin's disease following non-Hodgkin's lymphoma.
PUBDATE: 19920501
The risk of Hodgkin's disease following non-Hodgkin's lymphoma (NHL) was estimated using information collected by the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. Histopathologic material representing both diagnoses was reviewed for 11 patients in whom Hodgkin's disease was reported after NHL. Diagnoses of both diseases were confirmed in nine patients. Comparisons with population rates indicated that patients with NHL are at an almost threefold risk of subsequently having Hodgkin's disease. Survival in this series was poor; seven of the nine patients died within 16 months after the diagnosis of Hodgkin's disease.

9. DOCID:17909 SCORE: 0.00255116995483316
DOCNO: 1576913
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: S W Wong SW
AFFILIATION: Yang pu District Central Hospital, Shanghai.
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua zhong liu za zhi [Chinese journal of oncology].
COUNTRY: CHINA
TITLE: [CT guided direct intervention chemotherapy of lung cancer]
PUBDATE: 19921101
The results of 4 pathologically proven advanced lung cancer patients treated by CT guided percutaneous intubation of chemotherapeutic agent into the tumor are reported. Multidrug chemotherapy using mitomycin, cisplatin, cyclophosphamide or 5-Fu was given in a total of 11 treatments. All patients had symptomatic improvement with tumor reduction. There was no incidence of pneumothorax and other side reactions were mild. The authors believe that direct intervention chemotherapy of lung cancer is an effective and safe treatment of choice in advanced cases.

10. DOCID:17886 SCORE: 0.00255115224937058
DOCNO: 1649688
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Precancerous Conditions
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: D S O'Riordain DS
AUTHOR: P J O'Dwyer PJ
AUTHOR: A F Cullen AF
AUTHOR: E W McDermott EW
AUTHOR: J J Murphy JJ
AFFILIATION: Department of Surgery, University College, Dublin, Ireland.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Familial juvenile polyposis coli and colorectal cancer.
PUBDATE: 19910801
A 40-year-old mother and her 7-year-old son underwent colectomy for polyposis coli. Both colectomy specimens contained predominantly juvenile polyps. The mother's specimen also had numerous tubular adenomas and one 5-cm severely dysplastic villous adenoma without invasive carcinoma. Foci of adenomatous change in juvenile polyps were present in the son's specimen. The histologic features of both cases suggest a sequence of change from juvenile polyps to adenomatous polyps to cancer.

11. DOCID:19827 SCORE: 0.00253385191351631
DOCNO: 2133247
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: physiopathology
QUALIFIER: physiology
AUTHOR: M J Duffy MJ
AFFILIATION: Nuclear Medicine Department, St Vincent's Hospital, Dublin, Republic of Ireland.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
COUNTRY: ENGLAND
TITLE: Plasminogen activators and cancer.
PUBDATE: 19901201
Plasminogen activator (PA) is a specific serine protease which catalyses conversion of the inactive plasminogen into the broad-spectrum protease, plasmin. PA exists in two structurally related forms known as tissue-type PA (tPA) and urokinase-type PA (uPA). Conversion of normal cells into a malignant state frequently leads to increased production of uPA. There is increasing evidence that uPA is directly involved in the process of metastasis. High levels of uPA in human breast cancers is a marker for poor prognosis. Finally, uPA may be a target for anti-metastatic agents, either by inhibition of its synthesis, inhibition of its activity or its binding to receptor.

12. DOCID:19880 SCORE: 0.00251010725268
DOCNO: 1442159
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: A Andou A
AUTHOR: S Maruyama S
AUTHOR: T Matsutani T
AUTHOR: H Date H
AUTHOR: N Shimizu N
AUTHOR: S Teramoto S
AFFILIATION: Second Department of Surgery, Okayama University Medical School, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Acta medica Okayama.
COUNTRY: JAPAN
TITLE: A case of trans-sternal bilateral thoracotomy for bilateral lung cancer.
PUBDATE: 19921001
Trans-sternal bilateral thoracotomy was performed to resect the right upper lobe and the left S1 + 2 + S3, and to complete lymphadenectomy in a 35-year-old female case of lung cancer in whom multiple lesions were suspected. Trans-sternal bilateral thoracotomy was considered to be useful for one-stage surgery in patients in whom bilateral lung cancer is suspected or confirmed, because it provides a sufficient surgical field enabling the resection of lung and lymph nodes. This may be the first case report of trans-sternal bilateral thoracotomy to treat multiple primary lung cancer.

13. DOCID:18890 SCORE: 0.00241613324530641
DOCNO: 1889337
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gastroscopy
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: Z C Xu ZC
AFFILIATION: 81 Hospital, PLA, Nanjing.
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua zhong liu za zhi [Chinese journal of oncology].
COUNTRY: CHINA
TITLE: [Value of gastroscopy in postoperative patients with gastric cancer]
PUBDATE: 19910101
From September 1980 to May 1987, fiberoptic gastroscopy was performed in 3538 patients. Of them, 356 (10%) had received operation for gastric cancer. A second primary cancer was found in 31 cases, recurrent gastric cancer in 18 and adenoma in 87. Among the 138 asymptomatic operated patients, a second primary cancer developed in 8, and 6 of them were in the early stage. In the 218 symptomatic operated patients, a second primary cancer developed in 23, and 10 of them were in the early stage. The results suggest that gastroscopic examinations at regular intervals are mandatory for asymptomatic postoperative patients.

14. DOCID:16461 SCORE: 0.0024141113833308
DOCNO: 1825145
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: analogs & derivatives
QUALIFIER: drug therapy
AUTHOR: J Geller J
AFFILIATION: Medical Education Department, Mercy Hospital, San Diego, California.
PUBTYPE: Journal Article
JOURNALTITLE: The Urologic clinics of North America.
COUNTRY: UNITED STATES
TITLE: Megestrol acetate plus low-dose estrogen in the management of advanced prostatic carcinoma.
PUBDATE: 19910201
Megestrol acetate plus low-dose estrogen may be an effective, low-cost alternative to pharmacologic or surgical castration plus flutamide in the management of patients with advanced prostate cancer. The potential benefit of combined androgen ablation achieved by any means in comparison with conventional hormonal therapy appears to be limited.