0. DOCID:22012 SCORE: 0.00357643084251198
DOCNO: 8652450
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: drug effects
QUALIFIER: pharmacology
QUALIFIER: pharmacology
AUTHOR: K Kawamoto K
AFFILIATION: Kansai Medical University Depertment of Neurosurgery, Osaka, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Human cell : official journal of Human Cell Research Society.
COUNTRY: JAPAN
TITLE: [Flow cytometric analysis of cell cycle for the action mechanism of antineoplastic agents]
PUBDATE: 19950901
Cell kinetics of cancers have been described in books, texts and other reports, but the correlation with action mechanism of antineoplastic agents has rarely been mentioned in the literature. The action mechanism of the antineoplastic agents such as interferon, ACNU and cisplatin was analyzed with use of propidium iodide and BrdU double staining by flow cytometer. Interferon showed S phase accumulation, ACNU and cisplatin blocked the stage of G(2)M phase. Flow cytometry was useful for the analysis of cell kinetics.


1. DOCID:17713 SCORE: 0.00314115097921228
DOCNO: 1556050
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: secondary
AUTHOR: P W Kantoff PW
AUTHOR: H I Scher HI
AFFILIATION: Department of Medicine, Dana-Farber Cancer Institute, Boston, Massachusetts.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hematology/oncology clinics of North America.
COUNTRY: ENGLAND
TITLE: Chemotherapy for metastatic bladder cancer.
PUBDATE: 19920201
Over the past decade, a large amount of information has been acquired regarding the use of chemotherapy for metastatic bladder cancer. Combination regimens including M-VAC and CMV have been developed that generate high response rates; however, the impact of chemotherapy on survival has been modest. The available data would strongly suggest that therapy needs to be improved, and therefore current regimens should not be considered the standards of care as much as the standards of comparison for improved future treatments.


2. DOCID:23155 SCORE: 0.00305884864365039
DOCNO: 8689512
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: biosynthesis
AUTHOR: K Nishimura K
AUTHOR: M Higashino M
AUTHOR: T Hara T
AUTHOR: T Oka T
AFFILIATION: Department of Urology, Minoh City Hospital, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: International journal of urology : official journal of the Japanese Urological Association.
COUNTRY: JAPAN
TITLE: Bladder cancer producing granulocyte colony-stimulating factor: a case report.
PUBDATE: 19960301
A rare case of bladder cancer producing granulocyte colony-stimulating factor (G-CSF) is reported. A 63-year-old man with a progressive, grade 3 transitional cell bladder carcinoma, showed marked leukocytosis (maximum 181,800/mm3) and an elevated serum G-CSF to 131.7 pg/mL. After radical cystectomy and neoadjuvant chemotherapy, the tumor recurred locally. Immunohistochemical examination with monoclonal antibody specific for G-CSF revealed positive staining in the local recurrent tumor. To our knowledge, there have been only seven cases reported of bladder cancer producing G-CSF.


3. DOCID:23530 SCORE: 0.00291537626713191
DOCNO: 8946611
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: N Harpaz N
AUTHOR: I C Talbot IC
AFFILIATION: Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in diagnostic pathology.
COUNTRY: UNITED STATES
TITLE: Colorectal cancer in idiopathic inflammatory bowel disease.
PUBDATE: 19961101
The development of colorectal cancer is the most serious long-term problem faced by patients with extensive ulcerative colitis and Crohn's colitis, with an incidence 20-fold higher and an average age of onset 20 years younger than colorectal cancer in the general population. This report summarizes the epidemiology, pathology, and recent advances in the molecular pathogenesis of colorectal cancer in inflammatory bowel disease and of its acknowledged precursor, mucosal dysplasia. It also reviews the rationale behind the use of endoscopic surveillance for dysplasia as a means of reducing cancer mortality, as well as some of the issues involved in its effective implementation.


4. DOCID:23695 SCORE: 0.00291304394909283
DOCNO: 8113901
AUTHOR: T Misaki T
AUTHOR: R Takeuchi R
AUTHOR: S Miyamoto S
AUTHOR: K Kasagi K
AUTHOR: Y Matsui Y
AUTHOR: J Konishi J
AFFILIATION: Department of Nuclear Medicine, School of Medicine, Kyoto University, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
COUNTRY: UNITED STATES
TITLE: Radioiodine uptake by squamous-cell carcinoma of the lung.
PUBDATE: 19940301
A patient with a history of total thyroidectomy for papillary carcinoma showed a solitary hot spot in the chest on post-therapy radioiodine imaging. Subsequent evaluation demonstrated that this lesion was a primary squamous-cell lung cancer. Our case illustrates a rare but important differential diagnosis from lung metastasis of thyroid cancer in 131I scintigraphy. Alternatively, this "aberrant uptake" might be a rather common phenomenon for lung neoplasms, although the underlying mechanism is not yet known. Future experimental studies might lead to a new application of radioiodine imaging in pulmonary oncology.


5. DOCID:18267 SCORE: 0.00288834008256005
DOCNO: 1923245
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: E L Trimble EL
AUTHOR: P E Saigo PE
AUTHOR: G W Freeberg GW
AUTHOR: S C Rubin SC
AUTHOR: W J Hoskins WJ
AFFILIATION: Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Peritoneal sarcoidosis and elevated CA 125.
PUBDATE: 19911101
Although CA 125 is generally considered a serum marker of malignant tumors, it may be elevated in conditions characterized by peritoneal inflammation. We report a patient with known pulmonary sarcoidosis who presented with an adnexal mass and an elevated CA 125. At laparotomy, she was found to have miliary peritoneal disease simulating the appearance of metastatic cancer. Microscopic examination revealed a benign ovarian cyst and diffuse granulomatous disease similar to that present in the lung.


6. DOCID:17941 SCORE: 0.00279462602083513
DOCNO: 1756458
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosome Aberrations
DESCRIPTOR: Chromosomes, Human, Pair 14
DESCRIPTOR: Chromosomes, Human, Pair 7
QUALIFIER: genetics
AUTHOR: T L Kojis TL
AUTHOR: R A Gatti RA
AUTHOR: R S Sparkes RS
AFFILIATION: Jules Stein Eye Institute, Los Angeles, CA 90024-7008.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer genetics and cytogenetics.
COUNTRY: UNITED STATES
TITLE: The cytogenetics of ataxia telangiectasia.
PUBDATE: 19911001
Ataxia-telangiectasia (AT) is a heterogeneous autosomal recessive disorder marked by cerebellar ataxia, oculocutaneous telangiectases, hypersensitivity to ionizing radiation, immunodeficiency, and cancer susceptibility. AT is also a spontaneous chromosomal breakage syndrome, notable for tissue-specific cytogenetic changes and telomeric fusions. Molecular characterization of rearrangements specific to T-lymphocytes suggests that a DNA repair/processing defect is potentially responsible for the diverse array of chromosomal abnormalities observed in a variety of AT cell types.


7. DOCID:17242 SCORE: 0.00274295907608189
DOCNO: 2134503
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
AUTHOR: W Y Tan WY
AUTHOR: K P Singh KP
AFFILIATION: Department of Mathematical Sciences, Memphis State University, Tennessee 38152.
PUBTYPE: Journal Article
JOURNALTITLE: Mathematical biosciences.
COUNTRY: UNITED STATES
TITLE: A mixed model of carcinogenesis with applications to retinoblastoma.
PUBDATE: 19900301
This paper presents a mixed model of carcinogenesis and derives the incidence functions and the first four cumulants of the number of tumors. The model is then fitted to some retinoblastoma data from the SEER (Surveillance Epidemiology End Results) project of the National Cancer Institute for the years 1973-1982. In all the cases presented, the estimated incidence functions appear to fit the observed incidence curves quite well, suggesting the usefulness of the model.


8. DOCID:23029 SCORE: 0.00267479815707853
DOCNO: 7912881
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: H Kuroda H
AUTHOR: Y Yasunaga Y
AUTHOR: H Takatera H
AUTHOR: H Fujioka H
AUTHOR: A Ohnishi A
AUTHOR: M Tsujimoto M
AFFILIATION: Department of Urology, Osaka Police Hospital.
PUBTYPE: Journal Article
JOURNALTITLE: Hinyokika kiyo. Acta urologica Japonica.
COUNTRY: JAPAN
TITLE: [Growth fractions of bladder cancer determined by proliferating cell nuclear antigen immunostaining]
PUBDATE: 19940501
Immunohistochemical staining of proliferating cell nuclear antigen (PCNA) can be performed on conventionally fixed and processed tissue. We applied anti-PCNA monoclonal antibodies to transurethrally resected bladder cancer specimens. The labelling index (LI) of PCNA increased with tumor grade and that of the invasive tumor group was higher than that of the non-invasive tumor group. Especially in large tumors, there was intratumoral variation of labelled cell distribution, which may represent tumor heterogeneity. These findings suggest that PCNA might be a useful marker for bladder cancer proliferation.


9. DOCID:19943 SCORE: 0.00266909343588037
DOCNO: 7687966
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Laser Surgery
QUALIFIER: surgery
AUTHOR: C Garcia C
AUTHOR: T Collins T
AUTHOR: S Ide S
AUTHOR: L Herrera L
AUTHOR: H H Dosluoglu HH
AFFILIATION: Medical Center of Delaware, Wilmington.
PUBTYPE: Journal Article
JOURNALTITLE: Delaware medical journal.
COUNTRY: UNITED STATES
TITLE: Nd:YAG laser as a therapeutic option in the management of gastrointestinal cancer.
PUBDATE: 19930601
We report the use of ELT utilizing an Nd:YAG laser in a group of patients with cancer who represented a significant surgical risk. Effective palliation was achieved, with minimal morbidity, and the quality of life of most of our patients was preserved or enhanced, at a minimal physiologic cost. In carefully selected patients, ELT has proved to be a safe and highly effective procedure for the management of gastrointestinal cancers. It should be considered a valuable addition to the treatment armamentarium of the practicing clinician dealing with patients with advanced cancers or patients with significant medical conditions precluding surgical resection.


10. DOCID:19609 SCORE: 0.00261637819388329
DOCNO: 1874116
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nerve Block
QUALIFIER: physiopathology
QUALIFIER: surgery
AUTHOR: X X Yang XX
AFFILIATION: Affiliated First Hospital of Fujian Medical College, Fuzhou.
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua wai ke za zhi [Chinese journal of surgery].
COUNTRY: CHINA
TITLE: [Neural blockage of phenol-glycerine for cancer pain]
PUBDATE: 19910401
Neural blocking of phenol-glycerine was used for the treatment of cancer pain originated from the esophagus, stomach, liver, lung, rectum, ovary, nasopharynx, head and neck. According to the dose difference, 148 cases were divided into three groups of 7-10% 4-5 ml (30 cases), 15-20% 3-4 ml (70 cases), and 25% 2-2.5 ml (48 cases). The result observed among the three groups as good or fair was 46.7%, 80% and 89.6% respectively, however, complications occurred too within the rate of 13.3%, 34.3% and 14.6% respectively. It is indicated that 2.5 ml of 15-25% phenol-glycerine seems better.


11. DOCID:17867 SCORE: 0.00259868395567353
DOCNO: 1291468
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: blood
AUTHOR: P V Rao PV
AUTHOR: J G Ambekar JG
AFFILIATION: Department of Biochemistry, B.L.D.E.A's Medical College, Bijapur.
PUBTYPE: Journal Article
JOURNALTITLE: Indian journal of medical sciences.
COUNTRY: INDIA
TITLE: Evaluation of Ehrlich's test as screening test for cancer.
PUBDATE: 19921101
Ehrlich's test, serum mucoproproteins, phosphohexoisomerase (PHI), and lactate dehydrogenase (LDH) levels were studied in patients with cancer and age matched controls. All parameters studied were found to be significantly increased in cancer. Evaluation of Ehrlich's test, PHI and LDH for their validity as screening tests revealed that Ehrlich's test is better suited as a screening test for cancer. A positive correlation observed in the study between serum mucoproteins and Ehrlich's test strengthens the postulation that mucoproteins are responsible for the colour development in Ehrlich's test.


12. DOCID:19370 SCORE: 0.0025876300093482
DOCNO: 8511038
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genes, p53
DESCRIPTOR: Mutation
QUALIFIER: genetics
AUTHOR: T Soussi T
AUTHOR: T Leblanc T
AUTHOR: A Baruchel A
AUTHOR: G Schaison G
AFFILIATION: Unité de Génétique Moléculaire, Institut de Génétique Moléculaire, Unité INSERM 301, Paris, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nouvelle revue française d'hématologie.
COUNTRY: GERMANY
TITLE: Germline mutations of the p53 tumor-suppressor gene in cancer-prone families: a review.
PUBDATE: 19930201
Li-Fraumeni syndrome (LFS) is an autosomal dominant disorder that predisposes individuals to multiple forms of cancer including breast carcinoma, soft tissue sarcoma, osteosarcoma, leukemia and adrenocortical carcinoma. These diverse tumor types develop at unusually early ages. Analysis of the tumor suppressor gene p53 in family members with LFS have demonstrated that germline mutations in the p53 gene were present in most of the LFS family tested so far. Furthermore, germline p53 mutations were also found in cancer-prone individuals which were not indicative of the LFS.


13. DOCID:23123 SCORE: 0.00258063386001427
DOCNO: 9207316
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: therapy
QUALIFIER: analogs & derivatives
QUALIFIER: therapy
QUALIFIER: administration & dosage
QUALIFIER: antagonists & inhibitors
AUTHOR: A Gregor A
AFFILIATION: Department of Clinical Oncology, University of Edinburgh, Scotland.
PUBTYPE: Clinical Trial
PUBTYPE: Clinical Trial, Phase I
PUBTYPE: Journal Article
JOURNALTITLE: Seminars in oncology.
COUNTRY: UNITED STATES
TITLE: Gemcitabine plus radiotherapy for non-small cell lung cancer.
PUBDATE: 19970601
Radiosensitization promises to improve local control in patients with locally advanced non-small cell lung cancer (NSCLC). The nucleoside analogue gemcitabine, which is not only a potent radiosensitizer but also has significant antitumor activity in this disease, is an important candidate for such a strategy. This report describes the design of a clinical phase I study for treatment of patients with locally advanced NSCLC using gemcitabine and radiotherapy. It also discusses some of the practical constraints that must be taken into consideration when evaluating this type of combined modality strategy in the clinic.


14. DOCID:19227 SCORE: 0.0025595007247484
DOCNO: 1562981
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: L B Travis LB
AUTHOR: C L Gonzalez CL
AUTHOR: B F Hankey BF
AUTHOR: E S Jaffe ES
AFFILIATION: Division of Cancer Etiology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Hodgkin's disease following non-Hodgkin's lymphoma.
PUBDATE: 19920501
The risk of Hodgkin's disease following non-Hodgkin's lymphoma (NHL) was estimated using information collected by the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. Histopathologic material representing both diagnoses was reviewed for 11 patients in whom Hodgkin's disease was reported after NHL. Diagnoses of both diseases were confirmed in nine patients. Comparisons with population rates indicated that patients with NHL are at an almost threefold risk of subsequently having Hodgkin's disease. Survival in this series was poor; seven of the nine patients died within 16 months after the diagnosis of Hodgkin's disease.