0. DOCID:10789 SCORE: 0.0040482053549386
DOCNO: 3879860
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: F La Rosa F
AUTHOR: A Cresci A
AUTHOR: C Orpianesi C
AUTHOR: G Saltalamacchia G
PUBTYPE: Journal Article
JOURNALTITLE: European journal of epidemiology.
COUNTRY: ITALY
TITLE: Mortality from prostate cancer in Italy: 1950-1979. Cross-sectional rates and cohort analysis.
PUBDATE: 19850601
This paper studies prostate cancer mortality in Italy from 1950-1979 to evaluate its importance in relation to total cancers, examine the time trend for forecasting future mortality trends, and makes an attempt to interpretate mortality by analyzing demographic and risk factors. In the Authors' opinion findings from cross-sectional rates, cohort analysis and Devesa-Schneiderman method, indicate that in Italy even if the age-adjusted mortality rate has nearly doubled over the period, as in many other countries, mortality can be expected to remain constant or decrease in the future, since the data to hand show a decreasing trend in some age cohorts.


1. DOCID:11182 SCORE: 0.00386793194672431
DOCNO: 6982042
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: immunology
AUTHOR: K Ikuta K
AUTHOR: Y Nishi Y
AUTHOR: Y Shimizu Y
AUTHOR: H Higashi H
AUTHOR: N Kitamoto N
AUTHOR: S Kato S
AUTHOR: M Fujita M
AUTHOR: Y Nakano Y
AUTHOR: T Taguchi T
AUTHOR: M Naiki M
PUBTYPE: Journal Article
JOURNALTITLE: Biken journal.
COUNTRY: JAPAN
TITLE: Hanganutziu-Deicher type-heterophile antigen-positive cells in human cancer tissues demonstrated by membrane immunofluorescence.
PUBDATE: 19820301
The possible expression of Hanganutziu-Deicher (H-D)-type heterophile antigen on the cell surface of several types of human cancer tissues was investigated by the membrane immunofluorescence test with anti-H-D serum. Anti-H-D serum of high titer was obtained from chickens immunized with H-D antigen-active glycosphingolipid, N-glycolylneuraminyl-lactosylceramide (equine hematoside). H-D antigen was demonstrated in 3 to 6 gastric cancer tissues, 2 of 3 lung cancer tissues, and 2 of 4 breast tissues examined, but not in 5 colorectal cancer tissues examined.


2. DOCID:15612 SCORE: 0.00378667989497154
DOCNO: 3048355
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genes, Recessive
QUALIFIER: genetics
AUTHOR: A R Green AR
AFFILIATION: Imperial Cancer Research Fund Laboratories, St Bartholomew's Hospital, London, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Recessive mechanisms of malignancy.
PUBDATE: 19880801
It is increasingly recognised that recessive mutations play an important role in the pathogenesis of many forms of malignancy. Some of the affected loci may prove to be recessively-activated proto-oncogenes, but others are now known to be tumorigenic solely by virtue of their loss or inactivation and therefore form a distinct and novel family of tumour genes. Preliminary evidence suggests that such genes are likely to be functionally heterogeneous and to encode molecules involved in the inhibition of cellular proliferation and/or the induction of differentiation. Their further study is likely to illuminate fundamental mechanisms of normal cellular growth and differentiation as well as having important implications for the pathogenesis and management of cancer.


3. DOCID:7464 SCORE: 0.00353871750905741
DOCNO: 7189169
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Liver Circulation
QUALIFIER: physiopathology
AUTHOR: T Kashiwagi T
AUTHOR: K Kimura K
AUTHOR: T Suematsu T
AUTHOR: M Shichiri M
AUTHOR: T Kamada T
AUTHOR: H Abe H
PUBTYPE: Journal Article
JOURNALTITLE: Gut.
COUNTRY: ENGLAND
TITLE: Dynamic studies on portal haemodynamics by scintiphotosplenoportography: flow patterns of portal circulation.
PUBDATE: 19800101
Scintiphotosplenoportography (SSP) was performed in 190 instances in 161 patients. No significant complications, such as severe pain or splenic haemorrhage, were encountered in any of the patients studied. Flow patterns of SSP were classified into nine groups according to the direction of collateral flow. Hepatopetal collateral flow was frequently observed in pancreatic cancer. In portal hypertension, cephalic collateral flow was more frequently observed than caudal flow. In detecting oesophageal varices, both SSP and endoscopy were performed in 81 patients. In four out of 46 patients with cephalic flow, oesophageal varices could not be observed by endoscopy. Conversely, in three out of 44 patients with oesophageal varices, SSP failed to show cephalic flow. The combined use of SSP and endoscopy would therefore provide more useful information in the management of patients with portal hypertension.


4. DOCID:14643 SCORE: 0.00337823774744443
DOCNO: 3652316
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: S Gorgone S
AUTHOR: C Lorenzini C
AUTHOR: R Palmeri R
AUTHOR: N Belnome N
AUTHOR: L Calbo L
AUTHOR: P Dattola P
AUTHOR: P Melita P
AFFILIATION: Università degli Studi di Messina Istituto di Chirurgia Generale.
PUBTYPE: Journal Article
JOURNALTITLE: Chirurgia italiana.
COUNTRY: ITALY
TITLE: [Aminoglutethimide in the treatment of metastasizing breast carcinoma in old age]
PUBDATE: 19870401
After first analyzing the basic pathophysiological aspects and the mechanism of action of aminoglutethimide, the authors report on their experience with the use of this steroid biosynthesis inhibitor in a group of geriatric patients with advanced cancer of the breast. After illustrating the results of their study, the authors conclude by stressing that the use of this drug appears to improve the quality of life of the patients with a significant increase in rates of complete or partial remission of the neoplastic disease.


5. DOCID:3031 SCORE: 0.00333153458444358
DOCNO: 194494
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: T G Frazier TG
AUTHOR: E M Copeland EM
AUTHOR: H S Gallager HS
AUTHOR: D D Paulus DD
AUTHOR: E C White EC
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: Prognosis and treatment in minimal breast cancer.
PUBDATE: 19770601
Of 176 patients with minimal breast cancer, 138 had intraductal carcinoma in situ, 21 minimally invasive carcinoma, and 17 lobular carcinoma in situ. Various modalities of treatment were used including radical, modified radical, and simple mastectomy with and without radiation therapy. Long-term postoperative follow-up was available in all but five patients and ranged from one year to twenty-one years. Actuarial analysis projected a twenty year survival of 93.2 per cent for the entire group. Analysis of survival figures based on each of the several treatment modalities showed no definite advantage of one form of treatment over another. The data suggest that minimal breast cancer is a prognostically favorable diagnosis, provided invasive carcinoma is not present or does not develop in the opposite breast. It is also indicated that breast cancer is potentially a bilateral disease and that follow-up and treatment of the opposite breast must be of major concern in the care of these patients.


6. DOCID:10101 SCORE: 0.00332267811119515
DOCNO: 6371436
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: physiopathology
QUALIFIER: physiopathology
AUTHOR: T P Iakimova TP
AUTHOR: I N Lozinskaia IN
PUBTYPE: Journal Article
JOURNALTITLE: Meditsinskaia radiologiia.
COUNTRY: USSR
TITLE: [Thyroid and hypophyseal function during radiation therapy of breast cancer]
PUBDATE: 19840401
In breast cancer a decrease in triiodothyronine concentration was revealed with the normal level of thyroxine that may be associated with the disturbed peripheral metabolism into triiodothyronine. The lowering of thyroid functional activity is noted during radiation therapy of patients at menopause. Administration of thyroidin during radiation therapy to elderly patients with the III stage of the disease compensated for hormone deficiency producing a sparing effect on the thyroid, and influenced the therapeutic results favorably. A high level of the somatotropic hormone was observed in patients of the reproductive age and at menopause, the level of insulin was increased in all the patients.


7. DOCID:3654 SCORE: 0.00319488651783894
DOCNO: 1255802
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: adverse effects
AUTHOR: J Casagrande J
AUTHOR: V Gerkins V
AUTHOR: B E Henderson BE
AUTHOR: T Mack T
AUTHOR: M C Pike MC
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Exogenous estrogens and breast cancer in women with natural menopause.
PUBDATE: 19760401
/AbstractText:


8. DOCID:3578 SCORE: 0.00313294580268666
DOCNO: 184557
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: surgery
QUALIFIER: therapy
AUTHOR: J P Minton JP
PUBTYPE: Journal Article
JOURNALTITLE: Surgery.
COUNTRY: UNITED STATES
TITLE: Precise selection of breast cancer patients with bone metastasis for endocrine ablation.
PUBDATE: 19761001
To enhance the precision of selection of breast cancer patients with bone metastasis for endocrine ablation, 85 patients underwent a Levodopa test for 4 consecutives days. Assessment of the result of the test was made on the basis of thorough clinical evaluation, x-ray examination, and results of serum and skin tests as well as cancer receptor studies when tissue was available. Results of 23 surgical procedures were as follows: bilateral oophorectomy elicited good clinical response in five patients with positive preoperative Levodopa tests; one negative clinical response followed a negative Levodopa test; bilateral adrenaloophorectomy in nine patients elicited good response in seven who had positive Levodopa tests and negative responses in two patients who had negative Levodopa tests; bilateral adrenalectomy in eight patients elicited good response in five patients with positive Levodopa tests and negative responses in three who had negative Levodopa tests. There were no deaths and there was only one complication after operation. Levodopa testing appears to be an effective means for selection of patients with bone pain from recurrent breast cancer who will benefit from endocrine ablation. When the Levodopa test was negative for bone pain relief, endocrine ablation was of no benefit to the patient.


9. DOCID:3655 SCORE: 0.00300131222755286
DOCNO: 53505
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammography
QUALIFIER: diagnosis
AUTHOR: J Chamberlain J
AUTHOR: P Rogers P
AUTHOR: J L Price JL
AUTHOR: S Ginks S
AUTHOR: B E Nathan BE
AUTHOR: I Burn I
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Validity of clinical examination and mammography as screening tests for breast cancer.
PUBDATE: 19751101
This study is aiming to determine the validity and observer variability of clinical examination and mammography as screening tests for breast cancer. Women over the age of forty are given two independent clinical examinations of the breasts, and mammograms are taken and read independently by two radiologists. This paper presents the results of screening the first 1215 women to be enrolled in the study. At their first screening attendance, 231 women (19%) were referred for surgical opinion, 119 (9-8%) underwent biopsy, and cancer was diagnosed in 17 (1-4%). 2 further cancers were diagnosed in the ensuing six months among women who had been negative on initial screening, representing a false-negative rate of 2 out of 19 (11%). Clinical examination resulted in 189 referrals (15-6%), 90 biopsies (7-4%), and detected 11 cancers; corresponding figures for mammography were 76 referrals (6-3%), 55 biopsies ((4-5%), and 14 cancers. Observer variability was greater for clinical examination than for mammography. These early results suggest that as a screening test mammography compares favourably with clinical examination, but both tests are necessary if many false negatives are to be avoided.


10. DOCID:14549 SCORE: 0.00289504656673236
DOCNO: 2704119
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: prevention & control
QUALIFIER: organization & administration
AUTHOR: H Sawa H
AFFILIATION: Office of Life Science minister's Secretarical Ministry of Health and Wilfare.
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Comprehensive 10-year strategy for cancer control]
PUBDATE: 19890101
Since 1981, cancer has been No. 1 cause of death in Japan. A "Comprehensive 10-Year Strategy for Cancer Control" is a national project that was strongly promoted by the former Prime Minister Mr. Yasuhiro Nakasone in 1983. The program comprises project research studies and functions supporting them. These include the education and utilization of young researchers (research resident), international cooperation and research resources (cell and gene) bank. The aim of studies is clarification of the mechanism of human carcinogenesis within 10 years and the results will be applied to prevention, diagnosis and therapy of cancers.


11. DOCID:2548 SCORE: 0.0028457025878522
DOCNO: 1248005
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: enzymology
QUALIFIER: pathology
QUALIFIER: enzymology
AUTHOR: J A Kellen JA
AUTHOR: R S Bush RS
AUTHOR: A Malkin A
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Placenta-like alkaline phosphatase in gynecological cancers.
PUBDATE: 19760101
In 302 patients with tumors of the cervix, corpus uteri, and ovaries, assessment by clinical staging (tumors-nodules-metastasis system) (4) and histopathology has been related to the presence of serum heat-stable, placenta-lide alkaline phosphatase (PLAP) activity. Early stages of cervical tumors show the highest incidence of this isoenzyme. In advanced stages of this disease, a decrease in frequency was observed that might be interpreted as the result of gradual dedifferentiation of the tumor cells to a point where synthesis of PLAP became undetectable. The same observation was made in adenocarcinomas of the corpus uteri, i.e., patients with advanced disease tended to have the lowest incidence of serum PLAP. Only in cancers of the ovaries did we find a positive correlation between this enzyme marker and the extent of the disease. In more than one-third of the patients examined, PLAP levels were an index of the tumor burden.


12. DOCID:14015 SCORE: 0.00284436569588787
DOCNO: 2733054
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: E B Smith EB
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Medical Association.
COUNTRY: UNITED STATES
TITLE: Primary cancer of the pancreas: a surgical enigma.
PUBDATE: 19890201
Pancreatic cancer is a frequent gastrointestinal malignancy with demonstrable increases in blacks. Predisposing factors are nonspecific but statistically relevant. Early signs and symptoms are vague and the duration prior to medical or surgical evaluation is typically more than four months. The overt clinical picture represents advanced stages of pancreatic cancer that are nonresectable. Positive results or prolonged survivals in excess of five years for curative surgical procedures are meager. The best approaches toward cancer of the pancreas are improvements in education, prevention, early diagnosis, palliative surgical procedures with adjuvant medical measures, and radical surgery in selective cases and under specific circumstances.


13. DOCID:3934 SCORE: 0.00279180150100501
DOCNO: 199064
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: D Henson D
AUTHOR: R Tarone R
PUBTYPE: Journal Article
JOURNALTITLE: American journal of obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: An epidemiologic study of cancer of the cervix, vagina, and vulva based on the Third National Cancer Survey in the United States.
PUBDATE: 19771101
Cases of invasive and in situ carcinoma of the lower female genital tract as reported in the Third National Cancer Survey in the United States were analyzed according to age, race, and geographic distribution. Results indicate that the incidence rates of in situ and invasive carcinoma of the cervix were greater in black than in white women, with a relative risk rate for black women of approximately two for both types of cervical carcinoma. For white women, the age-specific rates for invasive carcinoma of the cervix remained relatively constant after age 45, while for black women the age-specific rates for invasive carcinoma continued to increase after age 45. For both races, the patterns of age-specific incidence rates for in situ and invasive carcinoma of the cervix were not similar to those for carcinoma of the vagina or vulva. The pattern of age-specific incidence rates of adenocarcinoma of the cervix did not resemble those for in situ or invasive squamous cell carcinoma of the cervix. The rates for adenocarcinoma of the cervix demonstrated patterns similar to those for intraductal carcinoma of the breast. Results of the study are discussed in relationship to the field theory of carcinogenesis as developed for the lower female genital tract.


14. DOCID:9130 SCORE: 0.00276193752163365
DOCNO: 4036740
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: T Yamamoto T
AUTHOR: K Nakamura K
AUTHOR: M Shiramizu M
AUTHOR: S Kimura S
AUTHOR: N Kuribayashi N
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Hinyokika kiyo. Acta urologica Japonica.
COUNTRY: JAPAN
TITLE: [Transitional cell carcinoma of the renal pelvis with various histological appearances: a case report]
PUBDATE: 19850401
A large left renal mass was removed from an 85-year-old male. Histological examination revealed various features: Anaplastic transitional cell carcinoma and glandular formation scattered with portions resembling cancer pearls. Sarcomatoid-like area at ureteral margin of the mass and carcinoma-in-situ at renal pelvic mucosa were also seen. Final interpretation was grade III, transitional cell carcinoma, with squamous and glandular differentiation, spindling, and pleomorphic areas.