0. DOCID:10789 SCORE: 0.0040482053549386
DOCNO: 3879860
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: F La Rosa F
AUTHOR: A Cresci A
AUTHOR: C Orpianesi C
AUTHOR: G Saltalamacchia G
PUBTYPE: Journal Article
JOURNALTITLE: European journal of epidemiology.
COUNTRY: ITALY
TITLE: Mortality from prostate cancer in Italy: 1950-1979. Cross-sectional rates and cohort analysis.
PUBDATE: 19850601
This paper studies prostate cancer mortality in Italy from 1950-1979 to evaluate its importance in relation to total cancers, examine the time trend for forecasting future mortality trends, and makes an attempt to interpretate mortality by analyzing demographic and risk factors. In the Authors' opinion findings from cross-sectional rates, cohort analysis and Devesa-Schneiderman method, indicate that in Italy even if the age-adjusted mortality rate has nearly doubled over the period, as in many other countries, mortality can be expected to remain constant or decrease in the future, since the data to hand show a decreasing trend in some age cohorts.

1. DOCID:11182 SCORE: 0.00386793194672431
DOCNO: 6982042
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: immunology
AUTHOR: K Ikuta K
AUTHOR: Y Nishi Y
AUTHOR: Y Shimizu Y
AUTHOR: H Higashi H
AUTHOR: N Kitamoto N
AUTHOR: S Kato S
AUTHOR: M Fujita M
AUTHOR: Y Nakano Y
AUTHOR: T Taguchi T
AUTHOR: M Naiki M
PUBTYPE: Journal Article
JOURNALTITLE: Biken journal.
COUNTRY: JAPAN
TITLE: Hanganutziu-Deicher type-heterophile antigen-positive cells in human cancer tissues demonstrated by membrane immunofluorescence.
PUBDATE: 19820301
The possible expression of Hanganutziu-Deicher (H-D)-type heterophile antigen on the cell surface of several types of human cancer tissues was investigated by the membrane immunofluorescence test with anti-H-D serum. Anti-H-D serum of high titer was obtained from chickens immunized with H-D antigen-active glycosphingolipid, N-glycolylneuraminyl-lactosylceramide (equine hematoside). H-D antigen was demonstrated in 3 to 6 gastric cancer tissues, 2 of 3 lung cancer tissues, and 2 of 4 breast tissues examined, but not in 5 colorectal cancer tissues examined.

2. DOCID:15612 SCORE: 0.00378667989497154
DOCNO: 3048355
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genes, Recessive
QUALIFIER: genetics
AUTHOR: A R Green AR
AFFILIATION: Imperial Cancer Research Fund Laboratories, St Bartholomew's Hospital, London, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Recessive mechanisms of malignancy.
PUBDATE: 19880801
It is increasingly recognised that recessive mutations play an important role in the pathogenesis of many forms of malignancy. Some of the affected loci may prove to be recessively-activated proto-oncogenes, but others are now known to be tumorigenic solely by virtue of their loss or inactivation and therefore form a distinct and novel family of tumour genes. Preliminary evidence suggests that such genes are likely to be functionally heterogeneous and to encode molecules involved in the inhibition of cellular proliferation and/or the induction of differentiation. Their further study is likely to illuminate fundamental mechanisms of normal cellular growth and differentiation as well as having important implications for the pathogenesis and management of cancer.

3. DOCID:22012 SCORE: 0.00357643084251198
DOCNO: 8652450
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: drug effects
QUALIFIER: pharmacology
QUALIFIER: pharmacology
AUTHOR: K Kawamoto K
AFFILIATION: Kansai Medical University Depertment of Neurosurgery, Osaka, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Human cell : official journal of Human Cell Research Society.
COUNTRY: JAPAN
TITLE: [Flow cytometric analysis of cell cycle for the action mechanism of antineoplastic agents]
PUBDATE: 19950901
Cell kinetics of cancers have been described in books, texts and other reports, but the correlation with action mechanism of antineoplastic agents has rarely been mentioned in the literature. The action mechanism of the antineoplastic agents such as interferon, ACNU and cisplatin was analyzed with use of propidium iodide and BrdU double staining by flow cytometer. Interferon showed S phase accumulation, ACNU and cisplatin blocked the stage of G(2)M phase. Flow cytometry was useful for the analysis of cell kinetics.

4. DOCID:7464 SCORE: 0.00353871750905741
DOCNO: 7189169
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Liver Circulation
QUALIFIER: physiopathology
AUTHOR: T Kashiwagi T
AUTHOR: K Kimura K
AUTHOR: T Suematsu T
AUTHOR: M Shichiri M
AUTHOR: T Kamada T
AUTHOR: H Abe H
PUBTYPE: Journal Article
JOURNALTITLE: Gut.
COUNTRY: ENGLAND
TITLE: Dynamic studies on portal haemodynamics by scintiphotosplenoportography: flow patterns of portal circulation.
PUBDATE: 19800101
Scintiphotosplenoportography (SSP) was performed in 190 instances in 161 patients. No significant complications, such as severe pain or splenic haemorrhage, were encountered in any of the patients studied. Flow patterns of SSP were classified into nine groups according to the direction of collateral flow. Hepatopetal collateral flow was frequently observed in pancreatic cancer. In portal hypertension, cephalic collateral flow was more frequently observed than caudal flow. In detecting oesophageal varices, both SSP and endoscopy were performed in 81 patients. In four out of 46 patients with cephalic flow, oesophageal varices could not be observed by endoscopy. Conversely, in three out of 44 patients with oesophageal varices, SSP failed to show cephalic flow. The combined use of SSP and endoscopy would therefore provide more useful information in the management of patients with portal hypertension.

5. DOCID:14643 SCORE: 0.00337823774744443
DOCNO: 3652316
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: S Gorgone S
AUTHOR: C Lorenzini C
AUTHOR: R Palmeri R
AUTHOR: N Belnome N
AUTHOR: L Calbo L
AUTHOR: P Dattola P
AUTHOR: P Melita P
AFFILIATION: Università degli Studi di Messina Istituto di Chirurgia Generale.
PUBTYPE: Journal Article
JOURNALTITLE: Chirurgia italiana.
COUNTRY: ITALY
TITLE: [Aminoglutethimide in the treatment of metastasizing breast carcinoma in old age]
PUBDATE: 19870401
After first analyzing the basic pathophysiological aspects and the mechanism of action of aminoglutethimide, the authors report on their experience with the use of this steroid biosynthesis inhibitor in a group of geriatric patients with advanced cancer of the breast. After illustrating the results of their study, the authors conclude by stressing that the use of this drug appears to improve the quality of life of the patients with a significant increase in rates of complete or partial remission of the neoplastic disease.

6. DOCID:3031 SCORE: 0.00333153458444358
DOCNO: 194494
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: T G Frazier TG
AUTHOR: E M Copeland EM
AUTHOR: H S Gallager HS
AUTHOR: D D Paulus DD
AUTHOR: E C White EC
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: Prognosis and treatment in minimal breast cancer.
PUBDATE: 19770601
Of 176 patients with minimal breast cancer, 138 had intraductal carcinoma in situ, 21 minimally invasive carcinoma, and 17 lobular carcinoma in situ. Various modalities of treatment were used including radical, modified radical, and simple mastectomy with and without radiation therapy. Long-term postoperative follow-up was available in all but five patients and ranged from one year to twenty-one years. Actuarial analysis projected a twenty year survival of 93.2 per cent for the entire group. Analysis of survival figures based on each of the several treatment modalities showed no definite advantage of one form of treatment over another. The data suggest that minimal breast cancer is a prognostically favorable diagnosis, provided invasive carcinoma is not present or does not develop in the opposite breast. It is also indicated that breast cancer is potentially a bilateral disease and that follow-up and treatment of the opposite breast must be of major concern in the care of these patients.

7. DOCID:10101 SCORE: 0.00332267811119515
DOCNO: 6371436
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: physiopathology
QUALIFIER: physiopathology
AUTHOR: T P Iakimova TP
AUTHOR: I N Lozinskaia IN
PUBTYPE: Journal Article
JOURNALTITLE: Meditsinskaia radiologiia.
COUNTRY: USSR
TITLE: [Thyroid and hypophyseal function during radiation therapy of breast cancer]
PUBDATE: 19840401
In breast cancer a decrease in triiodothyronine concentration was revealed with the normal level of thyroxine that may be associated with the disturbed peripheral metabolism into triiodothyronine. The lowering of thyroid functional activity is noted during radiation therapy of patients at menopause. Administration of thyroidin during radiation therapy to elderly patients with the III stage of the disease compensated for hormone deficiency producing a sparing effect on the thyroid, and influenced the therapeutic results favorably. A high level of the somatotropic hormone was observed in patients of the reproductive age and at menopause, the level of insulin was increased in all the patients.

8. DOCID:3654 SCORE: 0.00319488651783894
DOCNO: 1255802
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: adverse effects
AUTHOR: J Casagrande J
AUTHOR: V Gerkins V
AUTHOR: B E Henderson BE
AUTHOR: T Mack T
AUTHOR: M C Pike MC
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Exogenous estrogens and breast cancer in women with natural menopause.
PUBDATE: 19760401
/AbstractText:


9. DOCID:17713 SCORE: 0.00314115097921228
DOCNO: 1556050
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: secondary
AUTHOR: P W Kantoff PW
AUTHOR: H I Scher HI
AFFILIATION: Department of Medicine, Dana-Farber Cancer Institute, Boston, Massachusetts.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hematology/oncology clinics of North America.
COUNTRY: ENGLAND
TITLE: Chemotherapy for metastatic bladder cancer.
PUBDATE: 19920201
Over the past decade, a large amount of information has been acquired regarding the use of chemotherapy for metastatic bladder cancer. Combination regimens including M-VAC and CMV have been developed that generate high response rates; however, the impact of chemotherapy on survival has been modest. The available data would strongly suggest that therapy needs to be improved, and therefore current regimens should not be considered the standards of care as much as the standards of comparison for improved future treatments.

10. DOCID:3578 SCORE: 0.00313294580268666
DOCNO: 184557
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: surgery
QUALIFIER: therapy
AUTHOR: J P Minton JP
PUBTYPE: Journal Article
JOURNALTITLE: Surgery.
COUNTRY: UNITED STATES
TITLE: Precise selection of breast cancer patients with bone metastasis for endocrine ablation.
PUBDATE: 19761001
To enhance the precision of selection of breast cancer patients with bone metastasis for endocrine ablation, 85 patients underwent a Levodopa test for 4 consecutives days. Assessment of the result of the test was made on the basis of thorough clinical evaluation, x-ray examination, and results of serum and skin tests as well as cancer receptor studies when tissue was available. Results of 23 surgical procedures were as follows: bilateral oophorectomy elicited good clinical response in five patients with positive preoperative Levodopa tests; one negative clinical response followed a negative Levodopa test; bilateral adrenaloophorectomy in nine patients elicited good response in seven who had positive Levodopa tests and negative responses in two patients who had negative Levodopa tests; bilateral adrenalectomy in eight patients elicited good response in five patients with positive Levodopa tests and negative responses in three who had negative Levodopa tests. There were no deaths and there was only one complication after operation. Levodopa testing appears to be an effective means for selection of patients with bone pain from recurrent breast cancer who will benefit from endocrine ablation. When the Levodopa test was negative for bone pain relief, endocrine ablation was of no benefit to the patient.

11. DOCID:23155 SCORE: 0.00305884864365039
DOCNO: 8689512
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: biosynthesis
AUTHOR: K Nishimura K
AUTHOR: M Higashino M
AUTHOR: T Hara T
AUTHOR: T Oka T
AFFILIATION: Department of Urology, Minoh City Hospital, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: International journal of urology : official journal of the Japanese Urological Association.
COUNTRY: JAPAN
TITLE: Bladder cancer producing granulocyte colony-stimulating factor: a case report.
PUBDATE: 19960301
A rare case of bladder cancer producing granulocyte colony-stimulating factor (G-CSF) is reported. A 63-year-old man with a progressive, grade 3 transitional cell bladder carcinoma, showed marked leukocytosis (maximum 181,800/mm3) and an elevated serum G-CSF to 131.7 pg/mL. After radical cystectomy and neoadjuvant chemotherapy, the tumor recurred locally. Immunohistochemical examination with monoclonal antibody specific for G-CSF revealed positive staining in the local recurrent tumor. To our knowledge, there have been only seven cases reported of bladder cancer producing G-CSF.

12. DOCID:3655 SCORE: 0.00300131222755286
DOCNO: 53505
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammography
QUALIFIER: diagnosis
AUTHOR: J Chamberlain J
AUTHOR: P Rogers P
AUTHOR: J L Price JL
AUTHOR: S Ginks S
AUTHOR: B E Nathan BE
AUTHOR: I Burn I
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Validity of clinical examination and mammography as screening tests for breast cancer.
PUBDATE: 19751101
This study is aiming to determine the validity and observer variability of clinical examination and mammography as screening tests for breast cancer. Women over the age of forty are given two independent clinical examinations of the breasts, and mammograms are taken and read independently by two radiologists. This paper presents the results of screening the first 1215 women to be enrolled in the study. At their first screening attendance, 231 women (19%) were referred for surgical opinion, 119 (9-8%) underwent biopsy, and cancer was diagnosed in 17 (1-4%). 2 further cancers were diagnosed in the ensuing six months among women who had been negative on initial screening, representing a false-negative rate of 2 out of 19 (11%). Clinical examination resulted in 189 referrals (15-6%), 90 biopsies (7-4%), and detected 11 cancers; corresponding figures for mammography were 76 referrals (6-3%), 55 biopsies ((4-5%), and 14 cancers. Observer variability was greater for clinical examination than for mammography. These early results suggest that as a screening test mammography compares favourably with clinical examination, but both tests are necessary if many false negatives are to be avoided.

13. DOCID:23530 SCORE: 0.00291537626713191
DOCNO: 8946611
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: N Harpaz N
AUTHOR: I C Talbot IC
AFFILIATION: Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in diagnostic pathology.
COUNTRY: UNITED STATES
TITLE: Colorectal cancer in idiopathic inflammatory bowel disease.
PUBDATE: 19961101
The development of colorectal cancer is the most serious long-term problem faced by patients with extensive ulcerative colitis and Crohn's colitis, with an incidence 20-fold higher and an average age of onset 20 years younger than colorectal cancer in the general population. This report summarizes the epidemiology, pathology, and recent advances in the molecular pathogenesis of colorectal cancer in inflammatory bowel disease and of its acknowledged precursor, mucosal dysplasia. It also reviews the rationale behind the use of endoscopic surveillance for dysplasia as a means of reducing cancer mortality, as well as some of the issues involved in its effective implementation.

14. DOCID:23695 SCORE: 0.00291304394909283
DOCNO: 8113901
AUTHOR: T Misaki T
AUTHOR: R Takeuchi R
AUTHOR: S Miyamoto S
AUTHOR: K Kasagi K
AUTHOR: Y Matsui Y
AUTHOR: J Konishi J
AFFILIATION: Department of Nuclear Medicine, School of Medicine, Kyoto University, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
COUNTRY: UNITED STATES
TITLE: Radioiodine uptake by squamous-cell carcinoma of the lung.
PUBDATE: 19940301
A patient with a history of total thyroidectomy for papillary carcinoma showed a solitary hot spot in the chest on post-therapy radioiodine imaging. Subsequent evaluation demonstrated that this lesion was a primary squamous-cell lung cancer. Our case illustrates a rare but important differential diagnosis from lung metastasis of thyroid cancer in 131I scintigraphy. Alternatively, this "aberrant uptake" might be a rather common phenomenon for lung neoplasms, although the underlying mechanism is not yet known. Future experimental studies might lead to a new application of radioiodine imaging in pulmonary oncology.