0. DOCID:7464 SCORE: 0.00353871750905741
DOCNO: 7189169
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Liver Circulation
QUALIFIER: physiopathology
AUTHOR: T Kashiwagi T
AUTHOR: K Kimura K
AUTHOR: T Suematsu T
AUTHOR: M Shichiri M
AUTHOR: T Kamada T
AUTHOR: H Abe H
PUBTYPE: Journal Article
JOURNALTITLE: Gut.
COUNTRY: ENGLAND
TITLE: Dynamic studies on portal haemodynamics by scintiphotosplenoportography: flow patterns of portal circulation.
PUBDATE: 19800101
Scintiphotosplenoportography (SSP) was performed in 190 instances in 161 patients. No significant complications, such as severe pain or splenic haemorrhage, were encountered in any of the patients studied. Flow patterns of SSP were classified into nine groups according to the direction of collateral flow. Hepatopetal collateral flow was frequently observed in pancreatic cancer. In portal hypertension, cephalic collateral flow was more frequently observed than caudal flow. In detecting oesophageal varices, both SSP and endoscopy were performed in 81 patients. In four out of 46 patients with cephalic flow, oesophageal varices could not be observed by endoscopy. Conversely, in three out of 44 patients with oesophageal varices, SSP failed to show cephalic flow. The combined use of SSP and endoscopy would therefore provide more useful information in the management of patients with portal hypertension.


1. DOCID:6026 SCORE: 0.00267879997412829
DOCNO: 474706
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: C Bordi C
AUTHOR: M Ravazzola M
PUBTYPE: Journal Article
JOURNALTITLE: The American journal of pathology.
COUNTRY: UNITED STATES
TITLE: Endocrine cells in the intestinal metaplasia of gastric mucosa.
PUBDATE: 19790801
Sections of gastric mucosa removed during surgery for cancer or peptic ulcer and containing regions of intestinal metaplasia were studied by the immunofluorescence technique using several antiserums against intestinal hormones. Endocrine cells such as cells containing somatostatin, glicentin (gut GLI-I), motilin, and probably cholecystokinin were found within metaplastic intestinal epithelium while secretin and neurotensin, which are present in the normal intestinal mucosa, were not detected in metaplastic epithelium. The endocrine-cell population present in the intestinal metaplasia resembles that found in the cryptal region of the normal small intestine, a finding in accordance with the fact that intestinal metaplasia of gastric mucosa usually reproduces structural and histochemical characteristics of small intestinal crypts.


2. DOCID:6813 SCORE: 0.00263424481350676
DOCNO: 218328
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: E Migliori E
AUTHOR: S Sani S
AUTHOR: F Squartini F
PUBTYPE: Journal Article
JOURNALTITLE: Tumori.
COUNTRY: ITALY
TITLE: Possible histologic markers for early and late stages of breast cancer.
PUBDATE: 19781001
The degree of productive fibrosis, amount of lymphoid infiltrate and nuclear grade have been studied in 492 consecutive cases of duct-infiltrating breast cancer. It has been found that highly significant relationships exist between these morphologic parameters of breast cancer: lymphoid infiltrate is directly related to nuclear anaplasia and antagonized by productive fibrosis; conversely, productive fibrosis is inversely related to nuclear anaplasia and antagonized by lymphoid infiltrate. Significant inverse relationships between productive fibrosis and lymphoid infiltrate persist in tumors that have the same nuclear grade. It is suggested that lymphoid infiltrate and productive fibrosis are suitable candidates as morphologic markers to estimate the age of breast cancer, while the nuclear grade is a suitable tool to identify subgroups with different behaviour in the NOS (not otherwise specified) category of breast cancer.


3. DOCID:6229 SCORE: 0.00256025205041906
DOCNO: 7237367
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
AUTHOR: A B Miller AB
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Breast Cancer.
PUBDATE: 19810301
The pre-eminence of breast cancer as a significant cause of premature mortality and as the most prevalent cancer of women in North America justifies a major thrust in prevention. In the past, a number of hormonal risk factors were identified. Increasingly, evidence is being obtained to support the role of dietary risk factors and most particularly the total level of dietary fat. Overweight as a risk factor in postmenopausal women also points to the importance of dietary factors. It is concluded that the time is ripe for an active program of evaluating the effect of reduction in the consumption of total fat, particularly in adolescent, early adult and premenopausal women, and in reducing overweight in postmenopausal women, both as aspects of national policy and as special investigations in defined population groups.


4. DOCID:5088 SCORE: 0.00255222175032333
DOCNO: 376118
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hyperthermia, Induced
QUALIFIER: administration & dosage
QUALIFIER: therapeutic use
QUALIFIER: therapy
AUTHOR: C D Kowal CD
AUTHOR: J R Bertino JR
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Possible benefits of hyperthermia to chemotherapy.
PUBDATE: 19790601
The advantages of hyperthermia for chemotherapy are discussed in detail. These advantages are (a) synergy with chemotherapeutic drugs and also with ionizing radiation, (b) low host toxicity, (c) ease of control (heating precisions in the range of +/- 0.1 degrees C and specific definable localized areas), and (d) low resistance (chemotherapeutic resistance and hyperthermic resistance). The potential for hyperthermia and chemotherapy in the treatment of specific human cancers, both disseminated and solid tumors, are discussed with respect to current therapy and the possible benefit of hyperthermia treatment.


5. DOCID:7364 SCORE: 0.00250531278158371
DOCNO: 529047
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
AUTHOR: G R Pettit GR
AUTHOR: D P Gieschen DP
AUTHOR: W E Pettit WE
PUBTYPE: Journal Article
JOURNALTITLE: Journal of pharmaceutical sciences.
COUNTRY: UNITED STATES
TITLE: Antineoplastic agents LXIV: 1,4-Bis(2'-chloroethyl)-1,4-diazabicyclo[2.2.1]heptane dihydrogen dimaleate.
PUBDATE: 19791201
The 1,4-bis(2'-chloroethyl)-1,4-diazabicyclo[2.2.1]heptane dication (II) exhibits remarkable antineoplastic activity. Detailed evaluation of several dianion derivatives showed a curative response level against the murine P-388 lymphocytic leukemia, colon 26, CD8F1 mammary, and the Walker 256 carcinosarcoma (rat) tumor systems. In addition, significant cancer chemotherapeutic activity was found against the murine L-1210 lymphoid leukemia, colon 38, and B16 melanocarcinoma tumor systems. The bicyclo dication (II) first was isolated, evaluated, and stored as the diperchlorate derivative (IIa). Because of the promising anticancer activity of IIa, procedures were developed for obtaining other anion derivatives for comparative biological purposes. Several naturally occurring substances were evaluated, and the dihydrogen dimaleate derivative (IIi) obtained by an ion-exchange technique was the most suitable.


6. DOCID:7722 SCORE: 0.00247484686561655
DOCNO: 388793
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunologic Techniques
QUALIFIER: diagnosis
AUTHOR: P H Lange PH
PUBTYPE: Journal Article
JOURNALTITLE: The Urologic clinics of North America.
COUNTRY: UNITED STATES
TITLE: Immunologic testing of patients with genitourinary malignancies.
PUBDATE: 19791001
The discipline and techniques of immunology have been an important part of recent advances in genitourinary oncology. Although the initial promise of tumor immunology has not been realized in man, discoveries in the laboratory are revitalizing the expectation that this field will yet be of significant assistance in the diagnosis and treatment of cancer. Already tumor immunology studies along with new immunologic assay techniques have produced clinically important tumor markers, such as alpha-fetoprotein, human chorionic gonadotropin, and prostatic acid phosphatase, and have intensified the search for other markers. Finally, research activity is increasingly focusing on the tumor cell itself, again often using immunologic methods. Although most of this activity is still experimental, analysis of blood-group antigens in transitional cell carcinoma has produced sufficient data to suggest that such an approach will soon be a part of the urologist's clinical armamentarium in his efforts to treat patients with bladder tumors.


7. DOCID:6663 SCORE: 0.00241335320950617
DOCNO: 7301183
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: immunology
AUTHOR: P Bianucci P
AUTHOR: G Pastorino G
PUBTYPE: Journal Article
JOURNALTITLE: Minerva medica.
COUNTRY: ITALY
TITLE: [Immunochemotherapeutic treatment of gastrointestinal neoplasms]
PUBDATE: 19811101
The results obtained with a three-fold association of drugs (VCR, 5Fu, MeCCNU) in the treatment of 68 patients suffering from advanced carcinoma of the gastroenteric system followed up over an approximately four year period at the Savona Oncology Centre are reported. The percentage of positive responses (CR + PR) was 75% for carcinoma of the colon-rectum and 44.4% for stomach cancer. The results obtained in intestinal carcinoma proved more satisfactory than those reported in the literature. This could be attributed to the contemporaneous use of Corynebacterium parvum which boosts the immunitary state and so enhances the defences of the host organism, making it more sensitive to polychemotherapy. In the light of this hypothesis, stress is laid on the need to use an immunochemotherapy approach for the treatment of advanced carcinoma of the gastroenteric apparatus.


8. DOCID:6584 SCORE: 0.00240232102675179
DOCNO: 7014001
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Breast Neoplasms
DESCRIPTOR: Carcinoma in Situ
DESCRIPTOR: Neoplasms, Multiple Primary
AUTHOR: S Tinozzi S
AUTHOR: L Rovati L
AUTHOR: A Catona A
AUTHOR: G Volpato G
AUTHOR: M G Valesi MG
AUTHOR: P Arlandini P
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Chirurgia italiana.
COUNTRY: ITALY
TITLE: [Etiopathogenetic, diagnostic and clinical considerations on simultaneous bilateral carcinomas of the breast. II.]
PUBDATE: 19800601
In the first note the Authors have described five cases of bilateral simultaneous breast carcinoma. Now they shortly describe some opinions about the problems of the genetic independence between the two diseases. They draw attention about the histologic diagnosis and the identification of diseases underestimated and now explained as carcinoma "in situ" potentially fit for transformation in infiltrating cancer. For this reason it's important and justifiable to have the patients with cancer of the breast, a series of clinical research as well as mammography thermography and biopsy of controlateral breast in order to ascertain the presence of carcinoma "in situ" that could justify the prophylactic mastectomy.


9. DOCID:7788 SCORE: 0.00234674306326131
DOCNO: 638984
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
AUTHOR: A D Hamberger AD
AUTHOR: G H Fletcher GH
AUTHOR: J T Wharton JT
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Results of treatment of early stage I carcinoma of the uterine cervix with intracavitary radium alone.
PUBDATE: 19780301
A total of 151 patients with Stage I carcinoma of the uterine cervix received treatment with intracavitary irradiation alone between 1948 and 1971. All patients had a minimum follow-up of five years. There were no local failures. No patient with microinvasive carcinoma (Stage IA) had a regional failure. A maximum of 4% (4/93) of patients with invasive cancer less than 1 cm in diameter (Stage IB-Small Volume) had regional failures. The five year determinate survival rates for patients with Stage IA and IB (Small Volume) lesions were 100% and 96% respectively. The incidence of severe complications was low, with a fistula developing in only one patient. Treatment with intracavitary radium alone is sufficient for patients with invasive cancer less than 1 cm in diameter who have adequate anatomy that allows effective irradiation of the primary lesion and paracervical lymphatics.


10. DOCID:5699 SCORE: 0.00231010532517284
DOCNO: 7319674
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: J Ríos-Dalenz J
AUTHOR: P Correa P
AUTHOR: W Haenszel W
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: Morbidity from cancer in La Paz, Bolivia.
PUBDATE: 19810901
Data from a population-based Cancer Registry in La Paz, Bolivia, are presented. The city is located at approximately 4,000 meters above sea level and has a strong cultural influence consisting of Aymará Indians immigrating from the altiplano. Incidence rates in females are high for cancer of the cervix, the gallbladder and the thyroid gland. Males display unusually high rates of testicular cancer. Stomach cancer rates are lower than among other Andean populations. Smoking-related cancer and cancers related to sex-hormones are lower than average in incidence. Cancer of the nasal mucosa and paranasal sinuses is unusually high in frequency.


11. DOCID:6960 SCORE: 0.00227267974023755
DOCNO: 460744
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: N A Nealon NA
AUTHOR: W M Christopherson WM
PUBTYPE: Journal Article
JOURNALTITLE: Obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Cervix cancer precursors in young offspring of low-income families.
PUBDATE: 19790801
The revolutionary changes in the mores and practices of adolescent sexuality have not as yet resulted in a significant increase in the rates of cervical cancer precursors in a study of 29,600 young women under age 21. The study represents women from families of low socioeconomic status. Over a 21-year period no cases of carcinoma in situ nor of invasive cervix cancer occurred. The dysplasia rate was low (0.9/1000), and when prerevolutionary and revolutionary periods were compared, there were no significant differences in the rates. Cryocautery was successful in ablating dysplasia, as was follow-up without treatment. An attempt will be made to continue to monitor these young women of the sexual revolution since the effects of their past and current participation might not be discernible for years to come.


12. DOCID:7361 SCORE: 0.00226854766065506
DOCNO: 6987593
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunity, Cellular
QUALIFIER: methods
AUTHOR: G Offenstadt G
AUTHOR: A M Korinek AM
AUTHOR: P Hericord P
AUTHOR: A Zerhouni A
AUTHOR: P Amstutz P
PUBTYPE: Journal Article
JOURNALTITLE: Pathologie-biologie.
COUNTRY: FRANCE
TITLE: [Cell-mediated immunity study by skin testing in 129 critically ill patients (author's transl)]
PUBDATE: 19800101
Delayed hypersensitivity skin testing was performed in 129 critically ill patients. Six intradermal antigens were used: tuberculin, candidin, varidase, epidermophytin, trichophytin and CCB (a polyvalent microbial vaccine from the Pasteur Institute). The response was judged as positive when one test or more were positive. Patients were devided in four groups: group A (40 cases): non-infected patients, a priori without immunodeficiency; group B (14 cases); suspected of immunodeficiency (cancers, hemopathies, collagen diseases receiving corticosteroids); group C (24 cases): decompensated chronic respiratory insufficienceis; group D (50 cases): overwhelming sepsis (septicaemias, septic acute respiratory distress syndromes, thoracic empyemas, purulent meningitis, peritonitis, mediastinitis). A significant diminution of delayed hypersensitivity was observed in groups B, C and D. No relation was found between delayed hypertensitivity and prognosis in groups C and D.


13. DOCID:6324 SCORE: 0.00226113216077974
DOCNO: 6157383
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Relaxation Techniques
QUALIFIER: therapy
AUTHOR: A Meares A
PUBTYPE: Journal Article
JOURNALTITLE: Australian family physician.
COUNTRY: AUSTRALIA
TITLE: What can the cancer patient expect from intensive meditation?
PUBDATE: 19800501
The results of treatment of 73 patients with advanced cancer who have been able to attend at least 20 sessions of intensive meditation, indicates that nearly all such patients should expect significant reduction of anxiety and depression, together with much less discomfort and pain. There is reason to expect a ten per cent chance of quite remarkable slowing of the rate of growth of the tumour, and a ten per cent chance of less marked but still significant slowing. The results indicate that patients with advanced cancer have a ten per cent chance of regression of the growth. There is a fifty per cent chance of greatly improved quality of life and for those who die, a ninety per cent chance of death with dignity.


14. DOCID:6348 SCORE: 0.00224640785402901
DOCNO: 657166
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Folic Acid Antagonists
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
AUTHOR: W C Nichols WC
AUTHOR: L K Kvols LK
AUTHOR: J N Ingle JN
AUTHOR: J H Edmonson JH
AUTHOR: D L Ahmann DL
AUTHOR: J Rubin J
AUTHOR: M J O'Connell MJ
PUBTYPE: Clinical Trial
PUBTYPE: Controlled Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Cancer treatment reports.
COUNTRY: UNITED STATES
TITLE: Phase II study of triazinate and pyrazofurin in patients with advanced breast cancer previously exposed to cytotoxic chemotherapy.
PUBDATE: 19780501
The purpose of this phase II clinical trial was to evaluate the effectiveness of triazinate and pyrazofurin in the treatment of advanced breast cancer. Although an occasional patient experienced stability of disease, neither agent, as employed in this study, was able to produce an objective antitumor effect in this group of patients with previous chemotherapeutic exposure. At the dosages used in this study, neither agent can be recommended for further treatment of advanced breast cancer.